• Genomics & Informatics
• /
• v.15 no.3
• /
• pp.98-107
• /
• 2017

MicroRNAs (miRNAs) act as regulators of gene expression by binding to the 3' untranslated region (UTR) of target genes. They perform important biological functions in the various species. Among many miRNAs, miR-21-3p is known to serve vital functions in development and apoptosis in olive flounder. Using genomic and bioinformatic tools, evolutionary conservation of miR-21-3p was examined in various species, and expression pattern was analyzed in olive flounder. Conserved sequences (5'-CAGUCG-3') in numerous species were detected through the stem-loop structure of miR-21-3p. Thus, we analyzed target genes of miR-21-3p. Among them, 3' UTR region of PPIL2 gene indicated the highest binding affinity with miR-21-3p based on the minimum free energy value. The PPIL2 gene showed high expression levels in testis tissue of the olive flounder, whereas miR-21-3p showed rather ubiquitous expression patterns except in testis tissue, indicating that miR-21-3p seems to control the PPIL2 gene expression in a complementary repression manner in various tissues of olive flounder. Taken together, this current study contributes to infer the target gene candidates for the miR-21-3p using bioinformatics tools. Furthermore, our data offers important information on the relationship between miR-21-3p and target gene for further functional study.

• Journal of the Korea Convergence Society
• /
• v.9 no.6
• /
• pp.183-190
• /
• 2018

With decreasing the number of high school graduates, it is vital for each college to maintain its enrollment number as well as to preserve its dropout rate in a lower level. It is true that all universities and colleges have experienced inevitable dropouts that were in fact more serious in 2 to 3-year colleges. There have been prior studies to examine what factors affected to students' dropout in various ways. However, no specific programs were employed to mitigate the rates of dropout. In this study, new encouraging program is introduced for the students who were not ready to study and isolated from classroom. The result showed that the program led to the GPA enhancement in larger number of participants. Nevertheless, the sustainablity of the program would be unclear unless it combines with other existing programs.

• Journal of the Institute of Electronics Engineers of Korea SD
• /
• v.46 no.2
• /
• pp.78-84
• /
• 2009

In general video coding systems, motion estimation (ME) is regarded as a vital component in a video coder as it consumes a large amount of computation resources. Fractional pixel motion estimation can improve the video compression rate at the cost of higher computational complexity. It is based on the experimental results that the sum of absolute differences (SAD) shows parabolic shape and thus can be approximated by using interpolation technique. In this paper, we propose a fast fractional pixel search algorithm by combining SASR (Simplified Adaptive Search Range) and the CBCDS (Center Biased Cross-Diamond Search) pattern with the predicted motion vector. Compare with the fractional pel full search and the CBFPS, the proposed CBCDS algorithms can reduce fractional pel search points up to 81.4%, respectively with the PSNR lost about 0.05dB.

• Journal of Genetic Medicine
• /
• v.5 no.2
• /
• pp.89-93
• /
• 2008

"Personalized medicine," the goal of which is to provide better clinical care by applying patient's own genomic information to their health care is a global challenge for the $21^{st}$ century "genomic era." This is especially true in Korea, where provisions for clinical genetic services are inadequate for the existing demand, let alone future demands. Genomics-based knowledge and tools make it possible to approach each patient as a unique biological individual, which has led to a paradigm-shift in medical practice, giving it more of a predictive focus as compared with current treatment oriented approach. With recent advancements in genomics, many genetic tests, such as susceptibility genetic tests, have been developed for both rare single gene diseases and more common multifactorial diseases. Indeed, genetic tests for presymtomatic individuals and genetic tests for drug response have become widely available, and personalized medicine will face the challenge of assisting patients who use such tests to make appropriate and wise use of genetic risk assessment. A major challenge of genomic medicine lies in understanding and communicating disease risk in order to facilitate and support patients and their families in making informed decisions. Establishment of a health care system with provisions for genetic counseling as an integral part of health care service, in addition to genomic literacy of health care providers, is vital to meet this growing challenge. Realization of the promise of personalized medicine in the era of genomics for improvement of health care is dependent on further development of next generation sequencing technology and affordable sequencing test costs. Also necessary will be policy development concerning the ethical, legal and social issues of genomic medicine and an educated and ready medical community with clinical practice guidelines for genetic counseling and genetic testing.

• Journal of the Korean Society of Manufacturing Process Engineers
• /
• v.15 no.6
• /
• pp.83-88
• /
• 2016

Over the last five years, 568 people have died while hiking according to 2015 statistics from the public safety ministry. Among those deaths, approximately 33% were due to loss of footing or falling. In this respect, the highly advanced functions of hiking boots should be considered to prevent these unfortunate accidents. For example, by utilizing the Internet of Things (IoT) and Information and Communications Technology (ICT), hiking boots equipped with a Global Positioning System (GPS) or vital signs monitoring systems should be considered. In addition, many challenges remain for the production of 3D printed hiking boots, because the functions of hiking boots are variable, which is important when handling changing terrains and situations. The design of customized hiking boots was introduced in this paper, and 3D printing applications for midsoles using a Porous Polymer Printing (PPP) method was also suggested to verify the possibility of manufacturing hiking boots.

• Atmosphere
• /
• v.23 no.4
• /
• pp.413-424
• /
• 2013

Urban Heat Island (UHI) intensity is one of vital parameters in studying urban boundary layer meteorology as well as urban planning. Because the UHI intensity is defined as air temperature difference between urban and rural sites, an objective sites selection criterion is necessary for proper quantification of the spatial variations of the UHI intensity. This study quantified the UHI intensity and its spatial pattern, and then analyzed their connections with urban structure and metabolism in Seoul metropolitan area where many kinds of land use and land cover types coexist. In this study, screen-level temperature data in non-precipitation day conditions observed from 29 automatic weather stations (AWS) in Seoul were analyzed to delineate the characteristics of UHI. For quality control of the data, gap test, limit test, and step test based on guideline of World Meteorological Organization were conducted. After classifying all stations by their own local climatological properties, UHI intensity and diurnal temperature range (DTR) are calculated, and then their seasonal patterns are discussed. Maximum UHI intensity was $4.3^{\circ}C$ in autumn and minimum was $3.6^{\circ}C$ in spring. Maximum DTR appeared in autumn as $3.8^{\circ}C$, but minimum was $2.3^{\circ}C$ in summer. UHI intensity and DTR showed large variations with different local climate zones. Despite limited information on accuracy and exposure errors of the automatic weather stations, the observed data from AWS network represented theoretical UHI intensities with difference local climate zone in Seoul.

• Journal of Forest and Environmental Science
• /
• v.34 no.3
• /
• pp.199-208
• /
• 2018

Quercus floribunda (Tilonj oak) is among the five species of Quercus and an evergreen tree found in Kumaun Himalayan region. Timing of germination is a crucial event determining the success of seedling establishment and survival. The aims of the study were to investigate the effect of sowing date on the germination and morphological responses of Tilonj oak (Quercus floribunda), cultivated during the month of August-September, with supplementary irrigation. The experiment was conducted by sowing seeds at two dates with one month interval in glass house conditions at DSB Campus, Nainital, Uttarakhand, India. Present study revealed that higher germination percentage (46.67 %) was recorded at sowing time $S_2$ as compared to the sowing time $S_1$ (32.86 %). Germination percentage as well as seedling growth were affected by sowing date though the differences were insignificant. At both the sowing dates, highest germination percentage was recorded for large seeds (32.86-46.67 %) followed by medium (31.43-33.33 %) and lowest germination (6.67-7.14 %) was recorded for small size seeds. In all parameters assessed, sowing time $S_2$ had the best performance in combination with large seed size. Thus, September is suitable month for best germination, growth and seedling vigour and large seed size is recommended to silviculturists and tree planters. The information on seed germination and seedling growth is vital both for conservation and rehabilitation of degraded lands.

• Journal of Korean Society of Occupational and Environmental Hygiene
• /
• v.4 no.1
• /
• pp.117-126
• /
• 1994

Some of the important and vital roles performed by the Health Care Center of Pohang Iron & Steel Co., Ltd.(POSCO) are the periodic monitoring of the work sites as well as regular medical check-ups for each workers to ensure both pleasant and safe working conditions and to protect employees' health. Pohang Steel Works, which has 42 plants, 26 facilities and 12,000 employees, has an annual crude steel production capacity of 9,670,000 using 24,500,000 ton of raw materials. We have measured lots of areal and personal working environment according to Occupational Safety and Health Law semiannually. All data collected on industrial hygiene is stored and managed by personal computer. The developed of a computerized industrial hygiene control system linked to the company's main computer system will provide efficient evaluation of the working environment as well as critical informations on employees' health. Development of this system had begun in May, 1992 and was completed in March, 1994. The computerized industrial hygiene control system can; 1. store industrial hygiene data, providing key pertinent to the diagnosis of occupational related illnesses, and if necessary, the basis for improving the working environment, 2. decide type and time of medical examination of each work for exposure to specific agents, and supply proper protection periodically, 3. prevent occupational related illnesses through evaluation of environmental and biological monitoring, and performance of epidemiological surveillance, 4. facilitate proper job placement through linking of industrial hygiene control and personnel information systems, 5. monitor job processes. levels of chemical agents used, and new agents introduced, 6. and increase productivity by saving time resulting from the implementation of the computerized sysyte,

• Journal of Oriental Neuropsychiatry
• /
• v.29 no.1
• /
• pp.21-34
• /
• 2018

Objectives: The purpose of this study is to understand the theories about the psychophysiology and psychopathology of Korean Medicine. Methods: The concepts and functions of spirit (神), soul (魂魄), five spirits (五神), and seven emotions (七情) occurring in the Huangdineijing have been interpreted, and the correlation between thought and emotion considered. Results and Conclusions: (1) Spirit (神) refers to the source and discipline of vital activity and mental activity. (2) With soul (魂魄), ethereal soul (魂) manifests itself as the mental process, and corporeal soul (魄) as the physical sensory interaction, such as the nervous system. (3) In the five spirits, ethereal soul (魂) is the recognition process of drawing out memories. Spirit (神) is the process of creative thought. Cognition (意) is the ability to recognize and integrate information. Corporeal soul (魄) is the process of selecting what is important and choosing it. Will (志) is the process of storing memories. Ethereal soul (魂) and corporeal soul (魄) of the five spirits (五神) and soul (魂魄) use the same characters, but the meaning differs. Also, spirit (神) and the spirit (神) in five spirits (五神) are the same character, but, because the meaning is different, they need to be interpreted according to the context. (4) Heart (心), Cognition (意), Will (志), Thought (思), Consideration (慮), and Wisdom(智) are all cognitive processes, like perception, recognition, and thinking. (5) Psychopathology is when excessive emotion affects the five viscera, harming the Energy (氣) and Blood (血) and eventually affecting the five spirits, which causes problems in thinking. Therefore, for healthy mental functioning, not only must the emotions be regulated so that they do not become excessive, but the five viscera also need to be kept healthy.

• Journal of the Institute of Electronics Engineers of Korea SD
• /
• v.47 no.1
• /
• pp.79-85
• /
• 2010

In video standards such as H.264/AVC, motion estimation (ME) / compensation (MC) is regarded as a vital component in a video coder as it consumes a large amount of computation resources. The full search technique, which is used in general video codecs, gives the highest visual quality but also has the problem of significant computational load. To solve this problem, many fast algorithm has benn proposed. Among them, NPDS show that can maintain its video quality very close to the full search technique while achieving computation reduction by using a halfway-stop technique in the calculation of block distortion measure. In this paper, we proposed algorithm by determining minimum distortion measure with predictive motion vector and using the new search order. As the result, we can check that the proposed algorithm reduces the computational load 95% in average compared to the full search, respectively with the PSNR lost about 0.04dB.