• 월간산업보건
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• 통권339호
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• pp.37-41
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• 2016

• 디지털융복합연구
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• 제14권3호
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• pp.279-285
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• 2016

나노기술이 발전함에 따라 나노물질의 사용량이 증가하고, 그에 따른 환경 및 인체 유해성 문제가 사회적 이슈로 대두되고 있으나 나노물질에 대한 규제나 법규는 아직 제정되어 있지 않다. 이에 본 연구에서는 WPMN에서 지정한 제조나노물질 13종 중 국내에서 가장 많이 사용되고 있는 물질인 aluminium oxide의 거동평가를 실시하여 연구활동종사자들을 위한 안전지침의 기초 자료로 활용하고자 하였다. 실험은 실제 연구실을 1/6의 크기로 축소하여 제작한 chamber에서 진행되며, NIOSH method 0500에 준하여 질량농도를 측정하였다. 연구 결과 질량 농도는 물질의 입자 크기에 반비례하는 것으로 나타났으며, 환기 설비의 작동만으로 질량농도가 약 1/8배까지 감소하는 것을 확인 할 수 있었다. 본 연구를 향후 나노물질 관련 연구활동종사자를 위한 안전지침의 기초자료로 활용할 수 있을 것으로 보이나, 연구의 신뢰도를 높이기 위해 입경에 따른 질량농도, 수농도 측정등의 실험이 필요할 것으로 사료된다.

• 한국물환경학회지
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• 제28권2호
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• pp.313-319
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• 2012

Various nanomaterials may flow into the aquatic ecosystem via production, use, and treatment processes. Especially, gold nanoparticles (AuNPs) were categorized as manufactured nanomaterials presented by the Organization for Economic Cooperation and Development Working Party on Manufactured Nanomaterials (OECD WPMN) in 2010. AuNPs have been used in medical area, however, they were reported to induce cytotoxicity and oxidative DNA damage, as well as down-regulation of the DNA repair gene in mice and human cell lines. In this study, the aquatic toxicity data of AuNPs and gold ions were collected, with the specific test methods analyzed with respect to the form and size of AuNPs, test species, exposure duration, and endpoints. Currently, aquatic toxicity data of AuNPs and gold ions have been presented in 14 studies including 4 fish, 6 crustacean, 2 green algae, and 2 macrophytes studies, as well as a further 8 studies including 4 fish, 4 crustacean, 1 platyhelminthes, and 1 green algae, respectively. The AuNPs were 0.8-100 nm in size, as gold nanoparticles, gold nanorod, glycodendrimer-coated gold nanoparticles, and amine-coated gold nanoparticles. The tested endpoints were the individual toxicities, such as mortality, malformation, reproduction inhibition, growth inhibition and genetic toxicity such as oxidative stress, gene expression, and reactive oxygen species formation. The accumulation of AuNPs was also confirmed in the various receptor organs. These results are expected to be useful in understanding the aquatic toxicity of AuNPs and gold ions, as well as being applicable to future toxicity studies on AuNPs.