• Asian Pacific Journal of Cancer Prevention
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• 제14권8호
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• pp.4739-4742
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• 2013

Carboplatin, a second generation platinum drug, is widely used to treat different types of cancers. However, myelosuppression remains a major consideration in its use. Genetic polymorphisms of enzymes involved in drug disposition can influence therapeutic outcome. The homozygous null deletion of phase II metabolic gene GSTT1 that abolishes its xenobiotic- detoxifying ability may be associated with carboplatin toxicity. Further, since carboplatin generates oxidative stress, polymorphisms of oxidative stress genes that regulate the cellular level of free radicals may have important roles in generating drug- related adverse effects. We here investigated the null polymorphism of GSTT1, and the -463G>A promoter polymorphism of oxidative stress gene myeloperoxidase (MPO) for carboplatin toxicity in a population of northern India. Cancer patients who were treated with carboplatin, and developed toxicity was considered. The study group comprised of 10 patients who developed therapy- related adverse effects. Peripheral blood was taken from patients for DNA isolation. GSTT1 null genotype was determined by conducting duplex PCR and MPO-463 G>A was determined by PCR followed by RFLP. Hematologic toxicity was experienced by 5 patients, 2 of them had grade 3 and 4 toxicity and 3 others had grade 2 toxicity. They also had gastrointestinal (GI) toxicity. Remaining 5 individuals developed GI toxicity but no hematological toxicity. While GG homozygous of MPO was present in majority of patients having hematologic toxicity (in 4 out of 5 individuals), one A allele (AG genotype) was present in 4 patients who did not have any hematological toxicity. Thus variant A allele of MPO -463G>A may be related to lower hematological toxicity. These preliminary data, however, are required to be confirmed in larger studies along with other relevant polymorphisms.

• 대한골관절종양학회지
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• 제16권2호
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• pp.51-54
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• 2010

목적: 골 거대세포종 환자들의 치료결과 및 재발률을 평가하여 보고하고자 하였다. 대상 및 방법: 1980년 3월부터 2008년 12월까지 본원에서 치료 받은 거대세포종 환자 중 최소 12개월 이상 추적관찰이 가능하였던 54예에 대하여 후향적으로 조사하였다. 54예 중 남자 27예, 여자 27예로 평균 나이는 33.1세(13-67세)였다. 평균 추시 기간은 67개월(12-104개월)이었다. 결과: 54예 중 21예(38.9%)에서 국소재발이 발생하였으며 술 후 재발까지의 기간은 평균 21.5개월이었다. 국소재발에 통계적으로 유의한 영향을 가진 인자로는 해부학적 위치와 임상적 병기로 하지에서 상지보다 낮은 재발률을 보였으며(p=0.032), Campanacci 분류 grade I이 grade II와 grade III보다 재발률이 낮았다. 소파술 후 골시멘트 충진을 시행한 군(28예)과 동종골 이식을 시행한 군(18예) 사이에도 국소 재발률에 대해 통계적으로 유의한 차이를 보이지 않았고, 소파술 후 국소 보조요법으로 냉동을 시행한 군과 시행하지 않은 군에서도 통계적 유의성은 없었다. 결론: 골 거대세포종의 국소 재발을 방지하기 위해서는 종양세포의 철저한 제거가 여러 부가적인 처치보다 더 중요하다고 판단된다.

• 대한두경부종양학회지
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• 제14권1호
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• pp.40-45
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• 1998

Backgroud and Objectives: Major salivary gland tumor is a rare disease with a largely unknown origin. And also corresponding to the diversity of histopathologic characteristics is an equally wide distribution of clinical behavior that makes treatment decisions difficult. The aim of this study is to analysis the clinical experience of our major salivary gland tumor and to suggest a guidline of management. Materials and Methods : We studied clinical manifestations and treatment results of 104 patients who were diagnosed as major salivary gland tumors. Tumor site, patient age and sex of the patients were analysed. Histopathologic diagnosis, treatment modality, lymph nodes metastasis, recurrence rate and 5-year survival rate were studied on malignant tumors. Results: 1) 48 patients were male and 56 patients were female. 2) Benign tumors were 79 cases. They consisted of 57 cases(72%) of parotid tumor, 22 cases(27%) of submandibular tumor. And pleomorphic adenoma was the most common benign tumor. 3) Malignant tumors were 25 cases and were consisted of 19 cases(76%) of parotid tumor, 4 cases(l6%) of submandibular tumor and 2 cases(8%) of sublingual gland tumor with high-grade mucoepidermoid carcinoma as the most common cause. 4) In the malignant tumors, the number of stage I, II tumors was 14 and that of stage III, IV tumors was 11. Neck node metastasis was noted in 8 cases. 5) 8 cases of malignant tumor were died and all of them had high-grade malignancy. And they were dead before 17 months from the time of diagnosis. 6) Mean survival duration in the malignant salivary gland tumor was 56 months. 7) High-grade malignancy had a 5-year survival rate of 57.9%. A 5-year survival rate of TI, T2 patients was 92.9% and that of T3, T4 patients was 36.4%. That of patients who had neck node metastasis was 37.5% and that of those who had tree neck was 82.4%. Conclusion: The results of this study suggest that the survival rate is dependent on the tumor size, lymph node matastasis and histologic grade. And also the early diagnosis and radical surgery result in the increased survival rate and are effective for prevention of the tumor recurrance.

• Radiation Oncology Journal
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• 제13권4호
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• pp.349-357
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• 1995

목적 : 수술을 시행 받지 않은 IB, IIA, IIB 자궁경부암 환자에서 외부 방사선 조사 및 강내조사 방법에 따른 생존율과 방광 및 직장 합병증 발생률을 분석하여 보고자 하였다. 방법 : 1984년 11월 부터 1993년 12월 까지 인제대학교 부산백병원 치료방사선과에서 근치적 방사선치료 또는 화학요법을 병행한 자궁경부암 병기 IB, IIA, IIB 환자 127명 중 추적 가능하였던 환자 107명을 대상으로 생존율을 후향적 분석하였고, 합병증은 91명에서 추적 가능하였다. 방사선 단독으로 치료 받은 환자가 86명, 보조적 화학요법을 받은 환자는 21명이었다. 대상 환자들의 추적 조사 기간은 3개월에서 118개월이었고 (중앙값, 47개월), 환자의 연령은 31세에서 76세까지 (중앙값, 56세) 분포를 보였다. FIGO 병기 IB기가 26명, IIA기가 40명, IIB기가 41명 이었다. 강내 방사선 조사는 저선량률 강내조사를 받은 군(80명)과 고선량률 강내조사를 받은 군(21명)으로 나누어 분석하였다. 저선량률 강내조사는 1회 시행받은 환자군(63명)과 2회로 나누어 시행받은 환자군(17명)을 비교하여 보았고, 저선량률 강내조사를 받은 환자 중에서 전골반 외부 조사선량에 따라 4500cGy 이하인 환자군(18명)과 4501cGy 이상인 환자군(62명)으로 나누어 분석하였다. 외부 조사선량이 5000cGy 이상인 환자 중에서 중심선 차폐(midline block)를 한 군(36명)과 하지 않은 군(31명)을 나누어 분석하였다. 결과 : 전체 환자의 5년생존율은 $69{\%}$였고, 병기별 5년생존율은 IB $92{\%}$, IIA $75{\%}$, IIB $53{\%}$로 나왔다. 직장 합병증은 Grade 1이 20명($22{\%}$), Grade 2가 22명($24{\%}$) 이었고, 방광 합병증은 Grade 1이 22명($24{\%}$), Grade 2가 17명($19{\%}$) 이었으며 수술을 요할 정도의 심각한 합병증은 없었다. 방광 및 직장 합병증이 나타났던 군에서 합병증이 없었던 군보다 방광 및 직장에 조사된 최대 방사선량(maximum dose)의 평균치가 높았던 것으로 나타났다 (최대 방광 조사선량 평균 : 7608cGy v 6960cGy (p<0.01), 최대 직장 조사선량 평균 : 7041cGy v 6269cGy (p<0.01)). 외부 조사선량이 4500cGy 이하인 군과 4501cGy 이상인 군에서 생존율과 방광 합병증 발생율은 통계적 차이가 없었으나 Grade 2 직장 합병증 발생율은 각각 $6.3{\%},\;25.5{\%}$ (p<0.05)로 4500cGy 이하인 군에서 낮은 것으로 나타났다. 고선량률 강내조사를 받은 군과 저선량률 강내 조사를 받은 군 사이에 생존율은 병기별 분석에서 유의한 차이가 없었으며, 합병증 발생률은 고선량률 강내조사 군에서 더 높게 나타났지만 Point A와 직장에 조사된 방사선량이 저선량률 강내조사 군에 비해 높아 고선량률 강내치료 자체가 합병증 발생률을 높인 인자로 볼 수는 없었다 (p<0.01). 저선량률 강내조사의 횟수에 따른 생존율이나 합병증 발생률의 차이는 없었다. 외부조사시 중심선 차폐 여부에 따른 생존율과 직장 합병증 발생률의 유의한 차이는 없었으나 방광 합병증 발생률은 중심선 차폐를 시행한 군에서 더 높았다 (p<0.05). 결론 : 병기 IB, IIA, IIB 자궁경부암에서 방사선 치료방법에 따른 생존율은 통계적으로 유의한 차이는 없었으며, 직장 합병증은 외부 조사선량이 4500cGy이하인 군에서 4501cGy 이상인 군에서보다 낮은 것으로 나타났고, 최대 방광 선량과 최대 직장 선량이 합병증 발생률과 유의한 상관관계를 보여, 향후 전골반 외부 조사선량이 4500cGy를 넘지 않도록 주의하여야 되겠고, 강내 치료 계획시 직장 및 방광 선량을 가능한 낮추도록 치료 선량을 결정해야 할 것이다.

• Asian Pacific Journal of Cancer Prevention
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• 제16권5호
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• pp.1897-1900
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• 2015

Purpose: To evaluate acute toxicity in nasopharyngeal cancer (NPC) patients treated with intensity modulated radiotherapy (IMRT)/volumetric modulated arc therapy (VMAT) with or without cisplatin-based chemotherapy. Materials and Methods: A total of 45 newly diagnosed, histologically proven non-metastatic NPC patients treated with IMRT between May 2010 and December 2012, were evaluated retrospectively, 37 planned with Eclipse and 8 with Prowess Panther treatment planning system. The doses to the planning target volumes of primary tumor and involved lymph nodes, high risk region, and uninvolved regional nodal areas were 70 Gy, 60 Gy, and 54 Gy respectively and delivered simultaneously over 33 fractions to 39 patients. Another 6 patients irradiated with sequential boost technique. Some 84.4% of patients received chemotherapy. Acute toxicities were graded according to the Radiation Therapy Oncology Group scoring criteria and Common Terminology Criteria for Adverse Events (CTCAE) for chemotherapy side effects. Results: Median age was 43 years (14-79) and all patients were WHO type II. Grade 1 mucositis and dysphagia were observed in 17 (37.8%), and 10 (22.2%) patients, respectively. The incidence of acute grade 2 mucositis and dysphagia was 55.6% and 68.9%, respectively. The most common chemoradiotherapy related acute toxicities were nausea, leucopenia and thrombocytopenia. Grade 3 toxicity was detected in 13 (28.8%) cases. No grade 4 toxicity was occurred. Mean weight loss was 9%. None of the patients required the insertion of percutaneous endoscopic gastrostomy for nutritional support. Radiation therapy was completed without interruption in all patients. Conclusions: IMRT is a safe and effective treatment modality, and well tolerated by patients in the treatment of nasopharyngeal carcinoma. No unexpected side effects were observed.

• 대한족부족관절학회지
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• 제10권2호
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• pp.133-139
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• 2006

Purpose: To evaluate the results of mosaicplasty and microfracture after surgical treatments for symptomatic osteochondral lesion of talus (OLT) by second-look arthroscopy. Materials and Methods: 7 cases of mosaicplasty and 7 cases of microfracture were reviewed who undertook second-look arthroscopy at 6 months or one year after undertaking mosaicplasty or microfracture for OLT between December 2004 and October 2005. The mean age at first operation was 43.6 years (Range, 20-59) (Mosaicplasty; 43.9 years, Microfracture; 43.4 years). The mean size of cartilage defect was $15.0{\times}7.7\;mm$ in mosaicplasty and $7.1{\times}6.6\;mm$ in microfracture. Clinical outcomes were evaluated by Freiburg ankle score. Cartilage healing state was evaluated by Insall's classification for chondromalasia during second-look arthroscopy. Results: By the Freiburg ankle score, 9 ankles (6 in mosaicplasty, 3 in microfracture) had excellent and 5 (1 in mosaicplasty, 4 in microfracture) had good results at the times of second-look arthroscopy. By Insall's classification, consistency of the osteochondral grafts and congruity between grafts and native cartilage (Grade I) were shown in 9 (6 ankles in mosaicplasty, 3 ankles in microfracture), a fissuring (Grade II) in one ankle of mosaicplasty, a fasciculation (Grade III) in one ankle of microfracture, and partial exposure of subchondral bone (Grade IV) in 3 ankles of microfractures. Conclusion: Mosaicplasty was more excellent in consistency and hardness of cartilage than microfracture. In some cases of microfracture, cartilage healing was incomplete at 6 months postoperatively, so second-look arthroscopy is necessary to identify. If incomplete cartilage healing was shown, additional procedure such as microfracture or mosaicplasty was needed.

• Journal of Acupuncture Research
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• 제17권3호
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• pp.116-124
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• 2000

This clinical study was carried out 15 cases with lumbar spinal stenosis patients, who had been admitted and diagnosed by Computed Tomography from June, 1999 to May, 2000, in the department of acupuncture and moxibustion. Hanseo University Oriental Medical Nospital. The results obtained from this study were as follows; 1. We investigated 10 female and 5 male patients. The age distribution was from early 20's to 70's, among which 30's and 50's were most common. 2. The most common duration of symptom was less than a year(46.7%). 3. Regarding to the number of the involved levels, one was 12 cases(80%), two was 3 cases(20.0%). In the one level cases, L4~5 was the most common involved site. 4. Regarding to the clinical symptoms, low back pain was the most common, followed by lower extremity radiating pain, intermittent claudication, lower extremity paresthesia. 5. In orthopaedic examinations, positive sign in Milgram test was 80.0%, positive sign in straight leg raising test was 40.0%, and positive sign in Braggard test was 33.3%. Inneurologic examinations, sensory loss was seen in 60.0%, motor weakness and decreased deep tendon reflex were 26.7% in each. 6. According to clinical symptom scale proposed by Chae(1989), grade I1I was the most common (53.3%), followed by grade II, grade IV, grade I . 7. According to treatment outcome scale proposed by Chae(1989), Good was the most common (73.3%), followed by Excelleat, Fair and Poor.

• Journal of Korean Neurosurgical Society
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• 제66권2호
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• pp.183-189
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• 2023

Objective : The facial nerve trace on the ipsilateral side of the vestibular schwannoma was reconstructed by diffusion tensor imaging tractography to identify the adjacent relationship between the facial nerve and the tumor, and to improve the level of intraoperative facial nerve protection. Methods : The clinical data of 30 cases of unilateral vestibular schwannoma who underwent tumor resection via retrosigmoid approach were collected between January 2019 and December 2020. All cases underwent magnetic resonance imaging examination before operation. Diffusion tensor imaging and anatomical images were used to reconstruct the facial nerve track of the affected side, so as to predict the course of the nerve and its adjacent relationship with the tumor, to compare the actual trace of the facial nerve during operation, verify the degree of coincidence, and evaluate the nerve function (House-Brackmann grade) after surgery. Results : The facial nerve of 27 out of 30 cases could be displayed by diffusion tensor imaging tractography, and the tracking rate was 90% (27/30). The intraoperative locations of facial nerve shown in 25 cases were consistent with the preoperative reconstruction results. The coincidence rate was 92.6% (25/27). The facial nerves were located on the anterior middle part of the tumor in 14 cases, anterior upper part in eight cases, anterior lower part in seven cases, and superior polar in one case. Intraoperative facial nerve anatomy was preserved in 30 cases. Among the 30 patients, total resection was performed in 28 cases and subtotal resection in two cases. The facial nerve function was evaluated 2 weeks after operation, and the results showed grade I in 12 cases, grade II in 16 cases and grade III in two cases. Conclusion : Preoperative diffusion tensor imaging tractography can clearly show the trajectory and adjacent position of the facial nerve on the side of vestibular schwannoma, which is beneficial to accurately identify and effectively protect the facial nerve during the operation, and is worthy of clinical application and promotion.

• Journal of Chest Surgery
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• 제27권3호
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• pp.202-208
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• 1994

We reviewed 30 patients with tetralogy of Fallot who had underwent transannular patch reconstruction of the right ventricular outflow tract from January 1990 to May 1993. The patients were divided into two groups according to the approaching pattern for the corrective surgery: 12 patients[aged 11 months to 4 years; mean age, 2.3 years] in transatrial group who were repaired by transatrial-transpulmonary approach; 18 patients[aged 13 months to 6 years; mean age, 3.2 years] in transventricular group who were repaired by transventricular approach. The incidence of postoperative right bundle branch block was not statistically different between two groups. With follow up from 3 months to 32 months after operation, none in transatrial group revealed a remnant RVOT stenosis over 50mmHg or tricuspid regurgitation more than grade II with 2D-echocardiography, but two cases[7.7%] in transventricular group revealed these complications. Early postoperative death was 4 cases[13.3%] which all belonged to transventricular group. In conclusion successful repair of tetralogy of Fallot can be accomplished in most patients by transatrial-transpulmonary approach and we can anticipate better results by this approach in terms of postoperative right ventricular function and arrhythmia than conventional transventricular approach.

• 대한정형외과학회지
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• 제56권5호
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• pp.404-412
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• 2021

목적: 슬관절 내측 구획 골관절염으로 근위 경골 절골술 및 미세 골절술을 함께 시행한 환자 군에서 이차적 관절경 검사를 시행하여 연골 재생 정도를 평가하고 연골 재생에 영향을 미치는 요인을 규명하고자 한다. 또한 연골 재생의 정도와 기능적 결과가 연관성이 있는지 분석하고자 한다. 대상 및 방법: 2007년부터 2015년까지 근위 경골 절골술 및 미세 골절술을 함께 시행하였고, 최소 2년이 지나 금속판 제거술 및 이차 관절경 검사까지 시행 받은 81예를 대상으로 하였다. 술 전 대퇴부 연골 손상의 정도는 ICRS (International Cartilage Research Society) 분류를 이용하였고, 모두 grade III, IV 였다. 이차적 관절경 검사 이후에는 연골 재생이 양호한 그룹(grade I, II)과 불량한 그룹(grade III, IV)으로 분류하였다. 다변량 로지스틱 회기 분석을 통하여 연골 재생에 영향을 미치는 독립적인 요인을 파악하였다. 또한 두 그룹간의 수술 전후에 Knee Society score (KSS)와 Western Ontario and McMaster Universities Osteoarthritis Index score (WOMAC)를 이용하여 기능적 결과를 비교하였다. 결과: 연령, 성별, 체질량 지수, 술 전후 방사선학적 요인, 술 전 관절의 상태는 연골 재생의 정도에 유의한 영향을 끼치지 않았으며, 큰 연골 병변 범위(≥2.0 cm²) (p=0.011)와 키스 병변(kissing lesion)의 존재(p=0.027)는 불량한 연골 재생과 연관성이 있었다. KSS와 WOMAC 점수상에서는 연골의 재생이 양호한 그룹과 불량한 그룹 간의 유의한 차이는 없었다. 결론: 큰 연골 병변과 키스 병변의 존재는 근위 경골 절골술 및 미세 골절술 후 불량한 연골 재생과 관계가 있었다. 하지만 재생된 연골의 상태는 기능적 결과와 연관성을 보이지 않았다.