• Asian Pacific Journal of Cancer Prevention
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• 제13권7호
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• pp.3009-3013
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• 2012

Background: The clinical course of individual chronic lymphocytic leukemia (CLL) is highly variable and clinical staging systems do not help us to predict if and at what rate there will be disease progression in an individual patient diagnosed with early stage disease. Recently, several important observations related to other prognostic factors including lymphocyte doubling time (LDT), ${\beta}_2$-microglobulin (${\beta}_2$-MG), and percent of smudge cell in peripheral blood smears, cytogenetic and molecular analysis have been made. The aim of this study was to evaluate a range of prognostic factors in our CLL patients. Design and methods: Seventy patients with CLL were enrolled. Prognostic factors of disease including Binet staging, LDT, ${\beta}_2$-MG, ESR, LDH, percent of smudge cell in peripheral blood smear, absolute lymphocyte count, and conventional cytogenetic (CC) analysis were evaluated at diagnosis, and the patients were followed up to determine their outcome. We compared factors with each other and with Binet staging and prognosis. Results: Enrolled patients aged 37-85 years at diagnosis or during follow up. There was no relationship between serum LDH level (P=0.3), ESR (P=0.11), percent of smudge cells in peripheral blood smear (P=0.94), and absolute lymphocyte count (P=0.18) with the stage of disease and prognosis, but the ${\beta}_2$ macroglobulin level (p<0.0001), LDT (p<0.001) had direct and significant relation with staging and outcome. In 19% of patients cytogenetic alteration were seen. Conclusion: The detection of cytogenetic alteration only using the CC method is not sufficient and we need to use FISH, but because FISH study is an expensive method not available in all areas, instead we believe that ${\beta}_2$ MG can be applied in its place as a good prognostic factor for CLL at diagnosis and during follow up. We suggest to add it to Binet staging for prognostic subgrouping of CLL.

• 한국식품영양학회지
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• 제14권2호
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• pp.132-137
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• 2001

폐금속 광산 주변 경작지의 농산물에 대해 오염 실태를 파악하고 폐광산에 의한 오염방지 및 사후관리 대책 수립에 필요한 기초자료를 제공하기 위하여 전남지역에 분포한 광산지역 (4개 지역)을 대상으로 주변 경작지에서 7종의 농산물(상치. 양파, 감자, 무, 고추, 호박, 콩) 28건에 대해 미량금속 함유량을 조사하였으며 광산 지역별로 비교 검토하였다. 수은의 경우, 대부분의 검체에서 불검출이었으며, 일부 농산물에서 0.01 ppm이하의 양이 검출되었다. 비소는 28건의 시료중 7건에서 0.011∼0.038 ppm이 검출되었으며, 나머지 시료는 거의 불검출이었다. 납은 미량이지만 모든 검체에서 다양하게 검출되었고, 함유량은 N.D.∼0.176 ppm이었으며, 카드뮴은 거의 모든 시료에서 검출되었으며(N.D.∼0.101 ppm), 수은, 비소. 납, 카드뮴 등의 함유량은 오염된 수준이 아닌 자연 함유량 수준으로 판단된다. 구리의 경우 두류인 콩에서 4.356∼10.624ppm으로 타시료에 비해 높은 함유량을 나타냈으며, 광산 지역간에는 큰 차이를 보이지 않았다. 망간은 상치 (4.332∼24.385 ppm)가 가장 높은 함유량을 보였으며, 아연의 경우 콩과 상치, 고추에서 높은 함유량을 나타냈다.

• 대기
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• 제28권2호
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• pp.211-222
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• 2018

Cloud droplet activation process is well described by $K{\ddot{o}}hler$ theory and several parameterizations based on $K{\ddot{o}}hler$ theory are used in a wide range of models to represent this process. Here, we test the two different method of calculating the solute effect in the $K{\ddot{o}}hler$ equation, i.e., osmotic coefficient method (OSM) and ${\kappa}-K{\ddot{o}}hler$ method (KK). To do that, each method is implemented in the cloud droplet activation parameterization module of WRF-CHEM (Weather Research and Forecasting model coupled with Chemistry) model. It is assumed that aerosols are composed of five major components (i.e., sulfate, organic matter, black carbon, mineral dust, and sea salt). Both methods calculate similar representative hygroscopicity parameter values of 0.2~0.3 over the land, and 0.6~0.7 over the ocean, which are close to estimated values in previous studies. Simulated precipitation, and meteorological variables (i.e., specific heat and temperature) show good agreement with reanalysis. Spatial patterns of precipitation and liquid water path from model results and satellite data show similarity in general, but on regional scale spatial patterns and intensity show some discrepancy. However, meteorological variables, precipitation, and liquid water path do not show significant differences between OSM and KK simulations. So we suggest that the relatively simple KK method can be a good alternative to the OSM method that requires various information of density, molecular weight and dissociation number of each individual species in calculating the solute effect.

• 한국자원식물학회:학술대회논문집
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• 한국자원식물학회 2019년도 추계학술대회
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• pp.23-23
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• 2019

Cypripedium is an orchid genus of over 50 species widely distributed in the northern temperate zone, with a few taxa extending central America and the Himalayas and the southwesternmost tip of China in Asia. Of the known species approximately two thirds are found in China. In Korea, 4 species were reported to find with rare popularity ; C. macranthos, C. guttatum, C. japonicum, and C. calceolus. The seed has a firm brown fusiform testa with an opening at one end where the micropyle of the ovule was situated. Cypripedium has small, fusiform, wind-dispersed seeds that weigh about $1{\sim}2{\mu}g$ and range from 0.1 to 2 mm long and 0.07 to 0.4 mm across. The germination of Cypripedium was previously thought to be hard to cultivate in one's garden and impossible to propagate artificially, nowadays lab-propagated seedlings are readily available in EU or United States. We had already reported the successful micropropagation of lady's slipper orchids with green pod sowing methods. The collected Cypripedium species and hybrids were planted in Korea National Arboretum (KNA) on Oct. 2018. The 11 species including C. candidum and the 31 hybrids such as C. Ingrid were introduced from Germany with CITES certification. The lady's slipper orchids bloomed on May to June, and the flowers were pollinated in the same species or hybrids to get seeds for in vitro germination on 2~3 days after fully flowering. The green pods were collected after 49~70 days after pollination. The 6 species of Cypripedium seeds were easily germinated on the POM within 70 days after sowing, and the 12 hybrids PLBs were observed with small roots. We had established the scheme of lady's slipper orchids germination in 3 months with green pods, and get the possibility of seedling in 10 months of sowing in vitro.

• Restorative Dentistry and Endodontics
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• 제45권4호
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• pp.50.1-50.11
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• 2020

Objectives: In this study, we investigated the potential of amoxicillin-loaded polymeric microspheres to be delivered to tooth root infection sites via a bioactive reparative cement. Materials and Methods: Amoxicillin-loaded microspheres were synthesized by a spray-dray method and incorporated at 2.5% and 5% into a mineral trioxide aggregate cement clinically used to induce a mineralized barrier at the root tip of young permanent teeth with incomplete root development and necrotic pulp. The formulations were modified in liquid:powder ratios and in composition by the microspheres. The optimized formulations were evaluated in vitro for physical and mechanical eligibility. The morphology of microspheres was observed under scanning electron microscopy. Results: The optimized cement formulation containing microspheres at 5% exhibited a delayed-release response and maintained its fundamental functional properties. When mixed with amoxicillin-loaded microspheres, the setting times of both test materials significantly increased. The diametral tensile strength of cement containing microspheres at 5% was similar to control. However, phytic acid had no effect on this outcome (p > 0.05). When mixed with modified liquid:powder ratio, the setting time was significantly longer than that original liquid:powder ratio (p < 0.05). Conclusions: Lack of optimal concentrations of antibiotics at anatomical sites of the dental tissues is a hallmark of recurrent endodontic infections. Therefore, targeting the controlled release of broad-spectrum antibiotics may improve the therapeutic outcomes of current treatments. Overall, these results indicate that the carry of amoxicillin by microspheres could provide an alternative strategy for the local delivery of antibiotics for the management of tooth infections.

• 농약과학회지
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• 제18권3호
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• pp.196-201
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• 2014

본 연구는 참외 담배가루이의 경제적 피해수준과 요방제 수준을 설정하기 위하여 수행하였다. 참외 접목묘는 비닐하우스 내에서 2010년 6월 8일에 정식하였고, 담배가루이 성충을 7월 14일에 1, 5, 10, 20마리/10엽 밀도로 각각 접종하였다. 접종 60일 후 담배가루이 성충 밀도는 20마리 접종 처리구의 경우 초기 접종밀도보다 24.9배 증가하였다. 담배가루이에 의한 잎과 과실의 피해는 접종 후 20일째부터 나타나기 시작하였고, 접종 60일째에 피해엽율과 피해과율은 각각 28.5%와 31.5%였다. 담배가루이 접종밀도와 피해과율과의 관계를 회귀식을 이용하여 분석한 결과, Y = 0.961X + 0.0562($R^2$= 0.976)의 관계식을 얻을 수 있었다. 이 식에 따라 계산된 참외 담배가루이의 경제적 피해수준은 5.1마리/엽, 요방제 수준은 경제적 피해수준의 80%인 4.1마리/엽이었다.

• 한국토양비료학회지
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• 제45권2호
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• pp.143-148
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• 2012

경남지역 논토양의 양분관리를 위한 기초자료를 제공하기 위해 260 지점의 화학성분 변동을 1999년부터 2011년까지 4년 주기로 분석하였다. 논토양 pH, 유기물 함량, 유효인산 함량, 유효규산 함량, 치환성 칼슘 및 마그네슘 함량은 1999년에 비해 2011년에 유의적으로 증가하였다. 유기물 함량의 초과비율은 1999년 40.0%, 2003년 30.4%, 2007년 48.5%, 2011년 50.8%로 증가하였다. 유효인산 함량의 초과비율은 1999년 55.0%, 2003년 57.7%, 2007년 52.7%, 2011년 63.5%로 2배 이상 과잉 집적되었다. 유기물 함량은 홍적대지에서 가장 높았고 유효인산 함량은 산록경사지에서 가장 높았다. 논토양의 통계분석과 주성분 분석을 통하여 경남지역 논토양의 유효인산 함량은 지형별 화학특성을 구별할 수 있는 중요인자로 판단되었다.

• 한국경영과학회지
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• 제36권4호
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• pp.43-61
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• 2011

We first develop a value ecosystem framework to model the SDP(Service Delivery Process) of web services. Since the web service has been evolving from the basic web architecture (e.g., traditional world wide web) to a prosuming platform based on virtualization technologies, the proposed framework of the value ecosystem focuses on capturing the key characteristics of SDP in each type of web services. Even though they share the basic elements such as PP(Platform Provider), CA(Customization Agency) and user group, the SDP in the traditional web services (so-called Web1.0 in this paper) is quite different from the most recent one (so-called Web2.0). In our value ecosystem, users are uniformly distributed over (0, ${\Delta}$), where ${\Delta}$��represents the variety level of users' preference on the web service level. PP and CA provide a standard level of web service(s) and prosuming service package, respectively. CA in Web1.0 presents a standard customization package($s_a$) at flat rate c, whereas PP and CA collaborate and provide customization service with a usage-based scheme. We employ a multi-stage game model to analyze and compare the SDPs in Web1.0 and Web2.0. Our findings through analysis and numerical simulations are as follows. First, the user group is consecutively segmented, and the pattern of the segmentations varies across Web1.0 and Web2.0. The standardized service level s (from PP) is higher in Web1.0, whereas the amount of information created in the value ecosystem is bigger in Web2.0. This indicates the role of CA would be increasingly critical in Web2.0: in particular, for fulfilling the needs of prosuming and service customization.

• Ocean and Polar Research
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• 제40권2호
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• pp.69-75
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• 2018

We investigated the effects of environmental variations on the growth and survival rate of Stichopus japonicus to determine the optimum environmental conditions for its growth. Literature studies and a 12 month-long diver survey were carried out to understand the habitat, ecology and size of the surveyed area. Based on the collected data, we suggested optimum habitat conditions for releasing S. japonicus. Experiments on releasing S. japonicus were conducted in the breakwater of the Hwagye fishing cooperative in Hwagey-ri, Namhae-un, Gyeongsangnam-do, Korea. To implement the experiments, we divided the surveyed area into 4 sub-areas with different characteristics: (1) sand and silt zone; (2) artificial sea cucumber bank zone; (3) artificial rock bank zone; and (4) marine algae zone. The experiment lasted for 12 months. We released 32,000 sea cucumbers over $120m^2$ of each of the sand and silt zone, artificial rock bank zone and marine algae zone and released 6,000 sea cucumbers over $120m^2$ of the artificial sea cucumber bank zone. The average density of the released sea cucumbers from day 30 to day 360 after the releasing was conducted was the highest in the artificial sea cucumber bank zone ($23.7animal/m^2$), which was followed by artificial rock bank zone ($2.0animal/m^2$), marine algae zone ($1.9animal/m^2$) and sand and silt zone ($0.8animal/m^2$). The analysis on growth showed that the initial average weight of 2.3 g increased on day 360 after the releasing to 12.5 g in the artificial sea cucumber rank zone, 20.2 g in the sand and silt zone, 23.3 g in the artificial rock bank zone and 22.9 g in the marine algae zone. Results from the experiment along with the literature analysis suggest the following optimum habitat conditions: $10-15^{\circ}C$ water temperature; 28-34 psu salinity; 5-10 m water depth; 0.2-0.5 m/s velocity; rock, stone and muddy sand as substrate; and less than 20% mud in the substrate.

• 천문학논총
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• 제14권1호
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• pp.39-45
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• 1999

We have carried out measurements of 1.2-1.6GHz radio interferences around Seoul Radio Astronomy Observatory located in the campus of Seoul National University. We received interference signals using a pyramidal horn antenna and measured its power using a spectrum analyzer with 1MHz resolution after $\~60dB$ amplification. In order to check the spatial characteristics, we made observations at every $30^{\circ}$ in azimuth at elevation of $30^{\circ}\;and\;60^{\circ}$. Also, in order to check the temporal characteristics, we repeated the all-sky observations five times at every six hours. The results may be summarized as follows: (1) There are strong $({\geq}-20dBm)$ interferences between 1.2 and 1.4GHz. Particularly strong interferences are observed at 1.271 and 1.281GHz, which have maximum powers of -0.34dBm and -0.56dBm, respectively. (2) The characteristics of the interferences do not depend strongly on directions, although the interferences are in general weak at high elevation and in east-west direction. (3) The interferences appear for a very short $(\leq0.01s)$ period of time, so that the average power is much smaller than the maximum power. Strong interferences with large $(\leq-49.0dBm)$ average power have been observed at 1.271, 1.281, 1.339, and 1.576GHz. At these frequencies, the interferences appear repeatedly with a period of $\leq0.1s$ By analyzing the observed power, we find that, for the strongest 1.271GHz interference, the average intensity is $-171dBW/m^2/Hz$ and that the maximum intensity is $-122dBW/m^2/Hz$. If this interference is delivered to the detector without any shielding, then its power would be much greater than the rms noise of a typical line spectrum. Therefore, it is important to shield all the parts of receiver carefully from radio interferences. Also, without appropriate shielding, the sensitivity of a receiver could be limited by the interference.