• 대한한방내과학회지
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• 제43권4호
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• pp.769-778
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• 2022

Objectives: The purpose of this study was to report the effectiveness of Korean medicine in the treatment of persistent postural-perceptual dizziness. Methods: A patient with dizziness was treated with Banhabackchulchunma-tang and Gongjin-dan herbal medicines. The severity of symptoms was assessed with a daily visual analog scale (VAS) for dizziness and the frequency of subjective trembling feelings (over 30 minutes). Results: After the treatment, the severity of dizziness was reduced from VAS 5 to VAS 2, and fatigue was improved from VAS 5 to VAS 1. The frequency of subjective trembling feelings was reduced from once every 3-4 days to once every 10 days. Other symptoms, such as dyspepsia, sleep disturbance, and hot flashes, also showed improvement. Conclusion: Treatment with Korean medicine may be an effective option for the treatment of persistent postural-perceptual dizziness.

• Journal of Korean Neurosurgical Society
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• 제65권5호
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• pp.719-729
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• 2022

Objective : The ossification of the ligamentum flavum (OLF) is one of the major causes of thoracic myelopathy. Surgical decompression with or without instrumented fusion is the mainstay of treatment. However, few studies have reported on the added effect of instrumented fusion. The objective of this study was to compare clinical and radiological outcomes between surgical decompression without instrumented fusion (D-group) and that with instrumented fusion (F-group). Methods : A retrospective review was performed on 28 patients (D-group, n=17; F-group, n=11) with thoracic myelopathy due to OLF. The clinical parameters compared included scores of the Japanese Orthopedic Association (JOA), the Visual analogue scale of the back and leg (VAS-B and VAS-L), and the Korean version of the Oswestry disability index (K-ODI). Radiological parameters included the sagittal vertical axis (SVA), the pelvic tilt (PT), the sacral slope (SS), the thoracic kyphosis angle (TKA), the segmental kyphosis angle (SKA) at the operated level, and the lumbar lordosis angle (LLA; a negative value implying lordosis). These parameters were measured preoperatively, 1 year postoperatively, and 2 years postoperatively, and were compared with a linear mixed model. Results : After surgery, all clinical parameters were significantly improved in both groups, while VAS-L was more improved in the F-group than in the D-group (-3.4±2.5 vs. -1.3±2.2, p=0.008). Radiological outcomes were significantly different in terms of changes in TKA, SKA, and LLA. Changes in TKA, SKA, and LLA were 2.3°±4.7°, -0.1°±1.4°, and -1.3°±5.6° in the F-group, which were significantly lower than 6.8°±6.1°, 3.0°±2.8°, and 2.2°±5.3° in the D-group, respectively (p=0.013, p<0.0001, and p=0.037). Symptomatic recurrence of OLF occurred in one patient of the D-group at postoperative 24 months. Conclusion : Clinical improvement was achieved after decompression surgery for OLF regardless of whether instrumented fusion was added. However, adding instrumented fusion resulted in better outcomes in terms of lessening the progression of local and regional kyphosis and improving leg pain. Decompression with instrumented fusion may be a better surgical option for thoracic OLF.

• 대한한방내과학회지
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• 제43권3호
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• pp.396-412
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• 2022

Objective: The aim of this study was to identify the clinical features of post-acute COVID-19 syndrome and the efficacy and safety of Korean medicine treatment. Methods: This study was conducted on 15 patients with post-acute COVID-19 syndrome who visited the outpatient Allergy, Immune, and Respiratory System Department at Kyung Hee University Korean Medicine Hospital from January 10, 2021 to April 10, 2022. We retrospectively analyzed the charts of 15 patients and collected clinical characteristics, Korean medicine treatments, outcome variables (Numeral Rating Scale (NRS), modified Medical Research Council scale (mMRC), Leicester Cough Questionnaire (LCQ), Quality of Life Visual Analog Scale (QOL-VAS), The Post-COVID-19 Functional Status (PCFS)), adverse events, etc. Results: Of the 15 patients, seven (46.7%) were men, and the average age of all patients was 49.7±13 years. The most common symptom was cough (n=9, 60%), and it was followed by dyspnea or increased respiratory effort, fatigue, insomnia, anosmia, etc. The herbal medicine was prescribed for all 15 patients, and Saengmaek-san (n=8, 53.5%) was the most prescribed. Additionally, acupuncture and cupping were performed in four patients (26.7%) each, and electroacupuncture was applied to one patient (6.7%). As a result of Korean medicine treatment, NRS, mMRC, LCQ, QOL-VAS, and PCFS showed improvement, and adverse events were mild. Conclusions: This study presented the clinical features of post-acute COVID-19 syndrome and suggested that Korean medicine treatment may be effective in alleviating related symptoms and enhancing quality of life.

• 한국컴퓨터정보학회논문지
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• 제27권8호
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• pp.161-168
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• 2022

본 연구에서는 20대 경도비만 남성을 대상으로 시판 남성용 상체 보정속옷에 대한 착용만족도를 알아보고 개선점을 파악하고자 하였다. 피험자는 20대 남성이면서 BMI지수가 25~30인 (경도비만)인 사람으로 15명을 선정했다. 연구 결과, 남성들의 보정속옷에 대한 인지도와 관심도는 낮은 편이었다. 착용 만족도 조사에서는 입고 벗을 때 불편하다고 부정적으로 답한 사람이 많았다. 압박감면에서는 초반에는 압박감이 강하다고 느끼지만 시간이 지날수록 익숙진다고 하였다. 답답함과 더위와 관련하여 부정적으로 응답한 사람이 과반을 넘었고 땀 흡수 및 배출과 관련해서도 부정적인 의견이 많았다. 시각적인 부문에서는 가슴 보정, 허리 옆부분 보정, 허리 앞부분에서 모두 긍정적인 반응을 보였다. 결론적으로, 남성용 상체 보정속옷의 개선점은 과한 압박감이 가져다주는 답답함과 소화불량, 여름철을 고려하여 더위와 땀과 관련한 기능성 부분인 것으로 나타났다.

• 문화기술의 융합
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• 제8권6호
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• pp.667-674
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• 2022

침목플로팅궤도(STEDEF)의 콘크리트침목은 2개의 콘크리트블럭을 타이바로 연결하여 구성된 형태이며 침목방진패드 및 침목상자와 도상 콘크리트층에 매립되어 레일로 전달되는 열차하중을 지지하고 하중을 도상으로 분산시키는 역할을 수행하는 주요 궤도구성품이다. 침목방진패드는 열차의 반복운행에 따른 누적하중 증가, 장기간 사용에 따른 열화로 인해 재료적 성능이 저하되어 다른 궤도구성품의 손상을 유발할 수 있다. 실제 형상과 동일한 3D 모델링으로 운행하중 조건에서 발생되는 침목플로팅궤도구조의 거동을 파악하고, 수치해석을 통해 침목방진패드의 스프링강성 변화가 콘크리트침목의 손상에 미치는 영향을 분석하였다. 분석결과, 침목방진패드의 좌·우측 스프링강성 증가는 콘크리트침목의 최대 응력 및 인장응력, 변위는 증가하고 레일 직하부 침목의 최대 압축응력은 감소하며, 타이바접촉부 콘크리트에서 응력집중이 되는 것으로 분석되었다. 이는 현장조사결과의 콘크리트침목 손상유형과도 일치하는 것으로서 침목방진패드의 장기간 사용에 따른 스프링강성 변화는 콘크리트침목의 응력 증가를 초래할 수 있으며, 좌우 침목의 침하량의 차이가 증가되어 콘크리트침목의 손상에 영향을 미칠 수 있음을 해석적으로 입증하였다.

• Clinics in Shoulder and Elbow
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• 제24권4호
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• pp.231-238
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• 2021

Background: Extensor muscle strengthening exercises with counterforce braces (EX) is a conventional conservative treatment for lateral epicondylitis (LE) of the elbow. In addition, polydeoxyribonucleotide (PDRN) or extracorporeal shockwave therapy (ESWT) has been recently used for LE. Methods: Sixty-three patients with chronic LE participated in this study and randomly allocated in three groups (G1: EX, G2: EX+PDRN injection, and G3: EX+ESWT). All of the three groups were taught to perform EX at the first out-patient department (OPD) visit. Group 2 was injected with 3 mL PDRN (5.625 mg/3 mL), while group 3 received ESWT at the first OPD visit. Visual analog scale pain score, Mayo elbow performance score (MEPS), and ultrasonographic examination were checked before, 6 weeks, and 12 weeks after the treatments. Results: Overall functional scores and ultrasonographic findings in all three groups improved after treatment. The mean MEPS in group 2 improved more than groups 1 and 3 at 6 weeks (G1, 56.9>62.4; G2, 54.3>65.0; G3, 55.7>62.6), and more than group 1 at 12 weeks (G1, 56.9>67.9; G2, 54.3>73.6). The mean common extensor tendon depth (CETD) on ultrasonography in group 2 increased more than groups 1 and 3 at 6 and 12 weeks (6 weeks: G1, 0.385>0.386; G2, 0.332>0.392; G3, 0.334>0.357; 12 weeks: G1, 0.385>0.409; G2, 0.332>0.438; G3, 0.334>0.405 [cm]). Conclusions: PDRN injections combined with EX exhibited a greater improvement in mean MEPS and mean CETD compared to EX only or EX combined with ESWT for LE within the 12 weeks follow-up.

• 해양환경안전학회지
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• 제28권4호
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• pp.515-524
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• 2022

해상교통정보의 수집, 관리 및 공유를 개선하기 위해서는 해상교통정보 관련 기술 동향 파악 및 해상교통정보의 현황·문제점 분석이 우선되어야 한다. 따라서 본 연구에서는 먼저 해상교통정보의 국내외 기술 동향을 조사하였으며 국내 해상교통정보의 수집·관리·공유에 대한 현황·문제점을 분석하여 정리하였다. 자료를 토대로 문제점을 분석한 결과 우선 수집단계의 문제점은 주로 LTE 통신권을 벗어나는 원거리 RADAR·CCTV·카메라 영상정보 수집의 어려움으로 나타났으며 이로 인해 EEZ를 거쳐 영해로 진입하는 밀입국 선박 등의 조기 탐지가 어려운 것으로 나타났다. 그리고 관리단계의 문제점은 대부분 해상교통시스템이 자체 구축한 물리 저장 공간을 사용함으로써 저장 공간의 유연성 부족으로 인해 편리한 축소·확대가 어렵고 시스템 장애 발생 시 대비책으로 시스템 이중화·백업 등이 힘든 상황이다. 또한 공유단계의 문제점은 대부분 해상교통정보 공유시 주로 내부망을 사용하고 있는 현황상 운영기관 외부로의 정보 공유가 어려운 것으로 나타났으며 LRIT·SASS와 같이 정부 클라우드를 통해 정보 공유가 되고 있다고 하여도 정부 클라우드의 특성상 해양 빅데이터 등을 효과적으로 활용할 수 있는 다양한 애플리케이션의 제공이 원활히 되고 있지 않은 상황이다. 이러한 문제점들을 개선하기 위해 우선 수집단계의 경우 무인기·위성 등 수집장비의 추가 구축을 제시함으로써 수집구역을 확장하였고 관리·공유단계는 각 해상교통시스템의 운영 주체·정보 공개성을 고려한 민간 클라우드 도입 및 구축형태를 제시함으로써 클라우드 도입 시 전문성·보안성 향상을 기대하였다.

• 대한본초학회지
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• 제38권2호
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• pp.1-7
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• 2023

Objectives : From this study, we sight to identify Anti-stress effect of Chenwangbosim-Dan (Tianwangbuxin-Dan) Extract∘Fermented Rice Extract (GABA : gamma-aminobutyric acid 30%) Complex Methods : In order to measure the degree of functional evaluation of tension relief due to stress, it was evaluated whether the psychological indicators VAS(Visual Analog Scale) and POMS(Profile Of Mood State) were improved. Which is generally used for stress measurement and has a high frequency of clinical use. All clinical trial subjects were required to take the drug once a day at 9 ± 30 min in the morning for 2 weeks. Results : After intake, the group that Chenwangbosim-Dan(Tianwangbuxin-Dan) Extract∘Fermented Rice Extract (GABA : gamma-aminobutyric acid 30%) Complex had a statistically significant improvement effect compared to before intake due to an improved 30.81% of the VAS scores. The POMS-T score improved 54.13%, the POMS-V score improved 117.5% and the POMS-F score improved 59%, which had a statistically significant effect compared to Placebo group (p<0.001). There is a significant difference between two group, so even considering the placebo effect, the anti stress effect was confirmed in the Chenwangbosim-Dan (Tianwangbuxin-Dan) Extract∘Fermented Rice Extract (GABA : gamma-aminobutyric acid 30%) Complex intake group. Conclusions : The above results showed that the Chenwangbosim-Dan(Tianwangbuxin-Dan) Extract∘Fermented Rice Extract (GABA : gamma-aminobutyric acid 30%) Complex had an anti-stress effect. Therefore, it is expected to be developed as a safe and comfortable mental care health functional food that can reduce the risk of drug abuse.

• 한국농촌건축학회논문집
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• 제25권2호
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• pp.1-8
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• 2023

This study reveals the absence of standard design guidelines by region through investigation and analysis centered on public design cases by region in Jeollabuk-do and design elements that can reflect the integration, identity, and diversity of public design in each region by five regions. Through this, the following conclusions could be obtained. First, to improve the quality of street facilities in Jeollabuk-do, the design elements (design motif, color, pattern) applicable to the standard design were analyzed by dividing them into five regions. As a design motif, it was possible to extract patterns containing straight lines, sophistication, dignity, and smartness. In the Northeast region, it is comfortable with the motif of the mountain ridge reflecting geographical characteristics, and it can be extracted elements that contain warm and natural colors. In the southeastern region, patterns that reflect design elements were extracted by applying safe, lively, and peaceful colors with the design motif of curves that blend nature and agriculture. In the southwestern region, design pattern elements that highlight nature, history, and culture were extracted with various cultural assets and natural greenery as motifs. Lastly, in the Saemangeum region, the ocean flow and greenery could be used as a design motif to reflect a positive, clear, future-oriented image in the design spot zones by region. Second, based on the standard design elements (design motive, color, pattern) by region extracted for the standard design development of street facilities in each region in Jeollabuk-do, an integrated zone(Form, structure, material, color, functional element) to which regional design guidelines can be applied. Third, an integrated zone (form, structure, material, color, functional elements) was composed. In addition, design spot zones (patterns and colors in city and county units) that can contain the diversity and identity of each region were designated. By designating design spot zones (patterns and colors in city and county units) that can contain the diversity and identity of each region, standard design development plans (integrated pillars, jaywalking prevention fences, roundabouts (urban type, rural type), street trees) Eight standard designs, including protective covers, street planters, flat benches, light benches, visual media for user guidance, and parking zones for personal mobile devices) were presented.

• 한국가축번식학회지
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• 제9권2호
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• pp.133-139
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• 1985

An immunoassay may be defined as an analytical procedure involving the competitive reaction between a limiting concentration of specific antibody and two populations of antigen, one of which is labelled or immobillized. The advent of immunoassay has revolutionised our knowledge of reproductive physiology and the practice of veterinary and clinical medicine. Radioimmunoassay (RIA) was the first of these methods to be developed, which meausred the analyte with good sensitivity, accuracy and precision (1,2). The essential components of RIA are:-(i) a limited concentration of antibodies, (ii) a reference preparation, and (iii) an antigen labelled with a radioisotope (usually tritium or iodine-125). Most procedures invelove isolating the antibody-bound fraction and measuring the amount of labelled antigen. Good facilities are available for scintilltion counting, data reduction nd statistical analysis. RIA is undergoing refinement through:-(i) the introduction of new techniques to separate the antibody-bound and free fractions which minimize the misclassification of labelled antigen into these compartments, and the amount of non-specfic binding. (3), (ii) the development of non-extration for the measurement of haptens (4), (iii) the determination of a, pp.rent free (i.e. non-protein bound) analytes (5), and (iv) the use of monoclonal antibodies(6). In 1968, Miles and Hales introduced in important new type of immunoassay which they termed immunora-diometric assay (IRMA) based on t도 use of isotopically labelled specific antibodies(7) in a move from limited to excess reagent systems. The concept of two-site IRMAs (with a capture antibody on a solid-phase, and a second labelled antibody to a different antigenic determinant of the analyte) has enabled the development of more sensitive and less-time consuming methods for the measurement of protein hormones ovar wide concentration of analyte (8). The increasing use of isotopic methos for diverse a, pp.ications has exposed several problems. For example, the radioactive half-life and radiolysis of the labelled reagent limits assay sensitivity and imposes a time limit on the usefulness of a kit. In addition, the potential health hazards associated with the use and disposal of radioactive cmpounds and the solvents and photofluors necessary for liquid scientillation counting are incompatable with the development of extra-laboratory tests. To date, the most practical alternative labels to radioisotopes, for the measurement of analytes in a concentration > 1 ng/ml, are erythrocytes, polystyrene particiles, gold sols, dyes and enzymes or cofactors with a visual or colorimetric end-point(9). Increased sensitivity to<1 pg/ml may be obtained with fluorescent and chemiluminescent labels, or enzymes with a fluorometric, chemiluminometric or bioluminometric end-point. The sensitivity of any immunoassay or immunometric assay depends on the affinity of the antibody-antigen reaction, the specific activity of the label, the precision with which the reagents are manipulated and the nonspecific background signal (10). The sensitivity of a limited reagent system for the measurement of haptens or proteins is mainly dependent upon the affinity of the antibodies and the smalleest amount of reagent that may be manipulated. Consequently, it is difficult in practice to improve on the sensitivity obtained with iodine-125 as the label. Conversely, with excess reagent systems for the measurement of proteins it is theoretically possible to increase assay sensitivity at least 1000 fold with alternative luminescent labels. To date, a 10-fold improvement has been achieved, and attempts are being made to reduce the influence of other variables on the specific signal from the immunoreaction.