• PNF and Movement
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• 제5권1호
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• pp.9-17
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• 2007

Purpose : The purpose of this study was to test the effect of balance training for proprioceptive and vestibular sensory stimulation and therapeutic environment on expression of BDNF after traumatic brain injury in the rat. Subject : Twelve Sprague-Dawley rats were randomly assigned into group I and group II. After traumatic brain injury, group I was housed in standard cage for 7 days. Group II was housed in therapeutic cage after balance training for 7 days. Method : Traumatic brain injury was induced by weight drop model and after operation they were housed in individual standard cages for 24 hours. After 7th day, the rats were sacrificed and cryostat coronal sections were processed individually in goat polyclonal anti-BDNF antibody. The morphologic characteristics and the BDNF expression were investigated in injured hemisphere section from immunohistochemistry using light microscope. Result : Immunohistochemical response of BDNF in lateral nucleus, purkinje cell layer, superior vestibular nucleus and pontine nucleus appeared very higher in group II than in group I Conclusion : The present result revealed that simultaneously application of balance training for proprioceptive and vestibular sensory stimulation input and therapeutic environment in traumatic brain injured rats is enhance expression of BDNF and it is facilitates neural plasticity.

• 한국산학기술학회논문지
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• 제18권12호
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• pp.597-604
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• 2017

본 연구의 목적은 만성 뇌졸중 환자를 대상으로 전정자극훈련 프로그램이 정적 균형 및 동적 균형에 미치는 영향을 알아보는 것이다. 본 연구는 2014년 7월 15일부터 9월 6일까지 진행하였으며, 대상자는 뇌졸중 진단을 받은 환자 20명이 본 연구에 참여하였고, 무작위로 Group I(일반운동치료, n=10)과 Group II(전정자극훈련, n=10)로 나누었다. 두 군 모두 주 3회, 회당 40분씩 6주간 치료적 중재를 실시하였다. 균형 능력은 Good Balance System을 이용하여 정적 균형 및 동적 균형을 측정하였으며, 중재 전과 후를 비교하였다. 연구 결과, 전정자극 훈련군에서는 눈감고 선자세의 좌우 및 전후 균형, 눈뜨고 선자세의 좌우 및 전후 균형, 이동시간, 이동거리에서 통계학적으로 유의한 차이를 보였고, 일반운동 치료군에서는 눈뜨고 선자세의 좌우 균형을 제외한 모든 항목에서 통계학적으로 유의한 차이는 보이지 않았다. 결론적으로, 본 연구에서는 전정자극 훈련은 만성 뇌졸중 환자의 정적 균형 능력과 동적 균형 능력 향상에 긍정적인 영향을 미쳤으며, 이러한 뇌졸중 환자의 균형능력 향상을 위한 치료프로그램에 다양한 방법으로 활용될 수 있을 것이다.

• The Korean Journal of Physiology
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• 제16권1호
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• pp.31-40
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• 1982

The present experiment was carried out to elucidate interrelation between the vestibular canals and the extraocular oblique muscles. In urethane anesthetized rabbits, excitatory or inhibitory effect of the canal was produced by three different methods; selective electrical stimulation of the ampullary nerve, bidirectional (ampullofugal or ampullopetal) lymphatic fluid flow, and rapid freezing of the canal. Changes of isometric tension as well as electro-myographic activity of the oblique muscles were recorded in the ipsilateral and contralateral eyes, by means of a polygraphic recorder, and the following results were obtained. 1) Electrical stimulation of a unilateral vertical or horizontal nerve caused contraction of superior oblique muscle and relaxation of inferior oblique muscle in the ipsilateral eye, and contraction of inferior oblique muscle and relaxation of superior oblique muscle in the contralateral eye. 2) Ampullofugal flow in a vertical canal and ampullopetal flow in a horizontal canal caused the oblique muscle responses which were identical to those responses produced by the electrical stimulation of the same canal nerve. 3) Rapid freezing of a vertical canal elicited the oblique muscle responses which were opposite to those caused by electrical stimulation of the same canal nerve. From the above experimental results, functional interrelation between the individual vestibular canal and bilateral extraocular oblique muscles were better elucidated. When these results were compared to those reported by previous investigators (Utzumi, Suzuki et al.), some important discrepancies were found between them. We ascribed such discrepancies to experimental errors of the previous investigators, since their results reflected theoretical contradictions in terms of vestibular eye movements.

• 대한전자공학회:학술대회논문집
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• 대한전자공학회 2003년도 하계종합학술대회 논문집 V
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• pp.2741-2744
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• 2003

본 연구에서는 전기 전정 자극(GVS, Galvanic vestibular stimulation)이 일측 전정 기능 소실 환자에게서 정상인과 어떠한 특이성을 보이는가에 대하여 관찰하였다. 실험대상은 14 명(남:5, 여:9)의 일측 전정 기능 소실 환자(경와우절제술 12 례, 전정신경 절제술 2 례)로 자극 방법은 bipolar 로 하여 전류 세기를 1mA에서 3mA 까지 달리하며 실험하였다. GVS 에 대한 반응은 영상 안진기(VOG, Videooculograrh)를 이용하여 관찰하였다. 정상 기능이 있는 측면으로의 자극에 대해서는 정상인과 동일한 반응을 보였으나 일측 전정 기능 소실(unilateral loss)을 갖는 환자의 경우 병변이 있는 쪽에 음의 자극, 없는 쪽에 양의 자극을 가하였을 경우에는 대상자 모두에게서 어떠한 안진 반응도 일어나지 않았다. 자극 후 안진의 경우 정상인은 일반적으로 나타나지 않으나 피검자들에게서는 나타나는 특성을 보였다.

• 한국감성과학회:학술대회논문집
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• 한국감성과학회 1999년도 춘계학술발표논문집 논문집
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• pp.3-6
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• 1999

The study was performed to evaluate the sense of equilibrium by means of rotary chair system in middle school girls with dance learning. Control of equilibrium, which is the most important function in dancing, is maintained by vestibular, visual, and proprioceptive inputs. Experimental groups were divided into trained group with dance (experimental group, 13~14 ys, n=15) and untrained group (control group, 13~14 ys, n=15). experimental group was trained by programmed dancing for 12 weeks, 45 min/day and 5 day/week. Gain of eye movement was measured for vestibulocular reflex (VOR), visual vestibular stimulation (VVOR), optokinetic stimulation(OKN), and visual fixation (VFX). The gain of eye movement at higher than 0.08 hz was significant decrease in experimental group, and VVOR showed the similar fashion to VOR. The gain in OKN and VFX was not significant difference between experimental and control groups. These results suggest that programmed training of dancing improves control of balance by adaptation of the vestibular function, and rotary chair system would be useful to evaluate the sense of equilibrium ability.

• The Korean Journal of Physiology
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• 제26권2호
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• pp.151-157
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• 1992

In urethane anesthetized cats, each vestibular semicircular canal nerve was electrically stimulated, and reflex responses of the cervical extensor and flexor (the splenius capitis and sternomastoid muscles) were recorded by means of electromyography. Stimulation of a unilateral (anterior, horizontal or posterior) canal nerve elicited excitation of the contralateral cervical muscles and inhibition of the ipsilateral ones; during the canal nerve stimulation, the two muscles in one side of the neck revealed synergistic responses. Based on these experimental results, we formulated a diagram showing the functional connections between the vestibular semicircular canals and the cervical muscles in the vestibulocollic reflex.

• The Korean Journal of Physiology
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• 제6권2호
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• pp.49-56
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• 1972

This experiment was designed to explore specific functional relationship between the vestibular canals and the extraocular oblique muscles by observing the isometric tension responeses of the muscles to the selected vestibular canal excitation. The vestibular excitation was simulated by either stimulation of the individual canal nerve or endolymphatic fluid displacement in each canal. Each canal nerve was subjected to square wave pulses with a monopolar wire electrode placed closely to the ampullary nerve endings for electrical stimulation, and a fine stainless cannula was introduced into the each canal toward the ampulla and a minute amount $(0.5{\sim}3.5\;microliter)$ of fluid was injected in or ejected out by means of a microsyringe connected to the cannula to produce ampullopetal or ampullofugal displacement of endolymphatic fluid. The superior oblique muscle was contracted by the excitation of homolateral canals and was relaxed by contralateral canals. On the contrary, the inferior oblique was contracted by the contralateral canals and was relaxed by the homolateral canals. Summation of excitatory and inhibitory canal effects from the bilateral vestibular system was demonstrable on the tension changes of the oblique muscles. Excitation of either dual or triple canals of the unilateral vestibular system also caused summation effect on the tension response of the oblique pair; thus multiple signals from the different ampullary receptors seems to be converged into the relevant ocular motor muclei. Since the superior and inferior obliques are known to receive their motor fibers from the contralateral trochlear nuclei and intermediate nuclei of the homolateral oculomotor complex respectively, the above experimental evidences indicate that the ocular motor nuclei for oblique muscles receive excitatory signals from the contralateral vestibular canals and inhibitory signals from the homolateral canals.

• 한국감성과학회:학술대회논문집
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• 한국감성과학회 1997년도 한국감성과학회 연차학술대회논문집
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• pp.157-162
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• 1997

The purpose of this study was to develop a sinusoidal rotatory chair systim for evaluating the vestibular function in patients suffered from vertigo with vestibualr disorders. The sinusoidal rotatory chair system is composed of a rotatory chair systim and softwares. Maximum velocity of the rotatiry chair was upto 60 degree per second and frequency range was 0.01 to 0.64 Hz. To evaluate the vestibular function in vertigo patients, vestibuloocular reflex was measured by sinusoidal rotation of the whole body about vertical axis in the darkness, and optokinetic nystagmus, visual vestibuloocular reflex , and visual supression test were also performed. Eye movement was measured by means of a electronystgmograph amplifier through Ag-AgCI surface electrodes. Gain, phase, and symmetry were obtained from analysis of the eye movement ineuced by vestibular or visual stimulation. In healthy adults, sinusoidal rotation of the shole body produced nystagmus, of which gain was directly proportional to the velocity of stimulation. The gain of visual vestibuloocular reflex or optokinetic nystagmus, and it was suppressed markedly by visual suppression test. These results suggest that the sinusoieal rotatory chair systim which was developed by this study can evaluate the vestibular function quantitatively, also this system is very useful to diagnose and to dstimate the vestibualr function during recovery from vertigo

• The Korean Journal of Physiology and Pharmacology
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• 제21권4호
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• pp.423-428
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• 2017

Vestibular compensation is a recovery process from vestibular symptoms over time after unilateral loss of peripheral vestibular end organs. The aim of the present study was to observe time-dependent changes in long-term potentiation (LTP) at Schaffer collateral-CA1 synapses in the CA1 area of the hippocampus during vestibular compensation. The input-output (I/O) relationships of fEPSP amplitudes and LTP induced by theta burst stimulation to Schaffer's collateral commissural fibers were evaluated from the CA1 area of hippocampal slices at 1 day, 1 week, and 1 month after unilateral labyrinthectomy (UL). The I/O relationships of fEPSPs in the CA1 area was significantly reduced within 1 week post-op and then showed a non-significant reduction at 1 month after UL. Compared with sham-operated animals, there was a significant reduction of LTP induction in the hippocampus at 1 day and 1 week after UL. However, LTP induction levels in the CA1 area of the hippocampus also returned to those of sham-operated animals 1 month following UL. These data suggest that unilateral injury of the peripheral vestibular end organs results in a transient deficit in synaptic plasticity in the CA1 hippocampal area at acute stages of vestibular compensation.

• 한국감성과학회:학술대회논문집
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• 한국감성과학회 1999년도 춘계학술발표논문집 논문집
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• pp.237-242
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• 1999

The nature of the interactions between the vestibular and autonomic systems is complex and has not been fully defined. Vestibuloocular reflex induced by sinusoidal rotation and activity of the autonomic nerves in the heart were measured to investigate the interactions between the vestibular system and the autonomic nervous system in healthy adults. Eye movement induced by sinusoidal rotation of the whole body or optokinetic stimulation at 0.04 Hz was analyzed in gain, phase, and symmetry. EKG was measured during vestibular stimulation and analyzed in heart rate variability including mean R-R interval, standard deviation (SD) and coefficient of variance (CV) of R-R interval, and power spectrum of low frequency region (LF) and high frequency region (HF). Gain of eye movement was 0.65${\pm}$0.03 by ratatory stimulation, 0.70${\pm}$0.02 in optokinetic stimulation, 0.08${\pm}$0.02 in visual suppression, and 0.84${\pm}$0.04 in visual enhancement. In R-R interval, resting condition (control) was 0.82${\pm}$0.03 sec, and visual suppression showed significant increase and visual enhancement did significant decrease compared with control (p<0.01).CV was 0.06${\pm}$0.02 in control and visual enhancement increased significantly (p<0.05). In LF/HF control was 1.40${\pm}$0.23, which was not different from rotatory or optokinetic stimulation. But visual suppression decreased LF/HF significantly and visual enhancement increased significantly compared with control (p<0.01). These results suggest that degree of gain corresponds with LF/HF and increased gain in visual enhancement is deeply related to the activity of sympathetic nerves.