• The Korean journal of internal medicine
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• 제39권1호
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• pp.148-159
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• 2024

Background/Aims: We evaluated the efficacy and safety of denosumab treatment in severe chronic kidney disease (CKD) patients with osteoporosis. We also investigated whether the treatment affects the coronary artery calcifications. Methods: Twenty-seven postmenopausal women with Stage 3b-4 CKD and osteoporosis were enrolled. Twenty patients received denosumab plus calcium carbonate and vitamin D, and seven controls received calcium carbonate and vitamin D for 1 year. Dual-energy X-ray absorptiometry and coronary artery calcium (CAC) scoring computed tomography were performed before and after treatment. Hypocalcemic symptoms and serum calcium levels were evaluated. Results: After 1 year of treatment, the percent changes of femur neck (3.6 ± 3.2% vs. -0.7 ± 4.4%, p = 0.033) and total hip (3.4 ± 3.8% vs. -1.9 ± 2.1%, p = 0.001) bone mineral density (BMD) were significantly increased in the denosumab treated group compared to the control group. However, the percent change of lumbar spine BMD did not differ between two groups (5.6 ± 5.9% vs. 2.7 ± 3.9%, p = 0.273). The percent change of bone alkaline phosphatase was significantly different in the denosumab-treated group and control group (-31.1 ± 30.0% vs. 0.5 ± 32.0%, p = 0.027). CAC scores did not differ between groups. No hypocalcemic events occurred in both groups. Conclusions: If carefully monitored and supplemented with calcium and vitamin D, denosumab treatment for 1 year provides significant benefits in patients with Stage 3b-4 CKD and osteoporosis. However, denosumab treatment did not affect coronary artery calcifications in these patients.

• 한국식품저장유통학회지
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• 제7권3호
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• pp.278-284
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• 2000

한국산 인공재배 천만의 동결건조 분말은 수분 2.12%, 조단백질 4.41%, 조지방 1.20%, 조회분 2.25%, 조섬유 4.60%, 무질소물 85.15%로 분석되었다. 환원당 함량은 2.66%였으며 유리당은 glucose 13.14mg/g, sucrose 10.81mg/g, fructose 8.69mg/g 함유되어 있었다. 지방산은 11종이 검출되었으며 포화지방산이 18.69%, 불포화 지방산이 81.31%였으며 포화 지방산으로는 palmitic acid가 11.55%, 불포화 지방산으로는 linoleic acid가 63.13%로 가장 높았다. 그 외 불포화 지방산으로는 cis-5,8,11,14,17-eicosapentaenoic acid가 6.42%, linolenic acid가 4.33%를 차지하였다. 유기산으로는 oxalic acid, citric acid, malic acid, succinic acid, fumaric acid 등이 분리되었고 succinic acid의 함량이 1,238mg%로 가장 높았고 다음은 citric acid, malic acid, oxalic acid, fumaric acid의 순이었다. 분리된 18종의 총 아미노산중 aspartic acid가 522.8mg%로 가장 높은 함량을 차지했으며 taurin, hydroproline, alanine, threonine등이 존재했으며 taurin, hydroproline, alanine, threonine등이 존재하였다. 39종의 유리 아미노산 중 arginine이 15.01mg%로 가장 함량이 높았으며 asparagine, proline, sarcosine 순이었다. 총 페놀의 함량은 821.4mg%이었고 조사포닌의 함량은 3,738mg%를 나타내었다. 수용성 비타민으로는 ascorbic acid가 6.40mg%, 비타민 B1이 1.23mg%, 비타민 B2가 1.74mg% 함유되어 있었으며 지용성 비타민으로는 비타민 A가 1.22mg%, 비타민 E는 0.32mg%로 미량 함유되어 있었다.

• 한국식품과학회지
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• 제48권1호
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• pp.20-26
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• 2016

본 연구는 다수확 품종 쌀의 가공 이용성 증진을 위해 식미가 좋은 일반계통과 식미는 다소 떨어지지만 다수확 품종인 통일계통을 시료로 하여 일반성분, 영양성분 비교 분석 및 품질특성을 비교한 결과는 다음과 같다. 쌀 품종별 수분함량은 6.23-6.91%로 유의적 차이를 보이지 않았고, 조단백질 함량은 안다벼가 8.13%로 높았으며, 조회분 함량은 일미벼, 한아름 및 안다벼가 0.52-0.55%로 높았다. 조지방 함량은 일미벼가 1.24%로 가장 높았다. amylose 함량은 안다벼가 24.67%로 가장 높았고, 일미벼는 16.61%로 가장 낮았다. 유리당 함량은 호품벼가 656.51 mg%로 가장 높았고, 아미노산은 안다벼가 7,295,64 mg%로 시료구 중 가장 높았다. 품종별 vitamin $B_1$ 함량은 한아름벼 품종이 0.51 mg%로 가장 높았고, vitamin $B_2$ 는 호품벼와 일미벼 품종에서만 소량 검출되었다. 품종에 따른 쌀가루의 수분흡수지수는 일미벼와 인디카벼가 1.73으로 가장 높았고, 호품벼는 1.22로 가장 낮았다. 수분용해지수는 일미벼가 6.03%으로 가장 높았고, 호품벼는 3.26%로 가장 낮았다. 쌀가루의 팽윤력은 일미벼, 호평벼, 호품벼, 한아름벼 및 안다벼는 $80^{\circ}C$와 $85^{\circ}C$ 사이에서 급격하게 증가하는 경향을 보였으며, 인디카벼는 $70^{\circ}C$와 $75^{\circ}C$ 사이에서 급격하게 증가하는 경향을 보였다. 용해도는 $75^{\circ}C$와 $80^{\circ}C$ 사이에서 급격하게 증가하는 경향을 보였고, 전반적으로 일미벼의 용해도가 높은 것으로 나타났다. Amylograph에 의한 호화 특성조사 결과 인디카벼가 387.00 BU로 가장 높았고, 한아름벼는 201.67 BU로 가장 낮은 것으로 나타나 인디카벼가 가장 노화 경향이 큰 것으로 나타났으며, 한아름벼는 쌀가루 페이스트의 노화가 가장 지연되는 품종으로 나타났다. 따라서 다수확 품종인 안다벼와 한아름벼는 아밀로오스 함량이 높아 제빵 적성에 부합할 것으로 판단된다. 또한 아미노산과 vitamin $B_1$ 함량이 높았고, 노화특성에서 한아름벼가 페이스트의 노화가 지연 되는 품종으로 확인되어 가공용으로의 충분한 활용 가치가 있을 것으로 판단된다.

• 한국식생활문화학회지
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• 제15권4호
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• pp.313-323
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• 2000

Although it is rapidly increasing the number of day-care centers in Korea, the quality of food and nutrition services is not improved sufficiently. The purpose of this study was to investigate the nutrition and health status of children in day-care center. Menus for lunch of 253 centers were collected and the content of nutrients was analyzed. Nutrient intakes from lunch and snacks of 90 children were investigated using weighing method and those from breakfast and dinner by 24-hour recall method surrogated from their mothers. Anthropometric indices of height, weight, skinfold thickness, the ratio of fat were measured. The lunch menus for children contained $437.0{\pm}138.9\;Kcal$, $17.6{\pm}6.7gr$ protein, $153.9{\pm}87.7mg\;Ca$, $3.63{\pm}1.6mg\;Fe$, $164.5{\pm}158.2RE\;Vit\;A$. and $4.46{\pm}3.04mg\;Vit\;B_1$. Energy, Ca and Fe supplied were below one third of RDAs. Mean daily calorie intake of children aged 3 years was $1303.0{\pm}474.0Kcal/day$, $1322.3{\pm}442.4Kcal$ in aged four, $1307.0{\pm}545.9Kcal$ in aged five and $1497.1{\pm}93.5kcal$ in six year of age. Intake of iron, vitamin A and vitamin $B_1$ were below RDAs.

• 대한가정학회지
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• 제27권3호
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• pp.53-60
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• 1989

This study was carried out in order to investigate a suitable dietary guideline for athlets who need weight control. This dietary guideline will be a basic information to furnish further development of the computer program. The weight of Boxing and Judo players were diverse ranging from 49.5Kg to 95Kg whose overage age was 21. Also the quantity of energy expenditure during a day's activity depended on the indiviual's weight and physical conditions that will contribute to many factors among those surveyed, and the overall contribute to many factors among those surveyed, and the overall consumption of calorie per day was ranged from 3682Kcal to 7226Kcal. For those athlets, they suggested necessary nutritional intake of protein per 1Kg weight was 1.18㎎ and the recommended intake of vitamin B1, vitamin B2 and niacin was 0.5㎎, 0.6㎎, and 6.6㎎ each per 1,000Kcal of calorie needed. Taste perference of athletes showed that there was no extreme dislike toward and food items. However, this study showed that strongly flavored food was not prefered. On the other hand, there was a high preference toward protein foods, fruits and beverages.

• Nutrition Research and Practice
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• 제10권5호
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• pp.516-523
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• 2016

BACKGROUND/OBJECTIVES: This study was conducted to examine relationships between dietary habits and intakes of antioxidants and B vitamins and the risk of ischemic stroke, and to compare dietary factors according to the presence of cerebral artery atherosclerosis and stroke subtypes. SUBJECTS/METHODS: A total of 147 patients and 144 control subjects were recruited consecutively in the metropolitan area of Seoul, Korea. Sixty participants each in the case and control groups were included in analyses after 1:1 frequency matching. In addition, 117 acute ischemic stroke patients were classified into subtypes according to the Trial of Org 10172 in Acute Stroke Treatment (TOAST) guidelines. Dietary intake was measured using a semi-quantitative food frequency questionnaire composed of 111 food items and plasma lipid and homocysteine levels were analyzed. RESULTS: When compared with control subjects, stroke patients had unfavorable dietary behaviors and lower intakes of fruits ($73.1{\pm}83.2g$ vs. $230.9{\pm}202.1g$, P < 0.001), vegetables ($221.1{\pm}209.0g$ vs. $561.7{\pm}306.6g$, P < 0.001), and antioxidants, including vitamins C, E, $B_6$, ${\beta}$-carotene, and folate. The intakes of fruits, vegetables, vitamin C, and folate were inversely associated with the risk of ischemic stroke after adjusting for confounding factors. Intakes of vegetables, vitamins C, $B_6$, $B_{12}$, and folate per 1,000 kcal were lower in ischemic stroke with cerebral atherosclerosis than in those without. Overall vitamin $B_{12}$ intake per 1,000 kcal differed according to the TOAST classification (P = 0.004), but no differences among groups existed based on the post-hoc test. CONCLUSIONS: When compared with control subjects, ischemic stroke patients, particularly those with cerebral atherosclerosis, had unfavorable dietary intake, which may have contributed to the development of ischemic stroke. These results indicate that proper dietary recommendations are important for the prevention of ischemic stroke.

• 한국식품과학회지
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• 제33권6호
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• pp.669-675
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• 2001

본 연구는 aflatoxin $B_1(AFB_1)$에 의하여 유발된 마우스 간세포에서의 $AFB_1-DNA$ 부가체 형성과 세포의 산화적 손상에 대한 항산화 비타민의 효과를 조사하기 위하여 수행되었다. 먼저, 비타민 C와 비타민 E를 6 주령 수컷 ICR 마우스에 10mg/kg, 63.8mg/kg의 농도로 복강내에 각각 주사(i.p.; intraperitoneal injection) 하였고, $AFB_1$과 비타민 혼합 투여군은 비타민을 주사한 후 1시간이 경과한 다음 0.4mg/kg의 $AFB_1$을 투여하였다. 투여 횟수는 2일 간격으로 동일한 방법에 의해 4회 반복 투여하였다. 반면, $AFB_1$ 단독 투여군은 위와 같은 방법으로 비타민 없이 $AFB_1$만 투여하였다. ELISA에 의한 마우스 혈청내 $AFB_1$의 잔여 농도는 $AFB_1$ 단독 투여군에서 12.28, 18.78 ng/mL이 검출되었다. 그러나 항산화비타민 C 혼합 투여군에서는 7.60 ng/mL, 항산화 비타민 E 혼합 투여군에서는 4.85 ng/mL이 각각 검출되었다. 마우스의간에서 분석된 $AFB_1-DNA$ 부가체 농도에 의하면, $AFB_1$ 단독 투여군에서는 23.78, 25.48 ng/mL이었으며, 항산화 비타민 C 혼합 투여된 군에서는 5.26 ng/mL, 항산화 비타민 E 혼합투여군에서 7.81 ng/mL로 각각 조사되었다. 이들 결과에 대한 통계적 유의성은 p<0.01이었다. 또한 면역조직화학적 관찰에서 $AFB_1$ 단독 투여군에서는 중심정맥과 동양혈관 주변에 갈색의 침전이 두드러지게 나타났으며 이러한 현상은 항산화비타민 혼합 투여군에서 유의하게 감소한 것으로 나타났다.

• 한국식생활문화학회지
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• 제25권3호
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• pp.285-295
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• 2010

The purpose of this study was to compare the awareness of dietary patterns and health of full-time and employed housewives. The investigation gathered information on general characteristics, dietary lifestyle, nutritional status, and health by questionnaire as well as anthropometric measurements. The subjects included housewives living in Seoul and Gyeonggi Province (86 full-time and 127 working housewives) during November 2009 to January 2010. The average age, height, and weight of the housewives were $45.8{\pm}7.6\;yr$, $161.0{\pm}8.4\;cm$, and $55.7{\pm}6.3\;kg$, respectively. The average monthly income of the households was 3 million to 5 million won (31.4% full-time and 37.0% working housewives), and their average food expense was 200,000 to 500,000 won (46.5% full-time and 48.1% working housewives). More than 90% of the studied homes were nuclear families and the most common number of children was 2 to 3 (79.1% full-time and 76.4% working housewives). The ratio of employed housewives who ate regular meals was 35.4%, but that of the full-time housewives was 48.2% (p<0.05). Of the working housewives, 7.1% never ate breakfast and the primary reason for skipping breakfast was 'busy in the morning' (61.1%). The type of food that the housewives preferred when eating out was Korean food, both for the full-time and employed housewives (76.0%). All the housewives overate calories and the full-time housewives ate more protein, fat, vitamin A, vitamin B1, vitamin B6, niacin, vitamin C, vitamin E, folic acid, and cholesterol than the employed housewives (p<0.05). Both the full-time and employed housewives were more satisfied with supper than with other meals. About 30.6% of the full-time and 33.9% of the working housewives had no interest in health, but answered that regular exercise was very important for health (33.3% full-time and 39.7% working housewives). In conclusion, working housewives have poor dietary habits and nutrient intakes, thus substantial measures to improve these problems are urgently needed.

• Nutrition Research and Practice
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• 제18권1호
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• pp.19-32
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• 2024

BACKGROUND/OBJECTIVES: Atherosclerosis is associated with increased inflammation in the visceral adipose tissue (VAT). Vitamin D has been reported to modulate the inflammatory responses of stromal vascular cells (SVCs) and adipocytes in adipose tissue, but the role of vitamin D in atherosclerosis biology is unclear. This study examined the effects of in vitro 1,25-dihydroxyvitamin D₃ (1,25[OH]₂D₃) treatment on the inflammatory responses of SVCs and adipocytes from atherosclerotic mice. MATERIALS/METHODS: C57BL/6J (B6) mice were divided randomly into 2 groups and fed a 10% kcal fat control diet (control group, CON) or 41% kcal fat, 0.21% cholesterol (high fat + cholesterol, HFC) diet (obese group, OB), and B6.129S7-Ldlr^tm1Her/J (Ldlr^-/-) mice were fed a HFC diet (obese with atherosclerosis group, OBA) for 16 weeks. SVCs and adipocytes isolated from VAT were pre-incubated with 1,25(OH)₂D₃ for 24 h and stimulated with lipopolysaccarides for the next 24 h. Proinflammatory cytokine production by adipocytes and SVCs, the immune cell population in SVCs, and the expression of the genes involved in the inflammatory signaling pathway in SVCs were determined. RESULTS: The numbers of total macrophages and SVCs per mouse were higher in OB and OBA groups than the CON group. The in vitro 1,25(OH)₂D₃ treatment significantly reduced macrophages/SVCs (%) in the OBA group. Consistent with this change, the production of interleukin-6 and monocyte chemoattractant protein 1 (MCP-1) by SVCs from the OBA group was decreased by 1,25(OH)₂D₃ treatment. The 1,25(OH)₂D₃ treatment significantly reduced the toll-like receptor 4 and dual-specificity protein phosphatase 1 (also known as mitogen-activated protein kinase phosphatase 1) mRNA levels in SVCs and MCP-1 production by adipocytes from all 3 groups. CONCLUSIONS: These findings suggest that vitamin D can attribute to the inhibition of the inflammatory response in VAT from atherosclerotic mice by reducing proinflammatory cytokine production.

• Journal of Nutrition and Health
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• 제38권10호
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• pp.827-835
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• 2005

The purpose of this study was to investigate the relation among mineral intakes, blood pressure, and blood lipids for health management of Korean adults over 20 years old. Subjects were recruited from the district where they lived, which included rural (Yoju, n = 137) , coastal (Taean, n = 100) , and urban district (Suwon, n : 117) . hnthropornekical measurement, blood pressure measurement, dietary intake assessment using 24-hour recall method, and blood collection and analysis of blood lipids were conducted. The average age, height, weight, and BMI were 54.1 years, 168.5 cm, 67.3 kg, and 24.5 kg/$m^{2}$ for men and 53.9 years,153.8 cm,59.2 kg, and 25.0 kg/$m^{2}$ for women, respectively. The mean daily intakes of total food and energy were 1219.1 g and 1740.9 kcal for men and 1071.3 g and 1432.6 kcal for women. The mineral intakes of men and women were 448.5 mg and 400.4 mg for calcium,955.3 mg and 803.7 mg for phosphorus, 13.3 mg and 11.1 mg for iron, 4302.8 mg and 3393.3 mg for sodium,2588.0 mg and 2264.9 mg for potassium, and 8.9 mg and 7.3 mg for zinc. The daily intakes of energy, calcium, zinc, vitamin $B_{2}$, and vitamin I were $76.1\%$, $60.1\%$, $73.1\%$, $68.6\%$, and $80.4\%$ of RDAs, respectively. The intakes of energy, calcium, zinc, vitamin $B_{2}$ and I were not meet Korean RDAs. Especially, calcium, zinc, and vitamin $B_{2}$ were less than $75\%$ of RDAs. Blood pressure of the subjects was 128.3/75.5 mmHg for men and 124.1/73.7 mmHg for women. Serum lipids of men and women were 180.2 mg/dL and 184.9 mg/dL for total cholesterol, 160.8 mg/dL and 137.6 mg/dL for triglyceride,41.5 mg/dL and 44.7 mg/dL for HDL-cholesterol,106.6 mg/dL and 112.7 mg/dL for LDL-cholesterol, and 3.5 and 3.3 for atherogenic index. While serum triglyceride and AI of men was significantly higher, HDL-cholesterol was lower than those of women. In the relation among mineral intakes, blood pressure, and serum lipids, we found a significantly negative correlation of intakes of calcium, calcium/phosphorus, calcium density with systolic blood pressure. There were significantly negative correlation between intake of calcium/phosphorus and serum cholesterol, calcium density and serum cholesterol, sodium intake and serum HDL-cholesterol. Based on these results, we concluded that high intakes of calcium, calcium/phosphorus and low sodium intake were associated with favorable blood pressure and serum lipid profiles in adult men and women. (Korean J Nutrition 38(10): 827$\sim$835,2005)