• 정보처리학회논문지C
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• 제9C권5호
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• pp.765-774
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• 2002

정적 휴리스틱 분석은 알려지지 않은 악성 코드를 감지하는데 널리 사용되는 기법으로, 악성 코드에 보편적으로 존재하는 코드 조각들을 탐색하여 대상 코드의 악성 여부를 판단한다. 그러나, 스크립트로 작성된 악성 코드에서는 정형화된 코드 조각들을 찾아내기 어려우므로, 특정한 메소드 호출들의 존재만을 검사하는 것이 보편적이다. 이러한 감지 방식은 높은 감지 오류율을 보이게 되는데, 이는 많은 메소드들이 일반 스크립트에서도 빈번하게 사용될 수 있는 것들임에 기인한다. 따라서, 현재 정적 휴리스틱 분석은 일반 스크립트에서 거의 사용되지 않는 특별한 메소드 호출들로 이루어진 악성 행위만을 감지하는데 제한적으로 사용되고 있다. 본 논문에서는 메소드 호출 뿐 아니라 이에 관련된 파라미터와 리턴 값까지 고려하여 악성 행위 패턴을 정확하게 감지함으로써 이러한 단점을 극복할 수 있는 정적 분석 기법을 제안하고 그 구현을 제시한다. 또한, 구현된 시스템 상에서의 실험을 통해, 높은 긍정 오류 때문에 기존 기법의 적용이 어려웠던 악성 행위가 제안된 기법으로 감지될 수 있음을 보인다.

• 한국동물위생학회지
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• 제39권4호
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• pp.231-237
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• 2016

The present study was conducted to investigate the lesion of red internal organs in slaughtered pigs and provided assistant data for pig farms. During March to December 2015, a total of 1,160 lung samples out of 58 herds were collected randomly from pigs slaughtered in Jeonbuk province. In addition, 290 hilar lymph nodes from pig with pneumonic lung lesion (5 samples per herd) were screened for selected viral and bacterial pathogens. Gross lesions of lungs such as swine enzootic pneumonia (SEP), pleuritis, pleuropneumonia, pericarditis and liver white spots were examined. The overall prevalence of SEP was 64.3% (746/1,160). In the analysis of seasonal prevalence, there was an increase of occurrence during the spring months (287/400, 71.8%) and decrease during the fall months (93/200, 46.5%) among the whole herds. The mean number of SEP score per pig was $1.20{\pm}1.28$. The prevalence of pleuropneumonia, pleuritis, pericarditis, and milk spot was 25.5% (296/1,160), 44.1% (512/1,160), 3.8% (44/1,160) and 17.6% (204/1,160), respectively. The most frequent region with lung lesion was diaphragmatic lobes (left 17.1%, right 17.3%). In the detection of viral pathogens by PCR, porcine circovirus type2 (PCV2) was positive in 86.9% (252/290), while porcine reproductive and respiratory syndrome virus (PRRSV) was not detected, In the case of bacterial pathogens, 50 microorganisms were isolated by PCR and/or microbiological test. The most frequently isolated bacteria was Streptococcus suis (20, 34.4%), followed by Pasteurella multocida (17, 29.3%), Streptococcus spp. (11, 3.4%), Actinobacillus pleuropneumoniae (2, 8.9%).

• Journal of Korean Medical Science
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• 제33권46호
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• pp.304.1-304.7
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• 2018

Background: The Republic of Korea has a very low prevalence of human immunodeficiency virus (HIV) infection, but the number of new HIV diagnoses has steadily risen, strongly indicating a large number of undetected HIV infections. Thus, it is important for Korean public health authorities to adopt and encourage cost-effective HIV detection tools, such as rapid HIV screening tests. In this study, we aimed to evaluate the cost-effectiveness of enzyme-linked immunosorbent assays (ELISA) and rapid tests in a public health center (PHC) setting. Methods: We developed a decision analytic model to assess the per-examinee cost and the cost-effectiveness of identifying HIV patients in a PHC setting using two HIV testing strategies: conventional HIV screening by ELISA versus rapid HIV testing. Analysis was performed in two scenarios: HIV testing in an average-risk population and in a high-risk population. Results: Compared to the ELISA, the rapid test was cost-saving and cost-effective. The per-examinee cost was USD 1.61 with rapid testing versus USD 3.38 with ELISA in an average-risk population, and USD 4.77 with rapid testing versus USD 7.62 with ELISA in a high-risk population. The cost of identifying a previously undiagnosed HIV case was USD 26,974 with rapid testing versus USD 42,237 with ELISA in an average-risk population, and USD 153 with rapid testing versus USD 183 with ELISA in a high-risk population. Conclusion: Rapid testing would be more cost-effective than using conventional ELISA testing for identifying previously undiagnosed HIV-infected cases in Korea, a country with extremely low HIV prevalence.

• 생태와환경
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• 제54권3호
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• pp.190-198
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• 2021

사람 아이치바이러스(Aichivirus A; AiV-A)는 positivesense single-strand RNA 비외피 바이러스로 지난 10년 동안 하수, 강, 지표 및 지상의 다양한 물환경에서 전 세계적으로 검출이 보고되고 있다. 지하수 등 물환경에서 AiV-A 진단을 위한 고감도 및 특이성이 우수한 방법의 개발이 요구됨에 따라, 본 연구에서는 기존 및 신규 설계된 프라이머 세트를 기초로 역전사(RT) 및 이중 중합효소연쇄반응이 가능한 조합을 개발하였다. 개발한 방법을 국내 음용 지하수 시료에 적용 및 평가하였으며, 그 결과 지하수 시료에서 AiV-A를 성공적으로 검출 및 동정할 수 있는 RT-nested PCR primer sets가 선정되었고 후속적으로 동정할 수 있는 절차가 고안되었다. 본 연구 결과는 지하수 등 물 환경에서 AiV-A 오염을 탐지하기 위한 모니터링 시스템 마련에 기여할 것으로 기대된다.

• 한국임상수의학회지
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• 제36권1호
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• pp.15-22
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• 2019

Highly pathogenic avian influenza (HPAI) is among the top infectious disease priorities in Korea and the leading cause of economic loss in relevant poultry industry. An understanding of the spatial epidemiology of HPAI outbreak is essential in assessing and managing the risk of the infection. Though previous studies have reported the majority of outbreaks occurred clustered in what are preferred to as densely populated poultry regions, especially in southwest coast of Korea, little is known about the spatial distribution of risk areas vulnerable to HPAI occurrence based on geographic information system (GIS). The main aim of the present study was to develop a GIS-based risk index model for defining potential high-risk areas of HPAI outbreaks and to explore spatial distribution in relative risk index for each 252 Si-Gun-Gu (administrative unit) in Korea. The risk index was derived incorporating seven GIS database associated with risk factors of HPAI in a standardized five-score scale. Scale 1 and 5 for each database represent the lowest and the highest risk of HPAI respectively. Our model showed that Jeollabuk-do, Chungcheongnam-do, Jeollanam-do and Chungcheongbuk-do regions will have the highest relative risk from HPAI. Areas with risk index value over 4.0 were Naju, Jeongeup, Anseong, Cheonan, Kochang, Iksan, Kyeongju and Kimje, indicating that Korea is at risk of HPAI introduction. Management and control of HPAI becomes difficult once the virus are established in domestic poultry populations; therefore, early detection and development of nationwide monitoring system through targeted surveillance of high-risk spots are priorities for preventing the future outbreaks.

• Journal of Animal Science and Technology
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• 제63권4호
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• pp.864-871
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• 2021

Infectious calf diarrhea is one of the most significant diseases of neonatal calves. This study is conducted to identify the prevalence of pathogens in calf diarrhea for 2 years. A total of 544 feces samples from Korean native beef calves were obtained to investigate selected seven pathogens causing calf diarrhea: bovine rotavirus, bovine coronavirus, Cryptosporidium parvum, bovine viral diarrhea virus, Eimeria species, Escherichia coli K99, and Salmonella species. The presence of diarrhea, the number and species of detected pathogens, and the calves' ages were analyzed using various statistical methods depending on the case. Of the 544 calves, 340 calves (62.5%) had normal feces and 204 calves (37.5%) had diarrhea. The presence of pathogens was significantly associated with diarrhea (p < 0.01) and fecal scores and the number of detected pathogens showed a significant linear trend (p < 0.001). Of the 7 target pathogens, 6 were detected in samples, but only C. parvum (p = 0.001) and bovine rotavirus (p < 0.001) were found at significantly higher rates in diarrheic calves than in non-diarrheic calves. Only Eimeria spp. showed a significant linear trend between the detection rate of the pathogen and the age groups (p < 0.05).

• 정보보호학회논문지
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• 제14권6호
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• pp.91-103
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• 2004

기존의 네트워크 방화벽에 대한 연구는 정보에 대한 접근을 최대한 제한하는 거부(Deny)정책과 침입을 감지하는 감지 시스템 중심으로 연구 및 발전되어 왔다. 정부기관은 인트라넷(intranet)이라는 외부 인터넷과의 별도 망을 구축함에 따라 방화벽에 대한 문제점을 해결해 왔으나, 전자정부로의 전환에 따라 정부기관(경찰/군/관공서 등)에서는 거부정책과 정보공개 두 가지를 모두 만족시켜야 한다. 즉 상급부서와의 정보교환이나 민간인에 대한 대민 서비스 등을 위하여 부분적인 정보 공유, 네트워크 접속 및 불법접근을 차단하여야 한다. 또한, 현재 많이 문제시되고 있는 내부사용자에 대한 해킹과 Worm에 대한 공격에 대한 방어에 미흡한 점은 새로이 극복해야 하는 문제점으로 대두되고 있다. 따라서 본 연구에서는 정부기관들의 정보공유 및 대민서비스를 위한 "부분공개성" 및 불법 접근에 대한 "거부정책"을 충족시키기 위하여 IPS(Intrusion Prevention System)와 역할기반보안정책(Role-Base Security Policy)을 이용한 정보보호시스템을 제안하고자 한다.

• 정보보호학회논문지
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• 제20권6호
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• pp.221-235
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• 2010

특정 서비스를 보다 안전하게 제공받기 위한 사용자가 증가함에 따라 서비스수준협약 (SLA)에 대한 관심이 증가하고 있다. 그러나 침입차단서비스와 같은 보안서비스에 대해 기존의 SLA는 관련 보안 분야가 미비하여 제대로된 수준협약이 어려운 실정이다. 기존의 SLA에서 보안 분야는 권고사항의 수준으로 제공되고 있다. 이에 본 논문에서는 기존 침입차단서비스 제품의 보안 기능을 분석하여 공통보안기능과 개별보안기능을 분류하고, 이를 통해 보안서비스의 품질을 보장하기 위한 보안SLA(S-SLA : Security Service Level Agreement) 등급화 지표를 제안한다. 이를 통해 보안서비스에 대한 세분화된 서비스 협약이 가능할 것이다.

• The Korean Journal of Pain
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• 제35권4호
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• pp.468-474
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• 2022

Background: The new type of corona virus has a wide range of symptoms. Some people who have COVID-19 can experience long-term effects from their infection, known as post-COVID conditions. The authors aimed to investigate prolonged musculoskeletal pain as a symptom of the post-COVID-19 condition. Methods: This is a descriptive study on the patients who were diagnosed with COVID-19 in a university hospital, between March 2020 and March 2021. Patient records and an extensive questionnaire were used to obtain relevant demographic and clinical characteristics, including hospitalization history, comorbidities, smoking history, duration of the pain, the area of pain, and the presence of accompanying neuropathic symptoms. Results: Of the diagnosed patients, 501 agreed to participate in the study. Among the participants, 318 had musculoskeletal pain during COVID-19 infection, and 69 of them reported prolonged pain symptoms as part of their a post-COVID condition which could not be attributed to any other cause. The mean duration of pain was 4.38 ± 1.73 months, and the mean pain level was 7.2 ± 4.3. Neuropathic pain symptoms such as burning sensation (n = 16, 23.2%), numbness (n = 15, 21.7%), tingling (n = 10, 14.5%), stinging (n = 4, 5.8%), freezing (n = 1, 1.4%) were accompanied in patients with prolonged musculoskeletal pain. Conclusions: Patients with COVID-19 may develop prolonged musculoskeletal pain. In some patients, neuropathic pain accompanies it. Awareness of prolonged post-COVID-19 pain is crucial for its early detection and management.

• 한국어병학회지
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• 제35권2호
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• pp.225-230
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• 2022

Viral hemorrhagic septicemia (VHS) is one of the most serious viral diseases affecting farmed olive flounder (Paralichthys olivaceus) in Asian countries. VHS, caused by viral hemorrhagic septicemia virus (VHSV), occurs in over 80 different cultured and wild fish species worldwide. Our previous study demonstrated that VHSV infection can be restricted by adjusting the water temperature to over 17℃ from the host optima. We confirmed that the effective VHSV immersion vaccine treatment was a tissue culture infection dose (TCID) of 10^5.5 TCID₅₀/mL at 17℃. However, the safety of live VHSV immersion vaccines remains unclear. The objectives of this study were to 1) demonstrate the safety of the live VHSV immersion vaccine under co-habitant conditions and 2) estimate the pathogenicity of VHSV in live VHSV-vaccinated flounder at 10℃. No mortality was observed in olive flounder treated with the live VHSV immersion vaccine, and the vaccinated flounder challenged with VHSV did not transfer VHSV to naïve fish at 10℃ through cohabitation. VHSV titration was below the detection limit (< 1.3 log TCID₅₀/mL) in live VHSV immersion vaccine-treated flounder challenged with VHSV at 10℃. This study demonstrated that flounder treated with the live VHSV immersion vaccine were resistant to VHSV infection, and the live vaccine was also safe for naïve fish even at a water temperature known to be VHS infectious.