• 한방안이비인후피부과학회지
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• 제25권3호
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• pp.97-112
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• 2012

Objectives : The purpose of this study were to evaluate the effects of oriental medical therapy on obesity and different effects according to Body Mass Index(BMI), menopause, obesity treatment experience, age, treatment period in patients. Methods : 46 patients were treated from November 2011 to April 2012 in Oriental Obesity Center, Dong-eui Medical Center. They were measured change of body compositions by bioelectrical impedance analysis every 2~3 weeks and 27 patients out of 46 were checked body compositions every 2 weeks. 46 and 27 patients were divided into two or three groups according to BMI, menopause, obesity treatment experience, age, treatment period. We compared before and after treatment body compositions. Results : Body compositions, except edema index were significantly reduced. Abdominal Visceral Fat(AVF) was significantly reduced in Obese group. Body Weight(BW), BMI, Body Fat(BF), Body Fat Percetage(BFP), Abdominal Visceral Fat Level(AVFL), Abdominal Visceral Fat(AVF), Abdominal Subcutaneous Fat(ASF) were significantly reduced in non-menopause group(43 female patients). But in 26 female patients out of 27, there were no significantly differences between groups in menopause. There were no significantly differences between groups in obesity treatment experience. But in 27 patients, BMI and AVF were significantly reduced in non-experience group and AVFL was significantly reduced in experience group. BW, BMI, BF, BFP, VAF, ASF were significantly reduced in younger age group. But in 27 patients, BW and Muscle were significantly reduced in younger age group. BMI, BF, BFP, Edema, AFVL, Abdominal Visceral Fat Area(AVFA), AVF, ASF were significantly reduced in longer treatment period group. Conclusion : The BF, BMI, BF, BFP, Muscle, AVFL, AVFA, AVF, ASF were almost decreased significantly. It resulted that the effects of oriental medical therapy in obesity was positive. And it was meaningful study to know about different effects between groups.

• Journal of Nutrition and Health
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• 제46권5호
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• pp.410-417
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• 2013

본 연구는 만 19~60세의 BMI $23kg/m^2$ 이상 여성 61명을 대상으로 12 주간 열량 섭취 제한 시 체중 감량에 영향을 미치는 요인을 분석하고 이들의 상관성을 알아보고자 하였다. 12주간의 열량 섭취 제한으로 하루 평균 451.9 kcal가 감소하였고 열량 제한 후 체중은 평균 4.5% 감소하였고, 내장지방량은 11.9%, 피하지방량은 8.2% 감소하였으며, 혈압도 유의하게 감소하였다 (p < 0.01). 혈액지표 중 GPT 농도는 감소하였으며 (p < 0.05), 아디포넥틴 농도는 증가하였다 (p < 0.01). 연령이 증가함에 따라 섭취 열량 감소량이 낮게 나타났다 (r = 0.31, p = 0.02). 젊은 연령에서 열량 섭취량 감소가 컸으며, 연령이 증가할수록 열량 섭취량 감소가 낮게 나타났다. 연령은 독립적으로 신체 조성 변화와 유의한 관련이 있었으며 (p < 0.05), 연령이 증가함에 따라 열량 섭취 제한에 따른 체중 및 내장지방과 피하지방의 감소량이 낮았으며, 특히, 내장지방 감소량이 낮게 나타났다 (p < 0.05). 또한, 연령이 증가함에 따라 열량 섭취 제한에 따른 렙틴 농도 감소량도 낮았다 (p < 0.05).

• Journal of Nutrition and Health
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• 제36권9호
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• pp.924-932
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• 2003

In middle-aged men, abdominal obesity has been an important risk factor of coronary artery disease (CAD) as well as a predictor of hypertension, dyslipidemia, insulin resistance and glucose intolerance. Particularly, risks from abdominal obesity increase when adipose tissue accumulates in visceral compartment. Many studies showed that weight reduction by caloric restriction improves abdominal obesity and reduces lots of cardiovascular risk factors. Testosterone treatment also results in a significant decrease in visceral fat area and normalizes endocrine metabolism. However there is no study that compare the effect of caloric restriction with that of testosterone treatment. The purpose of this study is to investigate the effect of caloric restriction and that of testosterone treatment on body fat distribution, serum lipids and glucose metabolism in male patients with CAD. Forty five middle-aged overweight-obese men with CAD participated in 12 weeks' program. They were matched with age, body weight, body mass index (BMI) and divided into three groups : control group (n = 15) , caloric restriction group (-300 kcal/day, n = 15) and testosterone treatment group (testosterone undecanoate tablets, n = 15) . After 12 weeks, control group did not have any changes in anthropometries, lipid profile, body fat distribution, glucose metabolism and hormonal status. Expectedly, caloric restriction group showed decreases in body weight, BMI, waist to hip ratio, ％ body fat. Ten percentage of total cholesterol and 23% of triglyceride in serum were also decreased. In body fat distribution, total fat areas at both L1 and L4 levels were significantly reduced in this group without reduction in muscle of thigh and calf. However, testosterone treatment group did not have any significant changes in body weight, ％ body fat, serum lipid profile and abdominal fat distribution. In conclusion, weight reduction by caloric restriction is more beneficial in body fat distribution and serum lipid level than testosterone treatment in overweight male patients with CAD. This result suggests that modest weight reduction is possible to help decrease risk factors of CAD.

• 한방재활의학과학회지
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• 제21권4호
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• pp.167-179
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• 2011

Objectives: In this study, we used with visceral fat area(VFA)/subcutaneous fat area(SFA) ratio(V/S ratio) and bioelectrical impedence analysis(BIA) for a comparative study between VFA measured from several abdominal computed tomography(CT) images and obesity indexes, such as body mass index(BM), waist circumference(WC), and waist-hip ratio(WHR). Methods: A group of 63 test subjects were gathered in the oriental medical hospital of Kyung-Won university. BIA for body composition and body size for obesity indexes were estimated to evaluate the obesity indexes. Pearson correlation coefficients and regression analysis were used to select useful obesity index. Results: The VFA-CT was significantly related to BMI, SFA, WC, hip circumference(HC), body fat mass(BFM), basal metabolic rate(BMR), and VFA-BIA. Especially, we found that the VFA-BIA and BMI were significantly correlated to VFA-CT. Conclusions: VFA-BIA index is an optimized index for diagnosis and evaluation of obesity. Finally, we found that the BMI is optimized to represent VFA.

• 운동영양학회지
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• 제13권1호
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• pp.59-67
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• 2009

Houttuynia Cordata Thunb, well known as "E-Sung Cho" in Korea, has been used for the treatment of herpes simplex, chronic sinusitis and nasal polyps. Recently, some studies reported the antileukemic activity, anticancer activity, adjuvanticity, and antioxidant action of Houttuynia Cordata Thunb. In the present study, the anti-obesity activity of Houttuynia Cordata Thunb was investigated. Middle-aged women were examined over a period of 8 weeks (n=30). Participants were divided into four group: Houttuynia Cordata Thunb Exercise (HCE, n=7), Placebo Exercise (PE, n=8), Houttuynia Cordata Thunb Non Exercise (HCNE, n=8), and Placebo Non Exercise (PNE, n=7). Participants in Houttuynia Cordata Thunb groups were received 4.5 g Houttuynia Cordata Thunb and in placebo groups were received same dose of placebo thrice daily with meals. The result after 8 weeks demonstrated that HCE significant decreased visceral fat than PNE. Our present study provides the evidence that Houttuynia Cordata Thunb intake and exercise performance may reduce visceral fat and further studies with larger numbers of subjects are warranted to conclusively demonstrate effectiveness.

• 한방재활의학과학회지
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• 제19권2호
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• pp.261-273
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• 2009

Objectives : This study was performed to figure out the effects of herbal mesotherapy on abdominal fat in obese women. Methods : Forty obese women those who were diagnosed abdominal obesity had been recruited during February, 2008. They were randomly assigned experimental or control group under block-randomization. Experimental group were treated with Sobi-eum(Xiaofei-yin) injection during 6 weeks (2 times a week) and placebo group were treated with normal saline injection under same procedures. Anthropometry, body impedance analysis, fat computed tomography, blood test, and questionnaires had been administered before and after the treatment. Results : Four subjects were dropped out (voluntary give up), so 18 in experimental group and 18 in placebo group were evaluated. There were significant changes after treatments in both groups. Although no significant differences have been found in the result of anthropometry, body impedance analysis and fat computed tomography between two groups, in the experimental group, the changes of total fat area had a highly significant relationship with all part of abdominal fat. While the placebo group had highly significant relationships with subcutaneous fat area, superficial and deep subcutaneous fat area but not with visceral fat area. Conclusions : Compaired with saline group, herbal mesotheraphy Sobi-eum(Xiaofei-yin) is effective in reduction of visceral fat after adjusting TFA.

• Journal of Nutrition and Health
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• 제36권5호
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• pp.446-451
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• 2003

The purpose of this study was to investigate the effects of wax gourd on weight, triglyceride, leptin and fat cell size in rats fed a high-fat diet. Male Sprague Dawley rats were fed an experimental diet containing total dietary fat at 40% of calories with wax gourd 0%, 5%, 10% and 15% (w/w) for 4 weeks. Weight gain and triglyceride level fell significantly in the 15% wax gourd group compared to the control group. Epididymal fat pad, abdominal fat and perirenal fat tended to decrease in the 15% wax gourd group. Leptin and free fatty acid level were not significantly different among the groups. Fat cell size significantly decreased in the 10% and 15% wax gourd groups compared to the control group. Weight gain correlated positively with visceral fat masses and the levels of leptin and triglyceride. Fat cell size significantly correlated with visceral fat and leptin level. Therefore, the 15% wax gourd diet substantially reduced weight, triglyceride and fat cell size. (Korean J Nutrition 36(5): 446∼451, 2003)

• 약학회지
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• 제50권3호
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• pp.160-165
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• 2006

Germanium is found in a range of minerals and ores and is present in foods including beans, tomato juice, oysters, tuna and garlic. Germanium is a non-metallic element, which can exist in valence states of 2 and 4. Clinical trials and use in private practices for more than a decade have demonstrated organic germanium's efficacy in treating serious disease including cancer, arthritis and senile osteoporosis. But it was rarely reported that inorganic germanium has biological properties. STB-BM contains mineral complex, rare earth elements and a little amount of Inorganic germanium. The experiment was carried out the anti-obesity effect. To investigate anti-obesity effect of STB-BM, we measured the effect of body weight, fat weight (subcutaneous fat, epididymal fat, visceral fat, kidney fat and total fat) and serum biochemical level in rats fed high fat diets. STB-BM 35 mg/kg suppressed the increasing ratio of body weight, epididymal fat weight, visceral fat weight, total fat weight, triglyceride and LDL-cholesterol (p<0.05).

• 약학회지
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• 제51권6호
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• pp.455-462
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• 2007

The participants were recruited 77 healthy adult persons aged between 20 and 50 who have BMI above $25kg/m^2$ in this study. All subjects were randomly assigned to the Gentro $F^{(R)}$ drinking group and non-drinking group. We were investigated about abdomen fat decreasing effect of Gentro $F^{(R)}$, distillate of pepper. Total fat area (TFA), subcutaeneous fat area (SFA) and visceral fat area (VFA) and subcutaneous fat area/visceral fat area ratio (SVR) has been assessed by obesity index (BMI, body fat percent, waist circumference), CT scan taken on the $L4{\sim}5$ position, umbilicus level and blood analysis evaluated during 3 month. The obesity indexes were a little decreased in two groups. However, the waist circumference (WC) was decreased about 5% in drinking group after 3 month and there was significant difference in the change 2 and 3 between two group. TFA and VFA were significantly decreased in the drinking group compare to the non-drinking group (p<0.05) and in umbilicus and $L4{\sim}5$ position, were $370.33{\pm}92.30,\;380.35{\pm}97.64\;and\;114.90{\pm}44.91,\;101.99{\pm}41.24$, respectively. These result means that Gentro $F^{(R)}$ is effective on abdomen fat decreasing. Total cholesterol were decreased without difference in both groups. Lipid factors (TG, HDL- and LDL-cholesterol) were decreased without significance. The mea surement of SVR taken on the $L4{\sim}5$ position were more significantly correlated with obesity index that BMI was 0.787, body fat percentage was 0.754 than on the umbilicus level. The TFA and VSA was correlated with ALP, ASP, Albumin, Insulin and the SVR was correlated with the indexes of liver function and lipid factor found in the blood. Therefore, it is conclude that Gentro $F^{(R)}$ drinking leads to a decrease in abdominal obesity by reducing waist circumference and visceral fat area.

• 한국방사선학회논문지
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• 제17권3호
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• pp.315-325
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• 2023

본 연구는 복부 비만도에 따라 콩팥 크기의 상관관계를 분석하여 3차원 전산화단층영상(3-Dimensional Computed Tomography, 3D CT)의 콩팥 크기 계측으로 복부 비만도를 예측하고자 하였다. 대상자는 전주 예수병원 건강의학센터에서 종합검진을 받은 자로 기저질환이 없는 건강한 성인 178명으로 하였다. 복부 비만도는 CT의 배꼽 주변의 횡단면에서 내장지방 면적, 피하지방 면적, 비만도로 구분하여 측정하였다. 복부 비만도 간에 따라 분류한 콩팥 크기의 평균 비교는 일원배치 분산분석(One-way analysis of variance, ANOVA) 및 Scheffe 사후 검정을 통해 시행하였다. 모든 계측 값의 상관관계는 Pearson 상관분석 하였다. 그 결과 복부 비만도에 따른 콩팥 크기 ANOVA 분석 결과는 다음과 같다. 내장 지방도 간에 따른 콩팥 계측치의 평균은 모든 콩팥 계측치에서 유의한 차이가 있었다(p<0.05). 피하 지방도 간에 따른 콩팥 계측치의 평균은 3D CT 우측 콩팥 너비 계측 시 중증 비만군에서 유의한 차이를 보였다(p<0.05). 비만도 간에 따른 콩팥 계측치의 평균은 3D CT 우측 콩팥 너비와 좌측 콩팥 너비 계측 시 중증 비만군에서 유의한 차이를 보였다(p<0.05). 콩팥 계측치와 CT 복부 비만도 간의 Pearson 상관분석 결과 내장지방 면적은 3D CT 좌측 콩팥 너비와 상대적으로 높은 양의 상관관계(r=0.467)를 보였으며 피하지방 면적은 3D CT 우측 콩팥 너비와 양의 상관관계(r=0.249)를 보였다. 비만도에서는 3D CT 좌측 콩팥 너비와 양의 상관관계(r=0.291)를 보였다.