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Acupuncture on Siguan Points (LI4 and LR3) Restores Loperamide/Scopolamine-induced Intestinal Immotility in Mice

  • Shin Jang-Woo;Son Jin-Young;Yim Yun-Kyoung;Choi Sun Mi;Koo Sung-Tae;Son Chang-Gue
    • The Journal of Korean Medicine
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    • v.27 no.1 s.65
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    • pp.146-154
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    • 2006
  • Objectives : Siguan points (LI4, LR3) have been most frequently applied for various diseases, especially different digestive disorders such as constipation, abdominal pain or various intestinal inflammatory diseases. The fact that gastrointestina movement is closely connected with physiologic functions or pathologic process of alimentary canal led us to ask the question if Siguan points affects on intestinal motility. Design: To investigate the effect of Siguan acupuncture on the intestinal movement in both physiologic and pathologic conditions, we divided the experimental animals into 12 groups. Six groups were pre-treated with loperamide (0.5 mg/kg, sc) or scoploamine (0.5 mg/kg, sc) to suppress the intestinal movement and another three groups were pretreated with carbachol (0.5 mg/kg, po) to activate it, whereas the rest three groups didn't receive any pretreatment to be kept in the physiological condition. After the administration with charcoal meal, mice were acupunctured bilaterally on sham point or Siguan points as the manner of tap-stimulation, with the exception of no acupuncture groups. Methods : Mice were scarified in twenty minutes after the administration of charcoal to measure the distance of charcoal passage from stomach-duodenal junction. The effect on intestinal movement was presented by calculating the relative distance where charcoal arrived to total length of small intestine. Results : In physiological state, charcoal meal passed around 53%, and there was no significant difference between Siguan points and sham points groups. On the other hand. Siguan points-sitimulation significantly ameliorated loperamide or scoplolamine-induced suppressed travel rate of 17.3 % and 18.6% in sham point into 26% and 26.3% respectively (p<0.05). In carbachol-induced accelerated condition, Siguan points-stimulation didn't affect intestinal motility comparing to sham point group passed about 97.6%. Conclusions : These results postulate that acupuncture at Siguan points have a therapeutic effect by restoring cholinergic activity on pathogenically suppressed intestinal peristalsis, but does not affect the gastrointestinal motility in the normal or accelerated condition.

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Sea level slope of the Korean Peninsula Coast determined by Local Mean Sea Level (지역별 평균해수면에 의해 결정된 우리나라 해안의 해면경사)

  • KIM, Tae-Woo;YUN, Hong-Sik;KIM, Kwang-Bae
    • Journal of the Korean Association of Geographic Information Studies
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    • v.22 no.1
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    • pp.51-61
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    • 2019
  • Computing the sea level slope at the BM(Bench Mark) in the coast areas around the Korean Peninsula is important for establishing height of BM of the Korean geodetic leveling network. In this study, MSL(Mean Sea Level) was recalculated with the long-term tide observation data based on the IHO(International Hydrographic Organization) standard(18.6 years), and the BM height was reanalyzed by precision leveling. The sea surface topography was analyzed by leveling at Mokpo(Mokpo Starting Point), Busan (09-00-00) and Mukho(20-26-00) BMs, and the sea level slope was computed based on the Korean vertical origin point. As a result of this study, the sea level slope of the west and east coasts between Incheon(-2.27cm) and Mukho(17.56cm) located at $37.5^{\circ}N$ was analyzed as 19.83cm. Domestic geodesists and oceanologists have confronted each other with regard to the issue of latitudinal changes in long term MSL. In the west coast, the Mokpo is 1.12cm higher than Incheon, and the Busan is 2.18cm higher than Mukho. Therefore, the west and east coasts have been analyzed as sea level slope rising to the south. It can be used to solve the reestablishment of the Korean geodetic leveling network and the problem of the elevation discrepancy in the BM.

Fecundity and Hatchability of Natural Stone Flounder Kareius bicoloratus from the West Coast of Korea (서해 자연산 돌가자미, Kareius bicoloratus의 포란수와 부화율)

  • Jun, Je-Cheon;Kang, Hee-Woong;Kim, Byung-Gyun;Choi, Ki-Ho;Jo, Ki-Che
    • Korean Journal of Ichthyology
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    • v.21 no.4
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    • pp.239-246
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    • 2009
  • To establish a database for artificial seed production of stone flounder Kareius bicoloratus, experiments were conducted to study the characteristics of spawning and fecundity of this species. Broodstocks were captured in the area of Gyeokryeolbiyeoldo, Chungnam, Korea in October 2003 and induced to natural spawning. The broodstock consisted of 12 females (34.5~51.0 cm total length and 540~2,200 g body weight) and 23 males (29.0~38.0 cm total length and 310~680 g body weight). Gonad development began in December and proceeded in the direction of the tail; measurements were made with the naked eye. The tank-held broodstock were reared for 3 months before spawning, which continued for 77 days from January 9 to March 27, 2004. Daylength during the spawning was recorded at the yearly shortest of 9.8~12.1 hours and the water temperature was maintained at $8.4{\sim}12.2^{\circ}C$. The total fecundity was 19,844,000 individuals, among which 15,433,000 individuals (77.8%) were produced during the mid-spawning period. The average bloating rate, egg-fertilization rate and hatching rate of the total number spawned reached 50.4%, 58.5% and 55.6%, respectively, and 93.8% of the hatched fry appeared normal. The number of total eggs in absolute fecundity per total length was proportional to both lengths, as was the number of total eggs in relative fecundity per total length. The number of total eggs in absolute fecundity per body weight was proportional to body weight as was the number in relative fecundity per body weight except that the number in relative fecundity per gram decreased after a peak in increased body weight at a certain point.

Comparative Study of Therapeutic Effect of Needle-free Bee Venom Aqua-acupuncture (BVA) into Zusanli (ST36) in the Rat Formalin Test (포르말린으로 유도된 통증 유발 쥐에서 무침주입기를 이용한 봉독약침의 진통효과)

  • Jeong, In-Jae;Hahm, Dae-Hyun;Jung, Wu-Byung;Han, Ji-Hee;Chae, Youn-Byoung;Lim, Hyoung-Soo;Lee, Hye-Jung;Kang, Sung-Keel;Kim, Jang-Hyun
    • Journal of Physiology & Pathology in Korean Medicine
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    • v.20 no.2
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    • pp.365-371
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    • 2006
  • Bee Venom aqua-acupuncture (BVA) simultaneously exerts pharmacological effects of biologically active compounds, existed in the whole bee venom, and medicinal effect of the stimulation of acupuncture points. BVA has been considered as a promising therapeutic method for treating various chronic diseases, mainly accompanying severe pain and inflammation. As a painless injection device, jet injectors have been commercially marketed for various clinical applications including insulin injection and vaccination. Among them, a pressure-driven jet injector system could be used for intradermal delivery of a variety of drugs. The aim of this study was to investigate the analgesic effects of the BVA using a needle-free injector (Biojector $2000^{\circledR}$, Bioject Inc., OR, USA), compared to the conventional BV aqua-acupuncture using a typical syringe. Adult Sprague-Dawley rats were injected with bee venom $(0.08mg/kg,\;50{\mu}l)$ using Biojector $2000^{\circledR}$ (BVA-B) or a syringe (BVA-5) into the Zusanli (ST36) acupoint, 30 minutes before plantar injection of 2% formalin. It was found that BVA-B-, or BVA-5-treated rats, compared to controls, exhibited significantly less licking behavior during the late phase in the rat formalin test, when compared to controls. During early phase, however, those effects were not significant but substantial. The analgesic effect of BVA-B was also compatible with that of the conventional BVA-5. In the immunohistochemical studies, BVA-B significantly suppressed the expression of formalin-evoked c-fos, a biomarker of neuronal activity, in the lumbar dorsal horn of the spinal cord. These results indicated that BVA-B waseffective in the modulation of pain in the rat formalin test, compared to BVA-5. Taken together, the needle-free jet injector system could be substituted for the conventional aqua- acupuncture with the advantage of little pain.

Clinical Observation of Western Medical Treatment and Acupuncture Treatment on Frozen Shoulder Patients (유착성 관절낭염 치료에 있어서 한방 치료와 양방 치료의 임상적 고찰 - 동서협진 모델 개발을 위한 기초 연구를 중심으로 -)

  • Nam, Dong-Woo;Jung, In-Tae;Kim, Joo-Hee;Park, You-Seon;Lim, Sabina;Lee, Doo-Ik;Lee, Jae-Dong;Lee, Yun-Ho;Choi, Do-Young
    • Journal of Acupuncture Research
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    • v.23 no.5
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    • pp.177-185
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    • 2006
  • Objectives : To observe the effect of acupuncture treatment and western medical treatment on frozen shoulder patients. Methods : 39 voluntary patients were randomly assigned to the Eastern treatment group(E group, n=22) and the Western treatment group(W group, n=17). The E group received acupuncture treatment on LI15, TE14, GB21 and Master Dong's acupuncture points, Shin-gwan and Gyun-joong, twice a week for 4 weeks. The W group received suprascapular nerve block, subacromial injection and trigger point injection, twice a week for 4 weeks. Both groups were instructed to practice self exercise during their daily lives. Evaluations were made before treatment and after treatment using Constant Shoulder Assessment(CSA), Shoulder Pain and Disability Index(SPADI) and the patient's satisfaction concerning the treatment was measured by Visual Analogue Scale(VAS). The obtained data were analyzed and compared. Results : The E group showed significant improvement(p<0.05) according to the CSA and SPADI. The patient's satisfaction scored 5.67 on a scale of 10. The W group showed significant improvement(p<0.05) according to the CSA and SPADI. The patient's satisfaction scored 7.73. But the difference between the two groups were insignificant according to CSA and SPADI. Conclusion : Both acupuncture and nerve block treatment significantly improved frozen shoulder. But the difference of the two treatments was insignificant.

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Spatial Point-pattern Analysis of a Population of Lodgepole Pine

  • Chhin, Sophan;Huang, Shongming
    • Journal of Forest and Environmental Science
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    • v.34 no.6
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    • pp.419-428
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    • 2018
  • Spatial point-patterns analyses were conducted to provide insight into the ecological process behind competition and mortality in two lodgepole pine (Pinus contorta Dougl. ex Loud. var. latifolia Engelm.) stands, one in the Lower Foothills, and the other in the Upper Foothills natural subregions in the boreal forest of Alberta, Canada. Spatial statistical tests were applied to live and dead trees and included Clark-Evans nearest neighbor statistic (R), nearest neighbor distribution function (G(r)), and a variant of Ripley's K function (L(r)). In both lodgepole pine plots, the results indicated that there was significant regularity in the spatial point-pattern of the surviving trees which indicates that competition has been a key driver of mortality and forest dynamics in these plots. Dead trees generally showed a clumping pattern in higher density patches. There were also significant bivariate relationships between live and dead trees, but the relationships differed by natural subregion. In the Lower Foothills plot there was significant attraction between live and dead tees which suggests mainly one-sided competition for light. In contrast, in the Upper Foothills plot, there was significant repulsion between live and dead trees which suggests two-sided competition for soil nutrients and soil moisture.

A station-keeping method considering satellite attitude (자세를 고려한 위성체 궤도유지 기법)

  • 박재훈;이장규;김유단;최재원
    • 제어로봇시스템학회:학술대회논문집
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    • 1993.10a
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    • pp.799-804
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    • 1993
  • In this paper, the scheme of combining the orbit correction and attitude control of a 3-axis stabilized satellite is suggested. Being coupled and complimentary, it is preferable to achieve the required orbit correction and the desired attitude control simultaneously. A solution of the probes simultaneous control of orbit correction and attitude of a satellite, is obtained by solving the two point boundary value problem numerically. The first-order gradient algorithm is used to solve the numerical problem. The simulation results show that the East-West station keeping process with the combined system of an orbit correction and an attitude control is satisfactory.

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How Were the American Civil Engineers Born? (미국의 토목 엔지니어는 어떻게 탄생했는가?)

  • Kim, Deok-Ho
    • Journal of Engineering Education Research
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    • v.14 no.5
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    • pp.29-36
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    • 2011
  • This paper examines the birth of civil engineers in the United States. Unlike the advanced some European countries such as Great Britain or France, as a new nation America had to import high-tech technologies from them. In the process of transplantation she had mixed up the civil engineering of British style with French's. As a result, the training of the civil engineers in America had developed in various ways.

MULTI-JENSEN AND MULTI-EULER-LAGRANGE ADDITIVE MAPPINGS

  • Abasalt Bodaghi;Amir Sahami
    • Communications of the Korean Mathematical Society
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    • v.39 no.3
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    • pp.673-692
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    • 2024
  • In this work, an alternative fashion of the multi-Jensen is introduced. The structures of the multi-Jensen and the multi-Euler-Lagrange-Jensen mappings are described. In other words, the system of n equations defining each of the mentioned mappings is unified as a single equation. Furthermore, by applying a fixed point theorem, the Hyers-Ulam stability for the multi-Euler-Lagrange-Jensen mappings in the setting of Banach spaces is established. An appropriate counterexample is supplied to invalidate the results in the case of singularity for multiadditive mappings.

Estimation of non-point pollution reduction effect of Haean Catchment by application of Nature-based Solutions (자연기반해법 적용에 따른 강원도 양구군 해안면의 비점오염 저감 효과 추정)

  • Lee, Ji-Woo;Park, Chan
    • Journal of the Korean Society of Environmental Restoration Technology
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    • v.25 no.3
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    • pp.47-62
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    • 2022
  • The Ministry of Environment has been working to reduce the impact on biodiversity, ecosystems, and social costs caused by soil runoff from highland Agricultural fields by setting up non-point pollution source management districts. To reduce soil loss, runoff path reduction technology has been applied, but it has been less cost effective. In addition, non-point pollution sources cause environmental conflicts in downstream areas, and recently highland Agricultural fields are becoming vulnerable to climate change. The Ministry of Environment is promoting the optimal management plan in earnest to convert arable land into forests and grasslands, but since non-point pollution is not a simple environmental problem, it is necessary to approach it from the aspect of NbS(Nature-Based Solution). In this study, a scenario for applying the nature-based solution was established for three subwatersheds west of Haean-myeon, Yanggu-gun, Gangwon-do. The soil loss distribution was spatialized through GeoWEPP and the amount of soil loss was compared for the non-point pollution reduction effect of mixed forests and grasslands. When cultivated land with a slope of 20% or more and ginseng fields were restored to perennial grasslands and mixed forests, non-point pollution reduction effects of about 32% and 29.000 tons compared to the current land use were shown. Also, it was confirmed that mixed forest rather than perennial grassland is an effective nature-based solution to reduce non-point pollution.