• Animal cells and systems
• /
• 제16권6호
• /
• pp.469-478
• /
• 2012

Sex hormones have long been considered to play an important role in bone turnover rate, periodontal diseases, and wound healing. We have studied the effect of porcine testis steroid extract (PTSE), an extract of porcine testes, which holds a good ratio of 19-nortestosterone (nandrolone), testosterone, androstenedione, $17{\beta}$-estradiol, and estrone, on the healing rate of a standardized full-thickness linear wound on the back of the rat. Skin punch or carbon dioxide ($CO_2$) laser methods were used to create the deep skin injury in two groups of animals. The animals were treated with the PTSE cream, control cream and Vaseline (control) to find out the effect in re-epithelialization, contraction, and formation of granulation and scar tissues. Histological examination after 21 days showed 100, 87.4, and 80.5% recovery of epidermis, dermis, and hypodermis, respectively in the PTSE-treated animals. Similarly, on the 15th day of treatment, complete healing of intact skin was observed in the PTSE cream-treated animals among the laser radiation group. Even though the beginning of re-epithelialization phase and completion of serum crust formation was also observed in the base cream- and Vaseline-treated animals respectively, the complete healing cycle was observed only in the PTSE-treated group. The white blood cell count in the PTSE-treated group showed that PTSE cream is nontoxic to animals.

• 한국임상수의학회지
• /
• 제39권4호
• /
• pp.185-191
• /
• 2022

An Amur softshell turtle with multiple shell injuries was admitted to the Seoul Wildlife Center on 19 May 2021. The most severe lesion was a puncture wound requiring urgent closure. In addition to routine supportive therapy, the damaged shell was patched with biocompatible polymethyl methacrylate (PMMA) materials (bone cement and dental acrylic) and fiberglass. Despite a few methods to repair the carapace or plastron of hard-shelled turtles, shell repair in the Amur softshell turtle has rarely been reported. This paper reports the repair process of a puncture wound in the carapace of a softshell turtle using polymethyl methacrylate (PMMA). PMMA is a biocompatible acrylic polymer that forms a tight structure that holds the implant against tissue defects, such as skin, bones, and dentures. Fiberglass, a preferred fiber in various medical fields, was used with PMMA to provide extra strength and waterproof capability. After the procedure, there were no signs of edema, inflammation, bleeding, skin discoloration, or any other complications. Accordingly, this can be a method of choice in softshell turtles using biocompatible materials to cover the lesion in the carapace and provide appropriate wound management, supportive therapy, and a suitable course of antibiotics considering all other circumstances.

• 대한화상학회지
• /
• 제23권1호
• /
• pp.20-24
• /
• 2020

Diabetic patients have an increased risk of burn injuries on foot. Because of their diabetic neuropathy, they could contact with hot water or warming device without being aware of it. Split-thickness skin graft (STSG) is successful in treatment of various wound types; however, donor site wounds are sometimes problematic, and complications such as pain and impaired healing often occur. Although, donor site wounds in healthy young individuals can rapidly heal without complications, the wound-healing capacity of elderly patients or those with a comorbidity has been reported to be low. The dermatome is the most commonly used tool because it can harvest a large skin graft in one attempt. However, it is difficult to harvest tissues if the area is not flat. Furthermore, because the harvested skin is usually rectangular, additional skin usually remains after skin grafting. Therefore, use of razor blade and fragmented STSG on a large defect area is advantageous for harvesting a graft with a desired size, shape, and thickness. From January 2018 to July 2018, fragmented STSG was used in 9 patients who suffered from burn induced open wound on foot with diabetic neuropathy. With this approach, healing process was relatively rapid. The mean age of patients was 70 (57~86 years) and all of 9 patients had diabetes mellitus type 2. In all patients, the skin graft on the defect site healed well and did not result in complications such as hematoma or seroma.

• Journal of Trauma and Injury
• /
• 제28권3호
• /
• pp.211-214
• /
• 2015

The primary and secondary survey was designed to identify all of a patient's injuries and prioritize their management. However 15 to 22.3% of patient with missed injuries had clinically significant missed injuries. To reduce missed injury, special attention should be focused on patients with severe anatomical injury or obtunded. Victims of blunt trauma commonly had multiple system involvement. Some reports indicate that inexperience, breakdown of estalished protocol, clinical error, and restriction of imaging studies may be responsible for presence of missed injury. The best way of reducing clinical significant of missed injuries was repeated clinical assessment. Here we report a case of severe blunt hepatic injury patient and pericardial injury that was missed in primary and secondary survey. After damage control surgery of hepatic injury, she remained hemodynamically unstable. Further investigation found cardiac tamponade during intensive care. This was managed by pericardial window operation through previous abdominal incision and abdominal wound closure was performed.

• Journal of Trauma and Injury
• /
• 제30권4호
• /
• pp.145-157
• /
• 2017

Purpose: We accessed epidemioloy of 908 acute burns (7 years) in the military, of injuries and propose proper educational programs to suit community. Methods: We surveyed burn demographics, circumstances of injuries, size, result of treatment. Results: The mean age was 20.6 years. The flame burns (FB) (325, 35.8%) were most common, followed scald (SB) (305, 33.6%), contact (CB) (219, 24.1%), electric (EB) (45, 5.0%) and chemical burns (ChB) (14, 1.5%). The more occurred during winter (29.7%). SB had mean 3.9% total body surface area (TBSA). The 251 (82.3%) had superficial burns by spillage of hot water/food on lower limbs (45.6%), feet (33.8%) in summer (34.8%), treated with simple dressing (92.8%). Morbidity rate was 5.6%; post traumatic stress disease (PTSD) (0.7%). FB had large wound (9.3% TBSA). The 209 (64.3%) had superficial burns by ignition to flammable oils (31.7%) and bomb powders (29.2%) on head/neck (60.3%), hands (58.6%) in summer (31.7%), autumn (30.2%). They underwent simple dressing (83.4%) and skin graft (16.0%). Morbidity rate was 18.8%; PTSD (10.5%), inhalation injuries (4.0%), corneal injury (3.7%), amputations (0.9%), and mortality rate (1.2%). CB had small (1.1% TBSA), deep burns (78.5%) by hotpack (80.4%) on lower limbs (80.4%). The more (59.8%) underwent skin graft. EB had 6.8% TBSA. The 29 (64.4%) had superficial burns by touching to high tension cable (71.1%) on hand (71.1%), upper limbs (24.4%) in autumn (46.8%). They underwent simple dressing (71.1%) and skin graft (24.4%). They showed high morbidity rate (40.0%); loss of consciousness (13.3%), nerve injuries (11.1%), neuropathy (8.9%), amputations (2.2%), and mortality rate (2.2%). Conclusions: The cook should wear apron over the boots during work. The lighter or smoking should be strictly prohibited during work with flammable liquids or bomb powders. Don't directly apply hotpack to skin for a long time. Use insulating glove during electric work. Keep to the basic can prevent severe injury and proper education is important.

• Archives of Plastic Surgery
• /
• 제32권4호
• /
• pp.408-415
• /
• 2005

Following a transverse rectus abdominis musculocutaneous(TRAM) flap breast reconstruction, denervated state of the flap causes the flap skin prone to thermal injury, calling for special attention. During the last 5 years, 69 breast reconstruction with 72 free TRAM flaps, were performed. Four out of thesse 69 patients sustained burn injury. Heat sources were a warm bag(n=2), heating pad(n=1) and warming light (n=1). The thermal injuries occured from 2 days to 3 months following the reconstruction. Three patients healed with conservative treatment, but one patient required debridement and skin graft. Initially 3 out of 4 patients with the burn had shown superficial 2nd degree burn with small blebs or bullae. However all 4 patients healed with scars. Mechanism of burn injuries of the denervated flap are known to be resulting from; 1) loss of behavioral protection due to denervation of flap with flap elevation and transfer, 2) loss of autonomic thermoregulatory control with heat dissipation on skin flap vasculature contributing to susceptibility of burn injury. 3) changes of immunologic and normal inflammatory response increasing thromboxane, and a fall in substance P & NGF (nerve growth factor). Including the abdominal flap donor site, sensory recovery of the reconstructed breast varies individually from 6 month even to 5 years postoperatively. During this period, wound healing is delayed, resulting in easier scarring compared to that observed in the sensate skin. Patients should be carefully informed and warned of possible burn injuries and taught to avoid exposure to heat source at least until 3 years postoperatively.

• Journal of Chest Surgery
• /
• 제30권4호
• /
• pp.402-407
• /
• 1997

1986년 3월부터 1995년 3월까지 본 마산삼성 병원 흉부외과에서 경험한 총 28례의 외상성 횡 경 막 손상 환자를 분석 하였다. 들상에 의한 경우가 20례, 자상인 경우가 8례로서 둔상인 경우 1)례가 좌측, 자상인 경우 5례가 좌측으로 전반적으로 좌측이 우측보다 많았다. 대부분 다발성 손상을 동반하였으며 모든 예에서 흉통, 호흡곤란, 복통 등의 소견을 관찰할 수 있었고 내원당시 응급실에서 횡경막 파열을 의심할 수 있었던 경우는총25례로서 흉부X선 20례 UGI 3례, 폐쇄식 흉관 삽관식 손가락으로 파열공의 직접 확인이 2례 였다. 수술적 접근은둔상의 경우개흉술이 16례,개흉복술이 1례,개복술이 I례며,관통상의 경우는개흉술 3례, 개복술이 5례로서 수상후부 터 수술까지의 경과시간은 5시간 이내가 19례였다. 좌측 손상시 12례에서 위장이 늑막강내로 올라가 있었으며, 모든 결손은 비홉수성 봉합사를 사용하여 직접 단순 봉합을 하였으며, 술후 5례에서 패혈증, 저혈성 쇽크, 두부손상, 신부전 으로 술후 3일이내 사 망하였다.

• 치위생과학회지
• /
• 제15권6호
• /
• pp.845-850
• /
• 2015

이번 연구는 진료실 내 안전사고에 의한 외상 경험 실태와 예방 실천에 대해 파악하는 연구이다. 치과 병 의원에서 종사하고 있는 치과위생사 366명을 대상으로 자기기입식 설문조사를 실시하였다. 최근 6개월 동안 외상 경험은 연구대상자 366명 중 307명(83.9%)이 경험한 적이 있다고 응답하였고 유형으로는 전체응답자 366명 중 찔림이 294회(80.3%)로 가장 경험이 많았고 절상, 찰과상, 화상 순이었다. 외상 원인으로는 찔림의 원인이 된 기자재 중 explorer가 93명(25.4%)으로 가장 많았으며 needle이 66명(18.0%)로 그 다음으로 나타났다. 절상(베임)은 blade가 36명(9.8%), 화상 원인은 sterilizer로 26명(7.1%), 찰과상 원인은 movable cart 47명(12.8%)으로 가장 많았다. 찔림 경험을 한 후 응급처치로 알코올 솜으로 닦는 경우가 40.8%으로 가장 많았고, 응급실 방문은 없는 것으로 나타났다. 절상(베임)을 경험 한 후 응급처치로 베타딘으로 소독하는 경우가 42.8%으로 가장 많았고, 화상을 경험 후 응급처치는 찬물로 씻는 경우가 73.0%으로 절반이 넘게 나타났다. 일반적 특성에 따른 외상 경험의 차이를 조사한 결과 연령, 근무경력(p<0.001), 최종학력(p=0.006), 직위, 업무영역(p=0.001)에서 통계적으로 유의한 차이가 있다고 나타났다. 일반적 특성에 따른 안전사고 예방 실천도의 차이를 조사한 결과 외상 경험 여부(p=0.030), 연령(p=0.015)과 치과유형(p=0.003)이 통계적으로 유의한 차이가 있는 것으로 나타났다. 치과 외상 경험 실태와 안전사고 예방 실천에 관련된 연구를 통하여 진료실 내 안전사고 예방이 체계적인 과정으로 확립되어야 하고 정기적인 교육을 통하여 안전에 대한 중요성을 부여하여야 한다.

• Journal of Chest Surgery
• /
• 제14권4호
• /
• pp.311-318
• /
• 1981

A clinical evaluation was performed on 402 cases of chest trauma those were admitted and treated at the department of chest surgery, Chonnam National University Hospital, during the past 13 years and 7 months from Jan. 1968 to July 1980. 1. The ratio of male to female was 5.5:1 in 1968 and 3.4:1 in 1980 with progressive increase of female patient and age from 20 to 59 years is 81.0%. 2. The most common cause of chest trauma was stab wound in penetrating trauma and traffic accidents in nonpenetrating trauma. 3. The most common injury from chest trauma was hemothorax in penetrating trauma and rib fracture in nonpenetrating trauma. 4. Hemothorax was observed in 76 cases [18.9%] of total cases and rib fracture was observed in 163 cases [40.5%] of total cases. 5. Rib fracture was prevalent from 4th to 8th rib, and 1st and 2nd rib fractures were associated with major thoracic injuries and with other organ injuries. 6. Open thoracotomy was performed in 72 cases [17.9%] and others were treated with conservative nonoperative treatment. 7. Overall mortality was 4.5% [19 cases], and common causes of the death were shock and respiratory insufficiency.

• Archives of Plastic Surgery
• /
• 제45권1호
• /
• pp.80-84
• /
• 2018

Although uncommon, shark attacks can lead to devastating outcomes for victims. Surgeons also face unique challenges during operative management such as exsanguination, shock, specific injury patterns and infections. This case report presents the management of a 39-year-old previously healthy female attacked by a shark while on vacation in Mexico. The patient sustained severe injuries to her left arm and her left thigh. She was transferred to a Canadian institution after ambiguous operative management in Mexico and presented with no clear antibiotic coverage and a Volkman's contracture of the left upper extremity. In total, the patient underwent four washouts of wounds, two split-thickness skin grafts, one free anterolateral thigh flap, and one free transverse rectus abdominus myocutaneous flap for the reconstruction and salvage of the left lower extremity. This article highlights the specifics of this case and describes important points in managing these devastating injuries.