• Clinical and Experimental Reproductive Medicine
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• v.24 no.2
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• pp.233-239
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• 1997

Embryos of most mammalian species grown in vitro would undergo developmental arrest at the approximate time of genomic activation. Stage-specific cell block and the resulting rapid loss of embryo viability in conventional culture media have limited the duration for which embryos may be cultured prior to transfer. As a result, embryos are usually transferred to the uterus at the 4-to 8-cell stage to avoid the loss of viability associated with long-term in vitro culture. Early transfer has led to asynchrony of the endometrium-trophectoderm interaction at the time of implantation and a resultant reduction in the rate of implantation. To overcome these problems, a variety of co-culture systems has been devised in which embryos can develop for a longer period prior to embryo transfer. Vero cells, derived from African green monkey kidney, share a common embryologic origin with cells from the genital tract. In addition, they are potentially safe to use, since they are highly controlled for viruses and other contaminants. Therefore, co-culture using Vero cells has been widely utilized to enhance embryo viability and development, although not without controversies. We thus designed a series of experiments to demonstrate whether Vero cells do indeed enhance mouse embryo development as well as to compare the efficacy of co-culturing mouse 1-cell embryos on Vero cell monolayer in both Ham's F-10 and human tubal fluid (HTF) culture media. 1-cell stage ICR mouse embryos were cultured either in the presence of Vero cells (Group A) or in conventional culture medium alone (Group B). In Ham's F-10 significantly more 3-to-8cell embryos developed in group A than group B (59.8 versus 10.0%; p<0.01). In contrast, there was no significant difference in embryonic development both group A and group B in HTF. However, significant differences were noted only in later embryonic stage (13 and 0%; p<0.05 of group A and B respectively, hatching or hatched). In Ham's F-10, we also could observe the beneficial effect of Vero cell on hatching process (70.7 and 42.1%; p<0.05 of group A and group B respectively).

• Journal of Convergence for Information Technology
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• v.9 no.12
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• pp.1-7
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• 2019

As the cloud environment has become more prevalent among large companies, small and medium-sized companies are also trying to utilize various technologies (IoT, blockchain, etc.) that use cloud services as a way to coexist with large companies. In this paper, a blockchain-based IoT information collection model is proposed to efficiently handle large volumes of IoT data produced by small businesses in order to improve information efficiency of SMEs. The proposed model allowe d small businesses to improve their production efficiency by independently creating groups of the same information so that data that could be generated at the endpoints of small businesses can be block-chained and forwarded to the data center for analysis. In addition, the proposed model's performance assessment was assumed to handle the production throughput of data processed in IoT for small and medium businesses, not large enterprises, so the link between large volumes of data processed in the proposed model could be maintained evenly. One of the biggest features of the proposed model is the ability to expand processes to efficiently control the information of prod ucts produced, as well as the productivity of small and medium enterprises.

• Journal of the Korean Society for Railway
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• v.17 no.5
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• pp.328-335
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• 2014

Numerical prediction methods were applied to investigate the turbulent air currents and air-conditioning efficiency in an underground subway station, and the results compared to experimental data. The Shin-gumho Station($8^{th}$ floor underground and 43.6m in depth) in Seoul was selected for the analysis. The entire station was covered for simulation and the ventilation mode was ordinary. The ventilation diffusers were modeled as 95 square shapes of $0.6m{\times}0.6m$ in the lobby and as 222 square shapes in the platform. Cooling air of $47,316m^3/h$ was supplied and the returned air of $33,980m^3/h$ is exhausted in the lobby and the cooling air of $33,968m^3/h$ is supplied and the returned air of $76,190m^3/h$ was exhausted in the platform which is the same as the experimental data. The cases of the screen-door-closed and open were respectively investigated. A total of 7.5million grids were generated and the whole domain divided into 22 blocks for MPI efficiency of calculation. Large eddy simulation (LES) was applied to solve the momentum and energy equation.

• Journal of Adhesion and Interface
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• v.8 no.2
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• pp.15-21
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• 2007

To prepare a natural rubber-based pressure-sensitive adhesive (PSA) for protection film of opto- functionalized sheet, natural rubber (NR) was blended with a DCPD type tackifier and three types of aliphatic hydrocarbon resins, respectively. Also, to supply low cohesion strength of NR, in the fixed ratio of tackifier, synthetic rubber, styrene-isoprene-styrene (SIS) block copolymer was blended with NR as a function of SIS contents. PSA performance of prepared PSAs was evaluated using probe tack and peel strength. Probe tack of NR/tackifier blends was increased with increasing tackifier contents, and showed maximum peak. In addition, probe tack of NR/tackifier blends slightly increased with increasing softening point of aliphatic hydrocarbon resins. Their peel strength increased up to 50 wt% of tackifier contents, but in the over contents of tackifier, they showed stick-slip failure mode. Finally, probe tack of NR/SIS/tackifier blends showed the maximum values at 20~40 wt% of tackifier contents, but at 20 wt% of tackifier contents, they showed fibrillation. For this reason, peel strength showed maximum values at 40 wt% of tackifier contents.

• Journal of the Society of Cosmetic Scientists of Korea
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• v.34 no.3
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• pp.217-223
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• 2008

Elastin is an important component of elastic fibers in the skin. Recently, many studies have reported that elastin is also involved In inhibiting or repairing wrinkle formation, although collagen is a major factor in the skin wrinkle formation. Elastase is a metalloproteinase which acts on degradation of elastin. It is known that elastase activity is increased by ultraviolet (UV) B radiation. Thus, Increased elastase activity could be the major reason for skin elasticity reduction and winkle formation. Tannic acid is a polyphenol found in various fruits and nuts. This molecule has a potent ability to eliminate reactive oxygen species and reactive nitrogen species. In the present study, we investigated whether tannic acid has effects on elastase activity and tropoelastin synthesis. Our results showed that tannic acid reduced elastase activity significantly in a dose-dependent manner. However, the expression of tropoelastin protein and mRNA was not significantly affected by tannic acid. From these results, we suggest that tannic acid may contribute to block tortuosity of elastic fibers by inhibiting elastase. Thus, tannic acid might be developed for a possible agent to Inhibit skin aging.

• Journal of the Korea Society of Computer and Information
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• v.18 no.12
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• pp.1-9
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• 2013

Even though the multiple pages TLB are effective in improving the performance, a conventional method with OS support cannot utilize multiple page sizes in user application. Thus, we propose a new multiple-TLB structure supporting multiple page sizes for high performance and low power consumption without any operating system support. The proposed TLB is organised as two parts of a S-TLB(Small TLB) with a small page size and a L-TLB(Large TLB) with a large page size. Both are designed as fully associative bank structures. The S-TLB stores small pages are evicted from the L-TLB, and the L-TLB stores large pages including a small page generated by the CPU. Each one bank module of S-TLB and L-TLB can be selectively accessed base on particular one and two bits of the virtual address generated from CPU, respectively. Energy savings are achieved by reducing the number of entries accessed at a time. Also, this paper proposed the simple 1-bit LRU policy to improve the performance. The proposed LRU policy can present recently referenced block by using an additional one bit of each entry on TLBs. This method can simply select a least recently used page from the L-TLB. According to the simulation results, the proposed TLB can reduce Energy * Delay by about 76%, 57%, and 6% compared with a fully associative TLB, a ARM TLB, and a Dual TLB, respectively.

• Korean Journal of Optics and Photonics
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• v.21 no.3
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• pp.123-128
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• 2010

Sum frequency generation was utilized to obtain a yellow laser with the wavelength of 578.4 nm for a probe laser of an Yb lattice clock. The output of an Nd:YAG laser with wavelength of 1319 nm and that of an Yb-fiber laser with wavelength of 1030 nm were passed through a waveguided periodically-poled lithium niobate (WG-PPLN) for sum frequency generation. It is required that the probe laser has a linewidth of the order of 1 Hz to fully resolve the Yb lattice clock transition. Thus, the linewidth of the probe laser was reduced by stabilizing the frequency to a super-cavity. This was made of ULE with a low thermal expansion coefficient, and was mounted on an active vibration-isolation table at the optimal point for the reduced sensitivity to vibration. Also, this was installed in a vacuum chamber, and the temperature was stabilized to 1 mK level. This system was installed in an acoustic enclosure to block acoustic noise. The finesse of the super-cavity was measured to be 380 000 from the photon life time of the cavity.

• The Journal of Korean Society for School & Community Health Education
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• v.4
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• pp.61-78
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• 2003

This research was conducted to identify the factors that cause school related stress among middle school students, and to develop countermeasures in order to prevent the rebellious acts of middle school students that are on the rise and to pursue after effective guidance measures. To achieve these research objectives, 856 questionnaires were distributed to the two middle schools, situated in Goyang-si, Gyeonggi Province, and these questionnaires were analyzed, using the SPSS statistical package program. The conclusions were as follows; 1. Perceived factors for School Related Stress Overall average of the perceived degree school related stress factors was a level that goes beyond the normalcy. Stress on the grade was the highest Among these, the average of question items that addressed decrease in grade was the highest of all items followed by class factors, teacher-related factors, friend-related factors, and environmental factors. Accordingly, this research demonstrated that the students feel pressured by the university entrace examination and a school life that is focused on grades. The teacher-related factors and class factors were higher than the average, and others were relatively low. 2. School Related Stress according by Individual All the factors for school related stress were statistically significant difference according to the gender, and teacher-related factors, class factors, and environmental factors were statistically significant difference according to their school years. Their grade made their grade factors statistically significant difference, and the number of friends produced a statistically significant difference result on the teacher-related factors. Wheather they had extra classes or not made a statistically significant difference result on the class factors and environmental factors, and especially the time of doing physical exercises produced statistically significant difference on the environmental factors. 3. Countermeasures for School Related Stress according by Individual As for the countermeasures for school related stress according to the individuality, the active reacting was statistically significant difference according to the gender index, and the student's degree to react passively was statistically significant difference according to their grade. The students in different school years showed statistically significant difference reactions in both passive ways and active ways. students tended to react differently in an unreality index. Lastly, Wheather they had extra classes and physical exercises made then to react passively or actively. When the results are compiled, students are most affected by the stress related to grades, which reflected the university entrance examination oriented school life. An alternative is that the development of educational program that factors in the students' talents and aptitude is needed urgently. Moreover, character and career path related guidance and education are just as important as the academics. Given that the stress factors exert some degree of influence on the countermeasures, it is necessary to block the factors in advance and for all the teachers and parents to make an effort to react actively.

• The Journal of Society for e-Business Studies
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• v.23 no.3
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• pp.13-32
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• 2018

Btcoin has made a big progress through anonymity, decentralized authority, sharing economy, multi-ledger book-keeping, block-technology and the convenient financial vehicle. Bitcoin has the characteristics of mining and supply by decentralized suppliers, limited supply quantity and the partial money-like function as well as gold. The paper studies the hedge and safe-haven of Bitcoin and gold on daily frequency data over the period of July 20, 2010-Dec. 27, 2017 employing Asymmetric Vector GARCH. It finds that gold has the hedge and safe-haven against inflation and capital markets while Bitcoin has the weak hedge and the weak safe-haven. It shows insignificant effects of inflations of US and Korea on the volatilities of Bitcoin and gold. It also suggests the necessity of clearing of vagueness behind the anonymity for fair and transparent trade through the law application in the absence or fault in law (Lucken im Recht). following the spirit of the living constitution (lebendige gutes Recht oder Vorschrift). The relevant institutions are hoped to be given some of obligations such as registration, minimum required capital. report, disclosure, explanation, compliance and governance with autonomous corresponding rights. The study also suggests the reestablishment of the relevant financial law and taxation law. The hedge would not be successfully accomplished without the vigilant cautions of investors.

• Journal of Korean Home Economics Education Association
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• v.33 no.4
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• pp.65-84
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• 2021

The purpose of this study was to develop and evaluate the Home Economics(HE) Flipped Problem-Based Learning(FPBL) education plans focusing on 'food selection and storage' unit for middle school students. The results of this study are as follows. First, middle school students who participated in the class had mainly experienced lecture-style classes previously, but they preferred group activity classes to lecture-style classes. Their 'preferred on-line class tools' was 'Miricanvas', and the 'helpful on-line class tools for learning' was 'Tinkerbell'. Second, the HE FPBL education plan was designed and developed to conduct block time classes, twice a week for 3 weeks by applying the '13 stages of FPBL'. The main topic of the class is "food selection and storage that protects health and the environment". The practical and unstructured problems in the FPBL was to participate in the 'Food Selection and Storage to Protect Health and Environment' mission development contest of a TV entertainment program. Learning materials(stepping video, reading materials, activity sheets, and evaluation tools for process-based evaluation) were developed. The 206 senior students at a middle school in Haeundae-gu, Busan, took the class for three weeks and evaluated it as a good class that helps them learn, is satisfactory, interesting, and suitable, leads to class participation, and is differentiated from other teaching methods.