• Journal of Digital Convergence
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• v.13 no.7
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• pp.445-452
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• 2015

This study examined the effects of task-oriented occupational therapy without action observation training and action observation on hemiplegic patients' upper extremity functions and activities of daily living. The stroke patients were randomly and equally assigned to an experimental group (action observation) and a control group (task-oriented occupational therapy). They received the intervention five times per week, 30 minutes per each time, for five weeks. In order to look at upper extremity functions of the paretic side before and after the intervention, Jebsen-Taylor Hand Function Test (JTHFT) and Box and Bock Test (BBT) were conducted and in order to compare activities of daily living, Korean-Version of Modified Barthel index (K-MBI) was examined. According to the results, upper extremity functions and activities of daily living in both groups increased and there was no difference between the two groups. Therefore, action observation and task-oriented occupational therapy had positive effects on stroke patients' upper extremity functions and activities of daily living.

• Journal of the Society of Naval Architects of Korea
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• v.50 no.5
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• pp.324-333
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• 2013

Recently, rudder erosion due to cavitation has been frequently reported on a semi-spade rudder of a high-speed large ship. This problem raises economic and safety issues when operating ships. The semi-spade rudders have a gap between the horn/pintle and the movable wing part. Due to this gap, a discontinuous surface, cavitation phenomenon arises and results in unresolved problems such as rudder erosion. In this study, we made a rudder model for 2-D experiments using the NACA0020 and also manufactured gap flow blocking devices to insert to the gap of the model. In order to study the gap flow characteristics at various rudder deflection angles($5^{\circ}$, $10^{\circ}$, $35^{\circ}$) and the effect of the gap flow blocking devices, we carried out the velocity measurements using PIV(Particle Image Velocimetry) techniques and cavitation observation using high speed camera in Seoul National University cavitation tunnel. To observe the gap cavitation on a semi-spade rudder, we slowly lowered the inside pressure of the cavitation tunnel until cavitation occurred near the gap and then captured it using high-speed camera with the frame rate of 4300 fps(frame per second). During this procedure, cavitation numbers and the generated location were recorded, and these experimental data were compared with CFD results calculated by commercial code, Fluent. When we use gap flow blocking device to block the gap, it showed a different flow character compared with previous observation without the device. With the device blocking the gap, the flow velocity increases on the suction side, while it decreases on the pressure side. Therefore, we can conclude that the gap flow blocking device results in a high lift-force effect. And we can also observe that the cavitation inception is delayed.

• The Korean Journal of Zoology
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• v.33 no.1
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• pp.108-118
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• 1990

Fibronectin is a glycoprotein found in the extracellular matrix as well as in the serum, and has been known to exert pronouned effed on the myoblast fusion. Our previous studies have suggested that the decrease of fibronectin levels during myogenesis is due to the decreased availability of the receptor for the 28 kDa fragrnent of fibronetin. In the fusion-blocked myoblasts by EGTA, the levels of fibronetin and binding of 28 kDa fragment decreased but far less than the control level. In contrast, the levels of fibronetin and binding of 28 kDa fragment decreased to the control level in the myoblast released from the fusion block. On this account, we suggest that the decrease of fibronetin levels during myoblast fusion is closely associated with the loss or alteration of the receptor for 28 kDa fragment. Mild trypsin treatment decreased the binding of the 28 kDa fragment to the myoblasts significandy. Similarly, the presence of gangliosides in the binding media decreased the binding of the 28 kDa fragment in a dose-dependent manner. Furthermore, gel overlay of 125 I-28 kDa fragment on the SDS-PAGE of the myoblast homogenates revealed that the 28 kDa fragment bound to a 43 kDa protein and to gangliosides as well. These results suggest that myoblast fusion is correlated with decrease of the receptor for the 28 kDa fragment and that the receptor might be a glycoprotein that contains glyco-conjugate found in gangliosides.

• Radiation Oncology Journal
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• v.22 no.1
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• pp.69-75
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• 2004

Purpose : A new fiduciary plate and orientation marker have been devised to assist the quality assurance (QA) procedures for port films in radiation therapy department. The plate is used in conjunction with the film/cassette combination during weekly QA procedures, at Seoul National University Hospital (SNUH), in order to verify treatment fields in high radiation therapy. Materials and Methods : A new fiduciary plate was fabricated using an acrylic plate, cerrobend, standard blocking tray and mercury. The acrylic plate had the dimension of $1{\times}25{\times}25$ cm, with two fiduciary markers. The plate was rigidly attached onto the standard blocking tray, thus making it easier to set the fiduciary plate to the center on the radiation field on the linear accelerator. The plate had two 2-mm vertical and horizontal lines, with the minor scales in 2-cm steps. The orientation marker was a small mercury filled disk, which was inserted into the plate. Results : The geometrical structure of the lines in the plate makes it easier to correlate two different images between the simulation and port films. The marker clearly indicated the orientation of the film, for example, the anterior, posterior, left, right and various oblique orientations, without the placement of a conventional orientation marker. Also, the new orientation marker could easily be applied to the simulator by placing the small orientation marker onto the image intensifier or in front of the film/cassette holder. Conclusions : The new fiduciary plate appears to be useful in verifying the treatment fields, and the new orientation marker makes the film orientation simple, which is expected to lower the block fabrication errors.

• Journal of Life Science
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• v.18 no.3
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• pp.336-343
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• 2008

Histone deacetylases (HDACs) inhibitors have emerged as the accessory therapeutic agents for various human cancers, since they can block the activity of specific HDACs, restore the expression of some tumor suppressor genes and induce cell differentiation, cell cycle arrest and apoptosis in vitro and in vivo. In the present study, we investigated that the effect of trichostatin A (TSA), an HDAC inhibitor, on the cell growth and apoptosis, and its effect on the nuclear factor-kappaB $(NF-{\kappa}B)$ activity in 267B1 human prostate epithelial cells. Exposure of 267B1 cells to TSA resulted in growth inhibition and apoptosis induction in and dose-dependent manners as measured by fluorescence microscopy, agarose gel electrophoresis and flow cytometry analysis. TSA treatment inhibited the levels of IAP family members such as c-IAP-1 and c-IAP-2 and induced the proteolytic activation of caspase-3, -8 and -9, which were associated with concomitant degradation of poly (ADP-ribose)-polymerase, ${\beta}-catenin$ and laminin B proteins. The increase in apoptosis by TSA was connected with the translocation of $NF-{\kappa}B$ from cytosol to nucleus, increase of the DNA binding as well as promoter activity of $NF-{\kappa}B$, and degradation of cytosolic inhibitor of KappaB $(I{\kappa}B)-{\alpha}$ protein. We therefore concluded that TSA demonstrated anti-proliferative and apoptosis-inducing effects on 267B1 cells in vitro, and that the activation of caspases and $NF-{\kappa}B$ may play important roles in its mechanism of action. Although further studies are needed, these findings provided important insights into the possible molecular mechanisms of the anti-cancer activity of TSA.

• Elastomers and Composites
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• v.48 no.3
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• pp.225-231
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• 2013

In this study, we observed the effect of carboxylated SBR latex and zinc oxide on styrene-butadiene-styrene( SBS) composites for improving abrasion and debris. SBS composite, which added only silica, showed poor mechanical properties, NBS abrasion, and debris, caused by strong filler-filler interaction of silica. In case of adding carboxylated SBR latex, mechanical properties, NBS abrasion and debris of SBS composite were improved. Because of carboxyl group of carboxylated SBR latex interacted with silanol group of silica. Both carboxylated SBR latex and zinc oxide were added, SBS composite showed highest mechanical properties, NBS abrasion, and debris by forming ion cluster between carboxylated SBR latex and zinc oxide. By FT-IR analysis, ion clusters were confirmed that observed zinc carboxylated group stretch peak at $1550{\sim}1650cm^{-1}$ range. SBS composite, SC-4, showed excellent mechanical properties ; tensile strength $156kgf/cm^2$, elongation 936%, tear strength 59.4kgf/cm ; and excellent abrasion characteristics ; NBS abrasion 338%. Also, debris of SC-4 was minimized and showed wave-shape in fracture surface.

• Korean Journal of Plant Resources
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• v.22 no.1
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• pp.96-101
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• 2009

Dokdo was formed since when four million six hundred thousand to two million five hundred thousand. Dokdo, Ulreung Island and the mainland in Korea are not touch each other since the formation, therefore, Dokdo are very important island for discussion of plant evolution from plant geography point of view. Plants of Dokdo was enlisted as 60 taxa, 27 families, 52 genera, 50 species and 10 varieties. The naturalized plants of a wide sense is composed of 25 taxa, two tree species as Lonicera morrowii and Elaeagnus macrophylla, and 23 herbs. The naturalized plants were identified of 5 species as Sonchus oleraceus, Brassica juncea var. integrifolia, Rumex crispus, Chenopodium album, and Bromus unioloides. Total naturalized plants are 32 taxa, ratio of total naturalized plants per a existing species was 60 percentage. Accordingly Vegetational environment of Dokdo was interpreted very incomplete state as well as severe ecological disturb by invade species. Preparation of a regulating plan on naturalized plants and concern of a policy decision are requested in the conservational dimension for native species in Dongdo. For the conservation of native species in Dokdo, there are prepared that a regulating plan as block of the influx and eradication etc. and a policy decision of naturalized plants are prepared for view of the conservation for native species in Dokdo.

• Fire Science and Engineering
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• v.25 no.6
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• pp.21-26
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• 2011

The purpose of this paper is to present the damage patterns of cellular phone (SCH_W830) batteries according to energy sources and have them utilized as data for the settlement of disputes between manufactures and consumers. The reliability was secured by maintaining the ambient temperature and humidity at $22{\pm}2^{\circ}C$ and 40~60 %, respectively. The voltage of the battery used for the tests was measured to be 4.18V between positive pole (+) and negative pole (-)(1), and 4.19 V between positive pole (+) and negative pole (-)(2). This study applied the Korean Industrial Standard (KS) to the flammability test of cellular phones due to a general flame applied to them and found that no damage occurred to the built-in battery even though the flame was applied to the cases of cellular phones for 30 seconds. From the results of immersing the cellular phones in the saline solution (NaCl, 0.9 %) for 180 seconds, it was found that there was a trace of carbonization and melting due to the heat caused by leaking current. It can be seen that when the cellular phones were heated for 70 seconds using a microwave oven (MWO), the areas containing the metal holder, recharging connector, antenna, etc., were melted and discolored and that other areas showed no particular problems. That is, while the external carbonization of cellular phones, built-in metals and dielectric materials, and damage and deformation of the battery terminal block, etc., occurred differently depending on the types of energy sources, the voltage showed comparatively constant characteristics. Therefore, it is thought to be possible to attribute the cause of damage to the battery by performing analysis taking into consideration comprehensively the characteristics of the flame spread pattern as well as the melting and deformation of metals.

• Journal of the Mineralogical Society of Korea
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• v.18 no.3 s.45
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• pp.205-214
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• 2005

Some Quaternary faults developed in the eastern block of the Ulsan fault are Gaegok 1, Gaegok 2, Singye, Madong, Wonwonsa and Jinhyeon faults, which are characterized by thin gouge and narrow cataclasitic tones. This study was performed to emphasize the role of mineral alteration and microtexture in response to hydrothermal alteration of fault gouges during fault activity, using XRD, EPMA, BSE (backscattered electron image), and K-Ar age dating methods. Alteration minerals in fault gouges were formed in the age range of $44.3\~28.9Ma$ by hydrothermal alteration attributed to fault activity. XRD results show that fault gouges consist predominantly of clay minerals, quartz and feldspars. Clay minerals formed in the gouge zones are mainly composed of smectite with trace chlorite, illite and kaolinite. The evidence to support the hydrothermal alteration of preexisting minerals due to fault activity are easily recognized at the host rocks in contact with gouges zones. Injected gouge and calcite veins indicate that they were originated from multiple deformation by repeated fault activity. Gouge with green or greenish grey color, for example Jinhyeon fault, contains higher $Al_2O_3$ and lower MgO and CaO compared to those with reddish color. Various colors of fault gouge are intimately related to the chemical compositions of main constituent mineral as well as mineral assemblage.

• Korean Journal of Microbiology
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• v.31 no.1
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• pp.72-78
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• 1993

Since the 'promoter/enhancer region of the major immediate early (IE) ~ene of human cytomegalovirus (HCMV) contains the cyclic AMP (cAMP) response element (CRE) consensus sequence, it was reasonable to hypothesize that cAMP might affect HCMV replication. Cyclic AMP modulating drugs such as 8-bromoadenosine 3',5'-cyclic monophosphate (BrA), and papaverine were used to affect the intracellular levels of cAMP, and the effects of the drugs on HCMV replication were studied. While papaverine effectively inhibited HCMV multiplication and DNA synthesis, BrA exerted little effect on the production of infectious HCMV yields. The synthesis of DNA in HCMV-infected cells appeared to be stimulated by BrA In order to understand the effect of cAMP on the expression of HCMV major IE gene, plasmid (pCMVIE/CAT) containing a reporter gene driven by HCMV IE promoter was transfected into either permissive human embryo lung (HEL) cells or nonpermissive cells. PL,Javerine, which has been reported to block the HCMV-induced increase in cAMP, reduced the expression of pCMVIE/CA T in permissive HEL cells. Treatment of transfected cells with BrA increased the expression of HCMV major IE promoter not only in HEL cells, but also in nonpermissive HeLa and Vero cells. Therefore, it seems that the expression of HCMV major IE gene is regulated by cAMP.