• 한국미생물·생명공학회지
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• 제49권1호
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• pp.65-74
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• 2021

Serine proteases are the most versatile proteolytic enzymes with tremendous applications in various industrial processes. This study was designed to investigate the biochemical properties, critical residues, and the catalytic potential of alkaline serine protease using in-silico approaches. The primary sequence was analyzed using ProtParam, SignalP, and Phyre2 tools to investigate biochemical properties, signal peptide, and secondary structure, respectively. The three-dimensional structure of the enzyme was modeled using the MODELLER program present in Discovery Studio followed by Molecular Dynamics simulation using GROMACS 5.0.7 package with CHARMM36m force field. The proteolytic potential was measured by performing docking with casein- and keratin-enriched residues, while the effect of the inhibitor was studied using phenylmethylsulfonyl fluoride, (PMSF) applying GOLDv5.2.2. Molecular weight, instability index, aliphatic index, and isoelectric point for serine protease were 39.53 kDa, 27.79, 82.20 and 8.91, respectively. The best model was selected based on the lowest MOLPDF score (1382.82) and DOPE score (-29984.07). The analysis using ProSA-web revealed a Z-score of -9.7, whereas 88.86% of the residues occupied the most favored region in the Ramachandran plot. Ser327, Asp138, Asn261, and Thr326 were found as critical residues involved in ligand binding and execution of biocatalysis. Our findings suggest that bioengineering of these critical residues may enhance the catalytic potential of this enzyme.

• 토지주택연구
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• 제13권2호
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• pp.81-90
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• 2022

본 연구는 도심내 정신건강의 녹색치유공간의 사회적 필요성에 기인하여 생활밀착형 정원에 대한 현 시대의 사회적 인식요소 분석을 통해 발전방향을 모색하였다. 연구 방법으로 빅데이터 툴 중 덱스톰을 활용하여 웹정보 데이터를 수집하고, 텍스트마이닝을 진행하여 키워드 분석, 네트워크 분석과 담론분석을 통해 요소의 추출과 관계성을 파악하였다. 분석 결과 첫째, 치유공간과 치유환경은 도시 내부인 생활밀착의 공간 안에 친화적 건강 환경을 구축하고 있었다. 둘째, 생활밀착은 시설뿐 아니라 생활문화와 도시환경을 연동하여 국가와 지방행정, 시민이 참여하는 사업과 활동을 담고 있으며 생활밀착형 정원은 녹색복지와 서비스 프로그램을 통해 내실화되고 있다. 결론으로 정신건강에 유익하고 친근한 생활권의 공익형 정원은 긍정적 자극을 줄 수 있는 치유 환경으로서의 녹색인프라이다.

• 한국컴퓨터정보학회논문지
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• 제28권5호
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• pp.189-196
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• 2023

본 연구는 정보통신기술(IT)의 발전으로 외국어 교육과 학습에서 기존의 전통적인 '훈련과 연습(drill and practice)'의 방법에서 벗어난 '컴퓨터 보조언어학습(Computer-assisted learning: CALL)'과 '모바일 지원 언어학습(Mobile-based Language Learning: MALL)'이 실제로 어학 교육에 미치는 영향을 분석한다. 연구 대상은 비교적 영어 능력이 상대적으로 우수하지 않고, 또한 영어학습에 대한 동기부여를 충분히 느끼지 못하는 전문대학 1학년 학생들을 대상으로 진행하였다. 연구 방법은 멀티미디어 저작 도구를 이용하여 디지털 콘텐츠를 제작하여 이러닝(e-learning) 시스템에 등재하여 교육보조재료로 한 학기 동안 활용한다. 동영상 콘텐츠는 컴퓨터, 스마트폰, 테블릿, 노트북 등 다양한 매체로 접근하여 활용할 수 있도록 구성한다. 동영상 콘텐츠에 대한 설문조사를 통하여 콘텐츠의 구성, 학습에 도움 여부, 보완해야 할 부분, 콘텐츠 접근 빈도, 학습경로 등을 분석한다. 분석의 결과를 통하여 정보통신기술을 활용한 어학 학습의 효과, 교육용 콘텐츠의 개선해야 할 부분 및 교육에 어떻게 활용해야 하는지에 대해 제언한다. 궁극적으로는 '플립러닝((Flipped Learning)'을 위한 컴퓨터 및 모바일 매체에 대한 효용성 분석과 활용방안을 제언한다.

• 한국컴퓨터정보학회논문지
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• 제14권1호
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• pp.191-203
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• 2009

유비쿼터스 컴퓨팅 환경에서 실시간의 상황을 고려한 동적인 서비스를 제공하기 위하여 이전 연구를 통해 메타서비스 개념과 기술 규격, 메타서비스 라이브러리 구축 방법을 제안한 바 있다. 하지만, 제안한 프로세스는 각 단계에서 UML, OWL, OWL-S 기반의 분리된 모델을 생성하게 되고 모델간의 변환을 위한 일정한 체계를 제공하지 못하고 있다. 게다가, 다양한 온톨로지 언어와 온톨로지 편집 도구들, 제안한 메타서비스 규격에 대한 전문가의 개입을 전제로 한다. 본 연구에서는, 비전문가도 일관된 모델을 생성하고 메타서비스 라이브러리를 구축할 수 있도록 OWL 형식의 도메인 온톨로지에서 OWL-S 형식의 메타서비스 라이브러리로의 자동 변환 프로세스를 설계하고 이를 지원할 수 있는 시각 도구를 개발한다. 메타서비스 라이브러리 변환 프로세스는 일관성을 유지하면서 기존의 OWL 모델과 메타서비스모델을 조합하여 메타서비스 라이브러리에 대한 OWL-S 코드를 자동으로 생성하는 것을 목표로 한다.

• 대한족부족관절학회지
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• 제26권1호
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• pp.30-39
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• 2022

Purpose: This study aimed to report the current trends in the management of diabetic foot over the last few decades through a survey of the Korean Foot and Ankle Society (KFAS) members. Materials and Methods: A web-based questionnaire containing 40 questions was sent to all KFAS members in September 2021. The questions were mainly related to the demographics of patients with diabetic foot, diagnostic tools, and multidisciplinary treatment. Answers with a prevalence of ≥50% of respondents were considered a tendency. Results: Seventy-eight of the 550 members (14.2%) responded to the survey. The most common demographic factors of diabetic foot patients were male dominance with a high percentage in the 60- to 70-year-old. Although the need for multidisciplinary treatment is highly recognized in the treatment of diabetic foot patients, the actual implementation rate is about 39%. The contrast-enhanced magnetic resonance imaging (88.5%) was reported to be the most used tool for the diagnosis of osteomyelitis of the diabetic foot. It was reported that the use of antibiotics was started empirically and then changed based on bacterial culture tests in 82.1% of patients. Simple wound dressing and antibiotic treatment were most frequently reported for mild ulcers. Conclusion: This study provides updated information on the current trends in the management of a diabetic foot in Korea. Both consensus and variations in the approach to patients with diabetic foot were identified by this survey study. Further efforts are required for better access to a multidisciplinary approach, such as appropriate insurance payment policies and patient education.

• 대한토목학회논문집
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• 제30권6D호
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• pp.655-662
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• 2010

사회기반시설은 국가 경쟁력 지표로써, 전통적으로 정부의 SOC 재정으로 건설되어 왔다. 그러나 SOC 예산 축소에도 불구하고 사회기반시설의 확충 요구를 해결하기 위해 민간투자사업제도가 도입되었으며, 이 중 도로사업의 비중이 높다. 본 연구는 기 제안된 도로사업 사업계획서의 운영관리비와 사업계획서와 연계되는 재무모델의 운영관리비 항목을 분석하고, 도로사업의 특성을 반영하기 위해 한국도로공사의 사업비 항목과 운영관리 업무를 분석하였다. 분석 결과를 통해 분류체계를 마련하여 비용산정 기준을 마련하는 것이 요구된다. 또한 업무의 효율성을 고려하여 기존의 업무 도구를 웹기반으로 통합하여 하나의 시스템으로 개발하는 것을 제안하였다. 이를 통해 민간투자사업의 전체적인 사업성 확보에 기여하고, 수익성을 기반으로 하는 사회기반시설의 확충에 기여할 것으로 기대된다.

• Restorative Dentistry and Endodontics
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• 제48권4호
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• pp.37.1-37.17
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• 2023

This study aimed to compare the disinfectant ability of chlorhexidine (CHX) gel and sodium hypochlorite (NaOCl). Systematic searches were conducted from inception until December 8th, 2022 (MEDLINE/PubMed, Cochrane Library, Web of Science, Scopus, Embase, and Grey Literature databases). Only randomized clinical trials were included. The revised Cochrane risk of bias tools for randomized trials were used to assess the quality of studies. Meta-analyses were performed. The overall quality of evidence was assessed through the Grading of Recommendations Assessment, Development, and Evaluation tool. Six studies were included. Five had a low risk of bias and 1 had some concerns. Three studies assessed bacterial reduction. Two were included in the meta-analysis for bacterial reduction (mean difference, 75.03 [confidence interval, CI, -271.15, 421.22], p = 0.67; I² = 74%); and 3 in the meta-analysis for cultivable bacteria after chemomechanical preparation (odds ratio, 1.03 [CI, 0.20, 5.31], P = 0.98; I² = 49%). Five studies assessed endotoxin reduction. Three were included in a meta-analysis (mean difference, 20.59 [CI, -36.41, 77.59], p = 0.48; I² = 74%). There seems to be no difference in the disinfectant ability of CHX gel and NaOCl, but further research is necessary.

• 무역학회지
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• 제46권5호
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• pp.65-81
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• 2021

The technological development in the era of the 4th industrial revolution is changing the paradigm of various industries. Various technologies such as big data, cloud, artificial intelligence, virtual reality, and the Internet of Things are used, creating synergy effects with existing industries, creating radical development and value creation. Among them, the logistics sector has been greatly influenced by quantitative data from the past and has been continuously accumulating and managing data, so it is highly likely to be linked with big data analysis and has a high utilization effect. The modern advanced technology has developed together with the data mining technology to discover hidden patterns and new correlations in such big data, and through this, meaningful results are being derived. Therefore, data mining occupies an important part in big data analysis, and this study tried to analyze data mining techniques that can contribute to the logistics field and common logistics using these data mining technologies. Therefore, by using the AHP technique, it was attempted to derive priorities for each type of efficient data mining for logisticalization, and R program and R Studio were used as tools to analyze this. Criteria of AHP method set association analysis, cluster analysis, decision tree method, artificial neural network method, web mining, and opinion mining. For the alternatives, common transport and delivery, common logistics center, common logistics information system, and common logistics partnership were set as factors.

• 국제학술발표논문집
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• The 4th International Conference on Construction Engineering and Project Management Organized by the University of New South Wales
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• pp.213-220
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• 2011

In the current construction industry where various stakeholders take part, BIM Data exchange using standard format can provide a more efficient working environment for related staffs during the life-cycle of the building. Currently, the formats used to exchange the data from 3D-CAD application to structure energy analysis at the design stages are IFC, the international standard format provided by IAI, and gbXML, developed by Autodesk. However, because of insufficient data compatibility, the BIM data produced in the 3D-CAD application cannot be directly used in the energy analysis, thus there needs to be additional data entry. The reasons for this are as follows: First, an IFC file cannot contain all the data required for energy simulation. Second, architects sometimes write material names on the drawings that are not matching to those in the standard material library used in energy analysis tools. DOE-2.2 and Energy Plus are the most popular energy analysis engines. And both engines have their own material libraries. However, our investigation revealed that the two libraries are not compatible. First, the types and unit of properties were different. Second, material names used in the library and the codes of the materials were different. Furthermore, there is no material library in Korean language. Thus, by comparing the basic library of DOE-2, the most commonly used energy analysis engine worldwide, and EnergyPlus regarding construction materials; this study will analyze the material data required for energy analysis and propose a way to effectively enter these using semantic web's ontology. This study is meaningful as it enhances the objective credibility of the analysis result when analyzing the energy, and as a conceptual study on the usage of ontology in the construction industry.

• 여성건강간호학회지
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• 제29권3호
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• pp.160-178
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• 2023

Purpose: Since technology-based interventions can facilitate convenient access to healthcare for women with breast cancer, it is crucial to understand innovative approaches to maintaining the effectiveness of these interventions. Therefore, we conducted a systematic review of technology-based self-management interventions for women with breast cancer in six countries. We analyzed the characteristics of these interventions and examined their diverse health outcomes. Methods: Six databases were systematically searched to extract research articles using the keywords "breast cancer," "technology," and "self-management." The search was carried out up until June 12, 2023. From the 1,288 studies retrieved from the database search, 10 eligible papers were identified based on inclusion/exclusion criteria. Two authors independently extracted and compared the data from these articles, resolving any discrepancies through discussion. Results: Most of the 10 studies utilized web- or mobile-based technology, and one used artificial intelligence-based technology. Among the 12 health-related outcome variables, quality of life and symptom distress were the most frequently mentioned, appearing in six articles. Furthermore, an analysis of the intervention programs revealed a variety of common constructs and the involvement of managers in the self-management intervention. Conclusion: Incorporating key components such as self-management planning, diary keeping, and communication support in technology-based interventions could significantly improve the self-management process for breast cancer survivors. The practical application of technology has the potential to empower women diagnosed with breast cancer and improve their overall quality of life, by providing timely and sustainable interventions, and by leveraging available resources and tools.