• 대한영상의학회지
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• 제84권5호
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• pp.1080-1090
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• 2023

목적 이 연구의 목적은 한국 인구에서 NeuroQuant (이하 NQ)와 DeepBrain (이하 DB)에서 측정된 뇌 용적과 정상규준 백분위수를 비교하고, 두개골 형태와의 연관성을 확인하는 것이다. 대상과 방법 이 연구는 구조적 뇌 이상이 없는 163명의 한국인을 대상으로 NQ와 DB에서 측정된 뇌 용적과 정상규준 백분위수를 비교하고, 두개골 형태와의 연관성을 확인한 후향적 연구이다. 급내상관계수분석과 선형분석의 통계학적 분석을 시행하였다. 결과 정상규준 백분위수는 시상(90.8 vs. 63.3 percentile), 피각(90.0 vs. 60.0 percentile), 그리고 두정엽(80.1 vs. 74.1 percentile)에서 NQ가 DB보다 더 큰 것으로 나타났고, 후두엽(18.4 vs. 68.5 percentile)은 DB가 NQ보다 큰 것으로 나타났으며, 특히 후두엽의 경우 두개골 형태와의 비교 연구에서 유의미한 연관성을 보였고, 두개골의 전후 방향의 길이와 비례하고 상하방향의 길이와는 반비례했다. 결론 NQ와 DB에서 얻은 정상규준 백분위는 각 뇌 영역마다 유의미한 차이를 보였고, 그 차이는 한국 인구의 두개골 형태와 유의미한 관계가 있었다.

• 대한치과교정학회지
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• 제19권2호
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• pp.25-34
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• 1989

This experiment was performed to study the effect of prostaglandin $E_2$ on tooth movement and root resorption in orthodontically treated cats. Twenty five cats were divided into five groups and closed coil springs delivered 80gm were stretched between upper canine and 3rd premolar. $10{\mu}g$ of $PGE_2$ was injected locally in the submucosal area of the upper right canine, while the left side served as a control and was injected saline 0.1ml. The distance between canine tip and central cusp tip of the 3rd premolar was measured. Scanning electron photomicrographs were made of the coronal half of the distal root surface of canines and cemental craterings were observed and quantified using point-counting volumetry. Data were analyzed by 2-way ANOVA and paired t-test. The results were as follows: 1. The rate of tooth movement of the $PGE_2$ side was increased, particularly at 1 day, compared with the control side. 2. The rate of tooth movement was minimum from 7 days to 10 days. 3. The resorption of root surface of the $PGE_2$ side was decreased from 4 days to 10 days, compared with the control side.

• 한국분무공학회지
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• 제20권3호
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• pp.141-148
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• 2015

In order to research engine characteristics of spark-ignited engine with intake valve closing timing change for Miller cycle, two cam for LIVC(Late Intake Valve Closing) were designed and fabricated an prototype valvetrain. And intake valve closing timing were adjusted to build low compressing and high expansion cycle for HEV. In experimental study, it were investigated with different engine speed, spark timing and air-fuel ratio to compare base cam and LIVC cam type. It was found that the volumetry efficiency and effective work of compression process were decreased in case of LIVC cam. When compared with the existing results, the maximum pressure in the cylinder was reduced about 12~13 bar and the volumetric efficiency was reduced about 16%.

• Asian Pacific Journal of Cancer Prevention
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• 제15권5호
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• pp.2375-2378
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• 2014

Cancer, like any disease, is a pathologic biological process. Drugs are designed to interfere with the pathologic process and should therefore also be validated using a functional screening method directed at these processes. Screening for cancers at an appropriate time and also evaluating results is also very important. Volumetric measurement helps in better screening and evaluation of tumors. Volumetry is a process of quantification of the tumors by identification (pre-cancerous or target lesion) and measurement. Volumetric image analysis allows an accurate, precise, sensitive, and medically valuable assessment of tumor response. It also helps in identifying possible outcomes such disease progression (PD) or complete response as per Response Evaluation Criteria in Solid Tumors (RECIST).

• 생물정신의학
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• 제18권1호
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• pp.5-14
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• 2011

Neuroimaging in psychiatry encompasses the powerful tools available for the in vivo study of brain structure and function. MRI including the volumetry, voxel-base morphometry(VBM) and diffusion tensor imaging (DTI) are useful for assessing brain structure, whereas function MRI, positron emission tomography(PET) and magnetoencephalography(MEG) are well established for probing brain function. These tools are well tolerated by the vast majority of psychiatric patients because they provide a powerful but noninvasive means to directly evaluate the brain. Although neuroimaging technology is currently used only to rule in or rule out general medical conditions as opposed to diagnosing primary mental disorders, it may be used to confirm or make psychiatric diagnoses in the future. In addition, neuroimaging may be valuable for predicting the natural course of psychiatric illness as well as treatment response.

• 대한전자공학회:학술대회논문집
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• 대한전자공학회 2000년도 ITC-CSCC -1
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• pp.441-445
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• 2000

This study is to segment white matter, gray matter, and cerebrospinal fluid(CSF) on a brain MR image of coronal section and to calculate the volume of each. First, we segmented the whole region of a brain from a black colored background, a skull and a fat layer. Then, we calculated the partial volume of each component, which was present in scanning finite thickness, with the arithmetical analysis of gray value from the internal region of a brain showing the blurring effects on the basis of the MR image forming principle. Calculated partial volumes of white matter, gray matter and CSF were used to determine the threshold for the segmentation of each component on a brain MR image showing the blurring effects. Finally, the volumes of segmented white matter, gray matter, and CSF were calculated. The result of this study can be used as the objective diagnostic method to determine the degree of brain atrophy of patients who have neurodegenertive diseases such as Alzheimer’s disease and cerebral palsy.

• 한국멀티미디어학회논문지
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• 제21권2호
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• pp.147-157
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• 2018

Alzheimer's disease has the significant factors for the both specific and characteristic features according to the disease progressing that are the volumetry and surface area by the brain hippocampus shrinking and thinning. However, we have suggested a shape analysis to calculate the variance by the roughness, coarseness or uneven surface on 3D MR images. For the reasons we have presented two methods: the first method is the distance calculation from major axis to edge points and the second method is the distance calculation from centroidal point to edge points on a coronal plane. Then we selected the shortest distance and the longest distance in each slice and analyzed the ANOVA and average distances. Consequently we obtained the available and great results by the longest distance of the axial and centroidal point. The results of average distances were 44.85(AD), 45.04(MCI) and 49.31(NC) from the axial points and 39.30(AD), 39.58(MCI) and 44.78(NC) from centroidal points respectively. Finally the distance variations for the easily recognized visualization were shown by the color mapping. This research could be provided an indicator of biomarkers that make diagnosis and prognosis the Alzheimer's diseases in the future.

• Investigative Magnetic Resonance Imaging
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• 제19권3호
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• pp.168-177
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• 2015

Purpose: Brain surface intensity model (BSIM)-based cortical thickness analysis does not require complicated 3D segmentation of brain gray/white matters. Instead, this technique uses the local intensity profile to compute cortical thickness. The aim of the present study was to evaluate intra-rater and inter-rater reliability of BSIM-based cortical thickness analysis using images from elderly participants. Materials and Methods: Fifteen healthy elderly participants (ages, 55-84 years) were included in this study. High-resolution 3D T1-spoiled gradient recalled-echo (SPGR) images were obtained using 3T MRI. BSIM-based processing steps included an inhomogeneity correction, intensity normalization, skull stripping, atlas registration, extraction of intensity profiles, and calculation of cortical thickness. Processing steps were automatic, with the exception of semiautomatic skull stripping. Individual cortical thicknesses were compared to a database indicating mean cortical thickness of healthy adults, in order to produce Z-score thinning maps. Intra-class correlation coefficients (ICCs) were calculated in order to evaluate inter-rater and intra-rater reliabilities. Results: ICCs for intra-rater reliability were excellent, ranging from 0.751-0.940 in brain regions except the right occipital, left anterior cingulate, and left and right cerebellum (ICCs = 0.65-0.741). Although ICCs for inter-rater reliability were fair to excellent in most regions, poor inter-rater correlations were observed for the cingulate and occipital regions. Processing time, including manual skull stripping, was $17.07{\pm}3.43min$. Z-score maps for all participants indicated that cortical thicknesses were not significantly different from those in the comparison databases of healthy adults. Conclusion: BSIM-based cortical thickness measurements provide acceptable intra-rater and inter-rater reliability. We therefore suggest BSIM-based cortical thickness analysis as an adjunct clinical tool to detect cortical atrophy.

• Archives of Plastic Surgery
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• 제43권5호
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• pp.430-437
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• 2016

Background Accurate breast volume assessment is a prerequisite to preoperative planning, as well as intraoperative decision making in breast reconstruction surgery. The use of three-dimensional surface imaging (3D scanning) to assess breast volume has many advantages. However, before employing 3D scanning in the field, the tool's validity should be demonstrated. The purpose of this study was to confirm the validity of 3D-scanning technology for evaluating breast volume. Methods We reviewed the charts of 25 patients who underwent breast reconstruction surgery immediately after total mastectomy. Breast volumes using the Axis Three 3D scanner, water-displacement technique, and magnetic resonance imaging (MRI) were obtained bilaterally in the preoperative period. During the operation, the tissue removed during total mastectomy was weighed and the specimen volume was calculated from the weight. Then, we compared the volume obtained from 3D scanning with those obtained using the water-displacement technique, MRI, and the calculated volume of the tissue removed. Results The intraclass correlation coefficient (ICC) of breast volumes obtained from 3D scanning, as compared to the volumes obtained using the water-displacement technique and specimen weight, demonstrated excellent reliability. The ICC of breast volumes obtained using 3D scanning, as compared to those obtained by MRI, demonstrated substantial reliability. Passing-Bablok regression showed agreement between 3D scanning and the water-displacement technique, and showed a linear association of 3D scanning with MRI and specimen volume, respectively. Conclusions When compared with the classical water-displacement technique and MRI-based volumetry, 3D scanning showed significant reliability and a linear association with the other two methods.

• Asian Pacific Journal of Cancer Prevention
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• 제15권2호
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• pp.703-706
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• 2014

Objective: To evaluate the safety and efficacy of sequential transcatheter arterial chemoembolization (TACE) and portal vein embolization (PVE) before major hepatectomy for patients with hepatocellur carcinoma (HCC). Methods: In this retrospective case-control study, data were collected from patients who underwent sequential TACE and PVE prior to major hemihepactectomy. Liver volumes were measured by computed tomography volumetry before TACE, and preoperation to assess degree of future remnant liver (FRL) hypertrophy and to check whether intro- or extrohepatic metastasis existed. Liver function was monitored by biochemistry after TACE, prior to and after major hepatectomy. Results: Mean average FRL volume increased 32.3-71.4% (mean 55.4%) compared with preoperative FRL volume. After TACE, liver enzymes were elevated, but returned to normal in four weeks. During PVE and resection, no patient had intro- or extrohepatic metastasis. Conclusion: Sequential TACE and PVE is an effective method to improve resection opportunity, expand the scope of surgical resection, and greatly reduce postoperative intra- and extrahepatic metastasis.