• Osteoporosis and Sarcopenia
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• v.3 no.3
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• pp.117-122
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• 2017

Sarcopenia is the degenerative loss of muscle mass and function with aging. Recently sarcopenia was recognized as a clinical disease by the International Classification of Disease, 10th revision, Clinical Modification. An imbalance between protein synthesis and degradation causes a gradual loss of muscle mass, resulting in a decline of muscle function as a progress of sarcopenia. Many mechanisms involved in the onset of sarcopenia include age-related factors as well as activity-, disease-, and nutrition-related factors. The stage of sarcopenia reflecting the severity of conditions assists clinical management of sarcopenia. It is important that systemic descriptions of the disease conditions include age, sex, and other environmental risk factors as well as levels of physical function. To develop a new therapeutic intervention needed is the detailed understanding of molecular and cellular mechanisms by which apoptosis, autophagy, atrophy, and hypertrophy occur in the muscle stem cells, myotubes, and/or neuromuscular junction. The new strategy to managing sarcopenia will be signal-modulating small molecules, natural compounds, repurposing of old drugs, and muscle-specific microRNAs.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.22 no.5
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• pp.354-360
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• 2021

People hope to live a healthy and happy life achieving satisfaction by striking a good work-life balance. Therefore, there is a growing interest in well-aging which means living happily to a healthy old age without worry. This study identified important factors related to well-aging by analyzing news articles published in Korea. Using Python-based web crawling, 1,199 articles were collected on the news service of portal site Daum till November 2020, and 374 articles were selected which matched the subject of the study. The frequency analysis results of text mining showed keywords such as 'elderly', 'health', 'skin', 'well-aging', 'product', 'person', 'aging', 'female', 'domestic' and 'retirement' as important keywords. Besides, a social network analysis with 45 important keywords revealed strong connections in the order of 'skin-wrinkle', 'skin-aging' and 'old-health'. The result of the CONCOR analysis showed that 45 main keywords were composed of eight clusters of 'life and happiness', 'disease and death', 'nutrition and exercise', 'healing', 'health', and 'elderly services'.

• Proceedings of the KSME Conference
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• 2002.08a
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• pp.713-716
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• 2002

Aging effect on the cardiovascular circulation is simulated by lumped parameter model. Aging phenomena can be hemodynamically explained as (1) the increase of flow resistance induced by remodeling of artery vessels and increased viscosity of blood and (2) the reduction of the vessel capacitance caused by arteriosclerosis. Appropriate physiological parameters are evaluated from the clinical data of adults and old men. Simulation results well explain the hypertension with aging of cardiovascular system.

• Journal of muscle and joint health
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• v.26 no.3
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• pp.175-183
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• 2019

Purpose: This is a descriptive research examining the relationships between aging anxiety, perceived level of successful aging, and preparation for aging as well as factors influencing preparation for aging. Methods: Subjects of this study were 221 women aged between 40 and 59 years residing in area J. Data were collected from October 27, 2017 to November 9, 2017, using a structured questionnaire. The collected data were analyzed using the statistical program SPSS/WIN 24.0. Results: Regression analysis revaled that factors having a significant effect on the preparation for aging of the subjects were age, perceived health status, exercise, leisure activity, aging anxiety, and perception of successful aging. The total explanatory power was 42.3%. Conclusion: Based on the results of this study, it was found that aging anxiety and successful aging influenced the preparation for aging of middle-aged women. Therefore, it is necessary to develop a nursing intervention that properly manage aging anxiety and improves successful aging, in order to encourage middle-aged women to actively prepare for their later lives.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.22 no.3
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• pp.190-198
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• 2021

The purpose of this study is to identify characteristics of well-aging related research conducted in Korea and to analyze the concept definition to present the direction for future well-aging research in Korea. As a research method, an integrated literature review suggested by Whittemore & Knafl was conducted. Study results found research conducted in Korea consisted of 2 literature reviews, case studies, qualitative studies, 3 survey studies, and 2 experimental studies. In addition, there were 3 studies performed prior to 2017 and 8 studies after that included 2 dissertations and 9 dissertations in academic journals. The definition of well aging consisted of physical, emotional, social, economic, and self-realization aspects. Based on the results of this study, it is necessary to provide education and programs according to life cycles to prepare well aging, and in the future, well-aging studies should be conducted in various academic fields.

• 한국노년학
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• v.38 no.2
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• pp.309-327
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• 2018

Meta-analysis was conducted on 34 studies reported in Korea from February 2007 through March 2017 to systematically integrate factors of aging anxiety of the middle and old aged. The variables related to aging anxiety were divided into 6 groups of variable, and the effect sizes were computed for each variable of their groups. The results are as follows. First, the total effect size showed the middle effect size, and the effect size according to the variable group showed the largest effect size for the negative psychological variable group, followed by the positive psychological variable, the social variable, the physical variable, the familial variable and the demographic variable. Second, the largest effect size of the sub-variables showed psychological well-being and death anxiety. As described above, suggesting that these variables may have a strong influence on aging anxiety among the variables related to aging anxiety because the psychological well-being and death anxiety were shown as the largest effective variables related to aging anxiety.

• Molecules and Cells
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• v.38 no.11
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• pp.1013-1021
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• 2015

Most of the axons in the vertebrate nervous system are surrounded by a lipid-rich membrane called myelin, which promotes rapid conduction of nerve impulses and protects the axon from being damaged. Multiple sclerosis (MS) is a chronic demyelinating disease of the CNS characterized by infiltration of immune cells and progressive damage to myelin and axons. One potential way to treat MS is to enhance the endogenous remyelination process, but at present there are no available treatments to promote remyelination in patients with demyelinating diseases. Sulfasalazine is an anti-inflammatory and immune-modulating drug that is used in rheumatology and inflammatory bowel disease. Its anti-inflammatory and immunomodulatory properties prompted us to test the ability of sulfasalazine to promote remyelination. In this study, we found that sulfasalazine promotes remyelination in the CNS of a transgenic zebrafish model of NTR/MTZ-induced demyelination. We also found that sulfasalazine treatment reduced the number of macrophages/microglia in the CNS of demyelinated zebrafish larvae, suggesting that the acceleration of remyelination is mediated by the immunomodulatory function of sulfasalazine. Our data suggest that temporal modulation of the immune response by sulfasalazine can be used to overcome MS by enhancing myelin repair and remyelination in the CNS.

• The Korean Journal of Health Service Management
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• v.10 no.2
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• pp.145-154
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• 2016

Objectives : Because people have increasingly more interest in their quality of life, the anti-aging industry has grown worldwide. The purpose of this study is to suggest strategies for galvanizing the anti-aging industry in Korea. Methods : To accomplish this aim, we explored the definition, classification, problem and activating strategies of the anti-aging industry through a systematic review. Results : From the results, the following suggestions are given: planning a national strategy to galvanize the anti-aging industry, establishing an anti-aging research institute, developing a business model, developing an anti-aging cluster, statistics development and an information system related to anti-aging, training personnel, and legislation. Conclusions : The anti-aging industry has the potential to reduce health expenses through early intervention of diseases due to aging and through activation of the national economy by win-win growth of the industry related to aging. Therefore, understanding the anti-aging industry as well as political support is critical.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.19 no.6
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• pp.440-446
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• 2018

This study examines the contrasting effects of an aging workforce on organizational innovation and the moderating role of age diversity. By utilizing a knowledge-based view, this study asserts that an aging workforce can contribute to organizational innovation to some degree due to accumulated firm-specific knowledge and experiences as well as various social networks within and outside the firm. On the contrary, as the portion of an aging workforce increases, the negative effect of the aging workforce on organizational innovation can overwhelm the positive effects because of the limitations of new knowledge creation. In addition, this study explores the effect of age diversity to moderate the relationship between aging workforce and organizational innovation.Empirical findings showed that an aging workforce and organizational innovation had an inverted-U relationship, and age diversity moderated this curvilinear relationship as this study predicted. These theoretical arguments and empirical findings highlight the necessity to explore the complex effects of an aging workforce on organizational innovation as well as additional factors influencing the relationship between aging workforce and firm innovation.

• Journal of the Korean Society of Laryngology, Phoniatrics and Logopedics
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• v.25 no.1
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• pp.24-26
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• 2014

Aging causes a variety of changes in the structure of the vocal fold (VF), resulting in aging-induced dysphonia (presbyphonia). Several studies have investigated the structure of the VF of elderly people from autopsy as well as animal studies. There is an increasing evidence on correlation of structural changes of VF with deteriorated voice in elderly. Although the cellular mechanisms of aging VF have only partially been elucidated, there are many recent advances in biological treatment on aging VF using bioactive molecules such as growth factors. In this study, I'd like to address aging-related structural, biological, and physiological changes in previous literature about human and rodent aging VFs, to provide further insight into the mechanisms responsible for presbyphonia and to translate the basic researches for future clinical trials.