• The Korean Journal of Physiology and Pharmacology
• /
• v.16 no.5
• /
• pp.339-342
• /
• 2012

Inter-individual pharmacokinetic variation of H2-receptor antagonist is related to genetic polymorphism of CYP2C19. We investigated the frequency of CYP2C19 genetic polymorphism and the treatment duration of cimetidine by CYP2C19 genotypes in functional dyspeptic patients without definite causes who were treated with cimetidine in Korea. One hundred subjects with functional dyspepsia participated in this study from March 1, 2010 to June 30, 2011. They were tested by upper gastrointestinal endoscopy and treated for their dyspepsia with cimetidine. The single nucleotide polymorphisms (SNPs) of CYP2C19 were genotyped using the Seeplex CYP2C19 ACE Genotyping system. There were no significant differences in the demographic, clinical, or laboratory findings among the CYP2C19 subgroups which are wild type homozygote (W/W), heterozygote (W/V), and variant homozygote (V/V). The frequencies of CYP2C19 subgroups were 33 (33%) in W/W, 49 (49%) in W/V, and 18 (18%) in V/V, respectively. The mean duration of cimetidine treatment (in weeks) was the shortest in the V/V among the CYP2C19 genotypes (W/W: $5.1{\pm}1.5$, W/V: $4.0{\pm}1.7$, V/V: $2.1{\pm}0.7$; p<0.001). This study can also act as a basis for further investigation to identify the underlying genetic, epigenetic, or environmental factors in CYP2C19 enzyme activity.

• Journal of the Korean Institute of Electrical and Electronic Material Engineers
• /
• v.20 no.3
• /
• pp.234-239
• /
• 2007

This paper describes the TiW ohmic contact characteristics under the surface treatment of the polycrystalline 3C-SiC thin film grown on $SiO_2/Si(100)$ wafers by APCVD. The poly 3C-SiC surface was polished by using CMP(chemical mechanical polishing) process and then oxidized by wet-oxidation process, and finally removed SiC oxide layers. A TiW thin film as a metalization process was deposited on the surface treated poly 3C-SiC layer and was annealed through a RTA(rapid thermal annealing) process. TiW/poly 3C-SiC was investigated to get mechanical, physical, and electrical characteristics using SEM, XRD, XPS, AFM, optical microscope, I-V characteristic, and four-point probe, respectively. Contact resistivity of the surface treated 3C-SiC was measured as the lowest $1.2{\times}10^{-5}{\Omega}cm^2$ at $900^{\circ}C$ for 45 sec. Therefore, the surface treatments of poly 3C-SiC are necessary to get better contact resistance for extreme environment MEMS applications.

• Journal of the Korean Institute of Telematics and Electronics
• /
• v.20 no.5
• /
• pp.31-36
• /
• 1983

The indirect M.R.A.C. method using the W.L.S. algorithm is applied to the speed control of a D.C. motor on the assumption that the motor is the 1-st order, completely controllable and observable, non-minimum phase plant. By the help of M6809 microprocessor system the experiments are performed with respect to the sinusoidal and square reference input. The results show that the speed of a D.C. motor is well controlled by the indirect M.R.A.C. method using W.L.S, algorithm, and that the W.L.S. algorithm is quite suitable to the time-varying plant.

• Proceedings of the Korean Institute of Electrical and Electronic Material Engineers Conference
• /
• 2008.06a
• /
• pp.155-155
• /
• 2008

계속되는 반도체 산업의 발달로 반도체 배선 공정에서는 Al을 대체할 배선 금속으로 Cu에 대한 관심이 집중되고, 일부 공정에서는 Al을 대신하여 사용하고 있다. 이러한 Cu는 Al에 비교하여 많은 장점을 가지고 있지만 Si 기판과 저온에서 쉽게 확산되는 큰 문제점을 가지고 있다. 따라서 이러한 문제를 해결하기 위한 방법으로 현재까지 연구된 대안으로는 Cu와 Si기판 사이에 확산방지막을 삽입하는 것이 대안으로 알려져 있다. 본 연구는 Cu 금속배선 공정을 위하여 Cu와 Si기판과의 확산을 효과적으로 방지할 확산방지막을 텅스텐(W)을 주 구성 물질로 여기에 불순물을 첨가한 W-C-N 확산방지막에 대하여 연구하였으며, 특히 W-C-N 확산방지막의 결정 및 표면 구조에 대한 물성 특성을 연구하였다. 여러 조건변화에 따라서 확산방지막의 특성을 확인하기 위하여 조건이 다르게 증착된 W-C-N 확산방지막을 상온에서 고온으로 열처리하여 열처리 전후를 WET-SPM (Scanning Probe Microscope)을 사용하여 그 물리적 특성을 조사하였다. 이러한 분석을 통하여 가장 안정된 W-C-N 확산방지막의 증착조건을 확인하였으며, 이를 기반으로 박막의 물리적 특성을 연구하였다.

• Fire Science and Engineering
• /
• v.18 no.1
• /
• pp.31-36
• /
• 2004

The purpose of this study is to present data for the reusing, rehabilitation and estimation of safety of RC structure damaged by fire, and for the prevention of explosive spatting by investigation the properties of explosive spalling, compressive strength and ultrasonic pulse velocity according to kinds of fine aggregate, admixture and water-cement ratios. In explosive spalling properties with kinds of aggregate, explosive spalling does not appear or little at surface in the case of used sea sand, but the case of using recycled sand or crushed sand is worse and worse. Property with the kind of admixture does not appear specially. And high strength concrete with W/C 30.5% was taken spalling, but 55% does not appear. It is found that residual compressive strength after exposed at high temperature showed 45％ in W/C 55%, and 64％ in W/C 30.5％ of its original strength averagely. Ultrasonic pulse velocity is different with kinds of aggregate. W/C. and heating time. When 3 month age after heating ultrasonic pulse velocity is recovered abut 1.3％～8.4％ of its 1 month age after heating.

• Korean Journal of Materials Research
• /
• v.12 no.5
• /
• pp.414-422
• /
• 2002

Three different multi-component white cast irons alloyed with Cr, V, Mo and W were prepared in order to study their as-cast and solidification structures. Three combinations of the alloying elements were selected so as to obtain the different types of carbides and matrix structures : 3%C-10%Cr-5%Mo-5%W(alloy No.1), 3%C-10%V-5% Mo-5%W(alloy No. 2) and 3%C-17%Cr-3% V(alloy No.3). The as-cast microstructures were investigated with optical and scanning electron microscopes. There existed two different types of carbides, $M_7C_3$ carbide with rod-like morphology and $M_6C$ carbide with fishbone-like one, and matrix in the alloy No. 1. The alloy No. 2 consisted of MC carbide with chunky and flaky type and needle-like $M_2C$ carbide, and matrix. The chunky type referred to primary MC carbide and the flaky one to eutectic MC carbide. The morphology of the alloy No. 3 represented a typical hypo-eutectic high chromium white cast iron composed of rod-like $M_7C_3$ carbide which is very sensitive to heat flow direction and matrix. To clarify the solidification sequence, each iron(50g) was remelted at 1723K in an alumina crucible using a silicon carbide resistance furnace under argon atmosphere. The molten iron was cooled at the rate of 10K/min and quenched into water at several temperatures during thermal analysis. The solidification structures of the specimen were found to consist of austenite dendrite(${\gamma}$), $ ({\gamma}+ M_7C_3)$ eutectic and $({\gamma}+ M_6C)$ eutectic in the alloy No. 1, proeutectic MC, austenite dendrite(${\gamma}$), (${\gamma}$+MC) eutectic and $({\gamma}+ M_2C)$ eutectic in the alloy No. 2, and proeutectic $M_7C_3$ and $ ({\gamma}+ M_7C_3)$ eutectic in the alloy No 3. respectively.

• Proceedings of the IEEK Conference
• /
• 2000.06b
• /
• pp.153-156
• /
• 2000

This paper presents a SOC design methodology using the newly-emerging SystemC. The suggested methodology firstly uses SystemC to define blocks from the previously-developed system level algorithm with internal behavior and interface being separated and validate such a described blocks' functionality when integrated. Next, the partitioning between software and hardware is considered. With software, the interface to hardware is described cycle-accurate and the other internal behavior in conventional ways. With hardware, I/O transactions are refined gradually in several abstraction levels and internal behavior described on a function basis. Once hardware and software have been completed functionally, system performance analysis is performed on the built model with assumed performance factors and influences such decisions regressively as on optimum algorithm selection, partitioning and etc. The analysis then gives constraint information when hardware description undergoes scheduling and fixed-point trans- formation with the help of automatic translation tools or manually. The methodology enables C/C++ program developers and VHDL/Verilog users to migrate quickly to a co-design & co-verification environment and is suitable for SoC development at a low cost.

• Korean Journal of Fisheries and Aquatic Sciences
• /
• v.18 no.5
• /
• pp.439-446
• /
• 1985

This study was designed to compare the lipid components among wild and cultured eel, Anguilla japonica, and conger eel, Astroconger myriaster. The lipid components of cultured eel were analyzed and compared with those of wild and conger eel. In the content of total lipid, the lipid content in cultured eel was slightly higher than that in wild one, but 2 times higher than that in conger eel. The lipid contents in edible portion of wild and cultured eel were 5 times higher than those in viscera, but the lipid content in edible portion of conger eel showed a similar trend to that in viscera. In the fatty acid composition of neutral lipid in edible portion, percentages of $C_{14:0},\;C_{16:0}\;and\;C_{18:1}$ in cultured eel were higher than those in wild one, while percentages of $C_{16:1},\;C_{18:2},\;C_{18:3},\;C_{20:4},\;C_{20:5},\;C_{22:5}\;and\;C_{22:6}$ lower, and percentages of $C_{18:0},\;C_{20:4}\;and\;C_{22:6}$ in conger eel were noticeably higher than those in wild and cultured eels. In the case of phospholipid in edible portion, percentages of $C_{18:0}\;and\;C_{18:2}$ in cultured eel were higher than those in wild one, while percentages of $C_{16:0},\;C_{16:1},\;C_{18:1},\;C_{18:3},\;C_{20:4},\;C_{20:5},\;C_{22:5}\;and\;C_{22:6}$ lower. The unsaturation (TUFA/TSFA) of neutral lipid was no significant difference among wild and cultured eel, and conger eel, but that of phospholipid in wild eel was higher than that in cultured eel and conger eel. The essential fatty acid content(TEFA) of neutral lipid in edible portion of wild eel was 3 times higher than that of cultured one. but the TEFA of phospholipid in edible portion was no significant difference among wild and cultured eels, and conger eel. The w3 highly unsaturated fatty acid content (w3 HUFA) of neutral lipid in edible portion of wild eel was 2.0 to 2.5 times higher than that of cultured eel and conger eel, but the w3 HUFA of phospholipid in edible portion of wild eel was noticeably higher than that of cultured eel and conger eel. In the ratio (A/B) of fatty acid content (A) in cultured eel to that (B) in diet, the A/B ratios of $C_{18:2}\;w6,\;C_{18:3}\;w3,\;C_{20:5}\;w3\;and\;C_{22:6}\;w3$ were 0.23 to 0.48 much lower than the other fatty acid. Consequently, it is considered that the ratios of w3 HUFA is related to the biosynthesis of polyenoic acid and growth rate of cultured eel.

• Journal of the Korean Society of Fisheries and Ocean Technology
• /
• v.19 no.2
• /
• pp.125-129
• /
• 1983

It is customary to assume that the resistance of a jull at uniform speed may be regarded as the sum of viscous and wavemaking component resistance, or C sub(i)=C sub(v)+C sub(w), where C sub(v) is regarded as a function of Reynolds Number R and C sub(w) a function of Froude Number F. Formulae have been obtained for ∂C sub(w)/∂R, ∂C sub(v)/∂F which may be relevant in seeking theoretical grounds for possible interaction between viscous and wavemaking component resistances. The values of ∂C sub(w)/∂R are small. In general they are smaller than corresponding values of ∂C sub(v)/∂R. But although these values are small it does not follow that they are entirely negligible. The Froude assumption that the rate of change of C sub(w) with R is zero must bel regarded as incorrect.

• Proceedings of the Korean Magnestics Society Conference
• /
• 2007.05a
• /
• pp.245.2-245.2
• /
• 2007