• Journal of the Society of Cosmetic Scientists of Korea
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• v.29 no.2 s.43
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• pp.79-104
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• 2003

Introducing to the market place, safe and effective product is an important responsibility of clinical investigators as well as regulatory agencies in all developed countries. Products claiming to improve skin wrinkles are no exceptions. To date, Renova(R) (all-trans retinoic acid), Avage(R) (tazarotene), and Botox(R) (botulinum toxin) are the only agents FDA approved to ameliorate wrinkles associated with photoaged skin in the USA. For all three, clinical evaluation of wrinkle severity was the primary endpoint required for the approval process. No sophisticated instrument measurements of wrinkles were required, nor used in the pivotal studies. The Division of Dermatologic & Dental Products of the US FDA (Director, Jonathan Wilkin, MD) is not against the use of mechanical instruments in assessing wrinkle severity. Its position on this issue however, remains that any such device must be grounded in patients' or product users' perspective, which means that the evaluation instrument must be clinically relevant and clinically perceptible. Sophisticated devices that can detect minimal improvement, but imperceptible to the users are considered useless in the eyes of the US FDA. Two instruments that have been tried in some antiwrinkle studies in the USA are silicone replicas and Primos. Despite their sophistications, they have clear limitations; thus have never replaced clinical evaluations in these studies. At most, they have served as secondary measures to provide corroborative data on the clinical efficacy of antiwrinkle products. For the foreseeable future, at least in the USA, careful clinical assessment of wrinkles will continue to serve as the critical benchmark to determine whether an antiwrinkle product has enough efficacy to benefit its users. We must not lose sight of the fact that sophisticated devices are only to serve in generating supportive evidence, and not the primary evidence, in any clinical studies.

• Journal of the Society of Cosmetic Scientists of Korea
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• v.43 no.4
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• pp.321-327
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• 2017

This study was carried out to develop a stable plant-derived natural sunscreen (BHC-S) that replaces the artificially synthesized organic sunscreen agents. The natural sunscreen (BHC-S), which is composed of peanut extract, Centella asiatica extract, and Ecklonia stolonifera extract, has the same level of ultraviolet shielding effect as PARSOL MCX-XR (OMC), which is a synthetic sunscreen. and has safety against skin. MultiFunctional effect such as and anti-wrinkle improvement. Thus, it can be used as raw material for natural cosmetics for ultraviolet ray blocking, and anti-aging.

• Proceedings of the Korea Information Processing Society Conference
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• 2023.05a
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• pp.515-516
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• 2023

가상 피팅은 옷의 구매에 긍정적인 영향을 미치는 요소이다. 하지만 아직까지 여러 문제가 있어서 상용화가 되기 힘든 현실이다. 이러한 문제들 중에서 우리가 초점을 맞춘 것은 자연스러운 주름의 표현이다. 시간적 특성을 이용해 옷의 움직임을 자연스럽게 하고, 옷의 데이터를 얻어서 그 데이터로 옷의 주름표현과 텍스처 표현을 자연스럽게 할 수 있을 것이다.

• Journal of Korean Medicine Rehabilitation
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• v.19 no.1
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• pp.73-89
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• 2009

Objectives : This study was carried out to investigate the effects of Polygonum cuspidatum extract on several skin functions including inflammation and wrinkle formation. Methods : To investigate in vitro anti-oxidant activity assay, ethanol extracts of medicinal plants tested by DPPH method. In the next experiment, to investigate anti-inflammatory test, the RAW 264.7 macrophage cells was cultured using DMEM including the 10% FBS. To study anti-allergic effect, we blended cultured Human Mast Cells(HMC-1), and then observe $TNF-{\alpha}$, IL-8 by ELISA Results : Polygonum Cuspidatum extract has the effects of anti-inflammation and anti-allergy, which may be due to its inhibitory potential on the macrophage activation. Furthermore, Polygonum Cuspidatum extract has the anti-wrinkle effects through the inhibitory potential on the collagnease, elastase and gelatinase activities. Conclusions : The above results suggest that Polygonum Cuspidatum extract could be applicable for improvement of several skin functions.

• Textile Coloration and Finishing
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• v.29 no.4
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• pp.284-290
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• 2017

The glyoxal has been used as formaldehyde free DP(durable press) agents in wrinkle free treatment for cotton fabrics. However, the yellowing problem is a disadvantage of DP finishing process for cotton fabrics with glyoxal. In order to improve the whiteness, it was investigated that the effect of coreactant and treatment method with various whitening additives such as STB(sodium tetraborate, $Na_2B_4O_7$), SPB(sodium perborate, $NaBO_3$), SC(sodium chlorite, $NaClO_2$) and SPC(sodium percarbonate, $Na_2CO_3{\cdot}1.5$ $H_2O_2$). The increasing the concentration of whitening additives(STB, SPB, SC and SPC), the whiteness and the strength retention ratio of cotton fabrics were increased but the wrinkle recovery angles were decreased in one bath method. It was not suitable to improve whiteness because the whiteness value is about 60. In the case of SC used two bath method, the whiteness is near 70, which is similar to untreated fabrics, without decreasing of WRA and strength.

• KSBB Journal
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• v.28 no.4
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• pp.244-248
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• 2013

In order to investigate functional characterization of callus extracts of apple 'Hirosaki' for cosmetic materials, biological activities of its extracts including wrinkle improvement, hair growth, and anti-inflammatory effect were investigated. The callus extract showed similar activity with TGF-${\beta}$ used as positive control at 50 ${\mu}g/mL$ in the test of collagen synthesis, and increased 40% of proliferation of hair follicle dermal papilla cells. Especially, in case of anti-inflammatory effect, callus extract inhibited about 50% of COX-2 expression which was known as response for intermediating inflammation, and about 70% of eotaxin-1 production which was increased by atopy dermatitis.

• Journal of Fashion Business
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• v.25 no.2
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• pp.51-62
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• 2021

This study evaluated the cosmetic effects of a far-infrared hot and cool mask (BBSkinplus) on face skin moisturization, whitening, and wrinkles using a randomized clinical trial. Forty female participants (mean age 47.7 ± 4.6 years) were allocated into the treatment group (BBSkinplus treatment and lotion application twice a day) or the control group (only lotion application twice a day), and moisture, brightness, and wrinkles were measured at 0, 1 and 2 weeks. The average values of each measurement were changed significantly by BBSkinplus treatment compared to the control group. At the 2-week treatment time point, the statistical differences in improvement rates between the two groups were significant at 8.7% vs. 3.9% for moisture (p < 0.01), 0.7% vs. 0.4% for brightness (p < 0.01), and -3.1% vs. 0.0% as Ra and -6.3% vs. 1.5% as R3z for wrinkles (p < 0.05), respectively. No notable complaint was reported regarding any kind of adverse effects such as erythema, itching, or burning. This clinical data support the potential of BBSkinplus as a home beauty device providing moisturizing, whitening, and anti-wrinkle effects on the face.

• Journal of Microbiology and Biotechnology
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• v.34 no.7
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• pp.1401-1409
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• 2024

Postbiotics have various functional effects, such as antioxidant, anti-inflammatory, and anti-obesity. Levilactobacillus brevis BK3, the subject of this study, was derived from lactic acid bacteria isolated from Kimchi, a traditional Korean fermented food. The antioxidant activity of BK3 was confirmed through the measurements of 2,2-diphenyl-1-picryl-hydrazyl (DPPH), 2,2'-azino-bis (3-ethylbenzothiazoline-6-sulfonic acid) (ABTS), and total antioxidant capacity (TAC). The wrinkle improvement effect was validated by assessing elastase inhibitory activity and collagenase inhibitory activity. The intracellular activity was confirmed using human keratinocytes (HaCaT) and human fibroblasts (HFF-1). BK3 protects skin cells from oxidative stress induced by H₂O₂ and reduces intracellular reactive oxygen species (ROS) production. In addition, the expressions of the antioxidant genes superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx) were upregulated. Meanwhile, matrix metalloproteinase-1 (MMP-1) and collagen type I alpha 1 (COL1A1), involved in collagen degradation and synthesis, were significantly regulated. These results suggest the possibility of utilizing BK3 as a functional ingredient with antioxidant and wrinkle-improving effects.

• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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• v.28 no.2
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• pp.1-12
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• 2015

Objective : The goal of this study is to identify the effects of extract ofGentianae sino-ornata(GSO) on the anti-oxidative activity of skin.For this purpose, several functions of GSO were analyzed in terms of skin-lightening activity and wrinkle improvement. Methods : Cell viability was measured by neutral red (NR) assay, and GSO showed highly efficacy in DPPH radical scavenging activity. The level of tyrosinase and matrix metalloproteinase-1 (MMP-1) in media was analyzed by ELISA kit, and the expressions of p-JNK and p-ERK was measured by Western blot. To elucidate inhibitory effects of GSO on melanin synthesis, I determined the tyrosinase activity and melanin production in B16F10 cells. Results : MMP-1 production in UVB-stimulated HDF cells was inhibited by GSO treatments, and also GSO inhibited protein expression levels of p-JNK and p-ERK. GSO significantly reduced tyrosinase activity and melanin synthesis in B16F10 cells. Conclusions : From these results, GSO appears to be effective on skin elasticity increase, wrinkle improvement, whitening as anti-aging activity.

• Journal of the Society of Cosmetic Scientists of Korea
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• v.36 no.1
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• pp.65-69
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• 2010

Collagen is the most abundant animal protein in mammals, accounting for about 30 % of all proteins. It is present in connective tissue and contributes to the structural framework of most organs. The tripeptide (glycineproline-hydroxyproline) with the INCI name Tripeptide-29 is main component of collagen type I. The palmitoyl tripeptide (palmitoyl-glycine-proline-hydroxyproline) with the INCI name Paimitoyi Tripeptide-29 is a synthetic material that was designed as a topical agent to stimulate collagen production. We synthesized the palmitoyl tripeptide as a potential anti-wrinkle compound. This compound has been characterized using HPLC. This compound proved, through in vitro tests, to stimulate collagen production and fibroblast proliferation. These results were very promising, so human studies were subsequently performed. We investigated the skin improvement effect of the palrnitoyl tripeptide on human skin by using non-invasive instruments. We measured physiological effects such as skin wrinkles and elasticity after volunteers applied the cosmetic products for 8 weeks. We observed significant improvement in skin wrinkles and elasticity after use of the cosmetic products for 8 weeks. We concluded that the palmitoyl tripeptide had an anti-aging effect on human facial skin.