• Journal of the Korea Academia-Industrial cooperation Society
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• v.21 no.10
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• pp.471-479
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• 2020

In this paper, we analyze features of radical innovative businesses using their patents. Although patents have been used to evaluate outcomes of businesses from the 1980s, it is challenging to use patents for radical innovations. We examined the possibility of taking advantage of patents for an indicator that represents a radical innovation in pharmaceutical industry. To this end, we collected FDA approval data from the U.S. Food and Drug Administration and patent data of 18 pharmaceutical companies. For analysis, we utilized the network centrality analysis and Wilcoxon signed ranked test, which is a non-parametric statistical hypothesis test used to compare two related samples. We observed that a radical innovative company typically cooperates with other research groups, such as universities and companies, and acts as a hub for connectivity in pharmaceuticals. Also, we found that there are differences in centrality between radical firms and non-radical firms. Thus, we expect that the results of this study will help in developing strategies for research and development of pharmaceutical companies and identifying factors affecting radical innovation in the future.

• Child Health Nursing Research
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• v.24 no.4
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• pp.517-526
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• 2018

Purpose: This study compared nursing frequency, nursing time, and nursing intervention priorities depending on the method of neonatal induced hypothermia. Methods: We observed 15 neonatal subjects receiving therapeutic hypothermia for 3 days each. Forty-five nurses experienced with nursing neonatal patients under therapeutic hypothermia provided responses about nursing intervention priorities. Analyses with the chi-square, the Fisher exact test, the paired t-test, the Wilcoxon signed rank test, and the Wilcoxon rank-sum test were performed on the data using SAS version 9.4. Results: The frequency of nursing activities was higher for selective head therapeutic hypothermia (SHTH) than for systemic therapeutic hypothermia (STH), and nursing time was also significantly longer. In terms of nursing intervention priorities, there were priority differences in "risk for ineffective thermoregulation" and "risks for impaired skin integrity" for SHTH compared to STH. Conclusion: Since SHTH for neonatal therapeutic hypothermia requires more nursing time and frequent nursing activities than STH, STH is therefore recommended if the therapeutic efficacy is similar. Appropriate nursing personnel should be allocated for neonatal SHTH nursing. Nurses should be aware of nursing interventions for therapeutic hypothermia as the priorities are different for different methods of neonatal therapeutic hypothermia.

• Journal of Korean Medicine Rehabilitation
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• v.29 no.1
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• pp.21-29
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• 2019

Objectives This study is designed to verify the effectiveness of electroacupuncture (EA) on both side acupuncture point GB12, GB20 for chronic tension type headache (CTTH). Methods Subjects aged 18-65 years who had suffered from CTTH for more than 3months were recruited from September 2016 to May 2017. Thirty subjects were voluntarily recruited and they were randomly divided into 2 groups; 15 to EA group, another 15 to sham-EA group. The treatment sessions were performed every 2-4 days for a total of three sessions over 1 week. The symptoms of headache were assessed before the treatment and after a week from the last treatment by visual analogue scale (VAS), headache frequency (HF), Korean Headache Impact Test-6 (KHIT-6). Demographic characteristics of all participants were compared between the groups upon using chi-square test. Wilcoxon signed rank test was used to evaluate the values between baseline and follow-up. Wilcoxon rank sum test was performed to evaluate the differences between groups. p-values less than 0.05 were considered as significant. Results Before and after the intervention, no difference in VAS and KHIT-6 was observed between groups. HF of EA group decreased significantly compared with that of sham-EA group. Within the EA group VAS, HF and KHIT-6 decreased significantly after the treatment. Meanwhile, only KHIT-6 decreased significantly after the treatment in sham-EA group. Conclusions This study suggests that EA on both side acupuncture point GB12 and GB20 is applicable to improve symptoms in patients with CTTH.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.19 no.10
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• pp.313-323
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• 2018

This study was conducted to develop an individualized upper extremity exercise program for patients after mastectomy and evaluate its effectiveness. A nonequivalent control-group pretest-posttest design was used for this investigation. Research participants were patients with breast cancer who underwent mastectomy at two university hospitals (experimental group, n=17; control group, n=16). The experimental group received an individualized upper extremity exercise program three times a week for 7 weeks. Data were analyzed by the ${\chi}^2-test$, Fisher's exact test, Mann-Whitney U-test and Wilcoxon Signed Rank test using SPSS WIN 21.0. Inter-group comparison revealed significant differences between pre-test and post-test in hands behind the back, flexion, abduction, external rotation, internal rotation, and grip strength. Moreover, the experimental group showed significant improvements in hands behind the back, flexion, abduction, external rotation, internal rotation, and grip strength relative to the control. In conclusion, the individualized upper extremity exercise program was shown to be an effective intervention to improve physical functions in upper limbs and shoulders. Therefore, this program should be applied to patients after mastectomy in clinics since many patients have suffered from decreased physical functions in upper extremities.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.17 no.9
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• pp.519-532
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• 2016

Purpose: This study aimed to evaluate the effect of an HIV/AIDS education program for professional graduate medical school students using a teaching-learning methods. Methods: The design of this study was a nonequivalent control group pretest-posttest experiment. A total of 116 professional graduate medical school students in South Korea were included. They were randomly assigned to either a discussion-centered teaching-learning method group (n=60) or a lecture-centered teaching-learning method group (n=56). Data were collected between August and December 2015 and were analyzed using descriptive statistics, ${\chi}^2$-test, one-tailed independent t-test, one-tailed Mann-Whitney U-test, one-tailed Wilcoxon signed-rank test, and one-tailed paired t-test using SPSS WIN 19.0 program. Results: There was no statistically significant difference between the two groups with respect to HIV/AIDS knowledge, attitudes, and education satisfaction. However, the scores of knowledge and attitudes were statistically significantly increased after the education than before the education in both groups. Conclusion: To effectively improve the knowledge and attitude of HIV/AIDS, it is necessary to select an appropriate teaching-learning method for the target subjects and objectives of HIV/AIDS education.

• Korean Journal of Child Studies
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• v.29 no.5
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• pp.151-164
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• 2008

The purpose of this study was to develop a mother-infant interaction intervention program based on enhancing sensitivity to infant cues. Subjects were 9 infants, 3-26 months of age and their mothers, 6 Korean, 2 Mongolian and 1 North Korean. The intervention program was based on the Nursing Child Assessment Satellite Training model(NCAST; Barnard, 1994); data were analyzed by Wilcoxon Signed Rank Test and Mann-Whitney Test. Results were that the interaction score and infant caring confidence score of the intervention group was higher than the non-intervention group. Mother's sensitive responses to infant cues enhanced the degree of mother-infant interaction.

• The Korean Journal of Health Service Management
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• v.4 no.2
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• pp.85-95
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• 2010

This study was to understand perception level and education need on hospice, and to development effective education contents of hospice for medical students. Descriptive survey research design was used. Participants were 426 and the data collecting period was from July. 22. to July. 29. in 2008. The data were analyzed using descriptive analysis, chi-square test, Wilcoxon's signed rank test. The participants experiencing in hospice education program demonstrated higher perception level and education need about hospice than non-participants. Also, The participants experiencing in hospice education showed more concerning on effective education contents of hospice than non-participants. Therefore, hospice education program must be prepared in a continual and systematic way in order to provide for effective education of medical students in Korea.

• Journal of the Korean Data and Information Science Society
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• v.15 no.4
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• pp.973-980
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• 2004

Phase I clinical trials are often pharmacologically oriented and usually attempt to find the best dose of drug to employ. However, other purposes like determination of sizes and types of side effects and toxicity and organ system involved are equally important. Estimation of treatment effects or side effects is usually ignored since it is usually based on too small sample, even though Phase II clinical trials would be designed based on the Phase I studies. Statistical methods for constructing the approximate confidence interval for population median in case of small sample are considered and an improved method is proposed. The proposed estimator is compared with current methods through simulation studies.

• Magazine of the Korean Society of Agricultural Engineers
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• v.43 no.5
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• pp.145-152
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• 2001

농촌유역하천에서 수집된 수질측정자료를 이용하여 주요 오염원을 규명하였다. 분석에 이용된 수질항목은 BOD, COD. EC, pH. TN, TP,$NO_3-N,PO_4-P$ 등으로서 하천 본류내 구간별로 쌍대비교를 통해서 항목별 차이에 대한 유의성 검정을 하였다. 유의성 검정에 이용된 방법은 쌍대비교를 위한 비모수검정법인 Wilcoxon 순위검정법을 이용하였다. 검정결과, 유기성 오염물질의 지표로 이용되는 BOD와 COD가 상승하는 구간은 주로 생활하수가 유입되는 구간으로 나타났다. 인구밀도가 매우 높으나 생활하수가 처리장으로 배제되는 지역의 하천구간에서는 이들 농도변화는 없었다. 유역 내 축산농가가 밀집되어 있는 지역의 하천구간에서도 농도의 변화 또한 존재하지 않았다. 본 연구에서 조사된 유역에서와 같이 축산분뇨를 퇴비화 및 농지환원하는 경우에는 하천수질에 거의 영향을 미치지 않는다는 것을 알 수 있었다. 따라서 농촌지역의 하천 수질을 개선하기 위해서는 생활하수에 대한 처리가 선행되어야 한다.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.13 no.4
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• pp.1699-1705
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• 2012

This study was conducted to examine the differences of the quality of chest compression between 10 cm higher position of rescuer's knee from the bottom and its bottom position during implementation of CPR. It selected randomly subjects out of 66 students who attend the Dept. of Emergency Medical Technology in G college, G metropolitan city as the first grader and divided them into 31 experimental group and 32 control group from Nov. 8 to 9, 2011. Mattress was spread 10 cm higher from the bottom(material: B4 Copy Paper) and on the bottom(material: PVC, size: $185{\times}125{\times}0.65cm$) and only chest compression was conducted for 2 minutes. Experiment was conducted with 1 Resusci Anne mannequin and the results of experiment were recorded with Laerdal PC Skill Reporting System. Data collected were analyzed with $x^2$-test and Fisher's exact probability test using SPSS 14.0 for Window, Mann-Whitney U-test, and Wilcoxon signed rank test. As a result of the study, it was found that 10 cm higher position of rescuer knee from the bottom than the bottom position and group below 170 cm in their height and 65 kg in their weight were more effective in proper depth of chest compression and average chest compression depth.