• Journal of Pharmaceutical Investigation
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• 제22권3호
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• pp.205-210
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• 1992

In order to develop a controlled-release oral drug delivery system (DDS) of theophylline (TP), microporous membrane-coated tablets were prepared and evaluated in vitro and in vivo. Rapidly water-soluble core tablets of TP (300 mg) were prepared by wet granulation and compression technique, Then the core tablets were spray-coated with polyvinylchloride (PVC) in which micronized sucrose particles were dispersed. Effect of formula compositions of coating suspensions on the pharmaceutical characteristics such as membrane strength and dissolution was investigated in vitro. The membranes remained unbroken in pH 1.2 buffer at $37^{\circ}C$ at least for 2 hours after the disintergration test. TP was released from the coated-released tablets at a zero-order rate over 8 hours. The release at pH 1.2 and 4.0 was similar in rate but a little more rapid than that at pH 6.8. The coated tablets were administered to three healthy male volunteers and their saliva profiles of TP were compared with those from the commercial sustained release TP tablets such as Slobid and Asconthin. Saliva TP concentrations from the coated tablets were successfully sustained over 48 hours after the dosing and were comparable to those of the commercial sustained-release tablets. The membrane-coating technique is very simple and does not need any sophisticated equipments. In this respect, the membrane-coated tablets may be superior to the commercial sustained-release tablets and this technique is worth adopting by the pharmaceutical industries.

• 패션비즈니스
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• 제13권2호
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• pp.78-86
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• 2009

When scouring and contraction finishing at $90^{\circ}C$ using Relaxer or Rotary Washer contraction and weight loss ratio in warp and weft directions were excellent. Also surface state of fabric after drying or sanding treatment was excellent without crease. Low melting polyester fabric showed a complete melting bond by heat setting(P/S) at above $160^{\circ}C$. The alkali hydrolysis reaction of polyester showed the breakpoint in the weight loss behavior test, polyester yarn showed a breakpoint ranging from 25% to 28%. This is due to the difference of the hydrolysis rate between regular polyester and soluble polyester. Initially the soluble polyester was eluted and micro-fibrillized 5 times faster than a regular polyester. At a later time, a regular polyester was reduced weight to impart a proper flexibility and drape property to the fabric. As a result of surface sanding finishing, the surface of interior fabric showed a surface state most stabilized when using Mesh No. 220 in mono 0.2d after elution finishing. When the rotation direction of sanding roller was pro-, pro-, pro-, and retro-direction, a directional effect of tuft was not shown, a writing effect as suede was exhibited and a surface state was even. Sublimation fastness was 3-4 class for polyester and 2-4 class for nylon. Light fastness 3-4 class after lapse of 100 hours and 2-4 class after lapse of 160 hours. Abrasion fastness was 3-4 class on wet and 4-5 class on dry Laundry fastness was 2-4 class. As such, the abrasion fastness is slightly reduced upon wetting and the use thereof for interior is excellent, whereas laundry fastness is slightly lowered.

• 한국구조물진단유지관리공학회 논문집
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• 제18권1호
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• pp.68-74
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• 2014

최근 '먹는 물'에 대한 인식이 높아지고 양질의 물에 대한 요구가 이어짐에 따라 정수처리 시설은 수처리 시설을 확대하고 있다. 이에 따라 수처리시설에 적용되는 콘크리트 구조물 내부 방수 방식재의 개발 및 기준 마련의 필요성이 높아지면서 최근 활발한 연구가 진행 중이다. 하지만, 주로 상도의 내구성 향상에 집중된 연구의 한계성으로 콘크리트 표면과 하도 (프라이머)와의 부착력에 대한 연구가 부족한 실정이다. 이에 본 연구에서는 수처리시설의 내부 방수 방식재로서 사용되는 프라이머와 콘크리트 표면간의 부착력을 확인하고, 콘크리트 표면 상태 (건조 상태, 습윤 상태, 수압상태)에 따른 부착강도 및 특성에 대하여 알아보고자 한다.

• 한국염색가공학회지
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• 제18권6호
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• pp.16-24
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• 2006

The purpose of this study is to improve the defects of chitosan crosslinked viscose rayon by ECH and to describe the change of hand of chitosan crosslinked viscose rayon fabrics. The chitosan crosslinked viscose rayon were manufactured by crosslinking process using ECH as crosslinking agent, 2 wt% aqueous acetic acid as a solvent of chitosan and ECH, and 20 wt% aqueous sodium hydroxide as crosslinking catalyst. Viscose rayon were first immersed in the pad bath of the mixed solution of chitosan and ECH, padded up to 100 wt% wet pick-up on weight of fiber(owf), precured on pin frames at $130^{\circ}C$ for 2 minutes, immersed in NaOH solution and finally wash and dry. Antimicrobial properties of the viscose rayon treated with chitosan were measured by the shake flask C.T.M. 0923 test method with staphylococcus aureus(ATCC 6538) as the microorganism. When the concentration of chitosan was increased chitosan crosslinked viscose rayon's LT, WT, B, 2HB and MIU were increased and G, 2HG, SMD, T and $T_m$ were decreased. On the other hand, WT, EM were decreased and RT was increased at $1{\times}10^{-2}M$ ECH. The optimum condition for crosslinking was that ECH concentration was between $1{\times}10^{-2}M\;and\;5{\times}10^{-2}M$. Antimicrobial effects of rayon fabric treated with chitosan was excellent.

• 한국자동차공학회논문집
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• 제21권5호
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• pp.74-81
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• 2013

The high-speed machining in the manufacturing industry field has been widely applied for parts of vehicles, aircraft, ships, electronics, etc., recently, because the effect of cost savings for shortening processing time and improving productivity is great. The purpose in this study is to investigate the effect of cutting depth on the surface roughness of workpiece with the spindle rotational speed and feed rate of high-speed machines as a parameter to find the optimal depth in the finishing for ball end mill of the aluminum alloy 7075 which is used much in aircraft parts. When the cutting depth for the respective feed rate and spindle rotational speed is varied from 0.1 mm to 0.7 mm at intervals of 0.2 mm in the wet finishing of the aluminum alloy 7075 by the insoluble cutting oils and high-speed machining used in the rough machining of previous study, the surface roughness values and the cutting temperature are measured. In addition, the cutting surface shapes of test specimens are observed by optical microscope and compared with respectively. It is found that the surface roughness values and the temperature generated during machining are increased as the feed rate and cutting depth are raised, but those are decreased as the spindle rotational speed is increased.

• 한국지반신소재학회논문집
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• 제9권3호
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• pp.39-45
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• 2010

동절기 온도가 영하로 떨어짐에 따라서 지표면 부근의 수분을 포함한 흙은 공극속의 수분이 얼음으로 변하면서 부피가 팽창하고, 이렇게 팽창된 지반은 주변 구조물에 영향을 미쳐 지반 구조물의 안전에 위험한 영향을 초래할 수 있다. 동상현상은 토립자, 간극수, 공기로 구성된 다상(multi phase) 구조 속에서 동결이 형성됨에 따른 수분의 이동과 수분이 얼음으로의 상변화(phase change) 등 다변수의 복합적인 물리적 현상을 포함하고 있기 때문에 현재까지 다차원 수치해석에 구성방정식으로 사용할 수 있는 검증되고 신뢰성 있는 모델은 아직도 연구 단계에 있다. 본 논문에서는 간극수의 상변화에 따라 갑작스러운 열용량 증대로 발생하는 수치해석상의 문제를 극복할 수 있는 효율적인 간편식을 유도하고, 포화된 토사나 다공성 암반이 동결할 때의 거동을 재현할 수 있는 열전도 구성방정식과 해석법을 제안하였다. 제안된 식을 사용한 수치해석 결과는 알려진 이론해 및 실내 모형시험 결과와 잘 일치하였다.

• 한국지반신소재학회논문집
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• 제12권1호
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• pp.83-92
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• 2013

지중송전관로를 통한 송전용량 증대를 위해서는 송전 시 발생하는 열을 빠르게 소산시킬 수 있도록 습윤 시 $50^{\circ}C$-cm/Watt, 건조 시 $100^{\circ}C$-cm/Watt 이하의 열 저항률을 갖는 재료를 되메움재로 사용하는 것이 요구되며, 이를 위해 선행연구에서는 요구되는 조건을 만족시키는 열 소산 되메움재를 개발하였다. 이 연구에서는 개발된 열 소산 되메움재의 열 소산효과를 알아보기 위하여 1회선의 단면을 현장에 설치하고 개발된 열 소산 되메움재와 강모래, 현장토에 대하여 열을 직접 가하고 일정한 지점에서 온도를 측정함으로서 현장시험을 수행하였고, 시험결과와 유한요소해석과의 비교를 통해 열 소산효과를 비교하였다. 비교결과, 열원과 가까운 지점에서는 개발된 열 소산 되메움재가 강모래와 현장토에 비해 열평형상태에 빨리 도달하는 것으로 나타났으며, 열평형에 도달하는 온도도 높은 것으로 나타나 열 소산효과가 우수한 것으로 나타났다. 또한 다른 지점에서도 개발된 되메움재가 다른 재료보다 온도가 높아 열 소산효과가 우수한 것으로 나타났다. 또한 함수비의 변화에도 열 소산효과가 크게 변화하지 않는 것으로 나타났다.

• 셀메드
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• 제6권2호
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• pp.11.1-11.7
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• 2016

The aimed of the presence study was to determine the antiulcer potential of virgin coconut oil (VCO), either extracted by wet process (VCO_A) or fermentation process (VCO_B), and to compare their effectiveness against the copra oil (CO) using the HCl/ethanol-induced gastric ulcer model. Earlier, the oils underwent chemical analysis to determine the free fatty acids composition, physicochemical properties and anti-oxidant capability. In the antiulcer study, rats (n=6) were pre-treated orally for 7 consecutive days with distilled water (vehicle), 100 mg/kg ranitidine (positive group) or the respective oils (10, 50, and 100% concentration). One hour after the last test solutions administration on Day 7^th, the animals were subjected to the gastric ulcer assay. Macroscopic and microscopic analyses were performed on the collected rat's stomachs. From the results obtained, the chemical analysis revealed i) the presence of high content of lauric acid followed by myristic acid and palmitic acid in all oils and; ii) the significant (^*p< 0.05) different in anisidine- and peroxide-value, percentage of free fatty acid, total phenolic content and total antioxidant activity among the oils. The animal study demonstrated that all oil possess significant (^*p< 0.05) antiulcer activity with VCO_B being the most effective oil followed by VCO_A and CO. The macroscopic observations were supported by the microscopic findings. Interestingly, all oils were more effective than 100 mg/kg ranitidine (reference drug). In conclusion, coconut oils exert remarkable antiulcer activity depending on their methods of extraction, possibly via the modulation of its antioxidant and anti-inflammatory activity.

• Archives of Pharmacal Research
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• 제13권2호
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• pp.151-160
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• 1990

In order to develop a controlled-release oral drug delivery system (DDS) which sustains the plasma acetaminophen (AAP) concentration for a certain period of time, microporous membrane-coated tablets were prepared and evaluated in vitro. Firstly, highly water-soluble core tablet of AAP were prepared with various formulations by wet granulation and compression technique. Then the core tablets were coated with polyvinychloride (PVC) in which micronized sucrose particles were dispersed. Effect of formula compositions of core tablets and coating suspensions on the pharmaceutical characteristics such as drug release kinetics and membrane stability of the coated tablets was investigated in vitro. AAP was released from the coated tablets as a zero-order rate in a pH-independent manner. This independency of AAP release to pH change from 1.2 to 7.2 is favorable for the controlled oral drug delivery, since it will produce a constant drug release in the stomach and intestine regardless of the pH change in the GI tract. Drug release could be extended upto 10 h according to the coating condition. The release rate could be controlled by changing the formula compositions of the core tablets and coating suspensions, coat weight per each tablet, and especially PVC/sucrose ratio and particle size of the sucrose in the coating suspension. The coated tablets prepared in this study had a fairly good pharmaceutical characteristics in vitro, however, overall evaluation of the coated tablet should await in vivo absorption study in man.

• Journal of the Korean Wood Science and Technology
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• 제20권2호
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• pp.51-60
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• 1992

This study was performed to investigate the effect of green sorting before drying on the high-temperature drying characteristics of southern yellow pine dimension lumber(2"${\times}$6"${\times}$12'). To test the advantages of weight sorting, green lumber was seperated into heavy(above 55 1b), medium(50-55 1b), and light(below 50 1b)weight classes. Pieces in each weight class were subgrouped into high(above 35%) and low(below 30%) latewood groups. Groups were dried and seperated by a standard commercial high-temperature schedule; dry bulb temperature $245^{\circ}$ F, wet bulb temperature $180^{\circ}$ F, and air velocity 1200fpm. The results obtained were as follows; 1. There was a highly significant correlation between annual rings per inch(X) and percent-latewood(Y). The regression equation was Y=24, 5047+1.3272X. 2. There were highly significant correlations between either annual rings per inch($X_1$) or percent-latewood($X_2$) a.d specific gravity in green wood(Y). Their regression equations were Y=0.4260+0.0081$X_1$ and Y=0.3749+0.0029$X_2$, respectively. 3. Heavier weight charges dried more slowly than lighter weight charges. 4. Board-to-board variation in green or dry moisture content was less for all seperate weight classes than for unseperated control charges. 5. Lower latewood pieces had higher initial moisture content than higher latewood pieces, and then drying time for lower late wood pieces was longer than higher latewood pieces.