• Nuclear Engineering and Technology
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• v.26 no.2
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• pp.294-299
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• 1994

Margin benefits are quantatively assessed when a Digital Monitoring System(DMS) is assumed to be installed to an operating Westinghouse analog type plant. Applied plant and cycle is YongGwang Unit 1 Cycle 6. The referenced digital monitoring system is the COLSS (Core Operating Limit Supervisory System) of ABB-CE. Considered fuel design limits are DNBR and LDCA Fq. 2003-D Power distributions within the present CAOC (Constant Axial Offset Control) limits are calculated for the analysis. The most limiting DNB prevention event of CEA Withdrawal is analyzed with the ROPM (Required OverPower Margin) concept of ABB-CE. The result show that the DMS can bring around 7% more margins for both DNB and LOCA Fq standpoints of view. The DMS can also monitor the PCI (Pellet-Cladding Interaction) limits.

• Journal of the Architectural Institute of Korea Structure & Construction
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• v.34 no.4
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• pp.3-13
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• 2018

Load bearing capacity of dowel type fasteners loaded perpendicular to the shear plane is determined based on Johansen's yield theory (Johansen, 1949). In case of inclined screws whose axis is no longer perpendicular, the ultimate load of connection increases because of additional axial withdrawal capacity. To calculate load bearing capacity for inclined screws, KBC2016 and Eurocode5 provide design equations using the combination of two effects; axial and bending strength. Although their equations have been validated for a long time, there is still minimal information how to apply them for concrete-CLT joints. Since there are not many test data available, engineers have to make certain assumptions and thus results may look inconsistent in practice. In this paper, authors would like to describe the current approach and assumptions indicated by KBC2016 and Eurocode 5 and how they match the experimental results in terms of shear strength of CLT-concrete connections. To fulfill the objective, several push-out tests were performed on nine different test specimens. Each specimen has different penetration angles and depths. By analyzing load-displacement curves, the maximum shear strength, stiffness, and ductility were obtained. Shear strength values were compared with the current design codes and theoretical equations proposed in this paper. Observations on stiffness and ductility were briefly discussed.

• Journal of the Korean Wood Science and Technology
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• v.36 no.3
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• pp.85-92
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• 2008

Strength of logs and round posts is compared and analyzed to estimate the strength of the incised Larix round posts treated with CCA in this paper. There is no significant difference in MOR of logs and round posts. However, in the incised Larix round posts treated with CCA MOE is decreased to about 9%, and there is 29% reduction in MOR as strength ratio is 0.71. When calculating the allowable bending stress of incised round type round posts, not in nominal 2-in timbers, an adjustment factor for MOE and bending strength is proposed as 0.91 and 0.71, respectively. Logs, round posts and the incised Larix round posts treated with CCA do not show significant difference in nail withdrawal load. There is almost no difference between incised Larix round posts treated with CCA and round posts in the shear strength of bolted joint. When calculating the allowable shear stress of bolted joint, it is conformed that considering the application of incising factor is not necessary.

• Journal of Life Science
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• v.34 no.5
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• pp.320-332
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• 2024

The aims of this study were to compare the differences in hemodynamics between cigarette smoking and using heated tobacco products (HTPs) and to determine the acute effects of using HTPs on cardiac autonomic regulation. Another goal was to examine the acute cardiac autonomic responses when using different tobacco sticks in HTPs. Sixteen healthy male smokers completed an open-label, randomized, crossover trial consisting of non-smoking (NS), cigarette smoking, and the use of two different HTPs (IQOS with HEETS; lil SOLID with Fiit). Sub-trials, which included NS, lil SOLID with Fiit, and lil SOLID with HEET, were performed on eight smokers among the total subjects. Hemodynamic variables, such as systolic blood pressure (SBP) and diastolic blood pressure (DBP), and heart rate variability were measured before, during, and 30 minutes after using each tobacco product. Using HTPs resulted in a significant increase in both SBP and DBP, comparable to smoking cigarettes. Cardiac sympathetic activity significantly increased, and cardiac vagal tone (CVT) significantly decreased after acute exposure to HTP aerosol, similar to the effects of cigarette smoke exposure. Furthermore, differences in the withdrawal of CVT were observed when using different tobacco sticks in the same HTPs. The findings of this study indicate that acute exposure to HTP aerosol increases the hemodynamic burden and disrupts cardiac autonomic balance, similar to exposure to cigarette smoke. Moreover, depending on the type of tobacco stick inserted into the HTP device, acute withdrawal of CVT may have been enhanced.

• Women's Health Nursing
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• v.18 no.4
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• pp.290-301
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• 2012

Purpose: The purpose of this study was to investigate the contraceptive knowledge and practice among married immigrant women. Methods: A cross-sectional survey design with a convenient sampling was used. 170 married immigrant women were recruited in Daejeon city and Chungcheong area. A structured questionnaire was self-administered from November 1, 2011 to January 13, 2012. Results: 48.2% of subjects have used contraceptive practice. The widely used contraception methods were IUD, condom, oral pill and withdrawal. 73.2% of subjects got information about contraception from family and friends, and 18.3% of subjects had no source of information. The subjects' employment state (p = .006), duration of marriage (p = .019), number of baby (p = .021), family type (p = .046) have a significant influence on their contraceptive practice. The subjects' mean score of contraceptive knowledge was very low (5.72 points out of 15 points). There were significant differences in subjects' contraceptive knowledge depending on their education level (p = .002), employment state (p<.001), country of origin (p = .010), and family type (p = .003). Conclusion: To improve contraceptive knowledge and practice for married immigrant women, it is necessary to develop a proper contraceptive education program to enhance contraceptive knowledge and practice. Adjusted education program by this results will contribute to increase sexual health for married immigrant women.

• The Korean Journal of Physiology and Pharmacology
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• v.19 no.4
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• pp.349-355
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• 2015

We examined the effects of peripherally or centrally administered botulinum neurotoxin type A (BoNT-A) on orofacial inflammatory pain to evaluate the antinociceptive effect of BoNT-A and its underlying mechanisms. The experiments were carried out on male Sprague-Dawley rats. Subcutaneous (3 U/kg) or intracisternal (0.3 or 1 U/kg) administration of BoNT-A significantly inhibited the formalin-induced nociceptive response in the second phase. Both subcutaneous (1 or 3 U/kg) and intracisternal (0.3 or 1 U/kg) injection of BoNT-A increased the latency of head withdrawal response in the complete Freund's adjuvant (CFA)-treated rats. Intracisternal administration of N-methyl-D-aspartate (NMDA) evoked nociceptive behavior via the activation of trigeminal neurons, which was attenuated by the subcutaneous or intracisternal injection of BoNT-A. Intracisternal injection of NMDA up-regulated c-Fos expression in the trigeminal neurons of the medullary dorsal horn. Subcutaneous (3 U/kg) or intracisternal (1 U/kg) administration of BoNT-A significantly reduced the number of c-Fos immunoreactive neurons in the NMDA-treated rats. These results suggest that the central antinociceptive effects the peripherally or centrally administered BoNT-A are mediated by transcytosed BoNT-A or direct inhibition of trigeminal neurons. Our data suggest that central targets of BoNT-A might provide a new therapeutic tool for the treatment of orofacial chronic pain conditions.

• Nuclear Engineering and Technology
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• v.56 no.3
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• pp.973-979
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• 2024

In the framework of the Generation IV research and development project, in which the French Commission of Alternative and Atomic Energies (CEA) is involved, a main objective for the design of Sodium-cooled Fast Reactor (SFR) is to meet the safety goals for severe accidents. Among the severe ones, the Unprotected Transient OverPower (UTOP) accidents can lead very quickly to a global melting of the core. UTOP accidents can be considered either as slow during a Control Rod Withdrawal (CRW) or as fast. The paper focuses on fast UTOP accidents, which occur in a few milliseconds, and three different scenarios are considered: rupture of the core support plate, uncontrolled passage of a gas bubble inside the core and core mechanical distortion such as a core flowering/compaction during an earthquake. Several levels and rates of reactivity insertions are also considered and the thermal-mechanical behavior of an ASTRID fuel pin from the ASTRID CFV core is simulated with the GERMINAL code. Two types of fuel pins are simulated, inner and outer core pins, and three different burn-up are considered. Moreover, the feedback from the CABRI programs on these type of transients is used in order to evaluate the failure mechanism in terms of kinetics of energy injection and fuel melting. The CABRI experiments complete the analysis made with GERMINAL calculations and have shown that three dominant mechanisms can be considered as responsible for pin failure or onset of pin degradation during ULOF/UTOP accident: molten cavity pressure loading, fuel-cladding mechanical interaction (FCMI) and fuel break-up. The study is one of the first step in fast UTOP accidents modelling with GERMINAL and it has shown that the code can already succeed in modelling these type of scenarios up to the sodium boiling point. The modeling of the radial propagation of the melting front, validated by comparison with CABRI tests, is already very efficient.

• Journal of Korea Society of Digital Industry and Information Management
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• v.13 no.1
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• pp.173-183
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• 2017

The purpose of this study is to find out the difference of sense of self-efficacy and stress encountering strategy of university students under the stress situation depending on the smart-phone user group (addiction group, general user group). For this purpose, the study issues are established as follows. First, it has analyzed what is the correlation of smart-phone addiction, sense of self-efficacy, and stress encountering strategy. Second, it has studied if there is any difference of sense of self-efficacy and stress encountering strategy for the smart-phone user group. In order to verify such study issues, For 1,670 university students in the Chungcheong area, smart-phone addiction scale, sense of self-efficacy scale, and stress encountering method scale were administered. Looking into the study result, first, as a result of the relativity analysis, it displayed the correlation of preference of test difficulty, self-control efficacy and important negative from the smart-phone addiction and sense of self-efficacy. In addition, all sub-variables of smart-phone addiction and avoidance orientation from the stress encountering strategy displayed the important positive correlation, and from the smart-phone addiction, the virtual world orientation and pursuit of social-support displayed the important negative correlations, and all sub-variables (interference with ordinary living, virtual world striving direction, withdrawal, resistance) of smart-phone addiction and problem solving-orientation displayed the negative correlation. Second, as a result of verification for the difference of the smart-phone addiction group and general use group following the sense of self-efficacy, the general use group is shown to have higher self-control efficacy sense than the addiction group. And third, as a result of verifying the difference of stress encountering following the smart-phone addiction group and general use group, the addiction group is shown to be lower than the general use group in terms of social support pursuit and problem solution orientation with the avoidance orientation shown to be higher. This type of result is expected to provide the base data when developing the smart-phone addiction preventive education program by finding out in details for the characteristics of smart-phone addiction group for university students.

• Korean Journal of Biological Psychiatry
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• v.10 no.2
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• pp.159-167
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• 2003

Objective:Under the hypothesis that 5-HTTLPR polymorphism plays some role in the susceptibility or vulnerability of some subgroup of alcohol dependence, associations of 5-HTTLPR polymorphism with alcohol dependence were examined. Method:This association analysis included 109 Korean alcohol dependent and 113 Korean control subjects. DNA of all subjects were genotyped for the biallelic functional polymorphism in the 5-HTTLPR. Considering the likelihood of heterogeneity in the alcohol dependence phenotype, alcohol dependent subjects were subgrouped by onset age, family history of alcohol dependence and severity of withdrawal symptoms. Results:There were no significant differences in the frequencies of either the 5-HTTLPR genotype or the short vs. long allele in alcohol dependent and control subjects. The frequency of the S allele and S-carrier (LS or SS genotype) was significantly increased in the early onset alcohol dependent subjects and the familial alcohol dependent subjects compared with that in the control subjects. Conclusion:The results suggest that the 5-HTT 'S' promoter polymorphism is associated with an increased susceptibility or vulnerability to develop early onset alcohol dependence and familial alcohol dependence, which characterize Cloninger's type 2 alcohol dependence.

• Biomolecules & Therapeutics
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• v.5 no.2
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• pp.133-149
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• 1997

4-week repeated dose toxicity of DA-5018, a new capsaicin analogue analgesic agent, was examined in 5D rats at dosage levels of 0,0.4,2, 10 and 50 mg/kg/day. DA-5018 was administered orally to 17 males and 17 females per group at doses of 0, 10 and 50 mg/kg and to 12 males and 12 females per group at doses of 0.4 and 2 mg/kg. After the administration period, 5 males and 5 females at the 0, 10 and 50 mg/kg were placed on withdrawal for 2 weeks. Treatment-related clinical signs were observed at 10 and 50 mg/kg. Clinical signs observed immediately after the administration of DA-5018 were grooming, sedation or depression, lacrimation, atacia, reddening of extremities and ears, ventral or lateral recumvincy, respiratory distress, cyanosis and convulsion. Delayed-type clinical signs including focal scabbing and depilation around nose were also observed 1 or 2 weeks after the start of administration of DA-5018. Only at the 50 mg/kg group, corneal opacities, reduced body weight gain (male) and death (male 6/17, female 3/17) were noted. In blood biochemical analysis, serum levels of glucose and triglyceride decreased at 10 and 50 mg/kg. In hematological examination, there were increases in the number of red blood cell, hemoglobin content and percent of hematocrit at 10 and 50 mg/kg. Pulmonary enlargement and hemorrhagic spot, focal scabbing and depilation around nose and corneal opacities were seen at the necropsy of the animals died during the dosing of DA-5018 50 mg/kg. Focal scabbing and depilation around nose were observed in the animals terminally necropsied at doses of 10 and 50 mg/kg. Histopathological examination revealed pulmonary hemorrhage, focal necrosis in the scabbed area, corneal necrosis, fibrosis and neovasculization in the stroma. At 0.4 and 2 mg/kg, there were no significant toxic changes attributable to the administration of DA-5018. In conclusion, target organs following to 4-week repeated dose of DA-5018 in the rat were determined to be lung, skin and eyes. Definite toxic dose and no-observed-adverse-effect-level (NOAEL) were estimated to be 50 and 2 mg/kg/day, respectively.