• Asian Pacific Journal of Cancer Prevention
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• v.14 no.11
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• pp.6351-6356
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• 2013

Background: Goshajinkigan (GJG) is used for the treatment of several neurological symptoms. We investigated the efficacy of GJG and mecobalamin (B12) against neurotoxicity associated with docetaxel (DOC) in breast cancer patients. Materials and Methods: Sixty breast cancer patients were treated with DOC. Thirty-three patients (GJG group) received oral administration of 7.5 g/day GJG and 27 patients (B12 group) received oral administration of 1500 ${\mu}g/day$ B12. Neuropathy was evaluated according to DEB-NTC (Neurotoxicity Criteria of Debiopharm), Common Terminology Criteria for Adverse Events (NCI-CTC) ver. 3.0, and a visual analogue scale (VAS). This study employed a randomized open design. Results: The incidence of neuropathy was 39.3% in the GJG group, and 88.9% in the B12 group (p<0.01). In the GJG group, grade 1 DEB-NTC was observed in 2 cases, grade 2 in 5 cases and grade 3 in 5 cases. Grade 1 NCI-CTC was observed in 7 cases, grade 2 in 6 cases, and VAS was $2.7{\pm}2.2$. In the B12 group, grades 1, 2 and 3 DEB-NTC were observed in one case, 12 cases and 12 cases, respectively; and grades 1, 2 and 3 NCI-CTC were observed in 11 cases, 12 cases and one case, and VAS was $4.9{\pm}2.4$. Conclusions: Concomitant administration of GJG is useful in preventing neuropathy in breast cancer patients treated with a DOC regimen.

• Transactions of the Korean Society of Automotive Engineers
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• v.14 no.2
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• pp.158-165
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• 2006

In this paper, a new uni-axial bushing model for vehicle dynamics analysis is proposed. Bushing components of a vehicle suspension system are tested to capture the nonlinear and hysteric behavior of the typical rubber bushing elements using the MTS machine. The results of the tests are used to develop the Bouc-Wen bushing model. The Bouc-Wen model is employed to represent the hysteretic characteristics of the bushing. ADAMS program is used for the identification process and VisualDOC program is also used to find the optimal coefficients of the model. Genetic algorithm is employed to carry out the optimal design. A numerical example is suggested to verify the performance of the proposed model.

• Proceedings of the Korean Society for Technology of Plasticity Conference
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• 2007.10a
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• pp.262-265
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• 2007

Cooling circuit of injection mold affects part quality and cycle time of injection molding process. Examination on mold cooling circuit is usually omitted in part design stage because cooling circuit is designed in the mold design stage. It is desirable to examine mold cooling circuit with respect to part quality in the part design stage. In order to make the examination process convenient and fast, cooling circuit design should be automated without intervention of skilled designer. In this study, optimization of cooling circuit design is automated with commercial softwares; Visual DOC and Moldflow MPI. Effect of initial value for optimization is examined for the optimization result.

• Korean Journal of Computational Design and Engineering
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• v.9 no.2
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• pp.93-101
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• 2004

In mechanical design, optimization procedures have mostly been implemented solely by CAE codes combined by optimization routine, in which the model is built, analyzed and optimized. In the complex geometries, however, CAD is indispensable tool for the efficient and accurate modeling. This paper presents a method to carry out optimization, in which CAD and CAE are used for modeling and analysis respectively and integrated in an optimization routine. Application Programming Interface (API) function is exploited to automate CAD modeling, which enables direct access to CAD. The advantage of this method is that the user can create very complex object in Parametric and automated way, which is impossible in CAE codes. Unigraphics and ANSYS are adopted as CAD and CAE tools. In ANSYS, automated analysis is done using codes made by a script language, APDL(ANSYS Parametric Design Language). Optimization is conducted by VisualDOC and IDESIGN respectively. As an illustrative example, a mold design problem is studied, which is to minimize temperature deviation over a diagonal line of the surface of the mold in contact with hot glass.

• Transactions of the Korean Society of Automotive Engineers
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• v.14 no.6
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• pp.143-150
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• 2006

In this paper, a new bushing model for vehicle dynamics analysis using Bouc-Wen hysteretic model is proposed. Bushing components of a vehicle suspension system are tested to capture the nonlinear behavior of rubber bushing elements using the MTS 3-axes rubber test machine. The results of the tests are used to define parameters in Bouc-Wen bushing model, which was employed to represent the hysteretic characteristics of the bushing. Bushing parameters are obtained by using genetic algorithms and sensitivity analysis of parameters are also carried out. ADAMS program was used for the identification process and VisualDOC program was employed to find the optimal parameters. A half-car simulation was carried out to show the usefulness of the developed bushing model.

• Korean Journal of Computational Design and Engineering
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• v.11 no.2
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• pp.128-137
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• 2006

In this paper, a CAD/CAE integrated optimal design system is developed, in which design and analysis process is automated using CAD/CAE softwares for a complex model in which the modeling by parametric feature is not easy to apply. Unigraphics is used for CAD modeling, in which the process is automated by using UG/Knowledge Fusion for modeling itself and UG/Open API function for the other functions respectively. Structural analyses are also carried out automatically by ANSYS using the imported parasolid model. The developed system is applied for the PLS(Plasma Lighting System) consisting of more than 20 components, which is a next generation illumination system that is used to illuminate stadium or outdoor advertizing panel. The analyses include responses by static, wind and impact loads. As a result of analyses, tilt assembly, which is a link between upper and lower body, is found to be the most critical component bearing higher stresses. Experiment is conducted using MTS to validate the analysis result. Optimization is carried out using the software Visual DOC for the tilt assembly to minimize material volume while maintaining allowable stress level. As a result of optimization, the maximum stress is reduced by 57% from the existing design, though the material volume has increased by 21%.

• Proceedings of the Computational Structural Engineering Institute Conference
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• 2005.04a
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• pp.55-62
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• 2005

In this paper, a CAB/CAE integrated optimal design system is developed, in which design and analysis process is automated using CAD/CAE softwares, for a complicated model for which parametric modeling provided by CAD software is not possible. CAD modeling process is automated by using UG/OPEN API function and UG/Knowledge Fusion provided by Unigraphics. The generated model is transferred to the analysis code ANSYS in parasolid format. Visual DOC software is used for optimization. The system is developed for PLS(Plasma Lighting System), which is a next generation illumination system that is used to illuminate stadium or outdoor advertizing panel. The PLS system consists of more then 20 components, which requires a lot of human efforts in modeling and analysis. The analysis for PLS includes static load, wind load and impact load analysis. As a result of analysis, it is found that the most critical component is a tilt assembly, which links lower & upper body assembly. For more reliable analysis, experiment is conducted using MTS and compared with the Finite element analysis result. The objective in the optimization is to minimize the material volume under allowable stresses. The design variables are three parameters in the tilt assembly that are chosen to be the most sensitive in stress values of twelve parameters. Gradient based method and RSM(Response Surface Method) are used for the algorithm and the results are compared. As a result of optimization, the maximum stress is reduced by 57%.

• Proceedings of the KSME Conference
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• 2003.11a
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• pp.1340-1345
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• 2003

In this paper, an integrated optimal design software system for structural components has been developed which interfaces existing commercial codes for CAD, CAE and Optimization. They include specialized optimal design software codes such as iSIGHT and VisualDOC, optimization module imbedded in CAD software developed by CAD developers, and optimal design software systems based on API of commercial CAD software. The advantages of the CAD imbedded optimal design approach and those of specialized optimal design software are taken to develop the system. The user defines optimal design formulation in the user interface for problem definition in the CAD control stage, where design variables are directly selectable from the CAD model and various properties and performance functions defined. The commercial CAD codes, Open I-DEAS are used for the development. The resulting software is minimally connected to CAD and CAE systems while keeping maximum independence from each other. This assures flexibility and freedom for problem definition. Fatigue life optimization is taken as a nontrivial application area. As a specific example, the shape design of a knuckle part of an automobile is performed, where the minimum fatigue life over the material domain in terms of the number of cycles of a curb strike are maximized under the constraint of not exceeding the current mass. The fatigue life has been improved by four times of the initial life. The developed software is illustrated to maintain the advantages of existing optimal design software systems while improving independency and flexibility.

• Korean Journal of Environmental Biology
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• v.19 no.1
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• pp.59-69
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• 2001

Among the biodegradability tests, TOC-HANDAI and OECD method were utilized to examine the degree of biodegradation of endocrine disruptors, Bisphenol A (BPA) and Nonylphenol. Both methods used natural water microcosms and measured their biodegrada-bilities of BPA and Nonylphenol, in terms of TOC or DOC degradation with time for 28 days. Biodegradabilities for BPA, 73-78% with TOC-HANDAI method and 77-81% with OECD method were obtained respectively at the end of experiment. There was no difference in BPA degradation between two methods. BPA degradation was described by two distinct first order decay rates (k$_1$ and k$_2$) which could be separated by a simple visual fitting. Most of the initial decay reaction accelerated within 1-7 days with k$_1$of 0.24-0.34 $day^{-1}$. And the following another long term first order decay coefficient (k$_2$) showed 0.02-0.05 day$^{-1}$ with much flat slope. About 20-25% of initial BPA remained at the end of experiment. It suggests that the remaining TOC components in BPA biodegradation considered to be refractory metabolites of BPA. Nonylphenol at each sampling point was appeared to be mineralized 20-48% of initial TOC concentration. Consequently Nonylphenol seems more recalcitrant against biodegradation. BPA was not detected in the detection limit of ppb in the watershed of Daechung reservoir and Kum river. However 25 ppb concentration of BPA was detected at the influent of industrial wastewater treatment plant in Taejon.

• Journal of Applied Biological Chemistry
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• v.58 no.1
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• pp.39-50
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• 2015

Stabilization of heavy metals such as Pb, Cd, Zn, and Cu was evaluated in contaminated soil treated with poultry manure (PM) as well as its biochars pyrolyzed at $300^{\circ}C$ (PBC300) and $700^{\circ}C$ (PBC700) at the application rates of 2.5, 5.0, and 10.0 wt% along with the control, prior to 21-days incubation. After incubation, soil pH was increased from 6.94 (control) to 7.51, 7.24, and 7.88 in soils treated with PM 10 wt%, PBC300 10 wt%, and PBC700 10 wt% treatments, respectively, mainly due to alkalinity of treatments. In the soil treated with PM, the concentrations of the toxicity characteristic leaching procedure (TCLP)-extractable Pb, Cd, Zn, and Cu were increased by up to 408, 77, 24, and 955%, respectively, compared to the control. These increases may possibly be associated with an increased dissolved organic carbon concentration by the PM addition. However, in the soil treated with PBC700, TCLP-extractable Pb, Cd, Zn, and Cu concentrations were reduced by up to 23, 38, 52, and 36%, respectively, compared to the control. Thermodynamic modelling using the visual MINTEQ was done to predict the precipitations of $Pb(OH)_2$, $Cu(OH)_2$ and P-containing minerals, such as chloropyromorphite [$Pb_5(PO_4)_3Cl$] and hydroxypyromorphite [$Pb_5(PO_4)_3OH$], in the PBC700 10 wt% treated soil. The SEM-elemental dot mapping analysis further confirmed the presence of Pb-phosphate species via dot mapping of PBC700 treated soil. These results indicate that the reduction of Pb concentration in the PBC700 treated soil is related to the formations of chloropyromorphite and hydroxypyromorphite which have very low solubility.