• International Journal of Naval Architecture and Ocean Engineering
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• 제3권1호
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• pp.37-52
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• 2011

The present paper introduced a computer program, called WISH, which is based on a time-domain Rankine panel method. The WISH has been developed for practical use to predict the linear and nonlinear ship motion and structural loads in waves. The WISH adopts three different levels of seakeeping analysis: linear, weakly-nonlinear and weak-scatterer approaches. Later, WISH-FLEX has been developed to consider hydroelasticity effects on hull-girder structure. This program can solve the springing and whipping problems by coupling between the hydrodynamic and structural problems. More recently this development has been continued to more diverse problems, including the motion responses of multiple adjacent bodies, the effects of seakeeping in ship maneuvering, and the floating-body motion in finite-depth domain with varying bathymetry. This paper introduces a brief theoretical and numerical background of the WISH package, and some validation results. Also several applications to real ships and offshore structures are shown.

• 가정과삶의질연구
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• 제27권6호
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• pp.141-153
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• 2009

This study is focused on the residential spaces that the elderly wish to renovate and their willingness to improve residential environment as they grow old. The analysis shows, first, the most inconvenient places as they grow old are the stairs, following by the toilet and the bath. Second, the place that the elderly most wish to renovate is the floor, upgrading floors with non-slippery materials. And they wish to remove the height differences on the floor to protect them from tripping over, upgrade the floor plan for their convenience and renovate the storage and working spaces at the kitchen and dining areas. The more the government supports the costs of the residential renovation service, the more the elderly are willing to use the renovation service. The factors influencing their willingness to residential renovation are health, residential environment, experience to accidents and their allowances. The elderly who experienced accidents inside their residence are more willing to renovate their house. Even though the elderly wish to renovate their houses, it's not carried out due to the financial difficulties and the lack of information. Thus, the government should share the useful information about residential renovation for the safety of the elderly and find a way to raise money to cover the costs of the renovation.

• Journal of Dental Anesthesia and Pain Medicine
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• 제22권5호
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• pp.369-376
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• 2022

Background: Nonobstetric surgery is sometimes required during pregnancy, and neck abscess or facial bone fracture surgery cannot be postponed in pregnant women. However, dental surgery can be stressful and can cause inflammation, and the inflammatory response is a well-known major cause of preterm labor. Propofol is an intravenous anesthetic commonly used for general anesthesia and sedation. Studies investigating the effect of propofol on human amnion are rare. The current study investigated the effects of propofol on lipopolysaccharide (LPS)-induced inflammatory responses in human amnion-derived WISH cells. Methods: WISH cells were exposed to LPS for 24 h and co-treated with various concentrations of propofol (0.01-1 ㎍/ml). Cell viability was measured using the MTT assay. Nitric oxide (NO) production was analyzed using a microassay based on the Griess reaction. The protein expression of cyclooxygenase-2 (COX-2), prostaglandin E2 (PGE 2), p38, and phospho-p38 was analyzed using western blotting. Results: Propofol did not affect the viability and NO production of WISH cells. Co-treatment with LPS and propofol reduced COX-2 and PGE₂ protein expression and inhibited p38 phosphorylation in WISH cells. Conclusion: Propofol does not affect the viability of WISH cells and inhibits LPS-induced expression of inflammatory factors. The inhibitory effect of propofol on inflammatory factor expression is likely mediated by the inhibition of p38 activation.

• Journal of Hospice and Palliative Care
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• 제18권2호
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• pp.148-155
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• 2015

목적: 본 연구의 목적은 소아암 등의 난치병 환자들의 소원성취 프로그램에 대한 만족도가 질병 적응에 미치는 영향에서 레질리언스와 질병 스트레스가 갖는 매개효과를 파악하는데 목적이 있다. 방법: 한국메이크어위시재단에서 2010년부터 2014년까지 5년간 소원을 이루었던 1,597명의 환아 중 문장해독과 기억유지가 가능한 666명의 10대 이상에 해당하는 환아들에게 2015년 1월 2일에 모바일 설문지를 발송하였다. 그 결과 357명이 응답을 하였으나 성실하게 응답한 292명의 자료를 분석하였다. 결과: 소아 난치병 환아들이 소원성취 프로그램에 대해서 갖는 만족도는 레질리언스에 긍정적인 영향을 미치는 것으로 나타났다. 레질리언스는 질병 스트레스에 부정적인 영향을 미치고 질병 적응에는 긍정적인 영향을 미쳤으며, 질병 스트레스는 질병 적응에 부정적인 영향을 미치는 것으로 나타났다. 결론: 본 연구결과를 볼 때 소아 난치병 환자를 위한 소원성취 프로그램에 대한 만족도는 레질리언스의 향상과 질병 스트레스의 감소를 통하여 궁극적으로 이들의 질병에 대한 적응력을 높이는 효과가 있다는 것을 알 수 있다. 따라서 소아 난치병 환자들의 욕구와 특성을 면밀히 분석하여 소원성취 프로그램을 실행하고 만족도를 높이면 이들이 질병에 대해서 보다 적극적으로 대처할 수 있는 동시에 현재의 삶을 긍정적으로 영위할 수 있는 동기를 제공할 수 있을 것이다.

• Journal of Dental Anesthesia and Pain Medicine
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• 제22권4호
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• pp.277-287
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• 2022

Background: Inflammatory dental diseases that occur during pregnancy can cause preterm labor and/or intrauterine growth restriction. Therefore, proactive treatment of dental diseases is necessary during pregnancy. Dexmedetomidine (DEX) is a widely used sedative in the dental field, but research on the effect of DEX on pregnancy is currently insufficient. In this study, we investigated the effects of co-treatment with DEX and lipopolysaccharide (LPS) on inflammatory responses in human amnion-derived WISH cells. Methods: Human amnion-derived WISH cells were treated with 0.001, 0.01, 0.1, and 1 ㎍/mL DEX with 1 ㎍/mL LPS for 24 h. Cytotoxicity of WISH cells was evaluated by 3-(4,5-dimethylthiazol)-2,5-diphenyltetrazolium bromide (MTT) assay. The protein expression of cyclooxygenase-2 (COX-2), prostaglandin E₂ (PGE₂), p38, and nuclear factor kappa B (NF-𝜅B) was examined by western blot analysis. The mRNA expression of pro-inflammatory cytokines such as interleukin (IL)-1𝛽 and tumor necrosis factor (TNF)-𝛼 was analyzed by real-time quantitative polymerase chain reaction. Results: Co-treatment with DEX and LPS showed no cytotoxicity in the WISH cells. The mRNA expression of IL-1𝛽 and TNF-𝛼 decreased after co-treatment with DEX and LPS. DEX and LPS co-treatment decreased the protein expression of COX-2, PGE₂, phospho-p38, and phospho-NF-𝛋B in WISH cells. Conclusion: Co-treatment with DEX and LPS suppressed the expression of COX-2 and PGE₂, as well as pro-inflammatory cytokines such as IL-1𝛽 and TNF-𝛼 in WISH cells. In addition, the anti-inflammatory effect of DEX and LPS co-treatment was mediated by the inhibition of p38/NF-𝜅B activation.

• 한국산학기술학회논문지
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• 제14권1호
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• pp.285-293
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• 2013

본 연구는 여대생을 대상으로 미용성형 비경험군과 미용성형 경험군 각각의 미용성형욕구에 영향을 미치는 주요변수를 검증하기 위한 서술적 조사연구이다. 연구 목적은 미용성형 비경험군과 경험군의 미용성형욕구에 영향을 주는 변수를 검증하여 영향을 미치는 요인에 대한 올바른 이해를 증진시키고, 미용성형을 추구하는 여대생을 상담하고 지도하기 위한 기초자료를 제공하기 위하여 시행되었다. 연구대상자는 254명으로 K도에 소재하고 있는 일개 대학의 여대생으로 편의표출에 의하여 선정되었다. 254명의 여학생 중 성형경험이 없는 비경험군 여학생이 142명(55.9%), 성형경험이 있는 경험군 여학생은 112명(44.1%)이었다. 미용성형 비경험군과 미용성형 경험군의 자아존중감, 신체상(외모지향, 외모평가, 신체만족도), 성형수술태도(성형을 받아들이는 정도, 사회적 동기, 개인내적인 동기) 및 미용성형욕구를 비교한 결과 미용성형 경험군이 비경험군보다 성형을 받아들이는 정도가 높았고, 사회적동기도 더 높았으나, 미용성형욕구는 미용성형 비경험군이 경험군보다 더 높았다. 미용성형 비경험군과 미용성형 경험군 각각의 미용성형욕구에 영향을 미치는 변수를 확인하기 위하여 단계적 회귀분석을 하였다. 미용성형 비경험군을 분석한 결과 성형태도 중 성형을 받아들이는 정도(${\beta}$=.46, p<.001)와 신체이미지 중 신체만족도(${\beta}$=-.23, p<.05)가 영향을 주는 변수이었으며, 미용성형욕구를 23.0% 설명하였다. 미용성형 경험군에서 영향을 미치는 변수는 성형태도 중 성형을 받아들이는 정도(${\beta}$=.47, p<.001)로서 미용성형욕구를 20.0% 설명하였다. 이와 같이 성형 경험 유무에 따라 미용성형 욕구에 영향을 미치는 요인이 다르므로 미용성형을 추구하는 여대생을 상담 시 성형 경험 유무에 따라 다른 접근 방법을 사용하는 것이 효과적일 것임을 시사하고 있다.

• Journal of Dental Anesthesia and Pain Medicine
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• 제19권5호
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• pp.253-260
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• 2019

Background: Sometimes general anesthesia is required for dental surgery in pregnant women. Facial bone fractures or neck abscess should be treated immediately. Dental surgery, however, creates a stressful situation that can cause inflammation. Inflammatory responses are a well-known major cause of preterm labor and preterm birth. Here we demonstrate the effects of remifentanil on the factors related to preterm labor and its mechanism of action on amniotic-derived epithelial cells (WISH cells). Methods: WISH cells were exposed to lipopolysaccharide (LPS) for 24 h and co-treated with various concentrations of remifentanil. MTT assays were performed to measure cell viability. To explain the effects of remifentanil on the factors related to inflammation in WISH cells, activation of nuclear factor kappa B ($NF-{\kappa}B$) and p38 and the expression of interleukin $(IL)-1{\beta}$, tumor necrosis factor $(TNF)-{\alpha}$, cyclooxygenase (COX)2, and prostaglandin E $(PGE)_2$ were quantified using western blotting and RT-PCR, respectively. Results: Remifentanil did not affect WISH cell viability. In western blot analysis, co-treatment with remifentanil resulted in decreased phosphorylation of $NF-{\kappa}B$, and expression of COX2 and $PGE_2$ in LPS-induced inflammation, but the results were statistically significant only at low concentrations. Reduction of $IL-1{\beta}$ and $TNF-{\alpha}$ expression was also observed with RT-PCR. Conclusion: Co-treatment with remifentanil does not affect the viability of WISH cells, but reduces the expression of the factors related to inflammation, which can induce uterine contraction and preterm labor. These findings provide evidence that remifentanil may inhibit uterine contraction and preterm labor in clinical settings.

• 통상정보연구
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• 제11권1호
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• pp.407-440
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• 2009

I wish to examine plan about megalopolis formation with Japan and Busan, possess location condition that can be injured to center hub of North-east Asia. First for this, through competitive analysis of Korea and Japan in industrial structure, I will search competition relation. Second, examine what exports and specialization industry of two area are, through industrial structure of Busan and Kyushu area of Japan. Third, to form megalopolis, wish to present what business belt that can bind two area. Fourth, I wish to present preview point about this study in the conclusion. Examine from 2004 to 2007 through exports, degree of trade join(combination), index of trade specialization degree, index of Revealed comparative advantage, and etc, for analysis of this study how in changed industry competitive between two countries or two area have changed.

• 대한전자공학회:학술대회논문집
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• 대한전자공학회 2008년도 하계종합학술대회
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• pp.141-142
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• 2008

According as USN's application field is magnified, various results are appearing. Efforts to apply this results in life are progressing. In car field, is used in control that level of significance is less. In home network, is used in a household electric appli-ance control and electric lamp control, security etc.. In factory, is used in process control, and is used in various application because is involved with RFID leader recently. In this paper, patient's status monitoring, USN use wish to. Because USN can utilize existent network, it is system that can transmit various data as that change passed information.Wish to send information that get in health-care board. Information that can get in health-care board is blood pressure, blood sugar, stroke, SPO2, ECG, the activity amount, position. Also, wish to forecast use possibility to involved various service, silver industry with database.

• 한국품질경영학회:학술대회논문집
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• 한국품질경영학회 2010년도 춘계학술대회
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• pp.283-290
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• 2010

This paper suggest that the derivation of good and practical ideas is important for the successful use of Kano model. Wish List, Bug List and Forced Connection Method as well as Brainstorming were applied to PMP(Portable Multimedia Player) in order to derive customer attributes. Wish List and Bug List are variants of Brainstorming, which are contrary to each other. Forced Connection Method is designed to bring about bisociation which is a typical characteristic of creative thinking.