• Wind and Structures
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• 제29권4호
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• pp.235-246
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• 2019

Wind loading is one of important loadings that should be considered in the design of large hyperbolic natural-draught cooling towers. Both external and internal surfaces of cooling tower are under the action of wind loading for cooling circulating water. In the previous studies, the wind loads on the external surface attracted concernedly attention, while the study on the internal surface was relatively ware. In the present study, the wind pressure on the internal surface of a 220 m high cooling tower is measured through wind tunnel testing, and the effect of ventilation rate of the packing layer on internal pressure is a major concern. The characteristics of internal wind pressure distribution and its effect on wind-induced responses calculated by finite element method are investigated. The results indicate that the wind loading on internal surface of the cooling tower behaves remarkable three-dimensional effect, and the pressure coefficient varies along both of height and circumferential directions. The non-uniformity is particularly strong during the construction stage. Analysis results of the effect of internal pressure on wind-induced responses show that the size and distribution characteristics of internal pressure will have some influence on wind-induced response, however, the outer pressure plays a dominant role in the wind-induced response of cooling tower, and the contribution of internal pressure to the response is small.

• 대한한의학원전학회지
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• 제32권2호
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• pp.33-47
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• 2019

Objectives : To review the meaning of Open-Close-Pivot and its transition over time. Methods : Annotations and explanations in chapters where the theory of Open-Close-Pivot originated from in the "Suwen(素問)" and "Lingshu(靈樞)" were examined, followed by philological examination of key physicians. Results & Conclusions : Yang Shang Shan(楊上善) compared the 'Open-Close-Pivot' to a door. Wang Bing(王冰) explained it's movement and stillness to be the principle behind the Three-Yin-Three-Yang's threefold division. Wang Ji(汪機), in "XuSuwenChao(續素問鈔)" explained its physiological function as the entering and exiting of Ying Wei(營衛), and its scope to be exterior, interior, and center. Ma Shi(馬蒔) stratified it similar to "Shanghanlun(傷寒論)"'s six stages, while Wu Kun(吳崑) categorized Shaoyang(少陽) as being in-between exterior and interior. Zhang Jing Yue(張景岳) suggested a standard for the entering-exiting and exterior-interior-center concepts of the Open-Close-Pivot. Zhang Zhi Cong(張志聰) argued a theory of Open-Close-Pivot that emphasized the meaning of Three-Yin-Three-Yang, while Gao Shi Zong(高士宗) explained the relationship between Open, Close, Pivot and the functioning process. Shi Shou Tang(石壽棠) explained the physiology and pathology in the actions among Open-Close-Pivot with a focus on Pivot. Ke Qin(柯琴) applied Open-Close-Pivot to "Shanghanlun(傷寒論)" and used it as the basic principle to the Six Channel Ground Theory(六經地面說), also clinically applying it in the identification and treatment of the Six Channel patterns. Conclusions : Counting based word embedding methods seems to be more effective than.

• 국제강구조저널
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• 제18권4호
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• pp.1153-1166
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• 2018

This paper was concerned with the nonlinear analysis on the overall stability of H-type honeycombed composite column with rectangular concrete-filled steel tube flanges (STHCC). The nonlinear analysis was performed using ABAQUS, a commercially available finite element (FE) program. Nonlinear buckling analysis was carried out by inducing the first buckling mode shape of the hinged column to the model as the initial imperfection with imperfection amplitude value of L/1000 and importing the simplified constitutive model of steel and nonlinear constitutive model of concrete considering hoop effect. Close agreement was shown between the experimental results of 17 concrete-filled steel tube (CFST) specimens and 4 I-beams with top flanges of rectangular concrete-filled steel tube (CFSFB) specimens conducted by former researchers and the predicted results, verifying the correctness of the method of FE analysis. Then, the FE models of 30 STHCC columns were established to investigate the influences of the concrete strength grade, the nominal slenderness ratio, the hoop coefficient and the flange width on the nonlinear stability capacity of SHTCC column. It was found that the hoop coefficient and the nominal slenderness ratio affected the nonlinear stability capacity more significantly. Based on the results of parameter analysis, a formula was proposed to predict the nonlinear stability capacity of STHCC column which laid the foundation of the application of STHCC column in practical engineering.

• Journal of Ginseng Research
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• 제45권1호
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• pp.86-97
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• 2021

Background: Panax ginseng Meyer has been used as a nourishing edible herb in East Asia for thousands of years. 25-OH-PPT was first discovered as a natural rare triterpenoid saponin in ginseng stems and leaves by our group. Research found that it showed strong inhibitory effects on α-glucosidase and protein tyrosine phosphatase 1B, and protected cardiocytes (H9c2) through PI3K/Akt pathway. Methods: In the research, in order to optimize the 25-OH-PPT enrichment process, optimal macroporous resins and optimal purification conditions were studied. Meanwhile, the hypoglycemic effect and mechanism of 25-OH-PPT were evaluated by using STZ to establish insulin-dependent diabetic mice and the spontaneous type 2 diabetes DB/DB mice. Results and Conclusion: Research found that 25-OH-PPT can reduce blood glucose and enhance glucose tolerance in STZ model mice. It increases insulin sensitivity by upregulating GLUT4 and AMPK in skeletal muscle, and activating insulin signaling pathways. In DB/DB mice, 25-OH-PPT achieves hypoglycemic effects mainly by activating the insulin signaling pathway. Meanwhile, through the influence of liver inflammatory factors and lipids in serum, it can be seen that 25-OH-PPT has obvious anti-inflammatory and lipid-lowering effects. These results provide new insights into the study of ginseng as a functional food.

• KSII Transactions on Internet and Information Systems (TIIS)
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• 제15권7호
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• pp.2513-2530
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• 2021

With the fast development of information and communication technologies, video streaming services and applications are increasing rapidly. However, the network condition is volatile. In order to provide users with better quality of service, it is necessary to develop an accurate and low-complexity model for Quality of Experience (QoE) prediction of time-varying video. Memory effects refer to the psychological influence factor of historical experience, which can be taken into account to improve the accuracy of QoE evaluation. In this paper, we design subjective experiments to explore the impact of Short-Term Memory (STM) on QoE. The experimental results show that the user's real-time QoE is influenced by the duration of previous viewing experience and the expectations generated by STM. Furthermore, we propose analytical models to determine the relationship between intrinsic video quality, expectation and real-time QoE. The proposed models have better performance for real-time QoE prediction when the video is transmitted in a fluctuate network. The models are capable of providing more accurate guidance for improving the quality of video streaming services.

• 한국전자통신학회논문지
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• 제17권1호
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• pp.111-118
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• 2022

컴퓨터 비전 연구에서 2차원 인체 자세는 매우 광범위한 연구 방향으로 특히 자세 추적과 행동 인식에서 유의미한 분야다. 인체 자세 표적 획득은 이미지에서 인체 목표를 정확히 찾는 방법을 연구하는 것이 핵심이며 인체 자세 인식은 인공지능(AI)에 적용하는 한편 일상생활에 활용되고 있어서 매우 중요한 연구의의가 있다. 인체 자세 인식 효과의 우수성의 기준은 인식 과정의 성공률과 정확도에 의해 결정된다. 본 연구의 인체 자세 인식에서는 딥러닝 전용 데이터셋인 MS COCO를 기반하여 인체를 17개의 키 포인트로 구분하였다. 다음으로 주요 특징에 대한 세분화 마스크(segmentation mask) 방법을 사용하여 인식률을 개선하였다. 최종적으로 신경망 모델을 설계하고 간단한 단계별 학습부터 효율적인 학습에 이르기까지 많은 수의 표본을 학습시키는 알고리즘을 제안하여 정확도를 향상할 수 있었다.

• Journal of Microbiology and Biotechnology
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• 제32권4호
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• pp.522-530
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• 2022

In this study we aimed to develop novel ZnO-NP/chitosan/β-glycerophosphate (ZnO-NP/CS/β-GP) antibacterial hydrogels for biomedical applications. According to the mass fraction ratio of ZnO-NPs to chitosan, mixtures of 1, 3, and 5% ZnO-NPs/CS/β-GP were prepared. Using the test-tube inversion method, scanning electron microscopy and Fourier-transform infrared spectroscopy, the influence of ZnO-NPs on gelation time, chemical composition, and cross-sectional microstructures were evaluated. Adding ZnO-NPs significantly improved the hydrogel's antibacterial activity as determined by bacteriostatic zone and colony counting. The hydrogel's bacteriostatic mechanism was investigated using live/dead fluorescent staining and scanning electron microscopy. In addition, crystal violet staining and MTT assay demonstrated that ZnO-NPs/CS/β-GP exhibited good antibacterial activity in inhibiting the formation of biofilms and eradicating existing biofilms. CCK-8 and live/dead cell staining methods revealed that the cell viability of gingival fibroblasts (L929) cocultured with hydrogel in each group was above 90% after 24, 48, and 72 h. These results suggest that ZnO-NPs improve the temperature sensitivity and bacteriostatic performance of chitosan/β-glycerophosphate (CS/β-GP), which could be injected into the periodontal pocket in solution form and quickly transformed into hydrogel adhesion on the gingiva, allowing for a straightforward and convenient procedure. In conclusion, ZnO-NP/CS/β-GP thermosensitive hydrogels could be expected to be utilized as adjuvant drugs for clinical prevention and treatment of peri-implant inflammation.

• Journal of Ginseng Research
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• 제46권5호
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• pp.700-709
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• 2022

Background: Ginsenoside Rd is a natural compound with promising neuroprotective effects. However, the underlying mechanisms are still not well-understood. In this study, we explored whether ginsenoside Rd exerts protective effects on cerebral endothelial cells after oxygen-glucose deprivation/reoxygenation (OGD/R) treatment and its potential docking proteins related to the underlying regulations. Method: Commercially available primary human brain microvessel endothelial cells (HBMECs) were used for in vitro OGD/R studies. Cell viability, pyroptosis-associated protein expression and tight junction protein degradation were evaluated. Molecular docking proteins were predicted. Subsequent surface plasmon resonance (SPR) technology was utilized for validation. Flow cytometry was performed to quantify caspase-1 positive and PI positive (caspase-1+/PI+) pyroptotic cells. Results: Ginsenoside Rd treatment attenuated OGD/R-induced damage of blood-brain barrier (BBB) integrity in vitro. It suppressed NLRP3 inflammasome activation (increased expression of NLRP3, cleaved caspase-1, IL-1β and GSDMD-N terminal (NT)) and subsequent cellular pyroptosis (caspase-1+/PI + cells). Ginsenoside Rd interacted with SLC5A1 with a high affinity and reduced OGD/R-induced sodium influx and potassium efflux in HBMECs. Inhibiting SLC5A1 using phlorizin suppressed OGD/R-activated NLRP3 inflammasome and pyroptosis in HBMECs. Conclusion: Ginsenoside Rd protects HBMECs from OGD/R-induced injury partially via binding to SLC5A1, reducing OGD/R-induced sodium influx and potassium efflux, thereby alleviating NLRP3 inflammasome activation and pyroptosis.

• 문화기술의 융합
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• 제8권5호
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• pp.285-290
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• 2022

중국의 급속한 발전에 따라 중국예술과 미술관도 빠르게 부상하고 있다. 본 연구는 중국미술관의 역사와 발전과정을 분석하여 중국미술관의 근대에서 현대에 이르는 발전과정을 정리하고, 최근 현황과 트렌드를 분석하고자 하였다. 중국 미술관은 서방 선진국 미술관과 격차가 있지만, 그 격차가 점차 좁혀지고 있는 것으로 분석됐다. 양과 질적인 면에서 중국 미술관은 빠른 성장을 보여주고 있고, 최근 미술관의 트렌드를 반영하여 변화하고 있다. 이러한 성장에도 불구하고, 자금 부족으로 인한 운영난을 겪고 있고, 제도와 지원 미비와 이로 인한 발전에 대한 저항, 전문인재의 부족 등의 문제점들이 있다. 최근 세계적 관심을 받고있는 중국미술관에 관한 연구는 매우 부족하기 때문에, 본연구는 한국의 중국미술관 연구에 기여할 수 있다. 본 연구를 통해 중국미술관의 발전과정과 현황, 문제점 등을 이해할 수 있으며, 이를 바탕으로 한국 미술관의 발전에 시사점을 주고자 한다.

• Journal of Ginseng Research
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• 제47권2호
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• pp.274-282
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• 2023

Background: Ginsenoside compound K (CK) stimulated activation of the PI3K-Akt signaling is one of the major mechanisms in promoting cell survival after stroke. However, the underlying mediators remain poorly understood. This study aimed to explore the docking protein of ginsenoside CK mediating the neuroprotective effects. Materials and methods: Molecular docking, surface plasmon resonance, and cellular thermal shift assay were performed to explore ginsenoside CK interacting proteins. Neuroscreen-1 cells and middle cerebral artery occlusion (MCAO) model in rats were utilized as in-vitro and in-vivo models. Results: Ginsenoside CK interacted with recombinant human PTP1B protein and impaired its tyrosine phosphatase activity. Pathway and process enrichment analysis confirmed the involvement of PTP1B and its interacting proteins in PI3K-Akt signaling pathway. PTP1B overexpression reduced the tyrosine phosphorylation of insulin receptor substrate 1 (IRS1) after oxygen-glucose deprivation/reoxygenation (OGD/R) in neuroscreen-1 cells. These regulations were confirmed in the ipsilateral ischemic hemisphere of the rat brains after MCAO/R. Ginsenoside CK treatment reversed these alterations and attenuated neuronal apoptosis. Conclusion: Ginsenoside CK binds to PTP1B with a high affinity and inhibits PTP1B-mediated IRS1 tyrosine dephosphorylation. This novel mechanism helps explain the role of ginsenoside CK in activating the neuronal protective PI3K-Akt signaling pathway after ischemia-reperfusion injury.