• Korean Journal of Mineralogy and Petrology
• /
• v.34 no.3
• /
• pp.157-167
• /
• 2021

Lead (Pb) is one of the key trace elements, exhibiting a peculiar partitioning behavior into silicate melts in contact with minerals. Partitioning behaviors of Pb between silicate mineral and melt have been known to depend on melt composition and thus, the atomic structures of corresponding silicate liquids. Despite the importance, detailed structural studies of Pb-bearing silicate melts are still lacking due to experimental difficulties. Here, we explored the effect of lead content on the atomic structures, particularly the evolution of silicate networks in Pb-bearing sodium metasilicate ([(PbO)_x(Na₂O)_1-x]·SiO₂) glasses as a model system for trace metal bearing natural silicate melts, using ²⁹Si solid-state nuclear magnetic resonance (NMR) spectroscopy. As the PbO content increases, the ²⁹Si peak widths increase, and the maximum peak positions shift from -76.2, -77.8, -80.3, -81.5, -84.6, to -87.7 ppm with increasing PbO contents of 0, 0.25, 0.5, 0.67, 0.86, and 1, respectively. The ²⁹Si MAS NMR spectra for the glasses were simulated with Gaussian functions for Qⁿ species (SiO₄ tetrahedra with n BOs) for providing quantitative resolution. The simulation results reveal the evolution of each Qⁿ species with varying PbO content. Na-endmember Na₂SiO₃ glass consists of predominant Q² species together with equal proportions of Q¹ and Q³. As Pb replaces Na, the fraction of Q² species tends to decrease, while those for Q¹ and Q³ species increase indicating an increase in disproportionation among Qⁿ species. Simulation results on the ²⁹Si NMR spectrum showed increases in structural disorder and chemical disorder as evidenced by an increase in disproportionation factor with an increase in average cation field strengths of the network modifying cations. Changes in the topological and configurational disorder of the model silicate melt by Pb imply an intrinsic origin of macroscopic properties such as element partitioning behavior.

• Information Systems Review
• /
• v.22 no.2
• /
• pp.137-166
• /
• 2020

While South Koreans overseas travelling rate has been increased every year, domestic travelling rate has been at a standstill for several years. The purpose of this study is to analyze domestic traveling styles of Koreans according to their generations in order to provide generation-specific traveling services. For this purpose, we categorized the survey respondents into four different generations, which are Millennium (age 19~34), X generation (35~54), Baby Boomer (55~64) and senior by following the criterions of the Korea National Tourism Organization. After then, we analyze factors related to travel preparation process, the actual traveling activities and satisfaction after the travel. In this study, 16,713 data collected by the Ministry of Culture, Sports and Tourism are used. The results of this study show that Korean people tends to acquire domestic traveling information from their own or acquaintances past experiences. Also, they do not prefer the organized trip for domestic travels, thus do not buy package products a lot. In addition, natural scenery, rich in cultural heritage, and convenient accommodation are the most important determinant factors affecting the overall travel satisfaction of level for all generations. The traveling characteristics for each generation are as follows. Millennium get traveling information from the internet a lot, and more specifically, they refer portal sites and social network services (SNS) in many cases. Also, they tend to travel in summer peak season to popular destinations and pursues active traveling experiences. Generation X has similar traveling patterns with Millennium, however they major transportation method is using their own car. Also, transportation convenience and satisfactory leisure activity are important factors affecting the overall satisfaction level to Generation X. On the other hand, Baby boomer generation has a greater emphasis on appreciation of nature, visiting famous restaurants, and relaxation, rather than actively participating experiencing programs. They travel evenly in summer and spring/fall season to many different areas instead of focusing on popular tourist spots. In addition, shopping and eating delicious food are the important factors affecting the overall satisfaction level for them. Lastly, Senior generation has similar characteristics with Baby boomer in many ways, however, they travel a lot on the same day using public transportations or car rental service. They prefer spring and autumn trips rather than summer peak season, and tend to buy packaged travel products a lot compared with other generations. If these different traveling characteristics of each generation are considered for organizing and customizing tourism services, it is expected that domestic tourism satisfaction level will be ultimately increased.

• IMMUNE NETWORK
• /
• v.2 no.1
• /
• pp.41-48
• /
• 2002

Background: Viral antigens presented on the cell surface in association with MHC class I molecules are recognized by CD8+ T cells. MHC restricted peptides are important in eliciting cellular immune responses. As peptide antigens have a weak immunigenicity, pH-sensitive liposomes were used for peptide delivery to induce effective cytotoxic T lymphocyte (CTL) responses. In the previous study, as the HBx peptides could induce specific CTLs in vitro, we tested whether the HLA-A2/$K^b$ transgenic mice that were immunized by HBx-derived peptides could be protected from a viral challenge. Methods: HBx-peptides encapsulated by pH-sensitive liposomes were prepared. $A2K^b$ transgenic mice were immunized i.m. on days one and seven with the indicated concentrations of liposome-encapsulated peptides. Three weeks later, mice were infected with $1{\times}10^7pfu$/head of recombinant vaccinia virus (rVV)-HBx via i.p. administration. The ovaries were extracted from the mice, and the presence of rVV-HBx in the ovaries was analyzed using human TK-143B cells. IFN-${\gamma}$ secretion by these cells was directly assessed using a peptide-pulsed target cell stimulation assay with either peptide-pulsed antigen presenting cells (APCs), concanavalin A ($2{\mu}g/ml$), or a vehicle. To generate peptide-specific CTLs, splenocytes obtained from the immunized mice were stimulated with $20{\mu}g/ml$ of each peptide and restimulated with peptide-pulsed APC four times. The cytotoxic activity of the CTLs was assessed by standard $^{51}Cr$-release assay and intracellular IFN-${\gamma}$ assay. Results: Immunization of these peptides as a mixture in pH-sensitive liposomes to transgenic mice induced a good protective effect from a viral challenge by inducing the peptide-specific CD8+ T cells. Mice immunized with $50{\mu}g/head$ were much better protected against viral challenge compared to those immunized with $5{\mu}g$/head, whereas the mice immunized with empty liposomes were not protected at all. After in vitro CTL culture by peptide stimulation, however, specific cytotoxicity was much higher in the CTLs from mice immunized with $5{\mu}g/head$ than $50{\mu}g/head$ group. Increase of the number of cells that intracellular IFN-${\gamma}$ secreting cell among CD8+ T cells showed similar result. Conclusion: Mice immunized with XEPs within pH-sensitive liposome were protected against viral challenge. The protective effect depended on the amount of antigen used during immunization. XEP-3-specific CTLs could be induced by peptide stimulation in vitro from splenocytes obtained from immunized mice. The cytotoxic effect of CTLs was measured by $^{51}Cr$-release assay and the percentage of accumulated intracellular IFN-${\gamma}$ secreting cells after in vitro restimulation was measured by flow cytometric analysis. The result of $^{51}Cr$-release cytotoxicity test was well correlated with that of the flow cytometric analysis. Viral protection was effective in immunized group of $50{\mu}g/head$, while in the in vitro restimulation, it showed more spectific response in $5{\mu}g$/head group.

• 제어로봇시스템학회:학술대회논문집
• /
• 2004.08a
• /
• pp.138-142
• /
• 2004

In this paper, we present a new method for monitoring of ECU's sensor signals of vehicle. In order to measure the ECU's sensor signals, the interfaced circuit is designed to communicate ECU and the Embedded Linux is used to monitor communication result through Web the Embedded Linux system and this system is said "ECU Interface Part". In ECU Interface Part the interface circuit is designed to match voltage level between ECU and SA-1110 micro controller and interface circuit to communicate ECU according to the ISO, SAE communication protocol standard. Because Embedded Linux does not allow to access hardware directly in application level, anyone who wants to modify any low level hardware must develop device driver. To monitor ECU's sensor signals the most important thing is to match serial level between ECU and ECU Interface Part. It means to communicate correctly between two hardware we need to match voltage and signal level, and need to match baudrate. The voltage of SA-1110 is 0 ${\sim}$ +3.3V and ECU is 0 ${\sim}$ +12V and, ECU's communication Line K does multiple operation so, the interface circuit is used to match voltage and signal level. In Addition to ECU's baudrate is 10400bps, it's not standard baudrate in computer environment. So, we need to develop a device driver to control the interface circuit, and change baudrate. To monitor ECU's sensor signals through web there's a network socket program is working in Embedded Linux. It works as server program and manages user's connections and commands. Anyone who wants to monitor ECU's sensor signals he just only connect to Embedded Linux system with web browser then, Embedded Linux webserver will return the ActiveX webbased measurement software. It works in web browser and inits ECU, as a result it returns sensor signals through web. All the programs are developed with GCC(GNU C Compiler) and, webbased measurement software is developed with Borland C++ Builder.

• Journal of the Korean GEO-environmental Society
• /
• v.17 no.2
• /
• pp.5-11
• /
• 2016

$MWCNT-TiO_2$ nano composites and $Ag-MWCNT-TiO_2$ nano composites were prepared from Multi-Walled Carbon NanoTube (MWCNT), titanium (IV) butoxide (TNB) solution and silver nitrate ($AgNO_3$) by the sol-gel method. The dispersion and structure of Ag in the synthesized composites was observed by Scanning Electron Microscopy (SEM) and Field Emission Transmission Electron Microscopy (FE-TEM). X-Ray Diffraction (XRD) patterns of the composites showed that the composites contained an anatase phase. The Energy Dispersive X-ray spectroscopy (EDX) showed the presence of C, O, Ti and Ag peaks. The $TiO_2$ particles were distributed uniformly in the MWCNT network, and Ag particles were virtually fixed on the surface of the tubes. Also decomposition of the methylene blue was investigated according to UV radiation times for study photocatalytic activity. $Ag-MWCNT-TiO_2$ nano composites show high photodegradation than $MWCNT-TiO_2$ nano composites. The results indicate that the high conductivity of Ag improved the photoactivity of the $MWCNT-TiO_2$ composite.

• Science of Emotion and Sensibility
• /
• v.13 no.3
• /
• pp.467-474
• /
• 2010

Recently, Study of functional clothing for Vital sensing is focused on reducing artifact by human motions, in order to enhance the electrocardiogram(ECG) sensing accuracy. In this study, considering the factors for each element found from the analysis, a 3-lead electrode inside textile embroidered with silver yarn was developed, and draft designs off our types of vital-signal sensing garments, which are 'chest-belt typed' garment, 'cross-typed' garment 'x-typed' garment and 'curved x-typed' garment, were prepared. The draft designs were implemented on a sleeveless male shirt made of an elastic material so that the garment and the electrodes can remain closely attached along the contour of the human body, and the acquired data was sent to the main computer over a wireless network. In order to evaluate the effects caused by body movements and the ECG-sensing capability for each type in static and dynamic states, displacements were measured from one and two dimensional perspectives. ECG measurement evaluation was also performed for Signal-to-noise ratio(SNR) analysis. Applying the experimental results, the draft garment designs were modified and complemented to produce two types of modular approaches 'continuous-attached' and 'insertion-detached' for the ECG-sensing smart clothing.

• Journal of KIISE:Databases
• /
• v.33 no.3
• /
• pp.299-309
• /
• 2006

Due to the rapid development in mobile communication technologies, the usage of mobile devices such as cell phone or PDA becomes increasingly popular. As different devices require different applications, various new services are being developed to satisfy the needs. One of the popular services under heavy demand is the Location-based Service (LBS) that exploits the spatial information of moving objects per temporal changes. In order to support LBS efficiently, it is necessary to be able to index and query well a large amount of spatio-temporal information of moving objects. Therefore, in this paper, we investigate how such location information of moving objects can be efficiently stored and indexed. In particular, we propose a novel location encoding method based on hierarchical administrative district information. Our proposal is different from conventional approaches where moving objects are often expressed as geometric points in two dimensional space, (x,y). Instead, in ours, moving objects are encoded as one dimensional points by both administrative district as well as road information. Our method is especially useful for monitoring traffic situation or tracing location of moving objects through approximate spatial queries.

• Journal of Bio-Environment Control
• /
• v.27 no.1
• /
• pp.20-26
• /
• 2018

This study was conducted to develop a device for measuring the air flow by space variation through monitoring program, which acquires data by each point from each environmental sensor located in the greenhouse. The distribution of environmental factors(air temperature, humidity, wind speed, etc.) in the greenhouse is arranged at 12 points according to the spatial variation and a large number of measurement points (36 points in total) on the X, Y and Z axes were selected. Considering data loss and various greenhouse conditions, a bit rate was at 125kbit/s at low speed, so that the number of sensors can be expanded to 90 within greenhouse with dimensions of 100m by 100m. Those system programmed using MATLAB and LabVIEW was conducted to measure distributions of the air flow along the greenhouse in real time. It was also visualized interpolated the spatial distribution in the greenhouse. In order to verify the accuracy of CFD modeling and to improve the accuracy, it will compare the environmental variation such as air temperature, humidity, wind speed and $CO_2$ concentration in the greenhouse.

• Asian Pacific Journal of Cancer Prevention
• /
• v.17 no.8
• /
• pp.3971-3977
• /
• 2016

Background: Breast cancer, the commonest cancer among women in the world, ranks top in India with an incidence rate of 1,45,000 new cases and mortality rate of 70,000 women every year. Chemotherapy outcome for breast cancer is hampered due to poor response and irreversible dose-dependent cardiotoxicity which is determined by genetic variations in drug metabolizing enzymes and transporters. Pregnane X receptor (PXR), a member of the nuclear receptor superfamily, induces expression of drug metabolizing enzymes (DMEs) and transporters leading to regulation of xenobiotic metabolism. Materials and Methods: A genomic region spanning PXR 3' UTR was amplified and sequenced using genomic DNA isolated from 96 South Indian breast cancer patients. Genetic variants observed in our study subjects were queried in miRSNP to establish SNPs that alter miRNA binding sites in PXR 3' UTR. In addition, enrichment analysis was carried out to understand the network of miRNAs and PXR in drug metabolism using DIANA miRpath and miRwalk pathway prediction tools. Results: In this study, we identified SNPs rs3732359, rs3732360, rs1054190, rs1054191 and rs6438550 in the PXR 3; UTR region. The SNPs rs3732360, rs1054190 and rs1054191 were located in the binding site of miR-500a-3p, miR-532-3p and miR-374a-3p resulting in the altered PXR level due to the deregulation of post-transcriptional control and this leads to poor treatment response and toxicity. Conclusions: Genetic variants identified in PXR 3' UTR and their effects on PXR levels through post-transcriptional regulation provide a genetic basis for interindividual variability in treatment response and toxicity associated with chemotherapy.

• Journal of the Korean Association of Geographic Information Studies
• /
• v.10 no.3
• /
• pp.113-122
• /
• 2007

The rapid growth of aerial survey and remote sensing technology has enabled the rapid acquisition of very large amounts of geographic data, which should be analyzed using real-time visualization technology. The level of detail(LOD) algorithm is one of the most important elements for realizing real-time visualization. We chose the triangulated irregular network (TIN) method to generate normalized digital elevation model(DEM) data. First, we generated TIN data using contour lines obtained from a two-dimensional(2D) digital map and created a 2D grid array fitting the size of the area. Then, we generated normalized DEM data by calculating the intersection points between the TIN data and the points on the 2D grid array. We used constrained Delaunay triangulation(CDT) and ray-triangle intersection algorithms to calculate the intersection points between the TIN data and the points on the 2D grid array in each step. In addition, we simulated a three-dimensional(3D) terrain model based on normalized DEM data with real-time visualization using a Microsoft Visual C++ 6.0 program in the DirectX API library and a quad-tree LOD algorithm.