• Journal of Nutrition and Health
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• 제12권3호
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• pp.9-23
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• 1979

The known risk factors for atherosclerosis include plasma low density lipoproteins (LDL)or Cholesterol, low PUFA in the diet, hypertension, and high Na intake, obesity, diabetes, lack of exercise, cigarette smoking, sugar, low fiber and nicotinic acid in the diet, sources of Protein foods, and Psychological factors. Among various dietary factors, fat is known as the most serious causative agent for atherosclerosis. The genetic factor is a18o known as an important one but is out of scope in this paper. Since atherosclerosis is a progressive disease which may develop for many years before showing any definitive symptoms, it is very important to develop preventive programs especially in the country like Korea that is not quite overdevelopted as some western countries. In this paper all the factors mentioned above were reviewed and the dietary suggestion were made on the basis of the content of polyunsaturated and saturated fat in the diet to prevent or/and to cure this disease. Most of the available data on diet therapy with emphasis. on P/S ratio were tabulated together. after tile patient's habitual dietary intake is analized the guidelines of personalized fat-controlled diet can be recommended. It is of utmost importance to develop Korean diets for beth prevention and cure of atherosclerosis emphasizing individual eating habit in the near future which can be more Practicaly used both at home and in the hospital.

• Journal of Nutrition and Health
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• 제51권5호
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• pp.369-378
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• 2018

본 연구에서 고지방식이로 비만을 유도한 생쥐는 식이 4주 후 지방조직의 형태학적 변화가 관찰되었고 생식기 지방조직의 무게가 증가하였으며, 혈장 중성지방 및 혈당치도 현저하게 증가하였다. 고지방식이 6주 후 몸무게의 유의한 증가가 관찰되기 시작하였으며, 뒤다리넙적근과 어깨사이 지방조직의 무게는 감소하고, 생식기 지방조직 및 간의 무게는 증가하였다. 지방조직의 형태학적 변화가 시작되는 고지방식이 유도 4주 후 혈장 내 40종의 시토카인 및 케모카인의 변화를 동시에 관찰하여 대조군과 비교해 본 결과, CXCL12 (SDF-1)와 CXCL13 (BLC)의 발현이 가장 현저하게 증가하였으며, G-CSF의 발현도 다소 증가하였다. 혈장 내 염증성 시토카인의 발현은 전반적으로 낮았다. 이상의 결과를 종합하면 고지방식이 유도 비만 초기에 만성 염증 상태로 진입하기 전 혈장 내 CXCL12와 CXCL13의 발현이 현저히 증가하는 것을 밝혔으며, CXCL12와 CXCL13의 증가로 B 세포, T 세포 및 단핵구가 혈관을 빠져나가 지방조직 및 지방조직 주변 림프조직으로 이동하여 지방조직 재형성과 국소 지방조직 면역에 관여할 것으로 보인다.

• The Korean Journal of Physiology and Pharmacology
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• 제15권1호
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• pp.43-51
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• 2011

Natural products in Chonnam, Korea were screened via anti-angiogenesis experiments, and 1 candidate product was identified, Corni fructus, which exerted dose-dependent inhibitory effects against angiogenesis, adipogenesis, and cell adhesion. C. fructus extract (CFE) exhibits an angiogenesis inhibitory effect superior to that of the EGCG from green tea leaves. The expression level of angiogenesis and adipogenesis-related signal molecules in the western blotting was reduced by increasing the amount of added CFE. Moreover, a diet supplemented with CFE was deemed more effective in inducing weight loss in LB mice than a representative synthetic diet drug, orlistat, which incidently caused the side effect of denuding the mice of their hair. These results indicate that C. fructus may prove to be a useful anti-adipogenic compound, and these in vitro results may be reflected later under in vivo conditions.

• 한국응용약물학회:학술대회논문집
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• 한국응용약물학회 1992년도 제1회 신약개발 연구발표회 초록집
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• pp.54-54
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• 1992

약물, hormone, 독성물질등의 대사능과 발암 가능성등이 간장 장해시 및 ketosis시에 달라지는 원인과 기전, 독성물질 대사효소의 변동과 그 작용기전을 규명하고자, 대표적인 간장장해 물질인 carbon tetrachloride를 rat에 투여하여 간장 장해를 일으키고, 당뇨병, starvation, high-fat diet처리하여 ketosls상태를 만든 후에, specific cytochrome P45O polyclonal antibodies와 cDNA probes를 사용하여, enzyme activitieg, Western immunoblot analysis와 mRNA Northern blot analysis 등을 실험하여, 간장 장해와 ketosis시 cytochrome P45O의 변동과 그 작용기전, regulation을 규명하고자 하였다. 실험 결과, $CCl_4$투여후 P450IIE enzyme (aniline hydroxylase) 활성이 시간 의존적으로 급격히 떨어졌고, P450IIE protein양이 똑같은 방식으로 감소되었으나 mRNA level은 변화가 없었다. $CCl_4$에 의해서 P450IIE는 protein의 특이적인 파괴에 의한 post-translational reduction됨을 알 수 있었다. 반면에 당뇨병, starvation, high-fat diet등 ketosis시에는 P450IIE 효소활성이 2-3배 증가되었고, P450IIE protein양도 같은 수준으로 증가되었으며, mRNA도 증가 되었다. Ketosis시에는 P450IIE가 pretranslational activation됨을 알 수 있었다.

• 수산해양기술연구
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• 제48권4호
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• pp.379-386
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• 2012

The feeding habits of Sebastiscus marmoratus collected from the Western Coastal Waters of Jeju Island between June 2008 and July 2009 were studied based on examination of the stomach contents. A total 254 individuals of S. marmoratus ranged from 13.2 to 29.6cm (mean 20.7cm) in Standard length (SL). S. marmoratus consumed mainly teleosts such as Chromis notata and Sebastes inermis. Its diet also includes shrimps and crabs. The individuals smaller than 15cm SL consumed mainly shrimps, but on the other hand the individuals larger than 25cm SL consumed mainly fishes. The proportion of fish consumption increased with increasing size of S. marmoratus.

• 혜화의학회지
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• 제13권1호
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• pp.183-195
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• 2004

Objective: The aim of this study was to investigate the concept of purpura in the western and oriental medicine. Method: We surveyed the western and oriental medical books from to recent published books. Result and Conclusion: The cause of purpura is devided into two branchs. One is sthenia syndrome includes stomach-heat, blood-heat and abnormal weather in four seasons. The other is asthenia syndrome includes deficiency of stomache energy, spleen asthenia and deficiency of Yin. In children, the cause of purpura is improper diet, inherent defect and the above things. The treatment of oriental medicine is classified into herbal medication, acupuncture therapy and external treatment

• Journal of Community Nutrition
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• 제5권2호
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• pp.72-82
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• 2003

We here outlined our study on the variations in intake of nutrients based on four season 7 consecutive day weighed diet records (WDRs) from 80 Japanese female dietitians in 1996 - 1997. Furthermore, we reviewed Japanese, Korean and international articles investigating variability in consumption of foods as well as nutrients. The relative contributions of variation for all nutrients by person were greater than those by day, week and season. Within individual variances were greater than that between individual variances, being generally observed in Korea and in the world. The ratios of within- vs. between-individual variations ranged from 1.3-26.9 in our study, the ratios being greatest in Korean, followed by Japanese and western people. Based on within individual coefficients of variation, minimal days necessary for estimating nutrient consumption per person within 10％ (20％) of the true mean with 95％ confidence intervals were estimated. They ranged from 10-35 (3-9) days for energy and major nutrients and 15-640(4-160) days for micro-nutrients. Two Japanese studies reported that the ratios for foods were as a whole greater than those for nutrients, except for cereals, rice and milk. (J community Nutrition 5(2) : 72-82,2003).

• Nutrition Research and Practice
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• 제5권2호
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• pp.112-116
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• 2011

We investigated the effect of paternal folate status on folate content and expression of the folate transporter folate receptor ${\alpha}$ ($FR{\alpha}$) in rat placental tissues. Rats were mated after males were fed a diet containing 0 mg of folic acid/kg of diet (paternal folate-deficient, PD) or 8 mg folic acid/kg of diet (paternal folate-supplemented, PS) for 4 weeks. At 20 days of gestation, the litter size, placental weight, and fetal weight were measured, and placental folate content (n=8/group) and expression of $FR{\alpha}$ (n=10/group) were analyzed by microbiological assay and Western blot analysis, respectively. Although there was no difference observed in litter size or fetal weight, but significant reduction (10%) in the weight of the placenta was observed in the PD group compared to that in the PS group. In the PD group, placental folate content was significantly lower (by 35%), whereas $FR{\alpha}$ expression was higher (by 130%) compared to the PS group. Our results suggest that paternal folate status plays a critical role in regulating placental folate metabolism and transport.

• International Journal of Human Ecology
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• 제4권1호
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• pp.71-86
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• 2003

Over the past few decades, changes in patterns of behavior (e.g., diet, smoking, alcohol consumption, and physical activity) have led to major changes in health status, characterized by increases in obesity, Type II diabetes mellitus, cardiovascular disease, and some cancers. This epidemiologic transition is largely the result of rapid increases in immigration to developed countries and rural-urban migration within developing countries, which is usually accompanied by environmental and lifestyle changes. In particular, adoption of “Western” dietary patterns, which tend to be high in fat and low in fruits and vegetables, is of concern since diet is a potent contributor to chronic disease risk. However, until recently, the process by which immigrants and rural-urban migrants adopt the dietary practices predominant in their new environments, known as dietary acculturation, has received very little research attention. Dietary acculturation is multidimensional, dynamic, and complex, and varies considerably depending on a variety of personal, cultural, and environmental characteristics. Therefore, to intervene successfully on the negative aspects of dietary acculturation, it is important to understand the process and identify factors that predispose and enable it to occur. The purpose of this article is to provide a practical model for understanding and investigating the effect of dietary acculturation on food and nutrient intake. Thus, this report 1) gives an overview of acculturation, 2) defines dietary acculturation and presents a model for how it occurs, 3) discusses measurement issues around dietary acculturation,4) reviews the literature on dietary acculturation in Korean Americans; 4) suggests a paradigm for acculturation research; and 5) offers some recommendations for future research in this area.

• Clinical and Experimental Pediatrics
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• 제63권9호
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• pp.337-344
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• 2020

Inflammatory bowel disease (IBD) is a chronic relapsing immune-mediated disease of the intestinal tract. Although its prevalence is reportedly lower in Asia than in Western countries, the rapid increase in the incidence of IBD has drawn attention to its etiology, including genetic susceptibility and environmental factors. Specifically, recent studies concerning dietary treatments and intestinal microbiota suggest that these factors may interact with the immune system, and the imbalance of this relationship may lead to immune dysregulation in IBD. Changes in diet or alterations in the composition of the intestinal microbiota may be associated with the increasing incidence of IBD in Asia. Here, we aim to review recent studies on the role of diet and intestinal microbiota in IBD pathogenesis and the results of the investigations performed to modulate these factors.