• 대한한방소아과학회지
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• 제36권3호
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• pp.1-18
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• 2022

Objectives The purpose of this study was to investigate the current status of interventional clinical trial registration for children with precocious puberty and to secure basic data for the design of clinical trials for traditional Korean medicine treatment of precocious puberty. Methods The following resources were used to search for data: Clinicaltrial.gov, World Health Organization International Clinical Trials Registry Platform (WHO ICTRP), and Clinical Research Information Service (CRIS), using the search terms, 'Precocious puberty', 'child'. All clinical trials which were registered as of June 2022 were used. Results For the intervention and clinical trial design, gonadotropin releasing hormone (GnRH) analog was reported in 41.7% of trials, and single group assignment was performed in 66.7% of the studies. Prior consent had not been reported in 50% of the studies. Tanner stage and GnRH stimulation tests were reported by multiple trials as inclusion criteria, and prior treatment experiences for trial drugs were reported as exclusion criteria. The peak serum concentration of luteinizing hormone following GnRH stimulation test was used as a primary outcome in 45.8% of clinical trials, and other growth-related indicators such as growth rate, height, and predicted adult height were also reported. Conclusions In consideration of the design, eligibility criteria, and outcome measurement of the existing clinical trials identified in this study, it should be referred to in the design of clinical trials for traditional Korean medicine treatment of precocious puberty.

• 한국임상약학회지
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• 제32권2호
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• pp.106-115
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• 2022

Background: The World Health Organization (WHO) has focused on the need for interprofessional education (IPE) to improve interprofessional collaboration competency and patient health outcomes. Accordingly, most European and North American medical colleges have established IPE for students. However, IPE learning activity in medical wards for the clinical experience of pharmacy students has not been fully reviewed in Korea. Therefore, this study aims to examine the current status of IPE learning activities in wards at tertiary and secondary hospitals in order to identify ways to improve the program. Methods: The official document of cooperation consists of six self-administered questions regarding IPE learning activities in wards. The preceptor's response in each hospital was evaluated. Results: Of the 22 hospitals, 9 tertiary hospitals and 12 secondary general hospitals responded. For the introductory pharmacy practice experience (IPPE), participating in intensive care (IC) was provided at one secondary general hospital (8.3%) and no tertiary hospital. Ward rounds with medical staff members were provided at two tertiary hospitals (22.2%) and one (8.3%) secondary general hospital. A major barrier to executing IPE was lack of rewards and incentives for the faculty and preceptors who participated in the program. Conclusion: In both tertiary hospitals and secondary general hospitals, pharmacy students have limited exposure to IPE learning activities in wards at hospital, and IPPE at most hospitals was carried out in pharmacy settings only. This study suggests that it is necessary for the hospitals to improve and support IPE learning activities in wards in order to improve learners' competency.

• 한국치위생학회지
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• 제7권4호
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• pp.553-567
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• 2007

Migrant Worker are rapidly increasing in Korea since 1990. They are nowadays main sources of laborer groups engaging in medium-sized factories. The purpose of this study is to provide the basic information to establish proper oral health policy. Dental caries and periodontal disese are the most common disease that occur in the mouth. Periodontal disease is the most common disease in humans and the biggest reason for the loss of the teeth in the adult population. The CPITIN has been developed jontly by the international Dental Federation and the World Health Organization. CPITN is now an established index of level, of periodontal condition in populations for which specific intervention might be considered. This study was conducted to obtain the information regarding to CPITN of migrant workers located in Daegu, Questionaire survey was carried out for 289 workers from July 9 to August 8, 2006. Total survey was 289, 224 males and 65 females. The result was as follows: First, The number of nationality was 14. The first majority was China as 31.8% Among 14 nationalities were Cambodia 18.0%, Vietnam 12.8%, Sri Lanka 12.1%, Indonesia 7.3%, Nepal 4.2%, the other 13.8%, those who are aged from 20 to 29 were 43.9%, and salary from 1,000,000 won to 1,490,000 won 51.2%.(as for their residence, those who resided) over 3 years were 42.6% and not insured reached 68.5%. Second, more than 93.4% of the subjects need periodontal treatment, only 4.9% of non-smoker was health periodontal states, four times frequency of tooth brushing per a day was 16.7%. Third, 28.7% of migrant workers had experienced visit of dental clinic, and 22.9% had received treatment of decayed tooth. Fourth, It is difficult for them 65.1% of them to visit dental clinic in korea, the First was a communication problem and the second was time. Fifth, Most of them didn't have a oral health education but 85.1% of them said that they wish they attend oral health education. We conclude that the situation of migrant workers was very bad considering their working conditions, circumstances, and health condition. According to this study, more than 93.4% of the people need periodontal treatment. Besides they didn't have accurate knowledge about prevention of periodontal disease. Therefor our considering these facts, the policy of dental health by government should be established for migrant workers.

• 대한방사선기술학회지:방사선기술과학
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• 제22권2호
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• pp.41-46
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• 1999

Osteoporosis, which causes mainly fracture of the spine, proximal femur and distal radius by minimal trauma, is a major public health problem and its prevalence is steadily increasing in Korea according to the development of public health care. There are reliable methods for diagnosis based on bone densitometry. Early detection and intervention are important for reducing the incidence of fractures. A consensus definition of osteoporosis, based on bone density measurement, has been developed by the World Health Organization(WHO). In this study, bone mineral density(RMD) was measured by dual energy x-ray absorptiometry(DEXA) at the proximal femur and lumbar spine in 132 post-menopausal women. The purpose of this study is to find influential factors on the BMD of the proximal femur and the lumbar spine and to analyze correlation between BMD and the problematic factors. We obtained the following results : 1. Mean BMD score, T-score and Z-score of the proximal femur were $0.81(g/cm^2)$, -2.45(S.D.) and -2.09(S.D.) respectively and in the lumbar spine were $0.83(g/cm^2)$, -2.02(S.D.), -2.43(S.D.) respectively. 2. In correlation analysis between BMD and many factors, correlation coefficients were -0.467, 0.212, -0.321 and 0.241 in age, height, duration after menopause respectively. BMI and the residuals were comparatively small. 3. Correlation coefficients to age matched BMD, in height and body weight were 0.222 and 0.241, in age and duration after menopause were -0.268, -0.282. 4. The fracture threshold of proximal femur BMD to the 90th percentile was $0.845(g/cm^2)$. 5. At the result of multiple regression analysis, age, body weight, $BMI(kg/m^2)$ and duration after menopause described as significant variables.

• Asian Pacific Journal of Cancer Prevention
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• 제17권1호
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• pp.239-247
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• 2016

Background: The overall cervical cancer incidence rate is low in Iran; however, because of a higher risk of death for cervical cancer, a disease that kills women in middle age, a cervical cancer control program is needed. The aim of this study was to provide consensus recommendation for cervical cancer prevention in Iran and other Muslim societies with low incidences of cervical cancer. Materials and Methods: Through a practical guideline development cycle, we developed six questions that were relevant to produce the recommendation. We reviewed 190 full text records of cervical cancer in Iran (1971 to 2013) of which 13 articles were related to the data needed to answer the recommendation questions. We also reviewed World Health Organization, IARC, GLOBOCAN report, Iran Ministry of Health cancer registry report and 8 available foreign countries guidelines. Lastly, we also evaluated the Pap smear results of 825 women who participated in the Iranian HPV survey, of whom 328 were followed-up after a 5-year interval. Results: The obtained data highlighted the burden of HPV and cervical cancer situation in Iran. Experts emphasized the necessity of a cervical cancer screening program for Iranian women, and recommended an organized screening program with a cytological evaluation (Pap smear) that would start at the age of 30 years, repeated every 5 years, and end at the age of 69 years. Meanwhile, there is no need for screening among women with a hysterectomy, and screening should be postponed to post-partum among pregnant women. Conclusions: An organized cervical cancer screening is a necessity for Iran as more than 500-900 women in middle age diagnosed with an invasive cervical cancer every year cannot be ignored. This recommendation should be taken into account by the National Health System of Iran and Muslim countries with shared culture and behavior patterns. CUBA HPV test could be consideration in countries Muslim country with appropriate budget, resources and facility.

• 성인간호학회지
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• 제28권2호
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• pp.237-245
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• 2016

Purpose: The aim of this study was to examine the effects of an Advanced Practice Nurse (APN)-led self-management program on cardiovascular health status among Korean women at risk of developing or progressing cardiovascular disease. Methods: This pilot study used one-group pre- and post- test experimental design. At health fairs in a community, 30 women who had one or more risk factors for metabolic syndrome were recruited and agreed to participate in the study. A total of 25 women completed the study. The intervention consisted of weekly follow-up calls and self-monitoring diary after an hour of individual counseling regarding risk factors, fast walking, and healthy diet tailored to the participants' needs. Physical activity was assessed with the World Health Organization International Physical Activity Questionnaire and a pedometer. Results: Participants showed statistically significant improvements in blood pressure, body mass index, levels of triglyceride, total cholesterol and low density lipoprotein, numbers of metabolic syndrome factors, and the 10-year CV risk estimate after one month of concentrated intervention. In addition, their physical activity behavior significantly improved after the intervention. Conclusion: This APN-led self-management program targeting modifiable risk factors by offering tailored counseling and concentrated support during the transition might be effective in preventing progression to the cardiovascular disease.

• 대한치위생과학회지
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• 제4권1호
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• pp.39-51
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• 2021

Background: Limited information is available regarding the associations of various nutrients and periodontitis in Korea. Furthermore, these associations have been controversial in previous studies. Therefore, the present study aimed to evaluate the associations between several nutrients and periodontitis. Methods: Pooled data from the 2007~2010 and 2012 Korea National Health and Nutrition Examination Surveys (KNHANES) were used for the present study. Periodontitis was defined using the World Health Organization (WHO) Community Periodontal Index. All participants completed the Food Frequency Questionnaire (FFQ), which was analyzed using CAN-Pro 4.0. Vitamins A, B₁, B₂, and C, iron, phosphorus, calcium, and protein were selected for analysis. Multiple logistic regression analyses were used to estimate the odds ratios (ORs) for periodontitis. Results: Lower intake of phosphorus (adjusted odds ratio [AOR] = 1.86), calcium (AOR = 1.25), and protein (AOR = 1.52) were associated with periodontitis in males, and lower intake of vitamins A (AOR = 1.32), B1 (AOR = 1.21), B2 (AOR = 1.24), and C (AOR = 1.21), iron (AOR = 1.25), phosphorus (AOR = 1.33), and protein (AOR = 1.27) showed significant relationships with periodontitis in females. In the sociodemographic, somatic, and health behavior-adjusted models, lower phosphorus (AOR = 2.68) and protein (AOR = 1.68) intake in younger males, and lower vitamin A intake (AOR = 1.37) in middle-aged females were significantly associated with periodontitis. Conclusions: The results of the present study demonstrated a significant association between periodontitis and nutrient intake. To avoid an insufficient nutrient supply for a patient with periodontal disease, the patient's diet should be closely monitored.

• Journal of Yeungnam Medical Science
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• 제40권1호
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• pp.49-57
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• 2023

Background: Several previous studies have reported that quality of life (QoL) in hemodialysis patients affects mortality. However, the 36-item Short Form Health Survey, which has been used mainly in previous studies, is complicated in terms of questionnaire composition and interpretation. This study aimed to identify the impact of QoL on mortality in hemodialysis patients using an easier and simpler diagnostic tool. Methods: This retrospective study included 160 hemodialysis patients. QoL was evaluated using the World Health Organization Quality of Life Questionnaire-Brief version (WHOQOL-BREF). Psychosocial factors were evaluated using the Hospital Anxiety and Depression Scale, Multidimensional Scale of Perceived Social Support, Montreal Cognitive Assessment, and Pittsburgh Sleep Quality Index. We also evaluated medical factors, such as dialysis adequacy and laboratory results. Results: The mean hemodialysis vintage was 70.7±38.0 months. The proportion of patients who were elderly was higher in the mortality group than in the surviving group, and the Charlson Comorbidity Index score was also higher in the former group. Of the four domains of the WHOQOL-BREF, the physical health and psychological scores of the mortality group were significantly lower than those of the survival group. When the score in the physical health domain or psychological domain was ≤10, the 10-year mortality rate after hemodialysis initiation increased by approximately 2.3- and 2-fold, respectively. Conclusion: QoL may have a significant effect on mortality in patients undergoing hemodialysis. The WHOQOL-BREF is an instrument that can measure QoL relatively easily and can be used to improve the long-term prognosis of patients undergoing hemodialysis.

• 한국환경보건학회지
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• 제49권2호
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• pp.57-65
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• 2023

Background: The association between exposure to extremely low frequency-magnetic fields (ELF-MF) and childhood leukemia has been controversial. There is a need to clarify this relationship by summarizing key conclusions from systematic review articles. Objectives: The major aim of this study is to summarize key conclusions from systematic review articles on the association between exposure to ELF-MF and childhood leukemia based on childhood exposure to ELF-MF, proximity from childhood household to high voltage cables, and parental occupational exposure to ELF-MF. Methods: This study was conducted through a brief literature review focusing on systematic, meta-analysis, and pooled analysis methods. We conducted a literature search in PubMed using the key words "ELF-MF" and "childhood leukemia" singly or combined. Results: In 2002, the World Health Organization (WHO)'s International Agency for Research on Cancer (IARC) reviewed two manuscripts to conduct pooled analysis and concluded that there is a significant association between exposure to >0.3 μT or 0.4 μT and childhood leukemia. We found a total of four manuscripts for systematic or pool analysis that have been published since the IARC's conclusion. They consistently concluded that there was a significant association between exposure to >0.4 μT and childhood leukemia compared to ELF-MF exposure to below 0.1 μT. The proximity of children's households to high voltage cable lines and occupational exposure by their parents to ELF-MF during certain periods prior to or during pregnancy were inconsistently associated with childhood leukemia. The study found that many EU countries have implemented precautionary policies to prevent potential childhood leukemia due to exposure to ELF-MF. Conclusions: This study recommends implementing a precautionary policy that includes legal exposure limits for ELF-MF to minimize exposure to ELF-MF.

• 대한정형외과학회지
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• 제56권6호
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• pp.491-497
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• 2021

목적: 단순 방사선상 척추 추체의 골 음영이 감소된, 즉 골다공증이 의심된 남성에서 골밀도 검사를 통해 골다공증(또는 골감소증)의 유병률을 알아보고자 하였다. 대상 및 방법: 정형외과 진료를 받은 남성 중 척추의 단순 방사선상 골다공증이 의심되었던 98명(이하 의심군)에서 실제 유병률을 확인하기 위해 이중에너지 X-선 흡수계측법 골밀도 검사를 실시하였고, 그 결과를 대조군 168명, 골다공증성 골절로 치료받은 환자군 113명(이하 골절군)과 비교하였다. 각 군마다 세계보건기구(World Health Organization, WHO) 방법(요추 평균 및 대퇴골 경부 골밀도 중 최하값)과, Hansen 방법(요추 1-4번 골밀도 중 최저값)의 두 가지 방법으로 골밀도 값의 평균, 표준편차를 비교하였고, 각 군별 골다공증, 골감소증의 유병률에 대해 확인하였다. 결과: 각 군별 골밀도 값의 평균(±표준편차) 통계 조사 결과, 의심군이 -1.4 (±1.2), 대조군이 -0.8 (±1.1), 골절군이 -2.4 (±1.0)으로 통계적으로 유의한 결과를 나타냈다. 각 군별 골다공증의 유병률을 WHO 방법(요추 평균 및 대퇴골 경부 골밀도 중 최하값)으로 비교한 결과 의심군 17.3%, 대조군 8.3%, 골절군의 45.1%에서 골다공증이 진단되었고, 의심군의 40.8%에서 골감소증이 관찰되었다. Hansen 방법(요추 1-4번 골밀도 중 최저값)으로는 의심군 30.6%, 대조군 17.9%, 골절군 62.0%가 골다공증으로 진단되었다. 결론: 요추 단순 영상에서 골음영이 감소된 것으로 의심되어 골밀도 검사로 확인한 남성 환자들 중 17.4%에서 골다공증이, 40.8%에서 골감소증이 진단되었다. 대조군 또한 전체의 8%에서 골다공증이 확인되었다. 이러한 결과는 남성에서도 골다공증의 존재 가능성이 적지 않음을 일깨워 주는 것으로, 특히 단순 영상에서 골다공증이 의심될 경우 골밀도 검사를 통한 확인이 필요함을 말해 준다.