• Asian-Australasian Journal of Animal Sciences
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• v.17 no.3
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• pp.366-370
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• 2004

One hundred and sixty day-old Hainan chicks were randomly allotted into eight pens to investigate the effect of different dietary concentrations of chromium (Cr) in the form of chromium chloride, and different dosages of florfenicol on humoral immune responses by determining antibody titers to Newcastle disease (ND) vaccines using the hemagglutination inhibition test. The results indicated that ND antibody titers were significantly higher in chicks receiving Cr at low (5 mg/kg feed) and middle (10 mg/kg feed) dose compared with the control (p<0.01). However, ND antibody titers were significantly decreased in chicks receiving Cr at a high dosage of 500 mg/kg feed (p<0.01), though the ND antibody titers of the early days (d 21 and d 28 of age) were higher than that of the control group. It is suggested that excessive Cr intake has detrimental effects on ND antibody production in chicks. No significantly lower response was measured in chicks that received florfenicol at a low dosage of 50 mg/kg feed (p>0.05), but the ND antibody titers were significantly decreased in chicks receiving 200 and 400 mg/kg feed of the drug (p<0.01). The ND antibody titers of group receiving 200 mg/kg feed of florfenicol plus 10 mg/kg Cr were slightly higher than that of the group receiving single florfenicol of 200 mg/kg although, no significant differences were observed between these two treatments. It is suggested that the humoral immune response impaired by florfenicol (200 mg/kg feed) could not be significantly reversed by Cr (10 mg/kg feed).

• Journal of the FoodService Safety
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• v.1 no.1
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• pp.37-44
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• 2020

The virus isolated from patients with severe pneumonia of unknown etiology in Wuhan City, Hubei province in China was termed SARS-CoV-2 and the World Health Organization (WHO) named the disease caused by this virus as coronavirus disease 2019 (COVID-19). The COVID-19 infection has spread rapidly and become a pandemic. In July 2020, there were 13.25 million infected patients and over 570,000 deaths worldwide, and 13,711 infected patients and 294 deaths were reported in South Korea. Since the primary mode of transmission of COVID-19 is through respiratory droplets, the importance of preventive measures, including social distancing, has become important in daily life. In response to the continuous spread of COVID-19, this study developed three guidelines for preventing COVID-19 for the food service industry including childcare centers, institutional foodservices and restaurants by the integration of the manual of controlling foodborne illness. These are included the COVID-19 prevention action methods for food deliverers, for food service administrator, for foodservice works and for customers. All guidelines were designed for easy understanding using illustrations and have been systematically explained subject wise. Thus, these COVID-19 prevention guidelines can be appropriately applied depending on the specific situation and workplace. In addition, they are worthy as educational materials that contribute to the food safety.

• Journal of Microbiology and Biotechnology
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• v.29 no.5
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• pp.794-808
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• 2019

Bacillus velezensis strain WRN014 was isolated from banana fields in Hainan, China. Bacillus velezensis is an important member of the plant growth-promoting rhizobacteria (PGPR) which can enhance plant growth and control soil-borne disease. The complete genome of Bacillus velezensis WRN014 was sequenced by combining Illumina Hiseq 2500 system and Pacific Biosciences SMRT high-throughput sequencing technologies. Then, the genome of Bacillus velezensis WRN014, together with 45 other completed genome sequences of the Bacillus velezensis strains, were comparatively studied. The genome of Bacillus velezensis WRN014 was 4,063,541bp in length and contained 4,062 coding sequences, 9 genomic islands and 13 gene clusters. The results of comparative genomic analysis provide evidence that (i) The 46 Bacillus velezensis strains formed 2 obviously closely related clades in phylogenetic trees. (ii) The pangenome in this study is open and is increasing with the addition of new sequenced genomes. (iii) Analysis of single nucleotide polymorphisms (SNPs) revealed local diversification of the 46 Bacillus velezensis genomes. Surprisingly, SNPs were not evenly distributed throughout the whole genome. (iv) Analysis of gene clusters revealed that rich gene clusters spread over Bacillus velezensis strains and some gene clusters are conserved in different strains. This study reveals that the strain WRN014 and other Bacillus velezensis strains have potential to be used as PGPR and biopesticide.

• Journal of Korean Neurosurgical Society
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• v.65 no.1
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• pp.130-137
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• 2022

Objective : COVID-19 has spread worldwide since the first case was reported in Wuhan, China, in December 2019. Our institution is a regional trauma and emergency center in the northern Gyeonggi Province. The changing trend of patient care in the emergency room of this hospital likely reflects the overall trend of patients in the area. In the present study, whether changes in the surrounding social environment following the outbreak of COVID-19 changed the incidence of neurosurgical emergency patients and whether differences in practice existed were investigated. Methods : The overall trend was analyzed from January 2020 which is before the outbreak of COVID-19 to September 2020. To remove bias due to seasonal variation, the previous 2 year's records during the same period were reviewed and compared. Confirmed COVID-19 patients in the northern Gyeonggi Province were identified using data released by the government. And patients who came to the emergency department with head trauma and stroke were identified. Results : Based on the present study results, the total number of neurosurgery emergency patients decreased over the study period. In the trauma patient group, the number of patients not involved in traffic accidents significantly decreased compared with patients involved in traffic accidents. Among the stroke cases, the rate of ischemic stroke was lower than hemorrhagic stroke, although a statistically significant difference was not observed. Meanwhile, an increase in the risk of mortality associated with trauma or stroke cases was not observed during the COVID-19 outbreak compared with the same time period in the previous year. Conclusion : Due to the occurrence of COVID-19, non-essential activities have decreased and trauma cases not associated with traffic accidents appeared to decrease. Due to the decrease in overall activity, the number of stroke patients has also decreased. This trend is expected to continue even in the post-COVID-19 era, and accordingly, the results from the present study are relevant especially if the current situation continues.

• Wind and Structures
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• v.36 no.6
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• pp.405-421
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• 2023

Strong wind is the main factors of wind-damage of high-rise buildings, which often creates largely economical losses and casualties. Wind pressure plays a critical role in wind effects on buildings. To obtain the high-resolution wind pressure field, it often requires massive pressure taps. In this study, two traditional methods, including bilinear and bicubic interpolation, and two deep learning techniques including Residual Networks (ResNet) and Generative Adversarial Networks (GANs), are employed to reconstruct wind pressure filed from limited pressure taps on the surface of an ideal building from TPU database. It was found that the GANs model exhibits the best performance in reconstructing the wind pressure field. Meanwhile, it was confirmed that k-means clustering based retained pressure taps as model input can significantly improve the reconstruction ability of GANs model. Finally, the generalization ability of k-means clustering based GANs model in reconstructing wind pressure field is verified by an actual engineering structure. Importantly, the k-means clustering based GANs model can achieve satisfactory reconstruction in wind pressure field under the inputs processing by k-means clustering, even the 20% of pressure taps. Therefore, it is expected to save a huge number of pressure taps under the field reconstruction and achieve timely and accurately reconstruction of wind pressure field under k-means clustering based GANs model.

• Smart Structures and Systems
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• v.31 no.3
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• pp.259-273
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• 2023

Real-time hybrid simulation (RTHS) is an effective experimental technique for structural dynamic assessment. However, time delay causes displacement de-synchronization at the interface between the numerical and physical substructures, negatively affecting the accuracy and stability of RTHS. To this end, the authors have proposed a model-based adaptive control strategy with a Kalman filter (MAC-KF). In the proposed method, the time delay is mainly mitigated by a parameterized feedforward controller, which is designed using the discrete inverse model of the control plant and adjusted using the KF based on the displacement command and measurement. A feedback controller is employed to improve the robustness of the controller. The objective of this study is to further validate the power of dealing with a nonlinear control plant and to investigate the potential challenges of the proposed method through actual experiments. In particular, the effect of the order of the feedforward controller on tracking performance was numerically investigated using a nonlinear control plant; a series of actual RTHS of a frame structure equipped with a magnetorheological damper was performed using the proposed method. The findings reveal significant improvement in tracking accuracy, demonstrating that the proposed method effectively suppresses the time delay in RTHS. In addition, the parameters of the control plant are timely updated, indicating that it is feasible to estimate the control plant parameter by KF. The order of the feedforward controller has a limited effect on the control performance of the MAC-KF method, and the feedback controller is beneficial to promote the accuracy of RTHS.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.6
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• pp.2439-2445
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• 2014

Cryptotanshinone (CPT), is a quinoid diterpene isolated from the root of the Asian medicinal plant, Salvia miotiorrhiza bunge. Numerous researchers have found that it could work as a potent antitumor agent to inhibit tumor growth in vitro, buith there has been much less emphasis on its in vivo role against breast tumors. Using a mouse tumor model of MCF7 cells, we showed that CPT strongly inhibited MCF7 cell growth in vivo with polarization of immune reactions toward Th1-type responses, stimulation of naive CD4+ T cell proliferation, and also increased IFN-${\gamma}$ and perforin production of CD4+ T cells in response to tumor-activated splenocytes. Furthermore, data revealed that the cytotoxic activity of CD4+ T cells induced by CPT was markedly abrogated by concanamycin A(CMA), a perforin inhibitor, but not IFN-${\gamma}$ Ab. On the other hand, after depletion of CD4+ T cells or blocked perforin with CMA in a tumor-bearing model, CPT could not effectively suppress tumor growth, but this phenomenon could be reversed by injecting naive CD4+ T cells. Thus, our results suggested that CPT mainly inhibited breast tumor growth through inducing cytotoxic CD4+ T cells to secrete perforin. We further found that CPT enhanced perforin production of CD4+ T cells by up-regulating JAK2 and STAT4 phosphorylation. These findings suggest a novel potential therapeutic role for CPT in tumor therapy, and demonstrate that CPT performs its antitumor functions through cytotoxic CD4+ T cells.

• Proceedings of the Korean Institute of Navigation and Port Research Conference
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• v.1
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• pp.395-400
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• 2006

Among the various error sources in positioning and navigation, the paper focuses on the modeling and prediction of receiver clock bias and then tries to achieve positioning based on simulated and predicted clock bias. With the SA off, it is possible to model receiver clock bias more accurately. We selected several types of GNSS receivers for test using ARMA model. To facilitate prediction with short and limited sample pseudorange observations, AR and ARMA are compared, and the improved AR model is presented to model and predict receiver clock bias based on previous solutions. Our work extends to clock bias prediction and positioning based on predicted clock bias using only 3 satellites that is usually the case under urban canyon situation. In contrast to previous experiences, we find that a receiver clock bias can be well modeled using adopted ARMA model. Test has been done on various types of GNSS receivers to show the validation of developed model. To further develop this work, we compare solution conditions in terms of DOP values when point positioning is conducted using 3 satellites to simulate urban positioning environment. When condition allows, height component is derived from other ways and can be set as known values. Given this condition, location is possible using less than 2 GNSS satellites with fixed height. Solution condition is also discussed for this background using mode of constrained positioning. We finally suggest an effective predictive time span based on our test exploration under varied conditions.

• Journal of Fashion Business
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• v.25 no.3
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• pp.1-16
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• 2021

In December 2019, when the novel coronavirus (nCoV) was identified in Wuhan, Hubei, China, the number of people belonging to post-90s generation among about 42,000 medical staffs personnel supporting Hubei was 12,000 or more, accounting for about 33.3% of the total number of personnel. The term "post-90s generation" generally indicates young people born from 1990 to 1999. The study scope is the 1990-2020 period between the birth of post-90s generation and present. Literature and empirical studies are performed. Generational characteristics and fashion trends shown only by post-90s generation through precedent studies and reports are as follows: First, generational characteristics of post-90s generation can be categorized into the following three characteristics: "sang wenhua", "collective loneliness", and "diversified identity". Second, fashion trends of the post-90s generation can be categorized into the following three characteristics: "new Chinese style fashion", "masstige fashion", and "de-labeling fashion". The above results show that the post-90s generation uses "culture" and "me" as keywords. Further, the above trend is consequently divided into the following two characteristics: "diversification" and "individualization". This is because the post-90s generation is directly affected by the reform and opening and the 9-year compulsory education policy of China compared to the previous generations; hence, these people are greatly influenced by Western culture and fashion as well as their own culture and fashion. It refers having a tendency to express one's individuality with a variety of tastes and styles.

• Structural Engineering and Mechanics
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• v.81 no.6
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• pp.715-728
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• 2022

A new type of buckling-restrained braces (BRBs) with a longitudinally profiled steel plate working as the core (LPBRB) is proposed and experimentally investigated. Different from conventional BRBs with a constant thickness core, both stiffness and strength of the longitudinally profiled steel core along its longitudinal direction can change through itself variable thickness, thus the construction of LPBRB saves material and reduces the processing cost. Four full-scale component tests were conducted under quasi-static cyclic loading to evaluate the seismic performance of LPBRB. Three stiffening methods were used to improve the fatigue performance of LPBRBs, which were bolt-assembled T-shaped stiffening ribs, partly-welded stiffening ribs and stiffening segment without rib. The experimental results showed LPBRB specimens displayed stable hysteretic behavior and satisfactory seismic property. There was no instability or rupture until the axial ductility ratio achieved 11.0. Failure modes included the out-of-plane buckling of the stiffening part outside the restraining member and core plate fatigue fracture around the longitudinally profiled segment. The effect of the stiffening methods on the fatigue performance is discussed. The critical buckling load of longitudinally profiled segment is derived using Euler theory. The local bulging behavior of the outer steel tube is analyzed with an equivalent beam model. The design recommendations for LPBRB are presented finally.