• Asian Pacific Journal of Cancer Prevention
• /
• 제13권7호
• /
• pp.3119-3121
• /
• 2012

Non-small-cell lung cancer (NSCLC) is a leading cause of cancer deaths worldwide. Crizotinib has been approved by the U.S. Food and Drug Administration for the treatment of patients with advanced NSCLC. However, understanding of mechanisms of action is still limited. In our studies, we confirmed crizotinib-induced apoptosis in A549 lung cancer cells. In order to assess mechanisms, small molecular docking technology was used as a preliminary simulation of signaling pathways. Interesting, our results of experiments were consistent with the results of computer simulation. This indicates that small molecular docking technology should find wide use for its reliability and convenience.

• Journal of applied mathematics & informatics
• /
• 제30권5_6호
• /
• pp.759-772
• /
• 2012

In this paper, semi-infinite constrained programming, a class of constrained nonsmooth optimization problems, are transformed into unconstrained nonsmooth convex programs under the help of exact penalty function. The unconstrained objective function which owns the primal-dual gradient structure has connection with $\mathcal{VU}$-space decomposition. Then a $\mathcal{VU}$-space decomposition method can be applied for solving this unconstrained programs. Finally, the superlinear convergence algorithm is proved under certain assumption.

• Journal of applied mathematics & informatics
• /
• 제24권1_2호
• /
• pp.283-293
• /
• 2007

This paper considers single machine scheduling problems with group technology (GT) and deteriorating jobs. A sequence independent setup is required to process a job from a different group and jobs in each group are processed together. We consider the case of jobs whose processing times are a decreasing function of their starting time. The objectives of scheduling problems are to minimize the makespan and the total completion time, respectively. We also provide polynomial time algorithms to solve these problems.

• 한국수학교육학회지시리즈D:수학교육연구
• /
• 제22권4호
• /
• pp.305-318
• /
• 2019

To improve students' classroom engagement is not only the demand of curriculum revolution, but also the reflection of learning democracy. Students' responses and thinking are the main manifestations of students' participation in classroom learning. To reduce the amount of questions and increase the opportunities and time for students to think, this study, by employing SPSS, makes attempts to analyze the data by using multivariate GLM analysis to explore the effects of students' responses and thinking on learning results. The results indicated the students learning effect will be promoted through reducing the quantity and increasing the quality of question and adding the thinking opportunities.

• Wind and Structures
• /
• 제21권3호
• /
• pp.311-329
• /
• 2015

A method for analyzing the coupled wind-vehicle-bridge system is proposed that also considers the shielding effect of the bridge tower with triangular wind barriers. The static wind load and the buffeting wind load for both the bridge and the vehicle are included. The shielding effects of the bridge tower and the triangular wind barriers are incorporated by taking the surface integral of the wind load. The inter-history iteration is adopted to solve the vehicle-bridge dynamic equations with time-varying external loads. The results show that after installing the triangular wind barriers in the area of the bridge tower, the bridge response and the vehicle safety factors change slightly. The peak value of the train car body acceleration is significantly reduced when the wind barrier size is increased.

• Structural Engineering and Mechanics
• /
• 제66권3호
• /
• pp.387-397
• /
• 2018

In this paper, a general closed-form solution for evaluating the dynamic behavior of a Timoshenko beam on elastic foundation under a moving harmonic line load is formulated in the frequency-wavenumber domain and in a moving coordinate system. It is found that the characteristic equation is quartic with real coefficients only, and its poles can be presented explicitly. This enables the substitution of these poles into Cauchy's residue theorem, leading to the general closed-form solution. The solution can be reduced to seven existing closed-form solutions to different sub-problems and a new closed-form solution to the subproblem of a Timoshenko beam on an elastic foundation subjected to a moving quasi-static line load. Two examples are included to verify the solution.

• Bulletin of the Korean Chemical Society
• /
• 제34권2호
• /
• pp.394-398
• /
• 2013

An efficient process for the synthesis of N-azaaryl anilines via Smiles rearrangement as a tool. A variety of N-azaaryl anilines were generated by the reaction of substituted phenols, substituted anilines, aminopyridines and chloroacetyl chloride or pyridols, under base condition in good to excellent yields.

• 한국분말야금학회:학술대회논문집
• /
• 한국분말야금학회 2006년도 Extended Abstracts of 2006 POWDER METALLURGY World Congress Part 1
• /
• pp.201-202
• /
• 2006

An apparatus measuring changes of various forces directly and continuously was developed by a way of direct touch between powders and transmitting force component, which can be used to study forces state of powders during warm compaction. Using the apparatus, warm compaction processes of iron-based powder materials containing different lubricants at different temperatures were studied. Results show that densification of the iron-based powder materials can be divided into four stages, in which powder movement changes from robustness to weakness, while its degree of plastic deformation changes from weakness to robustness.

• Journal of Power Electronics
• /
• 제17권4호
• /
• pp.963-971
• /
• 2017

Torque ripple is one of the major sources inducing vibration and noise in brushless DC motors. This is especially true in applications such as the spindle motors used in hard disk drives. However, the relationship between torque ripple and acoustic noise/vibration is quite complicated. This paper presents a way to investigate this relationship with acoustic noise measurement and analysis. Results obtained with three different drive modes are used in the analysis. The results show that the acoustic noise analysis is very helpful in designing a high-performance drive strategy for BLDC motors.

• Geomechanics and Engineering
• /
• 제13권3호
• /
• pp.517-533
• /
• 2017

In this paper, with a graphical approach, a series of stability charts for homogeneous slopes with benches are presented based on the upper bound limit analysis theory and strength reduction technique. The objective function of the slope safety factor $F_s$ is optimized by the nonlinear sequential quadratic programming, and a substantial number of examples are illustrated to use the stability charts for homogeneous slopes with benches driven by only the action of the soil weight. These charts can be applied to quick and accurate estimations of the stability status of homogeneous slopes with benches. Moreover, the failure modes and the formula for safety factor Fs of homogeneous slopes with benches are provided to illustrate the stability analysis of slopes with benches, which is validated by samples.