• Journal of Ginseng Research
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• 제25권2호
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• pp.74-81
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• 2001

The effect of Korean Ginseng saponins (total saponin, PD saponin and PT saponin) on the serotonin type 3 receptor, which is known to be involved in nausea and vomiting following anticancer chemotherapy or the general anesthesia, was investigated. after in vitro transcribed recombinant serotonin type 3 receptor in the Xenopus laevis oocyte, classic two electrodes voltage clamp technique was used. All of ginseng saponins inhibited the response of the agonist, serotonin, on the serotonin type 3 receptor in a dose-dependent manner. PT saponin showed to have the inhibitory effect more than 2 times as potent as PD saponin. Total saponin shifted the serotonin dose response plot to the right (EC$\_$50/, 0.70$\pm$0.17 $\mu$M into 3.57$\pm$1.42 $\mu$M, and Hill coefficient, 2.14$\pm$0.60 into 1.52$\pm$1.00). Ginseng saponin did not change the reversal potential (∼0 mV) of serotonin type 3 receptor. These results suggest that Korean ginseng saponin may have the inhibitory effect on serotonin type 3 receptor.

• Journal of Power Electronics
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• 제19권2호
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• pp.363-379
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• 2019

Resonant converters have attracted a lot of attention because of their high efficiency due to the soft-switching performance. An isolated high step-up converter with secondary-side resonant loops is proposed and analyzed in this paper. By placing the resonant loops on the secondary side, the current stress for the resonant capacitors is greatly reduced. The power loss caused by the equivalent series resistance of the resonant capacitor is also decreased. Clamp diodes in parallel with the resonant capacitors ensure a unique discontinuous current mode in the converter. Under this mode, the active switches can realize soft-switching during both turn-on and turn-off transitions. Meanwhile, the reverse-recovery problems of diodes are also alleviated by the leakage inductor. The converter is essentially a step-up converter. Therefore, it is helpful for decreasing the transformer turn-ratio when it is applied as a high step-up converter. The steady-state operation principle is analyzed in detail and design considerations are presented in this paper. Theoretical conclusions are verified by experimental results obtained from a 500W prototype with a 35V-42V input and a 400V output.

• 전력전자학회논문지
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• 제16권2호
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• pp.105-113
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• 2011

태양광 발전 시스템이 대용량화됨에 따라 태양전지 어레이 구성 시 부정합(mismatch) 문제가 대두되는 가운데, 태양전지 모듈을 직접 계통에 연계하는 AC 모듈형 태양광 모듈 집적형 전력변환장치(PV-MIC)에 관한 연구가 지속되고 있다. PV-MIC는 수명 및 고효율이 가장 큰 문제이며 이 문제를 해결하기 위해서 본 논문에서는 ZVS 동작을 통하여 스위칭 손실을 저감시키고 입력전류 리플감소를 통하여 입력 커패시턴스를 저감할 수 있는 능동 클램프 전류원 하프 브릿지 컨버터를 적용한 PV-MIC를 제안하고, 이에 관한 제어분담 및 설계에 대하여 고찰한다.

• The Korean Journal of Physiology and Pharmacology
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• 제4권4호
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• pp.333-338
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• 2000

We have examined whether bile acids can affect the electrical and mechanical activities of circular smooth muscle of canine colon and ileum, using isometric tension measurement or patch clamp technique. It was found that a dilution of canine bile $(0.03{\sim}2%\;by\;volume)$ enhanced or inhibited the amplitude of spontaneous contractions. An individual component of bile, deoxycholic acid (DCA) enhanced the frequency and amplitude of the spontaneous contractile activity at $10^{-6}\;M,$ while DCA at $10^{-4}\;M$ inhibited the contraction. Similarly, the response to cholic acid was excitatory at $10^{-5}\;M$ and inhibitory at $3{\times}10^{-4}\;M.$ Taurocholic acid at $10^{-4}\;M$ enhanced the amplitude of muscle contraction. Electrically, canine bile at 1% reversibly depolarized the colonic myocytes under current clamp mode. Bile acids also elicited non-selective cation currents under voltage clamp studies, where $K^+$ currents were blocked and the $Cl^-$ gradient was adjusted so that $E_{Cl}^-$ was equal to -70 mV, a holding potential. The non-selective cation current might explain the depolarization caused by bile acids in intact muscles. Furthermore, the bile acid regulation of electrical and mechanical activities of intestinal smooth muscle may explain some of the pathophysiological conditions accompanying defects in bile reabsorption.

• Smart Structures and Systems
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• 제13권4호
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• pp.567-585
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• 2014

The piezoelectric transverse $d_{15}$ shear sensing mechanism is firstly assessed experimentally for a cantilever smart sandwich plate made of a piezoceramic axially poled patched core and glass fiber reinforced polymer composite faces. Different electrical connections are tested for the assessment of the sensor performance under a varying amplitude harmonic (at 24 Hz) force. Also, the dynamic response of the smart sandwich composite structure is monitored using different acquisition devices. The obtained experimentally sensed voltages are compared to those resulting from the benchmark three-dimensional piezoelectric coupled finite element simulations using a commercial code where realistic features, like equipotential conditions on the patches' electrodes and mechanical updating of the clamp, are considered. Numerically, it is found that the stiffness of the clamp, which is much softer than the ideal one, has an enormous influence on the sensed voltage of its adjacent patch; therefore, sensing with the patch on the free side would be more advantageous for a cantilever configuration. Apart from confirming the latter result, the plate benchmark experimental assessment showed that the parallel connection of its two oppositely poled patches has a moderate performance but better than the clamp side patch acting as an individual sensor.

• Korean Journal of Acupuncture
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• 제18권1호
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• pp.143-156
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• 2001

Modulatory effect of cAMP-PKA system on inhibitory- and excitatory herbs-induced ion currents were investigated by nystatin-perforated patch clamp method under voltage-clamp condition. Ion currents induced by Bupleuri radix and Coptidis rhizoma were not affected by cAMP-PKA system. Ion current induced by Ecliptae herba was partially inhibited by cAMP-PKA system. Ion currents induced by Aconiti tuber and Boshniakiae herba were inhibitory modulated and ion current induced by Zingiberis rhizoma was excitatory modulated by cAMP-PKA system. Modulation of cAMP-PKA system on ion currents induced by Ginseng radix was fluctuated. In this results, it can be seen generally that excitatory herbs-induced ion currents were modulated by cAMP-PKA system while cAMP-PKA system did not affect inhibitory herbs-induced ion currents.

• International Journal of Oral Biology
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• 제32권4호
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• pp.153-160
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• 2007

The superficial dorsal horn, particularly substantia gelatinosa (SG) in the spinal cord, receives inputs from small-diameter primary afferents that predominantly convey noxious sensation. Reactive oxygen species (ROS) are toxic agents that may be involved in various neurodegenerative diseases. Recent studies indicate that ROS are also involved in persistent pain through a spinal mechanism. In the present study, whole cell patch clamp recordings were carried out on SG neurons in spinal cord slice of young rats to investigate the effects of hydrogen peroxide on neuronal excitability and excitatory synaptic transmission. In current clamp condition, tert-buthyl hydroperoxide (t-BuOOH), an ROS donor, depolarized membrane potential of SG neurons and increased the neuronal firing frequencies evoked by depolarizing current pulses. When slices were pretreated with phenyl-N-tert-buthylnitrone (PBN) or ascorbate, ROS scavengers, t-BuOOH did not induce hyperexcitability. In voltage clamp condition, t-BuOOH increased the frequency and amplitude of spontaneous excitatory postsynaptic currents (sEPSCs), and monosynaptically evoked excitatory postsynaptic currents (eEPSCs) by electrical stimulation of the ipsilateral dorsal root. These data suggest that ROS generated by peripheral nerve injury can modulate the excitability of the SG neurons via pre- and postsynaptic actions.

• 조명전기설비학회논문지
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• 제12권3호
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• pp.114-123
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• 1998

The multi-resonant converter(MRC) minimizes a parasitic oscillation by using the resonant tank circuit absorbed parasitic reactances existing in a converter circuit. So it si possible that the converter operated at a high frequency has a high efficiency because the losses are reduced. Such a MHz high frequency applications provide a high power density [W/inch3] of the converter. But the resonant voltage stress across a switch of the resonant tank circuit is 4~5 times a input voltage. This h호 voltage stress increases the conduction loss because of on-resistance of a MOSFET with higher rating. Thus, in this paper we proposed the alternated multi-resonant converter (AT MRC) differ from the clamp mode multi-resonant converter and applicated it to the forward MRC. The AT forward MRC can reduce the voltage stress to 2~3 times a input voltage by using two series input capacitor. The control circuit is simple because tow resonant switches are driven directly by the output pulse of the voltage controled oscillator. This circuit type is verified through the experimental converter with 48V input voltage, 5V/50W output voltage/power and PSpice simulation. the measured maximum voltage stress is 170V of 2.9 times the input voltage and the maximum efficiency of 81.66% is measured.

• Journal of Power Electronics
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• 제17권6호
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• pp.1402-1412
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• 2017

This paper presents a new high step-up dc/dc converter for renewable energy systems in which a high voltage gain is provided by using a coupled inductor. The operation of the proposed converter is based on a charging capacitor with a single power switch in its structure. A passive clamp circuit composed of capacitors and diodes is employed in the proposed converter for lowering the voltage stress on the power switch as well as increasing the voltage gain of the converter. Since the voltage stress is low in the provided topology, a switch with a small ON-state resistance can be used. As a result, the losses are decreased and the efficiency is increased. The operating principle and steady-states analyses are discussed in detail. To confirm the viability and accurate performance of the proposed high step-up dc-dc converter, several simulation and experimental results obtained through PSCAD/EMTDC software and a built prototype are provided.

• 전력전자학회논문지
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• 제15권2호
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• pp.103-110
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• 2010

본 논문에서는 대용량급 전력변환회로를 대상으로, 기존 위상천이 풀 브리지 컨버터의 환류 전류 문제를 해결하기 위하여 새로운 모드 가변형 비대칭 풀 브리지 컨버터를 제안한다. 제안된 회로는 구동시비율 D에 따라 50% 이하에서는 비대칭 풀 브리지 컨버터로 동작하며, 50% 이상에서는 능동 클램프 풀 브리지 컨버터로 동작하게 된다. 따라서 제안된 회로는 정상상태시 약 50% 시비율로 동작되므로 기존 위상천이 풀 브리지 컨버터의 문제점인 환류전류를 제거 할 수 있으며, 이를 통하여 도통 손실을 줄일 수 있다. 또한, 넓은 부하범위에서 영전압 스위칭 동작이 가능하며, 출력 전류 리플도 매우 작은 장점이 있다. 특히 순간정전시 능동 클램프 컨버터로 동작 모드가 변하여 50~100% 시비율로 동작되므로 넓은 입력전압범위에 대해 대응이 가능하다. 본 논문에서는 제안된 회로의 동작원리 및 PSIM simulation을 수행하였으며, 1.2kW급 시작품을 제작하여 제안된 회로의 타당성을 검증하였다.