• Title/Summary/Keyword: What-If

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A Study on the Mechanism of Insulin Sensitivity to Glucose Transport System: Distribution of Subcellular Fractions and Cytochalasin B Binding Proteins (인슐린의 포도당 이동 촉진 기전에 관한 연구 -세포내부 미세구조와 Cytochalasin B 결합단백질의 분포-)

  • Hah, Jong-Sik
    • The Korean Journal of Physiology
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    • v.24 no.2
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    • pp.331-344
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    • 1990
  • What makes glucose transport function sensitive to insulin in one cell type such as adipocyte, and insensitive in another such as liver cells is unresolved question at this time. Recently it is known that insulin stimulates glucose transport in adipocytes largely by redistributing transporter from the storage pool that is included in a low density microsomal fraction to plasma membrane. Therefore, insulin sensitivity may depend upon the relative distribution of gluscose transporters between the plasma membrane and in an intracellular storage compartment. In hepatocytes, the subcellular distribution of glucose transporter is less well documented. It is thus possible that the apparent insensitivity of the hepatocyte system could be either due to lack of the constitutively maintained, intracellular storage pool of glucose transporter or lack of insulin-mediated transporter translocation mechanism in this cell. In this study, I examined if any intracellular glucose transporter pool exists in hepatocytes and this pool is affected by insulin. The results obtained summarized as followings: 1) Distribution of subcellular fractions of hepatocyte showed that there are $24.9{\pm}1.3%$ of plasma membrane, $36.9{\pm}1.7%$ of nucleus-mitochondria enriched fraction, $23.5{\pm}1.2%$ of lysosomal fraction, $9.6{\pm}1.0%$ of high density microsomal fraction and $4.9{\pm}0.5%$ of low density microsomal fraction. 2) In adipocyte, there were $29.9{\pm}2.6%$ of plasma membrane, $19.4{\pm}1.9%$ of nucleus-mitochondria enriched fraction, $26.7{\pm}1.8%$ of high density microsomal fraction and $23.9{\pm}2.1%$ of low density microsomal fraction. 3) Surface labelling of sodium borohydride revealed that plasma membrane contaminated to lysosomal fraction by $26.8{\pm}2.8%$, high density microsomal fraction by $8.3{\pm}1.3%$ and low density microsomal fraction by $1.7{\pm}0.4%$ respectively. 4) Cytochalasin B bound to all of subcellular fractions with a Kd of $1.0{\times}10^{-6}M$. 5) Photolabelling of cytochalasin B to subcellular fractions occurred on 45 K dalton protein band, a putative glucose transporter and D-glucose inhibited the photolabelling. 6) Insulin didn't affect on the distribution of subcellular fractions and translocation of intracellular glucose transporters of hepatocytes. 7) HEGT reconstituted into hepatocytes was largely associated with plasma membrane and very little was found in low density microsomal fraction which equals to the native glucose transporter distribution. Insulin didn't affect on the distribution of exogeneous glucose transporter in hepatocytes. From the above results it is concluded that insulin insensitivity of hepatocyte may due to lack of intracellular storage pool of glucose transporter and thus intracellular storage pool of glucose transporter is an essential feature of the insulin action.

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A Study on dental hygienist subjectivity toward relationship with inaccessible patients: the cases of Seoul, Gyeonggi province and Incheon (치과위생사가 경험한 어려운 환자와의 관계에 대한 주관성 연구 -서울, 경기, 인천 지역을 중심으로-)

  • Han, Kyung-Soon;Kim, Young-Nam;Lee, Myeong-Ju
    • Journal of Korean society of Dental Hygiene
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    • v.5 no.2
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    • pp.279-296
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    • 2005
  • The purpose of this study was to examine what types of experiences dental hygienists underwent with patients who were unapproachable in an effort to find out the latter group's needs and expectations, explore how to treat them of different personality type, and provide better dental services in response to their needs. To attain the purpose, Q-methodology was employed, which made a subjective and systematic assessment of human subjectivity. There were three types of subjectivity among dental hygienists in conjunction with their experiences with patients who were hard to please. Each group whose subjectivity was different also had a different preference for patients, which was not exclusive to one another but unique. Type 1 was "avoiding patients who showed off". Dental hygienists of this type found it unpleasant to treat patients who boasted of their background, position or relations with the head of hospital and wanted to be given special treatment. They avoided those patients, since giving special treatment to specific patients was likely to do damage to others. They believed that better medical services could be provided through mutual concern and good manners between medical personnels and patients. Dental hygienists of type 2 considered it hard to treat patients who were picky and looked at treatment or its outcome negatively. Those who had to be separated from others on account of possible cross-infection or who called for special decontamination methods of dental instruments were also difficult to deal with. Dental hygienists of this type could be said to "avoid picky patients", as they preferred to fare with patients by offering good, faithful treatment rather than by giving special treatment. Dental hygienists of type 3 believed that smooth and successful treatment hinged on mutual trust, confidence and collaboration between medical personnels and patients. According to them, patients who choose a specific hospital or a particular medical team at their own option have to cooperate if necessary, listen carefully to medical personnels and treat them without any hostility or bias. Therefore, they could be said to "avoid patients who were not cooperative".

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A Study of Development a Curriculum for Character Designer -Focused on Two-Year Course Work of College Education (캐릭터디자이너 양성을 위한 교육과정 개발 -2년제 전문교육을 중심으로)

  • 김용우
    • Archives of design research
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    • v.17 no.3
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    • pp.231-244
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    • 2004
  • The curriculum in the vocational training shall be planed and operated on a basis what is the occupational category that the students can be employed after their graduation and the ability necessary to the engagement in their occupations. Accordingly, the course selecting the quality of education in the curriculum plan for the vocational training shall be developed continuously and gradually through the maintenance of dose relation by the participation of the persons in the industries related to the major field. If the curriculum in the vocational training is for the preparation of employment, the focus of curriculum shall be adjusted to the employment. It needs to collect and analyze the related data between the universities and industries, particularly regional industries synthetically in order to develop the curriculum in the vocational training. The curriculum shall be planned on a basis of the data. As for the data related to the local community, it needs to develop new programs considering the prospect of demand of manpower by the industry, necessary knowledge, technology and attitudes, particularly considering the occupational category available in the employment with a bright prospect hereafter. Also, the contents to improve in the existing curriculum(a change of technology, a form of facilities for experimentㆍpractice, and a type of continuing & further education) shall be investigated and analyzed objectively. Accordingly, this study is to develop the curriculum more systematically in order to foster the character designer specially who to engage in the character industry that increases its role and expectation all the more with the development of animation industries and the extension of markets now. The purpose of this study is to decrease the estrangement between the school education that has been problems and the practical affairs in the field, to foster the special manpower that can satisfy the industries demand.

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The Research about Role Area of RT in Digital Environment - Centers on PACS Workplace -

  • Jung, Young-Tae;Park, Bum-Jin;Son, Gi-Gyeong;Jung, Jae-Ho;Kang, Hee-Doo
    • Korean Journal of Digital Imaging in Medicine
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    • v.13 no.1
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    • pp.13-20
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    • 2011
  • Now a days in our society, occupation boundaries have become blurred, and come into the limelight in the prior occupation or miss about new workplace. Medical area is no exception also, So we face urgent problem about protecting and spreading RT work-sphere simultaneously. This research allow to identify on RT role area of digital environment that is obscure profession-realm specially, and open up a new field hereafter. We examined present RT role area of digital environment in the more than thirty medical facility(general or university hospital) through questionnaire/visit survey from PACS administrator. Survey sentence comprises total 29 sentence over all main quadrisection-(eX. hospital formation & treatment state and PACS team composition & organization and PACS team workplace and PACS team daily workload), We performed comparative analysis in general contents perspectively. further more, divided main 5 section based on upper analysis and then manufactured output in consideration of each medical facility's operation state. There are comparative problem of hospital policy, So we maintained information security of each facility exhaustively. First, we separated a survey output into main 5 section as follows-(eX. PACS server & maintenance manage, Client/interlock manage, PACS data conversion, 3D reconstruction, PACS data im/export)-that received by 35 medical facility. And then manufactured output with comparative analysis about RT role area each section, general IT managing team about medical environment was out of existence that fill up with RT manpower in the surveyed medical facility consequently. What is worse, hospitals that entirely fill up with another worker were 3 place amazingly. Our specific statistic results show, the respondents was 63% that agree with reorganization of formation base on independence team, and supplement of the personnel average -continuous with upper agreement simply-was about 2.64. Further more, if reorganization break out with only RT manpower, quota TO will increase by geometric progression. Protecting and spreading role workplace is much accounted of the our inevitable project surely and more than 95% PACS administrator's have confidence in this proposition unconditionally. Henceforth, look forward to meeting the RT vision of many-sided multiplayer, based on acquire a specialized IT knowledge actively and open up a new work-field with frontier spirit.

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Impacts of Resource Attributes on Resource Sharing: An Approach from Resource-based View (경영자원의 속성이 자원공유에 미치는 영향: 자원기반관점을 중심으로)

  • Hwang, Jaewon;Park, Kyoungmi
    • Journal of the Korea Academia-Industrial cooperation Society
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    • v.15 no.10
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    • pp.6004-6013
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    • 2014
  • The research on resource sharing in the diversification field is concerned mainly with sharing, but there has been little interest in resources. This research examined resource sharing with the main variables and logics of resource-based view. Based on a survey of 263 affiliates of 35 diversified firms, the impacts of resource quantity, resource quality, and resource exploitability on inter-affiliate resource sharing were hypothesized and verified. To confirm the performance implications of resource sharing, the impacts of the combination of resource quantity and resource sharing, the combination of resource quality and resource sharing, and the combination of resource exploitability and resource sharing on the affiliate performance were also hypothesized and verified. According to the empirical results from multiple regression analyses, resource sharing increases in the order of low resource quantity, high resource quality, and high resource exploitability. The performance was advanced in resource sharing under a low resource quantity and resource sharing under high resource exploitability, but it was not advanced in resource sharing under high resource quality. The results highlight the need for a further study on why the resource quality and resource exploitability affect resource sharing in the opposite directions, as expected in the hypotheses, why resource sharing under high resource quality does not lead to high performance, even though resource quality increases resource sharing, and what they would be if resources are subdivided by the types.

Hospice volunteer's Attitude Toward Care of the Dying (호스피스 자원 봉사자들의 말기 환자 돌봄에 대한 태도)

  • Lee, Mi-Ra;Lee, Won-Hee
    • Journal of Hospice and Palliative Care
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    • v.4 no.1
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    • pp.57-67
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    • 2001
  • Purpose : The purpose of this study was to identify attitudes of hospice volunteers toward care of for terminally ill patients. Method : This was a descriptive study with a sample of 84 adults who were registered for a hospice volunteer education program at Severence Hospice Center. The Frommelt (FATCOD) scale on attitudes toward the care of the dying (Cronbach alpha=.778) and an open ended questions on "what if you only have 6 months to live" were used to collect the data. The data was analyzed using SPSS/W and content analysis. Results : 1) The hospice volunteers were mostly female, with an average age of 45 years, half of them were college graduates and their religious preference was Protestant. 2) The participants of this study demonstrated positive attitudes to care for the dying which is in coherence with hospice philosophy and principles. However they indicated difficulties in maintaining close relationships with people who are dying, and in communicating and sharing, and encouraging those who are dying to express their feelings. In the open ended questions, they identified that their most important issues would be guilt feelings toward their children, family concerns, and the burden of unfinished business in their lives. They also identified the fear of pain in the dying process and fear of the afterlife. The care they would like to receive was to have peace of mind, have a good listener, spiritual counselling, and pain relief and to be respected as a human being. The source of strength would be faith in God and they would like to overcome their of dying. The FATCOD scale has limitation in describing and identifying the need and attitude toward the care of the dying revisions were made. Conclusion : We all are the potential clients for the hospice rare. In a hospice volunteer education program, communication and interpersonal skill are essential. The fear of dying, afterlife, concerns about family with children, and human dignity are major concerns in hospice and palliative care.

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What Kinds of Rearing Stress Do the Mothers of the Gifted Have?: Using a Concept Mapping Approach (영재 자녀를 둔 어머니들의 양육 스트레스 분석: 개념도 기법을 활용하여)

  • Han, Ki-Soon;Lee, Young-Mi
    • Journal of Gifted/Talented Education
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    • v.22 no.4
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    • pp.893-916
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    • 2012
  • This research investigates gifted students' mothers' rearing stress based on the concept mapping method. For this, 12 gifted students' mothers solicited, gathered and analyzed related statements, and then did multidimensional scaling and hierarchical cluster analysis. The stress value was .273 which was appropriate for the two level concept mapping study. In addition 101 mothers of gifted students rated for the rearing stresses they experience. Results were as follows. First, 79 concrete statements were solicited and as a result of concept mapping were categorized as 'burden and conflict as mothers of the gifted', 'possible negative characteristics due to the giftedness', and 'self-esteem and pressure by the title of the gifted'. Especially following items showed relatively high average: worrying about how to give the child a specific help for his/her career(M=4.65); worrying that she might be intervening too much in their child's behaviors(M=4.60); getting pressured supporting the child to get involved in the gifted education system continually(M=4.46); worrying if her child is not developing his/her talent enough due to the lack of time and money(M=4.44); being concerned that her high expectations might be putting her child under too much pressure (M=4.43). Implications of the study related to gifted education practices were discussed.

Dynamic Single Path Routing Mechanism for Reliability and Energy-Efficiency in a Multi Hop Sensor Network (다중 홉 센서 네트워크에서 신뢰성과 에너지 효율성을 고려한 동적 단일경로 설정기법)

  • Choi, Seong-Yong;Kim, Jin-Su;Jung, Kyung-Yong;Han, Seung-Jin;Choi, Jun-Hyeog;Rim, Kee-Wook;Lee, Jung-Hyun
    • The Journal of the Korea Contents Association
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    • v.9 no.9
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    • pp.31-40
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    • 2009
  • What are important in wireless sensor networks are reliable data transmission, energy efficiency of each node, and the maximization of network life through the distribution of load among the nodes. The present study proposed DSPR, a dynamic unique path routing machanism that considered these requirements in wireless sensor networks. In DSPR, data is transmitted through a dynamic unique path, which has the least cost calculated with the number of hops from each node to the sink, and the average remaining energy. At that time, each node monitors its transmission process and if a node detects route damage it changes the route dynamically, referring to the cost table, and by doing so, it enhances the reliability of the network and distributes energy consumption evenly among the nodes. In addition, when the network topology is changed, only the part related to the change is restructured dynamically instead of restructuring the entire network, and the life of the network is extended by inhibiting unnecessary energy consumption in each node as much as possible. In the results of our experiment, the proposed DSPR increased network life by minimizing energy consumption of the nodes and improved the reliability and energy efficiency of the network.

Biennale is a Preacher for the Globalization of Art? (과연 비엔날레는 세계화의 전도사인가?)

  • Choi, Tae-Man
    • The Journal of Art Theory & Practice
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    • no.3
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    • pp.85-106
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    • 2005
  • As biennale exhibitions has been expanded into all of the world since 1990s, these trends of blockbuster exhibitions have caused several problems. For instance, some major curators monopolized most global size exhibitions despite of a variety of cultural and historical backgrounds. Besides, due to a strong connection between these curators and their own artists, the young emerging artists' opportunities tend to be reduced as a result of the power game. In addition, major curators' power have influence on the exhibition style as well as on the theme itself. Some artists who did not involved that kind of huge scale exhibitions dispute that the direction of the exhibition is concentrating on the curator's interest instead of artists or viewers. Although these dissatisfactions could not portray correctly the process of organizing and managing system of a biennale exhibition, those biennale exhibitions held in recent have shown tautologic discourses without any passion and positive attitude direct to the exploitation of our society as a vanguard. In the process of comparing several kinds of biennale exhibitions, I could find that some artists who participated several biennale exhibitions at the same time did not present their creative vision, although the triumph of an exhibition was typically measured by the amount of visitors. Thus, the aim of this article is to prove that the biennale can show us new cultural discourse as well as progressive method of understanding our times. Is biennale producing the real 'global standard'? If biennale has done it, could this global standard present upto-date paradigm for the unique exhibition system? Is biennale providing an useful opportunity for the understanding and communicating of contemporary art through the recontextualization which is pronounced by the publicity of curator and organizing committee? How can we find the distinctive strategy from each biennale exhibition including Venice Biennale? Biennale, as a blockbuster exhibition, always requires a degree of hype, otherwise it would not be a special event and would not attract a big enough audience. It is the actual reason why major biennale exhibitions seem to be similar artistic events. Unfortunately, it seems that the excess of biennale exhibitions might bring about the lack of contents. In this case, the biennale syndrome would being a kind of the center of poverty, in spite of the visual splendor. After all, following the global standard may not be a matter of great importance now. What really matters is how each biennale exhibition which started under the different conditions can search their own identity.

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Museum Politics: A Study of Orientalism as Represented in the National Museum of Indonesia (박물관의 정치학: 인도네시아 국립박물관에 표상된 오리엔탈리즘 연구)

  • Song, Seung-Won
    • The Southeast Asian review
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    • v.21 no.1
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    • pp.137-184
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    • 2011
  • This article is aimed at understanding the political narratives represented in the National Museum of Indonesia. Starting initially as a colonial museum, the National Museum of Indonesia functioned as a useful tool for the Dutch colonial force to fuel its imaginations of the colonial territory and the people within it. The Dutch used the cultural display to advertize its benevolent colonial rule. All the while, the museum also inevitably reflected orientalism on the people and the culture of the colony. The republic of Indonesia inherited the colonial museum's practices and its display patterns. The business surrounding the museum also played a key role in the newly-born nation-state laying out a future for its redefined territory and people. Thus, what the colonial force imagined for the colonial territory through the study of museum displays was rather directly transferred to the republic without serious consideration of the decolonization process. Four main characteristics have been seen in the museum displays. The first is an emphasis on the glorious Hindu-Buddha history, from which numerous temples, statues, and jewelry have been found. Secondly, the Islamic period, which spanned between the Hindu-Buddha times to the colonial era, has almost completely been eliminated from the display. Third, the colonial era has been depicted as the time of Europe's exportation of scientific tools and adaption of sophisticated living patterns. Fourth, the images of ethnic groups were represented as being stagnant without reflecting any challenges and responses that these groups had faced throughout history. Looking at these display patterns, it can be concluded that all the dynamic internal developments and anti-colonial resistance that took place during the Islamic and Colonial Era have simply not been represented in the museum display. These display patterns do not reflect the real history or culture of the archipelago. Two considerations are thought to have influenced the neglecting of social realities in the display. The first of which is the Dutch's and Republic's apprehension over the possible political upheaval by the Islamic forces. Yet, more fundamentally, cultural displays themselves are distinct from historical education in that the former pays more attention to business ideas with an aim to attract tourists rather than to project objective historical knowledge. Thus, in cultural displays, objects which work to stimulate fantasies and spur curiosity on archipelagic culture tend to be selected and emphasized. In this process, historical objectivity is sometimes considered less vital. Cultural displays are set up to create more appealing narratives for viewers. Therefore, if a narrative loses its luster, it will be replaced by another flashy and newly-resurrected memory. This fact reveals that museums, as transmitters of historical knowledge, have a certain degree of limitation in playing their role.