• 대한핵의학회지
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• 제27권2호
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• pp.195-202
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• 1993

$^{123}Iodine$-metaiodobenzylguanidine (MIBG) which is a norepinephrine analogue, can be used to evaluate the sympathetic innervation of the heart. In this study, cardiac imaging with $^{123}I-MIBG$ was performed in patients with 9 dilated cardiomyopathy, 2 ischemic cardiomyopathy and 1 acute myocardial infarction to evaluate the sympathetic nervous function. $^{123}I-MIBG$ imaging showed multifocal defects (8), diffuse defect (2), near non-visualization (2). The defects of MIBG scans were found to be larger and more severe on 4 hours image than 30 minutes. Heart to lung, heart to mediastinum ratios were decreased at 4 hours than those at 30 minutes. Measured LVEF values were not correlated with the severity of MIBG uptake. $^{99m}Tc-MIBI$ imaging was also performed in all patients to find the relationship with $^{123}I-MIBG$ scan. $^{99m}Tc-MIBI$ scan showed multifocal defects in 9 patients, diffuse defects in 1 patient and no defect in 2 patients. The defects are similar in size, severity and extent, but more larger and severe on $^{123}I-MIBG$ imaging. Therefore, cardiac $^{123}I-MIBG$ imaging is a useful method to evaluate the sympathetic nervous function in cardiomyopathy.

• KIEE International Transactions on Electrophysics and Applications
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• 제5C권6호
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• pp.251-256
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• 2005

Directionally melt-textured high $T_c\;(Y_{0.5}Nd_{0.25}Sm_{0.25})Ba_{2}Cu_{3}O_y$ [(YNS)-123] superconductor was systematically investigated by the zone melt growth process in air. A sample prepared by this method showed well-textured microstructure, and $(Y_{0.5}Nd_{0.25}Sm_{0.25})_{2}BaCuO_5$[(YNS)211] inclusions were uniformly dispersed in large $(Y_{0.5}Nd_{0.25}Sm_{0.25})Ba_{2}Cu_{3}O_y$ [(YNS)123] matrix. High irreversibility field and magnetization hysteresis loop of the zone melt-textured (YNS)-123 sample exhibited the enhanced flux pinning, compared with $YBa_{2}Cu_{3}O_y$ (Y-123) sample without RE(rare earth). Critical current density of (YNS)-123 sample was $2.5{\times}10^4\;A/cm^2$ at 2 T and 77 K.

• 한국의학물리학회지:의학물리
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• 제7권1호
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• pp.79-89
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• 1996

목적 : $^{99m}Tc$, $^{123}I$, $^{131}I$과 lucite cylindrical phantom 을 이용 갑상선 탐침 (thyroid probe)의 계수불능시간 (dead time)을 알아본 후 그의 보정방법에 대해 알아보고자 하였다. 재료 및 방법 : 갑상선 탐침과 lucite cylindrical phantom 을 사용하여 $^{99m}Tc$ 10.5mCi는 약 43시간, $^{123}I$ 2.08mCi는 약 79시간동안 2시간 간격으로, $^{131}I$ 2.06mCi 는 약 910시간 동안 6시간 간격으로 medical spectrometer를 통해 계수하였다. 이때 실제 선량과 계수곡선을 이용 계수불능시간의 영향을 받기 시작하는 지점을 측정하기 위해 매 실험시 dose calibrator를 사용하여 선량을 측정하였다. 결과 : $^{99m}Tc$ 은 모든 거리에서 약 0.80mCi, $^{123}I$은 1.00mCi 지점에서 dead time의 영향을 받기 시작했다. 20%의 계수손실이 일어나는 지점에서의 방사능세기는 이 $^{99m}Tc$의 경우는 1.29 (center), 1.28(2cm), 1.31(4cm), 1.13(6cm)mCi 이었고 $^{123}I$은 1.39mCi 이었다. 각 방사능핵종에 대한 correction factor값의 일예로 선량이 2mCi 일 때 $^{99m}Tc$의 경우는 각각 1.52 (center), 1.52(2cm), 1.50(4cm), 1.58(6cm)이였고 $^{123}I$의 경우는 1.58이었다.

• 약학회지
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• 제49권2호
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• pp.185-191
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• 2005

The absorption of a P-gp substrate, rhodamine 123, from a liposomal dosage form was investigated across Caco-2 cell monolayers, rat intestines and rat intestinal Peyer's patches in Ussing chamber, Rhodamine 123 was incorporated into liposomes according to the standard evaporation method, which led to a production of liposomes with a mean diameter of 71.3 nm. The permeability (Papp of rhodamine 123 from a water solution across the monolayer was $2.45{\times}10^{-6}$ cm/s for $A{\leftrightarrow}B$ (apical to basal) and $14.0{\times}10^{-6}$ cm/s for $B{\leftrightarrow}A$ (basal to apical) directions, consistent with the fact that rhodamine 123 is one of the P-gp substrates. The transport of rhodamine 123 from the liposomal dosage form was much lower for both directions compared to the solution of rhodamine 123. The transport of rhodamine 123 across the rat intestine was also significantly decreased for both directions, I.e., influx and efflux, by the liposomal incorporation of the compound. The transport of rhodamine 123 across the Peyer's patch was substantially reduced by liposomal incorporation. No difference was found in the transport between the Peyer's patch and non-Peyer's patch. These observations suggest that the contribution of transport via Peyer's patches in the uptake of liposomes may be minimal, especially for rapidly absorbed compounds like rhodamine 123. Therefore, the increased absorption of P-gp substrates does not appear to be feasible by incorporating the compounds in liposomes, due to negligible involvement of Peyer's patches in the uptake of particulate dosage forms like liposomes. Liposomes may rather represent a sustained release dosage form of incorporated compounds.

• Progress in Superconductivity
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• 제14권1호
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• pp.39-44
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• 2012

The fabrications condition and superconducting properties of top-seeded melt growth (TSMG) processed $GdBa_2Cu_3O_{7-y}$ (Gd123) bulk superconductors were studied. Processing parameters (a maximum temperature ($T_{max}$), a temperature for crystal growth ($T_G$) and a cooling rate ($R_G$) through a peritectic temperature ($T_P$) for the fabrication of single grain Gd123 superconductors were optimized. The magnetic levitation forces, trapped magnetic fields, superconducting transition temperature ($T_c$) and critical current density ($J_c$) of the Gd123 bulks superconductors were estimated. Single grain Gd123 bulk superconductors were successfully fabricated at the optimized processing condition. The $T_c$ of a TSMG processed Gd123 sample was 92.5 K and the $J_c$ at 77 K and 0 T was approximately $50kA/cm^2$. The trapped magnetic field contour and magnetic levitation forces were dependent on the top surface morphology of TSMG processed Gd123 samples. The single grain Gd123 samples, field-cooled at 77 K using a Nd-B-Fe permanent magnet with 5.27 kG and 30 mm dia., showed the trapped magnetic field contour of a single grain with a maximum of 4 kG at the sample center. The maximum magnetic levitation forces of the single grain Gd123 sample, field-cooled or zero field-cooled, were 40 N and 107 N, respectively.

• 한국정밀공학회:학술대회논문집
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• 한국정밀공학회 2010년도 추계학술대회 논문집
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• pp.365-366
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• 2010

• 대전발전포럼
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• 통권32호
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• pp.123-123
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• 2010

• 월간 닭고기
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• 제17권8호
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• pp.123-123
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• 2011

• 프린팅코리아
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• 통권60호
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• pp.123-123
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• 2007

• 한국생태학회:학술대회논문집
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• 한국생태학회 1998년도 춘계공동 학술발표대회
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• pp.123.2-123.2
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• 1998