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중풍환자의 통증 치료에 관한 체계적 고찰 연구 (A Systematic Review of Treatment for Chronic Pain after Stroke)

  • 김태인;정지원;최재완;김운정;이지원;김윤서;천경진;배선규;김지유;채우리;정재원;송규석;이해솔;박정수;이주아;김영지;공경환;고호연
    • 대한한방내과학회지
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    • 제37권6호
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    • pp.929-939
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    • 2016
  • Objectives: Strokes have diverse symptoms and signs. One of ten stroke patients has chronic pain after a stroke. Pain after a stroke interrupts rehabilitation and worsens quality of life, but there is no efficient treatment for this pain. This study surveyed and reports on the clinical studies of treatment for chronic pain after a stroke. Methods: We searched journals for reports on clinical studies of treatment for chronic pain after a stroke through the databases OASIS (http://oasis.kiom.re.kr), NDSL (ndsl.kr), Kmbase (http://kmbase.medric.or.kr/), and PubMed (http://www. pubmed.com). The search words were "stroke & pain", "jungpung中風 & pain", "pungbi風痺", "cerebral hemorrhage & pain", and "cerebral infarction & pain". Results: Twenty-nine studies of treatment for chronic pain after a stroke were found. Of these, 15 were randomized controlled trials, 10 were nonrandomized controlled trials, and 4 were "before and after" studies. Treatments were diverse, including acupuncture, electroacupuncture, herbal acupuncture, herbal medicine, and more. The treatment periods were longer than 3 weeks on average. Conclusions: These results show that good quality randomized controlled trials of treatment for chronic pain after a stroke are small in number. We need larger and more diverse studies of treatment for chronic pain after a stroke.

잔디 생산 특허기술의 현황 및 산업화 (Commercialization of Patented Technology on Turfgrass Production in Korea)

  • 윤정호;이재필;김두환
    • 아시안잔디학회지
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    • 제20권1호
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    • pp.107-118
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    • 2006
  • 본 연구는 국내외 잔디 생산 특허 기술과 국내 잔디생산 특허기술의 산업화 사례를 소개하여 특허기술의 권리화와 산업화를 위한 기초 자료를 제공하고자 하였다. 연구는 1948년 11월 20일부터 2005년 11월 30일까지 57년간 공개된 잔디관련 특허출원 및 등록 기술을 대상으로 분석하였다. 또한 특허기술의 사업화 사례는 특허등록번호 제 434389 호(다용도파종장치)와 제 478194 호(한지형 잔디 생산기술)을 중심으로 조사하였다. 잔디 특허 검색대상은 잔디 산업분야 중 잔디 품종 및 생산에 관련된 특허를 중심으로 분석하였다. 특허 자료의 분석은 한국특허기술정보원(www.kipris.or.kr) 홈페이지를 통하여 분석하였으며 그 결과를 요약하면 다음과 같다. 1. 국내 잔디 특허 생산기술은 합성수지로 된 플라스틱 필름 이용한 방법과 천연수지를 이용한 방법 있으며, 국외는 합성수지를 깐 후 상토층의 구성과 배합비율에 관한 내용으로 조사되었다. 2. 특허 등록된 다용도파종장치는 모래, 토양개량제, 비료, 농약 및 종자의 균일한 혼합뿐만 아니라 일시에 혼합토를 포설할 수 있는 장치이다. 또한 영양번식 하는 지피식물의 줄기 및 뿌리를 상토와 혼합하여 포설할 수 있는 장치이다. 3. 특허 등록된 한지형 잔디 생산기술은 용도별(스포츠용, 조경용, 옥상용) 적합 상토의 조합 및 배합비율을 제시하였다. 조합 및 배합비율은 입자 직경이 $0.002{\sim}2.0mm$인 모래가 부피 기준으로 $50{\sim}90%$, 펄라이트가 $3{\sim}40%$, 토탄이 $1.5{\sim}20%$, 피트모스가 $1.5{\sim}20%$, 버미큘라이트가 $2{\sim}25%$, 제오라이트가 $1{\sim}20%$ 및 숯이 $1{\sim}20%$ 내외의 비율이다. 이상의 연구결과 잔디 관련 원천 특허기술은 주로 국외 의존하는 실정으로 국내외에서 통용될 수 있는 잔디 관련 특허기술의 개발이 필요할 것으로 판단된다. 또한 국내 특허 출원의 목적은 판매나 계약의 수단, 벤처기업 확인, 정부의 정책적 금융적 중소기업 지원 혜택을 기대하면서 출원하는 경우가 많았다. 따라서 기술의 진보성, 독창성 및 사업성이 높은 특허기술의 개발이 필요할 것으로 판단된다.

Gramene database: A resource for comparative plant genomics, pathways and phylogenomics analyses

  • Tello-Ruiz, Marcela K.;Stein, Joshua;Wei, Sharon;Preece, Justin;Naithani, Sushma;Olson, Andrew;Jiao, Yinping;Gupta, Parul;Kumari, Sunita;Chougule, Kapeel;Elser, Justin;Wang, Bo;Thomason, James;Zhang, Lifang;D'Eustachio, Peter;Petryszak, Robert;Kersey, Paul;Lee, PanYoung Koung;Jaiswal, kaj;Ware, Doreen
    • 한국작물학회:학술대회논문집
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    • 한국작물학회 2017년도 9th Asian Crop Science Association conference
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    • pp.135-135
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    • 2017
  • The Gramene database (http://www.gramene.org) is a powerful online resource for agricultural researchers, plant breeders and educators that provides easy access to reference data, visualizations and analytical tools for conducting cross-species comparisons. Learn the benefits of using Gramene to enrich your lectures, accelerate your research goals, and respond to your organismal community needs. Gramene's genomes portal hosts browsers for 44 complete reference genomes, including crops and model organisms, each displaying functional annotations, gene-trees with orthologous and paralogous gene classification, and whole-genome alignments. SNP and structural diversity data, available for 11 species, are displayed in the context of gene annotation, protein domains and functional consequences on transcript structure (e.g., missense variant). Browsers from multiple species can be viewed simultaneously with links to community-driven organismal databases. Thus, while hosting the underlying data for comparative studies, the portal also provides unified access to diverse plant community resources, and the ability for communities to upload and display private data sets in multiple standard formats. Our BioMart data mining interface enable complex queries and bulk download of sequence, annotation, homology and variation data. Gramene's pathway portal, the Plant Reactome, hosts over 240 pathways curated in rice and inferred in 66 additional plant species by orthology projection. Users may compare pathways across species, query and visualize curated expression data from EMBL-EBI's Expression Atlas in the context of pathways, analyze genome-scale expression data, and conduct pathway enrichment analysis. Our integrated search database and modern user interface leverage these diverse annotations to facilitate finding genes through selecting auto-suggested filters with interactive views of the results.

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Fine mapping of qBK1, a major QTL for bakanae disease resistance in rice

  • Ham, Jeong-Gwan;Cho, Soo-Min;Kim, Tae Heon;Lee, Jong-Hee;Shin, Dongjin;Cho, Jun-Hyun;Lee, Ji-Yoon;Yoon, Young-Nam;Song, You-Chun;Oh, Myeong-Kyu;Park, Dong-Soo
    • 한국작물학회:학술대회논문집
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    • 한국작물학회 2017년도 9th Asian Crop Science Association conference
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    • pp.92-92
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    • 2017
  • Bakanae disease is one of the most serious and oldest problems of rice production, which was first described in 1828 in Japan. This disease has also been identified in Asia, Africa, North America, and Italy. Germinating rice seeds in seed boxes for mechanical transplantation has caused many problems associated with diseases, including bakanae disease. Bakanae disease has become a serious problem in the breeding of hybrid rice, which involves the increased use of raising plants in seed beds. The indica rice variety Shingwang was selected as resistant donor to bakanae disease. One hundred sixty nine NILs, YR28297 ($BC_6F_4$) generated by five backcrosses of Shingwang with the genetic background of susceptible japonica variety, Ilpum were used for QTL analysis. Rice bakanae disease pathogen, CF283, was mainly used in this study and inoculation and evaluation of bakanae disease was performed with the method of the large-scale screening method developed by Kim et al. (2014). SSR markers evenly distributed in the entire rice chromosomes were selected from the Gramene database (http://www.gramene.org), and the polymorphic markers were used for frame mapping of a $BC_5F_5$ resistant line. Here, we developed 168 near-isogenic rice lines (NILs, $BC_6F_4$) to locate a QTL for resistance against bakanae disease. The lines were derived from a cross between Shingwang, a highly resistant variety (indica), and Ilpum, a highly susceptible variety (japonica). The 24 markers representing the Shingwang allele in a bakanae disease-resistant NIL, YR24982-9-1 (parental line of the $BC_6F_4$ NILs), were located on chromosome 1, 2, 7, 8, 10, 11, and 12. Single marker analysis using an SSR marker, RM9, showed that a major QTL was located on chromosome 1. The QTL explained 65 % of the total phenotype variation in $BC_6F_4$ NILs. The major QTL designated qBK1 was mapped in 91 kb region between InDel15 and InDel21. The identification of qBK1 and the closely linked SSR marker, InDel18, could be useful for improving rice bakanae disease resistance in marker-assisted breeding.

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Effect of different plant densities on growth and yield of sorghum(Sorghum bicolor L. Moench.)

  • Cho, Young Dae;Jung, Ki Yuol;Chun, Hyun Chung;Lee, Sang Hun;Kang, Hang Won
    • 한국작물학회:학술대회논문집
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    • 한국작물학회 2017년도 9th Asian Crop Science Association conference
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    • pp.206-206
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    • 2017
  • Sorghum is a crop with a various plant height depending on the planting density. If the height exceeds 1.8m, which is the harvestable height of the combine, loss is caused by clogging of the installation, entrance of the threshing section and the threshing section. The purpose of this study is to set the planting distance and number of plants per hill suitable for combine harvesting as the plant length does not exceed 1.8m. The experimental variety was Nampungchal. The experiment design was a split-plot design with three replications. The treatments were as follow: Main-plot were 1 and 2 plants as number of plants per hill and sub-plots were $60{\times}20cm$ (practice), $70{\times}15$, 20, 25, 30 cm as planting distance. The amount of nitrogen, phosphate and potassium fertilization were 100, 70, $80kg\;ha^{-1}$. Data were collected: (1) grain yield: weight of grain in $kg\;ha^{-1}$, (2) 1000 grain weight: average weight of 1000 grain, (3) plant height: distance from soil to top of panicle, (4) ear length: distance from top of stem to top of ear in cm, (5) stem diameter: diameter of second internode, (6) tiller number per hill. Analyses of variance were performed using R version 3.3.1(https://www. r- project. org). The Duncan's multiple range test(DMR) was used to separate treatment means at P < 0.05. As number of plants per hill increased, plant height and yield increased and tiller number decreased. As planting distance increased, plant height and yield decreased and tiller number increased. At 1 plant per hill, the plant height did not exceed 1.8m at all planting distance. At 2 plants per hill, the plant height did not exceed 1.8m from the planting distance of $70{\times}25cm$. At 1 plant per hill, the tiller number increased to 0.23, 0.27, 0.60 and 0.70 as the planting distance increased to $70{\times}15$, 20, 25 and 30 cm, respectively. At 2 plants per hill, the tiller number increased to 0.03, 0.03, 0.14 and 0.40 as the planting distance increased to $70{\times}15$, 20, 25 and 30 cm, respectively. At 1 plant per hill, the yield decreased to 6030, 4280, 3400 and $3230kg\;ha^{-1}$ as the planting distance increased. At 2 plant per hill, the yield decreased to 7850, 5770, 5720 and $4960kg\;ha^{-1}$ as the planting distance increased. We recommend that the optimum number of plants per hill and planting distance is 2 and $70{\times}25cm$ suitable for combine harvesting.

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Effect of prohexadium-calcium on growth, lodging and yield of proso millet (Panicum miliaceum L.)

  • Choi, Young Dae;Jung, Ki Yuol;Chun, Hyun Chung;Lee, Sang Hun;Kang, Hang Won
    • 한국작물학회:학술대회논문집
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    • 한국작물학회 2017년도 9th Asian Crop Science Association conference
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    • pp.207-207
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    • 2017
  • The proso millet is vulnerable to lodging due to high plant height and shallow root. A lodging results in a hard mechanical harvesting and yield loss. One of solutions on this problem is inhibition of internode elongation. The objective of this study was to set up use time and dose of prohexadium-calcium, is growth inhibitor. The experimental variety was Ibaekchal. The experiment design was a split-plot design with three replications. The treatments were as follow: Main-plots were 25 and 35 day after sowing(DAS) as use time and sub-plots were 0%, 50%, 100%(diluted solution of 1000 times, $1000{\ell}\;ha^{-1}$), 150% as dose. The amount of nitrogen, phosphate and potassium fertilization were 90, 70, $80kg\;ha^{-1}$, respectively. The size of high ridge and plant spacing were $90{\times}30cm$ and $60{\times}15cm$, respectively. Proso millet was sown on June 9, 2016 by hands and was adjusted at 2 plant per hill. The growth survey of vegetative growth stage was conducted at 1 day before treatment and with one week interval after treatment. Data were collected: (1) grain yield: weight of grain in $kg\;ha^{-1}$, (2) 1000 grain weight: average weight of 1000 grain, (3) plant height: distance from soil to top of panicle or leaf in cm, (4) ear length: distance from top of stem to top of ear in cm, (5) stem diameter: diameter of second internode (6) degree of lodging: percentage of lodging area, etc. Analyses of variance were performed using R version 3.3.1(https://www. r- project. org). The Duncan's multiple range test(DMR) was used to separate treatment means at P < 0.05. There was a significant difference in plant height and number of stem among the use time and dose of prohexadium-calcium during vegetative growth stage. At 25 DAS, the difference with no treatment increased until 25 day after treatment and decreased since then. The difference in number of stem increased until 18 day and decreased since 25 day. At 35 DAS, the difference with no treatment in plant height and number of stem increased until 22 day after treatment and decreased since then. We assumed that the effect of prohexadium-calcium was inhibition of internode elongation and promotion of tillering, continued untel 25day after treatment. At 25 DAS, the degree of lodging deceased to 100%, 30%, 10% and 0% as dose increased. At 35 DAS, the degree of lodging decreased to 100%, 20%, 0% and 0% as dose increased. At 25 DAS, the yield was 2910, 2710, 3190, $2310kg\;ha^{-1}$ among dose. At 35 DAS, the yield was 2750, 2630, 2220, $2050kg\;ha^{-1}$. We recommend that the optimum use time and dose of prohexadium-calcium for proso millet is 1000 times diluted solution of $1000{\ell}$ per ha at 25 day after sowing.

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Ac/Ds-mediated gene tagging system in rice

  • Eun, Moo-Young;Yun, Doh-Won;Nam, Min-Hee;Yi, Gi-Hwan;Han, Chang-Deok;Kim, Doh-Hoon;Park, Woong-June;Kim, Cheol-Soo;Park, Soon-Ki
    • 한국식물생명공학회:학술대회논문집
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    • 한국식물생명공학회 2005년도 추계학술대회 및 한일 식물생명공학 심포지엄
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    • pp.95-105
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    • 2005
  • Transposon-mediated insertional mutagenesis provides one of the most powerful tools for functional studies of genes in higher plants. This project has been performed to develop a large population of insertional mutations, and to construct databases of molecular information on Ds insertion sites in rice. Ultimate goals are to supply genetic materials and information to analyze gene function and to identify and utilize agronomically important genes for breeding purpose. Two strategies have been employed to generate the large scale of transposon population in a Japonica type rice, Dongjin Byeo; 1) genetic crosses between Ac and Ds lines and 2) plant regeneration from seeds carrying Ac and Ds. Our study showed that over 70% of regenerated plants generally carried independent Ds elements and high activity of transposition was detected only during regeneration period. Ds-flanking DNA amplified from leaf tissues of F2 and T1 (or T2) plants have been amplified via TAIL-PCR and directly sequenced. So far, over 65,000 Ds lines have been generated and over 9,500 Ds loci have been mapped on chromosomes by sequence analysis. Database of molecular information on Ds insertion sites has been constructed, and has been opened to the public and will be updated soon at http://www.niab.go.kr. Detailed functional analysis of more than 30 rice mutants has been performed. Several Ds-tagged rice genes that have been selected for functional analysis will be briefly introduced. We expect that a great deal of information and genetic resources of Ds lines would be obtained during the course of this project, which will be shared with domestic and international rice researchers. In addition to the Japonica rice, we have established the tagging system in an rice line of indica genetic background, MGRI079. MGRI079 (Indica/Japonica) was transformed with Agrobacteria carrying Ac and Ds T-DNA vectors. Among transgenic lines, we successfully identified single-copy Ds and Ac lines in MGR1079. These lines were served as ‘starter lines’ to mutagenize Indica genetic background. To achieve rapid, large scale generation of Ds transposant lines, MGR1079 transformants carrying homozygous Ac were crossed with ones with homozygous Ds, and $F_2$seeds were used for plant regeneration. In this year, over 2,000 regeneration plants were grown in the field. We are able to evaluate the tagging efficiency in the Indica genetic background in the fall.

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한국의 잔디병해 연구사 (Research Review on Turfgrass Disease in Korea)

  • 심규열;이정한
    • Weed & Turfgrass Science
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    • 제7권2호
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    • pp.87-97
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    • 2018
  • 잔디는 공익적 기능, 오락 및 휴양 그리고 미적인 측면에서 인간에게 다양한 이점을 제공한다. 잔디병해는 골프장, 운동장, 공원, 잔디재배지 등에 피해를 일으키는 주요 원인이며 이를 방제하기 위하여 막대한 비용이 소요된다. 한국의 잔디병해 연구는 아직 다른 분야에 비하여 관심이 낮은 편이지만 잔디병해에 대한 연구의 필요성은 매우 높다고 본다. 본 연구에서는 지금까지 우리나라에서 이루어진 잔디병 관련 연구 결과들을 분석하고, 국내 잔디병 연구사를 정리하여 앞으로의 잔디병리 분야의 발전방향을 고찰하고자 한다. 연구논문은 국내학술지와 한국교육학술정보원에서 제공하는 논문탐색 시스템을 이용하여 잔디병과 관련된 논문을 수집, 분석하였다. 국내 잔디병과 관련된 논문은 약 80여 편이 한국잔디학회지에 게재되어 전체 논문의 50%를 차지하였다. 이 중 잔디병 방제에 대한 논문이 전체논문 대비 50%를 차지하였다. 잔디병해 별로는 라이족토니아마름병(large patch)에 대한 연구가 36%로 가장 많았으며 다음으로 동전마름병(dollar spot) 18%, 피티움마름병(Pythium blight) 10%, 설부병(Typhular blight) 8% 순으로 나타났다. 국내에서 처음으로 보고된 잔디병은 15종류이다. 잔디병 방제를 위하여 국내에 등록된 약제의 수는 542개로 갈색잎마름병, 녹병, 누른잎마름병, 동전마름병, 라이족토니아마름병, 설부소립균핵병, 여름잎마름병, 탄저병, 피티움마름병, 흰가루병과 조류에 등록되어 있다. 향후 우리나라에서 미보고된 잔디병해의 학문적 탐색과 병명의 정립이 필요하고, 효과적인 병방제를 위하여 잔디병에 대한 생리, 생태학적인 연구와 더불어 친환경적 방제 방법의 개발이 필요할 것으로 본다.

유무선 인터넷 환경에서 TCP와 SCTP의 성능 비교 (Performance Comparison of TCP and SCTP in Wired and Wireless Internet Environment)

  • ;서태정;이용진
    • 대한공업교육학회지
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    • 제33권2호
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    • pp.287-299
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    • 2008
  • HTTP는 월드 와이드 웹에서 가장 널리 사용되는 프로토콜의 하나로 신뢰성을 제공하기 위해 전송 계층 프로토콜로 TCP를 사용한다. HTTP는 개별적인 파일 요청에 대해 분리된 TCP 연결을 사용하기 때문에 파일 수신에 있어서 불필요한 오버헤드인 헤드-오브-라인 (head-of-line) 블로킹을 유발시킨다. 웹 응용은 일반적으로 전송되는 크기가 작기 때문에 무선 환경에서는 TCP로 인한 핸드오버의 지연이 증가한다. 이에 비해 최근에 제안된 SCTP(stream control transmission protocol)는 멀티-스트리밍과 멀티-호밍과 같은 매력적인 기능을 갖고 있다. SCTP의 이러한 기능들은 TCP의 헤드-오브-라인 블로킹을 제거하고, 무선 환경에서 TCP의 핸드오버 지연을 줄이는 것으로 기대되고 있다. 평균 응답 시간은 대부분의 웹 응용에 있어서 중요한 측정 요소이다. 본 논문에서는 NS-2 시뮬레이터를 이용하여 유무선 인터넷 환경에서 SCTP와 TCP의 평균 응답 시간을 비교하였다. 이를 위해, 유선 환경에서는 패킷 손실률, 대역폭, RTT(Round Trip Time) 및 웹 객체의 개수의 변화에 따른 평균 응답 시간이 비교되었고, 무선 환경에서는 이동속도 및 반경의 크기에 따른 평균 응답 시간과 패킷 손실률이 비교되었다. 시뮬레이션 결과는 SCTP가 TCP의 평균 응답 시간을 감소시키는 것으로 나타났다.

치매노인의 낙상예방을 위한 중재 프로그램에 대한 국내·외 논문 분석 (Analyses of Studies on the Intervention programs for the Prevention of Falls in Elderly with Dementia)

  • 차현수;황성우
    • 한국산학기술학회논문지
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    • 제19권6호
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    • pp.391-404
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    • 2018
  • 이 연구의 목적은 치매노인의 낙상을 예방하기 위한 중재연구의 현황을 파악하고 낙상예방을 위한 중재 프로그램의 내용과 효과를 알아보는 것이다. 문헌 검색은 치매, 알쯔하이머, 알츠하이머, 낙상, 낙상예방을 검색어로 하여 한국교육학술정보원(http://www.riss4u.net), 국회도서관, 한국학술정보(http://kiss. kstudy.com)와 pubMed, CINAHL을 통해 2000년 1월부터 2016년 12월까지 발표된 연구 논문을 검색하였다. 전자 자료를 검색한 후 연구자가 원본을 확인하여 선별한 13편의 논문을 최종 분석 하였다. 연구에 적용된 중재분야는 운동 치료(8편, 61.5%), 물리 치료와 작업 치료(2편, 15.4%), 보완대체요법(2편, 15.4%), 음악 치료(1편, 7.7%)이었다. Scottish Intercollegiate Guideline Network의 체크 리스트로 논문의 질적 평가를 실시하였다. 논문의 질적 평가 결과 10점 만점에 9점인 연구가 2편, 8점인 연구가 5편, 7점인 연구가 6편이었다. 낙상예방 중재내용을 분석한 결과 중재시간은 1회당 평균 55분을 시행하였고 중재 총 시행 횟수는 평균 37회이었다. 분석한 연구 결과에 의하면 운동 치료(타이치 포함), 음악 치료, 물리 치료와 작업 치료, 율동 동작 치료 등이 치매노인의 낙상예방에 효과가 있는 것으로 나타났다. 향후 이 결과를 활용하여 임상 현장에서 간호사에 의한 낙상예방 중재 프로그램 개발에 근거 자료로 활용하기를 기대한다.