• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• v.32 no.4
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• pp.308-316
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• 2006

Objectives Despite considerable advances in technique, experience and skill, the precise place of surgery in the treatment of facial nerve injury remains uncertain. We designed a facial nerve crush injury model in rats and evaluated the recovery of crushed nerve which is the most common injury type of facial nerve using adenovirus vector mediated in vivo gene transfer of Brain derived neurotrophic factor(BDNF). Materials and methods In 48 Sprague Dawley rats, we made a facial nerve crush injury model to main trunk before the furcation, and injected a $10^{11}$pfu adenoviral BDNF in experimental group(BDNF adenoviral injection group; ad-BDNF) and $3{\mu}l$ saline in control group(Saline injection group; saline). After a period of regeneration from 10 to 40 days, nerve regeneration was evaluated with functioinal test (vibrissae and ocular movement), electrophysiologic study(threshold, peak voltage, conduction velocity) and histomorphometric study of axon density. Results Vibrissae and ocular movement, threshold and conduction velocity improved as time elapse in both group, however axon density was increased significantly only in experimental group. Functional test in 10 days and 20 days showed no difference between experimental group and control group. Vibrissae movement, threshold, conduction velocity and axon density in 30 days revealed that the regeneration in quality of experimental group was significantly superior to that of control group. Conclusion In general, there is tendency for nerve regeneration in experimental group (BDNF-adenovirus injection group) during 40 days, functional recovery was detected successfully after facial nerve crush in 30 days postoperatively.

• The Transactions of the Korean Institute of Electrical Engineers B
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• v.51 no.2
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• pp.69-76
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• 2002

To obtain a high performance in a vector controlled induction motor, it is essential to know the instantaneous position of the rotor flux which depends on the rotor time constant. But the rotor time constant mainly varies due to the temperature rise in the motor winding, so real time compensating algorithm is necessary. This paper proposes that it uses short duration pulses added to the constant flux command current and then resultant torque command current produced by speed controller is utilized for the rotor resistance estimation. This method has advantage with a low computational requirement and does not require voltage sensors. The proposed method is proved by simulations and experimentals.

• The Transactions of the Korean Institute of Power Electronics
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• v.15 no.1
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• pp.69-74
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• 2010

In a grid connected variable speed wind turbine, the PCC voltage and the wind power fluctuate as the wind velocity changed. And this voltage variation is changed due to location of PCC. This paper calculate the value of PCC voltage variation which is proportional to the product of the line impedance from the ideal generator to the PCC and the wind turbine output current. And to reduce this PCC voltage variation, this paper calculate the required reactive power analytically using the vector diagram method. Output reactive current is changed, if the reactive current is limited by inverter capacity or grid code have the margin of voltage variation. If the grid connected inverter is controlled by proposed algorithm, the PCC voltage variation is minimized though the wind turbine output change at random. To verify calculated voltage variation and required reactive power, this paper utilized Matlab and PSCAD/EMTDC simulation and real small wind turbine and power system in Sapsido, island in the Yellow Sea.

• Proceedings of the KIEE Conference
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• 2001.04a
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• pp.285-287
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• 2001

To obtain a high performance in a vector controlled induction machine, it is essential to know the instantaneous position of the rotor flux which depends on the rotor time constant. But the rotor time constant mainly varies due to the temperature rise in the motor winding, so real time compensating algorithm is necessary. This paper proposes that it uses short duration pulses added to the constant flux command current and then resultant torque command current produced by speed controller is utilized for the rotor resistance estimation. This method has advantages with a low computational requirement and does not require voltage sensors. The proposed method is proved by simulations.

• The Journal of the Korea institute of electronic communication sciences
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• v.11 no.3
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• pp.283-292
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• 2016

The performance of 4-switch 3-phase inverter(: FSTPI) which replace two switches of 6-switch 3-phase inverter(: SSTPI) is mainly affected by the compensator unbalanced voltages and output voltage control method. This paper proposes a DC offset current injection method to compensate the capacitor unbalanced voltages for FSTPI. A simplified SVPWM method which can be applied to FSTPI is also proposed. The validity of the proposed methods is verified by simulation and experiment using SPMSM.

• The Transactions of the Korean Institute of Electrical Engineers B
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• v.53 no.11
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• pp.664-670
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• 2004

This paper presents a new velocity estimation strategy of a non-salient permanent magnet synchronous motor (PMSM) drive without high frequency signal injection or special PWM pattern. This approach is based on the d-axis current regulator output voltage of the drive system that has the information of rotor position error. The rotor velocity can be estimated through a rotor position tracking PI controller that controls the position error to zero. For zero and low speed operation, PI controller gains of rotor position tracking controller have a variable structure according to the estimated rotor velocity. In order to boost the bandwidth of PI controller around zero speed, a loop recovery technique is applied to the control system. The proposed method only requires the flux linkage of permanent magnet and is insensitive to the parameter estimation error and variation. The designers can easily determine the possible operating range with a desired bandwidth and perform the vector control even at low speeds. The experimental results show the satisfactory operation of the proposed sensorless algorithm under rated load conditions.

• Journal of international Conference on Electrical Machines and Systems
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• v.1 no.1
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• pp.84-90
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• 2012

Various methods have been proposed to identify the flux position in an interior permanent magnet synchronous motor (IPMSM) without the use of mechanical sensors. To achieve this, a method that uses both the back electromotive force (EMF) and the saliency to identify the flux position in the IPMSM without the injection of high-frequency components at low speeds has been reported. This method was then extended in order to drive the motor with no load to a light load. We propose a combination of these methods with different proportional-integral (PI) controllers for controlling $di_{dest}$/dt and $di_{qest}$/dt. We also introduce compensation values $F_L$ and $F_H$ to reduce the position error when the estimation rule is being selected.

• Proceedings of the KIEE Conference
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• 1999.07c
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• pp.1049-1053
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• 1999

It is important to measuring and monitoring about state vectors of power system for precise operation control. All state vectors cannot be measured because it is economically disadvantageous, so that some state vectors are determined using state estimator. Determination of observability is a important precondition of power system state estimation because state estimation can be performed when given power system is observable. Recently as time-synchronization technique progress, using the PMU(Phasor Measurement Unit), state vector can be measured directly so that voltage phasor and current phasor measurements can be used for power system estimation. In this paper, observability algorithm is proposed to determinate the observability with real/reactive injection power measurements and real/reactive lineflow power measurements of existing measurement system and with phasor measurements of PMU. The jacobian matrix is newly composed for state estimation with measurements of added PMU, and state estimation is performed with least square estimatior. Comparison between state estimation result of existing measurement system and that of measurement system added PMU is presented.

• Maxillofacial Plastic and Reconstructive Surgery
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• v.28 no.5
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• pp.375-395
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• 2006

Purpose: Lingual nerve (LN) damage may be caused by either tumor resection or injury such as wisdom tooth extraction, Although autologous nerve graft is sometimes used to repair the damaged nerve, it has the disadvantage of necessity of another operation for nerve harvesting. Moreover, the results of nerve grafting is not satisfactory. The nerve growth factor (NGF) is well-known to play a critical role in peripheral nerve regeneration and its local delivery to the injured nerve has been continuously tried to enhance nerve regeneration. However, its application has limitations like repeated administration due to short half life of 30 minutes and an in vivo delivery model must allow for direct and local delivery. The aim of this study was to construct a well-functioning $rhNGF-{\beta}$ adenovirus for the ultimate development of improved method to promote peripheral nerve regeneration with enhanced and extended secretion of hNGF from the injured nerve by injecting $rhNGF-{\beta}$ gene directly into crush-injured LN in rat model. Materials and Methods: $hNGF-{\beta}$ gene was prepared from fetal brain cDNA library and cloned into E1/E3 deleted adenoviral vector which contains green fluorescence protein (GFP) gene as a reporter. After large scale production and purification of $rhNGF-{\beta}$ adenovirus, transfection efficiency and its expression at various cells (primary cultured Schwann cells, HEK293 cells, Schwann cell lines, NIH3T3 and CRH cells) were evaluated by fluorescent microscopy, RT-PCR, ELISA, immunocytochemistry. Furthermore, the function of rhNGF-beta, which was secreted from various cells infected with $rhNGF-{\beta}$ adenovirus, was evaluated using neuritogenesis of PC-12 cells. For in vivo evaluation of efficacy of $rhNGF-{\beta}$ adenovirus, the LNs of 8-week old rats were exposed and crush-injured with a small hemostat for 10 seconds. After the injury, $rhNGF-{\beta}$ adenovirus($2{\mu}l,\;1.5{\times}10^{11}pfu$) or saline was administered into the crushed site in the experimental (n=24) and the control group (n=24), respectively. Sham operation of another group of rats (n=9) was performed without administration of either saline or adenovirus. The taste recovery and the change of fungiform papilla were studied at 1, 2, 3 and 4 weeks. Each of the 6 animals was tested with different solutions (0.1M NaCl, 0.1M sucrose, 0.01M QHCl, or 0.01M HCl) by two-bottle test paradigm and the number of papilla was counted using SEM picture of tongue dorsum. LN was explored at the same interval as taste study and evaluated electro-physiologically (peak voltage and nerve conduction velocity) and histomorphometrically (axon count, myelin thickness). Results: The recombinant adenovirus vector carrying $rhNGF-{\beta}$ was constructed and confirmed by restriction endonuclease analysis and DNA sequence analysis. GFP expression was observed in 90% of $rhNGF-{\beta}$ adenovirus infected cells compared with uninfected cells. Total mRNA isolated from $rhNGF-{\beta}$ adenovirus infected cells showed strong RT-PCR band, however uninfected or LacZ recombinant adenovirus infected cells did not. NGF quantification by ELISA showed a maximal release of $18865.4{\pm}310.9pg/ml$ NGF at the 4th day and stably continued till 14 days by $rhNGF-{\beta}$ adenovirus infected Schwann cells. PC-12 cells exposed to media with $rhNGF-{\beta}$ adenovirus infected Schwann cell revealed at the same level of neurite-extension as the commercial NGF did. $rhNGF-{\beta}$ adenovirus injected experimental groups in comparison to the control group exhibited different taste preference ratio. Salty, sweet and sour taste preference ratio were significantly different after 2 weeks from the beginning of the experiment, which were similar to the sham group, but not to the control group.