• Journal of Preventive Medicine and Public Health
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• 제31권4호
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• pp.828-843
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• 1998

To find the association of perception of health status with lifestyle of different ethnic groups living in north-eastern part of China, a cross-sectional questionnaire survey was done by 10 local health workers for 375 Korean immigrants and 217 Chinese whose age was 30 years old or more. Because Korean immigrants showed higher mortality than Chinese, we expected to find significant lifestyle related with perception of health status which was known to be a predictor of mortality by different ethnic groups. The results were as follows : 1. We found that 59.7% of Yanbian Koreans and 42.9% of Yanbian Chinese felt unhealthy (p=0.000). 2. For Yanbian Koreans, significant variables associated with perception of health status were selected through logistic regression analysis and they were sex; female to male with an OR=2.45 (95% confidence interval[CI] 1.06, 5.64), prevalence of chronic illness with an OR=5.48 (95% CI: 4.62, 15.56), mont of meal; small or moderate to full with an OR=2.67 (95% CI : 1.40, 5.09), preference of spicy food with an OR=1.78 (95% CI : 1.04, 3.04), and less amount intake of vitamin $B_2$, with an OR=2.29 (95% CI : 1.33, 3.93). 3. For Yanbian Chinese, significant variables associated with perception of health status were prevalence of chronic illness with an OR=4.97 (95% CI : 2.11, 11.68), history of taking ginseng with an OR=3.72 (95% CI : 1.33, 10.43), and less intake of vitamin C with an OR=0.18 (95% CI : 0.07, 0.46). In conclusion, sex, presence of chronic illness, dietary habit, and amount of $vitamin-B_1$ intake were associated with perception of health status in Yanbian Koreans. Presence of chronic illness, experience of ginseng intake, and amount of vitamin C intake were associated with perception of health status in Yanbian Chinese. To prove cause-effect relation between perception of health status and lifestyle, further study is needed for these different ethnic groups.

• Biomolecules & Therapeutics
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• 제28권4호
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• pp.320-327
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• 2020

In current study, we aimed to investigate whether the gentiopicroside (GPS) derived from Gentiana manshurica Kitagawa could block the progression of alcoholic hepatic steatosis to fibrosis induced by chronic ethanol intake. C57BL/6 mice were fed an ethanol-containing Lieber-DeCarli diet for 4 weeks. LX-2 human hepatic stellate cells were treated with GPS 1 h prior to transforming growth factor-β (TGF-β) stimulation, and murine hepatocyte AML12 cells were pretreated by GPS 1 h prior to ethanol treatment. GPS inhibited the expression of type I collagen (collagen I), α-smooth muscle actin (α-SMA) and tissue inhibitor of metal protease 1 in ethanol-fed mouse livers with mild fibrosis. In addition, the imbalanced lipid metabolism induced by chronic ethanol-feeding was ameliorated by GPS pretreatment, characterized by the modulation of lipid accumulation. Consistently, GPS inhibited the expression of collagen I and α-SMA in LX-2 cells stimulated by TGF-β. Inhibition of lipid synthesis and promotion of oxidation by GPS were also confirmed in ethanol-treated AML12 cells. GPS could prevent hepatic steatosis advancing to the inception of a mild fibrosis caused by chronic alcohol exposure, suggesting GPS might be a promising therapy for targeting the early stage of alcoholic liver disease.

• Journal of Ginseng Research
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• 제44권5호
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• pp.704-716
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• 2020

Background: Ginsenoside Rh2 (GRh2) is a characterized component in red ginseng widely used in Korea and China. GRh2 exhibits a wide range of pharmacological activities, such as anti-inflammatory, antioxidant, and anticancer properties. However, its effects on Toxoplasma gondii (T. gondii) infection have not been clarified yet. Methods: The effect of GRh2 against T. gondii was assessed under in vitro and in vivo experiments. The BV2 cells were infected with tachyzoites of T. gondii RH strain, and the effects of GRh2 were evaluated by MTT assay, morphological observations, immunofluorescence staining, a trypan blue exclusion assay, reverse transcription PCR, and Western blot analyses. The in vivo experiment was conducted with BALB/c mice inoculated with lethal amounts of tachyzoites with or without GRh2 treatment. Results and conclusion: The GRh2 treatment significantly inhibited the proliferation of T. gondii under in vitro and in vivo studies. Furthermore, GRh2 blocked the activation of microglia and specifically decreased the release of inflammatory mediators in response to T. gondii infection through TLR4/NF-κB signaling pathway. In mice, GRh2 conferred modest protection from a lethal dose of T. gondii. After the treatment, the proliferation of tachyzoites in the peritoneal cavity of infected mice markedly decreased. Moreover, GRh2 also significantly decreased the T. gondii burden in mouse brain tissues. These findings indicate that GRh2 exhibits an antieT. gondii effect and inhibits the microglial activation through TLR4/NF-κB signaling pathway, providing the basic pharmacological basis for the development of new drugs to treat toxoplasmic encephalitis.

• 한국지역지리학회지
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• 제17권1호
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• pp.122-139
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• 2011

연변지역은 문화 역사적으로 한국뿐만 아니라 중국에 있어서도 관심 지역이다. 연변지역에 대한 문화 역사적 연구는 많지만 유적 지도화에 대한 연구는 찾아보기 힘들다. 본 연구에서는 구글어스 영상을 이용하여 연변지역의 문화 역사 유적을 지도화하고 공간적 특징을 분석하고자 하였다. 석기시대부터 청나라까지 시기별로 문화 역사 유적 분포도를 제작하였다. 지도화 기호체계는 사기별로 색상기호와 유형별 기호를 제작하였다. 지도화 결과 연변지역에는 다른 시기와 비교해 발해와 요 금나라의 유적이 많은 비중을 차지하였다. 특히 고구려, 발해, 요 금나라의 유적은 시 공간적 누층구조를 보였다. 분포특정은 초기에 분지지역과 하천지역에 위치해 있었고, 역사시기 이후에는 구릉과 산지지역으로 이동하였다. 연구결과는 문화 역사 유적 관련 후속연구에 정보를 제공해 줄 수 있을 것으로 기대된다.

• Parasites, Hosts and Diseases
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• 제55권5호
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• pp.579-582
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• 2017

To investigate the prevalence of intestinal parasite infections in Yanbian Prefecture, Jilin Province, China, epidemiological surveys were conducted on a collaboration basis between the Korean Centers for Disease Control and Prevention and the Yanbian Center for Disease Control and Prevention. A total of 8,396 (males 3,737 and females 4,659) stool samples were collected from 8 localities and examined with the formalin-ether sedimentation technique, and additionally examined with the cellotape anal swab to detect Enterobius vermicularis eggs. The overall rate of intestinal parasites was 1.57%. The prevalence of Ascaris lumbricoides was the highest (0.80%), followed by Entamoeba spp. (0.23%), heterophyid flukes (0.15%), Clonorchis sinensis (0.08%), Enterobius vermicularis (0.07%), hookworms (0.06%), Trichostrongylus spp. (0.06%), Giardia lamblia (0.04%), Paragonimus spp. (0.02%), Diphyllobothrium spp. (0.02%), Trichuris trichiura (0.02%). The prevalence by sex was similar, 1.58% (n=59) in males and 1.57% (n=73) in females. By the present study, it is partly revealed that the prevalences of intestinal parasite infections are relatively low among the inhabitants of Yanbian Prefecture, Jilin Province, China.

• The Korean Journal of Physiology and Pharmacology
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• 제26권6호
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• pp.469-478
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• 2022

WNT signaling plays an important role in cardiac development, but abnormal activity is often associated with cardiac hypertrophy, myocardial infarction, remodeling, and heart failure. The effect of WNT signaling on regulation of atrial natriuretic peptide (ANP) secretion is unclear. Therefore, the purpose of this study was to investigate the effect of Wnt agonist 1 (Wnta1) on ANP secretion and mechanical dynamics in beating rat atria. Wnta1 treatment significantly increased atrial ANP secretion and pulse pressure; these effects were blocked by U73122, an antagonist of phospholipase C. U73122 also abolished the effects of Wnta1-mediated upregulation of protein kinase C (PKC) β and γ expression, and the PKC antagonist Go 6983 eliminated Wnta1-induced secretion of ANP. In addition, Wnta1 upregulated levels of phospho-transforming growth factor-β activated kinase 1 (p-TAK1), TAK1 banding 1 (TAB1) and phospho-activating transcription factor 2 (p-ATF2); these effects were blocked by both U73122 and Go 6983. Wnta1-induced ATF2 was abrogated by inhibition of TAK1. Furthermore, Wnta1 upregulated the expression of T cell factor (TCF) 3, TCF4, and lymphoid enhancer factor 1 (LEF1), and these effects were blocked by U73122 and Go 6983. Tak1 inhibition abolished the Wnta1-induced expression of TCF3, TCF4, and LEF1 and Wnta1-mediated ANP secretion and changes in mechanical dynamics. These results suggest that Wnta1 increased the secretion of ANP and mechanical dynamics in beating rat atria by activation of PKC-TAK1-ATF2-TCF3/LEF1 and TCF4/LEF1 signaling mainly via the WNT/Ca²⁺ pathway. It is also suggested that WNT-ANP signaling is implicated in cardiac physiology and pathophysiology.

• 한국자원식물학회:학술대회논문집
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• 한국자원식물학회 1996년도 International Symposium on the Development of Anti Cancer Resources From Plants및 1996년도 한국자원식물학회 정기학술 발표회
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• pp.12-12
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• 1996

• 한국지역지리학회지
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• 제14권2호
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• pp.93-104
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• 2008

이 논문은 연변지역의 농업 변화과정을 일제시기, 사회주의시기, 개혁개방시기 등 3개시기로 나누고 각 시기 연변지역의 농업이 외부환경의 변화에 따라 어떻게 시계열적으로 변화 발전되어 왔는지에 대해 살펴보았다. 그 결과를 요약하면 다음과 같다. 첫째, 일제시기 연변의 농경지는 이민정책, 자작농창정, 집단부락건설 등의 형식으로 일제의 수중에 집중되면서 자신들의 전쟁 수요와 국내 수요에 따라 농작물 재배를 통제할 수 있고 또한 농작물을 마음대로 약탈 할 수 있는 기반을 마련하여 전형적인 주변부 특징을 띠고 있었다. 둘째, 사회주의 시기 연변지역은 농촌의 인민공사화를 실현함에 따라 토지는 전부 국가소유로 되었다. 이와 같은 토지의 국가 소유는 농업생산에 있어 강력한 국가의 개입을 가능케 하였다. 그리하여 당시 계획경제체제 하에서 농업생산은 시장 논리에 의해 좌우된 것이 아니라 식량생산만을 중요시하는 '이양위강(以糧爲綱)'정책의 영향으로 농업 내부에 있어 경작업만 중요시하고 경작업 내부에서도 식량생산만을 중요시 하여 풍부한 자연자원을 효과적으로 이용할 수 없게 되었다. 셋째, 개혁개방 이후 농촌에서 호도거리책임제를 실시함에 따라 농민들이 토지를 장기간 임대할 수 있게 되어 농민들의 생산의지가 크게 고양되었다. 게다가 사회주의 상품경제에서 시장경제체제로 전이함에 따라 시장의 수요에 따라 농작물을 재배할 수 있게 되었다. 그리하여 연변지역의 농업은 전통적인 식량작물 생산 위주에서 점차 다각화 방향으로 발전하게 되었다.

• Journal of Animal Science and Technology
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• 제63권4호
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• pp.934-953
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• 2021

Ciglitazone is a member of the thiazolidinedione family, and specifically binds to peroxisome proliferator-activated receptor-γ (PPARγ), thereby promoting adipocyte differentiation. We hypothesized that ciglitazone as a PPARγ ligand in the absence of an adipocyte differentiation cocktail would increase adiponectin and adipogenic gene expression in bovine satellite cells (BSC). Muscle-derived BSCs were isolated from six, 18-month-old Yanbian Yellow Cattle. The BSC were cultured for 96 h in differentiation medium containing 5 µM ciglitazone (CL), 10 µM ciglitazone (CM), or 20 µM ciglitazone (CH). Control (CON) BSC were cultured only in a differentiation medium (containing 2% horse serum). The presence of myogenin, desmin, and paired box 7 (Pax7) proteins was confirmed in the BSC by immunofluorescence staining. The CL, CM, and CH treatments produced higher concentrations of triacylglycerol and lipid droplet accumulation in myotubes than those of the CON treatment. Ciglitazone treatments significantly increased the relative expression of PPARγ, CCAAT/enhancer-binding protein alpha (C/EBPα), C/EBPβ, fatty acid synthase, stearoyl-CoA desaturase, and perilipin 2. Ciglitazone treatments increased gene expression of Pax3 and Pax7 and decreased expression of myogenic differentiation-1, myogenin, myogenic regulatory factor-5, and myogenin-4 (p < 0.01). Adiponectin concentration caused by ciglitazone treatments was significantly greater than CON (p < 0.01). RNA sequencing showed that 281 differentially expressed genes (DEGs) were found in the treatments of ciglitazone. DEGs gene ontology (GO) analysis showed that the top 10 GO enrichment significantly changed the biological processes such as protein trimerization, negative regulation of cell proliferation, adipocytes differentiation, and cellular response to external stimulus. Kyoto Encyclopedia of Genes and Genomes pathway analysis showed that DEGs were involved in the p53 signaling pathway, PPAR signaling pathway, biosynthesis of amino acids, tumor necrosis factor signaling pathway, non-alcoholic fatty liver disease, PI3K-Akt signaling pathway, and Wnt signaling pathway. These results indicate that ciglitazone acts as PPARγ agonist, effectively increases the adiponectin concentration and adipogenic gene expression, and stimulates the conversion of BSC to adipocyte-like cells in the absence of adipocyte differentiation cocktail.

• 농촌계획
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• 제11권1호
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• pp.35-43
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• 2005

Practically, it is very hard to investigate the rural villages in North Korea. The Korean rural village in Yanbian is proximate from North Korea and most of inhabitants of the village have been emigrated from Hamgyeong-Do and Pyeongan-Do. In this sense, it can be meaningful to study Korean villages in Yanbian is an alternative approach toward researches of North Korean rural villages. In this study, spatial characteristics of the Ryongsan village, Ryongjeong city was studied as a representative korean rural village in Yanbian. The Ryongsan village has been formed based on the traditional culture and custom of North Korea. The case of planning and design is provided through drawings of components for planning of rural villages based on the results of spatial characteristics analysis.