• Bulletin of the Korean Chemical Society
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• 제32권5호
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• pp.1471-1474
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• 2011

A series of new polymers containing 1,2,3-triazoles were synthesized and their structures and properties were characterized by FT-IR, $^1H$ NMR, TGA, DSC and GPC. The results showed that the polymers modified by alkyl groups had good solubility, thermal stability and reasonable molecular weights. It was also demonstrated that the properties of fluorine-containing polymers were seriously affected by fluorine atoms with hydrophobic and chemical proof properties.

• 대한구순구개열학회지
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• 제12권2호
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• pp.65-72
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• 2009

Quadrilateral flap technique for primary cheiloplasty in patients with cleft lip was initially developed by Hagedorn in 1884. After Le Mesurier presented this procedure in 1940's, many surgeons adopted this technique for clinical advantage of reconstruction of Cupid's bow and lesser amount of tissue discarding than straight line technique. However, owing to its drawbacks such as sacrifice of Cupid's bow and prominent scar on philtral ridge, other techniques like Tennison's triangular flap and Millard's rotation-advancement flap have gradually taken its place. Nevertheless, some clinicians like Dr. Wang has modified this quadrilateral flap technique for better clinical outcomes. In this report we present 3 cases of unilateral complete cleft lip patients who underwent primary cheiloplasty with favorable outcomes based on Dr. Wang's modified quadrilateral flap technique.

• 전자공학회논문지B
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• 제32B권11호
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• pp.1383-1392
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• 1995

In this paper, the method to incorporate TCVQ(Trellis Copded Vector Quantizer) into the encoding of the wavelet trans formed(WT) image followed by a variable length coding(VLC) or an entropy coding(EC) is considered. By WT, an original image is separated into 10 bands with various resolutions and directional components. TCVQ used to compress these WT coefficients is a finite state machine that encodes the input source on the basis of the current input and the current state. Wavelet basis used in this paper is designed by orthogonal spline function. A modified set partitioning algorithm to Wang's is also presented. A simple modification to Wang's algorithm gives a highly time-efficient result. Proposed WT-TCVQ encoder shows a very competitive result, giving 37.46dB in PSNR at 1.002bpp when encoding 512$\times$512 LENA.

• 대한한의학원전학회지
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• 제33권1호
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• pp.1-16
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• 2020

Objectives : This study aims to organize the genealogy of the Ministerial Fire Theory in relation to Wangbing's Dragon Fire discourse through examining how Wang's Dragon Fire content first mentioned in the annotation of 『Suwen』 was included into the discourse of the Ministerial Fire Theory in explaining the concept of Ministerial Fire and its therapeutic application. Methods :First to examine the inclusion and application of the Dragon Fire concept into the Ministerial Fire Theory, Zhudanxi's theory and critiques on him were studied. Next the concept of Dragon Fire within the Ministerial Fire Theory was analyzed, followed by comparison between generations of doctors's therapeutic application of Ministerial Fire and Wangbing's Dragon Fire application. Conclusions & Results : Wangbing's dragon fire concept held an important position in discussing its characteristic as fire within water, which was adopted and differentiated by later doctors in aspects of pathology, deficiency and excessiveness, influenced by various theoretical elements of later periods. In the midst of expansion of the concept from combination of dragon fire and ministerial fire, the therapeutic aspect of it was maintained from Wangbing's original mentioning. This tendency manifested in either awkward combination of Wang's therapeutic methods and the new theory or modification of Wangbing's methods.

• Journal of Ginseng Research
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• 제48권3호
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• pp.298-309
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• 2024

Background: 20(S)-ginsenoside Rh2(GRh2), an effective natural histone deacetylase inhibitor, can inhibit acute myeloid leukemia (AML) cell proliferation. Lactate regulated histone lactylation, which has different temporal dynamics from acetylation. However, whether the high level of lactylation modification that we first detected in acute promyelocytic leukemia (APL) is associated with all-trans retinoic acid (ATRA) resistance has not been reported. Furthermore, Whether GRh2 can regulate lactylation modification in ATRA-resistant APL remains unknown. Methods: Lactylation and METTL3 expression levels in ATRA-sensitive and ATRA-resistant APL cells were detected by Western blot analysis, qRT-PCR and CO-IP. Flow cytometry (FCM) and APL xenograft mouse models were used to determine the effect of METTL3 and GRh2 on ATRA-resistance. Results: Histone lactylation and METTL3 expression levels were considerably upregulated in ATRA-resistant APL cells. METTL3 was regulated by histone lactylation and direct lactylation modification. Overexpression of METTL3 promoted ATRA-resistance. GRh2 ameliorated ATRA-resistance by downregulated lactylation level and directly inhibiting METTL3. Conclusions: This study suggests that lactylation-modified METTL3 could provide a promising strategy for ameliorating ATRA-resistance in APL, and GRh2 could act as a potential lactylation-modified METTL3 inhibitor to ameliorate ATRA-resistance in APL.

• Journal of Korean Neurosurgical Society
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• 제64권2호
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• pp.297-308
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• 2021

Objective : Shunt infection is a common complication while treating hydrocephalus. The antibiotic-impregnated shunt catheter (AISC) was designed to reduce shunt infection rate. A meta-analysis was conducted to study the effectiveness of AISCs in reduction of shunt infection in terms of age, follow-up time and high-risk patient population. Methods : This study reviewed literature from three databases including PubMed, EMBASE, and Cochrane Library (from 2000 to March 2019). Clinical studies from controlled trials for shunt operation were included in this analysis. A subgroup analysis was performed based on the patient's age, follow-up time and high-risk population. The fixed effect in RevMan 5.3 software (Cochrane Collaboration) was used for this meta-analysis. Results : This study included 19 controlled clinical trials including 10105 operations. The analysis demonstrated that AISC could reduce the infection rate in shunt surgery compared to standard shunt catheter (non-AISC) from 8.13% to 4.09% (odds ratio [OR], 0.48; 95% confidence interval [CI], 0.40-0.58; p=0.01; I2=46%). Subgroup analysis of different age groups showed that AISC had significant antimicrobial effects in all three groups (adult, infant, and adolescent). Follow-up time analysis showed that AISC was effective in preventing early shunt infections (within 6 months after implant). AISC is more effective in high-risk population (OR, 0.24;95% CI, 0.14-0.40; p=0.60; I2=0%) than in general patient population. Conclusion : The results of meta-analysis indicated that AISC is an effective method for reducing shunt infection. We recommend that AISC should be considered for use in infants and high-risk groups. For adult patients, the choice for AISC could be determined based on the treatment cost.

• 동양고전연구
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• 제34호
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• pp.207-224
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• 2009

본 연구는 금대 문학 비평가인 왕약허의 시론에 대한 탐구이다. 왕약허는 ${\ll}$호남유로집${\gg}$이라는 대표 저작을 남겼는데, 본고는 그 가운데 ${\ll}$시화${\gg}$ 3권에 나타난 시학이론을 고찰한 것이다. 특히, 시론 원리, 창작 기술, 실제 비평 등 호남시화의 장단점에 대하여 살펴보았다. 왕약허는 중국문학사상에서는 저명한 인물은 아니지만, 그의 비평이론과 시화 가운데 비평이론은 톡특한 견해를 지니고 있다. 왕약허의 시론은 무엇보다도 자연, 의미, 진리, 내용을 중요하게 여겼다. 그는 현실주의적 문학관을 드러내는데, 두보 소식 황정견이 어떻게 다른지 분석하였고, 두보 백거이 소식의 현실주의 시를 높이 평가하였다. 또한 그는 형식주의에 반대하였으나 시가의 형식을 경시하지는 않았다. 그의 시화 비평은 소식과 백거이 등의 작품을 높이 평했으나 비판 또한 서슴치 않았고, 자신만의 독특한 비평 기준을 정하여 다른 사람의 의견을 맹목적으로 받아들이지 않았으며, 자신이 생각하는 바와 다른 점을 제기하였다. 특히 자구의 수식과 문법, 전체 문맥이 잘 조화를 이루는지를 중요시하였다. 그러나 왕약허의 시론은 합리성을 지나치게 중시한 나머지 글자마다 세세하게 분석하여 시가 드러내고자 하는 정취를 간파하지 못하는 경우도 있다. 자구에 지나치게 얽매여 시가 주는 본연의 감정과 상상의 즐거움을 깨우치지 못하고 결국 시인의 시상에 까지 악영향을 끼쳤다.

• 상하수도학회지
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• 제26권3호
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• pp.423-430
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• 2012

This study was conducted to qualify the equality of the flow distribution from open channel between rapid mixing basin and flocculation basins in a domestic S_ water treatment plant, and to suggest a remedy for improving the equality. In order to evaluate the feasibility of the suggested remedy, computational fluid dynamics (CFD) technique are used, and for verifying the CFD simulation results tracer tests were carried out. From the results of CFD simulation and tracer tests, it was investigated that the modification of hydraulic structure in the distribution channel, which is to install the longitudinal orifice baffle in flow direction, could improve the equality of the flow distribution over 75%.

• Nuclear Engineering and Technology
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• 제52권3호
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• pp.477-484
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• 2020

The control rod drive mechanism needs to be debugged after reactor fresh fuel loading. It is of great importance to monitor the subcriticality of this process accurately. A modified method was applied to the subcriticality monitoring process, in which only a single control rod cluster was fully withdrawn from the core. In order to correct the error in the results obtained by Neutron Source Multiplication Method, which is based on one point reactor model, Monte Carlo neutron transport code was employed to calculate the fission neutron distribution, the iterated fission probability and the neutron flux in the neutron detector. This article analyzed the effect of a coarse mesh and a fine mesh to tally fission neutron distributions, the iterated fission probability distributions and to calculate correction factors. The subcriticality before and after modification is compared with the subcriticality calculated by MCNP code. The modified results turn out to be closer to calculation. It's feasible to implement the modified NSM method in large local reactivity addition process using Monte Carlo code based on 3D model.

• Wind and Structures
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• 제4권2호
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• pp.119-130
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• 2001

The paper addresses the suitability of wind pressure coefficients specified in contemporary design standards and codes of practice for gable roofs of intermediate slope (roof angle $10^{\circ}-30^{\circ}$). In a recent research study, a series of low building models with different roof slopes in this intermediate range were tested in a boundary layer wind tunnel under simulated open country terrain conditions. This was different from the original study in the 70's, which produced the current provisions on the basis of a model tested only for a single roof slope (4:12) in this range. The results of the study suggest that a modification to the American wind provisions would be warranted to make them more representative of the true local and area-averaged wind loads imposed on gable roofs of intermediate slope.