• 한국신재생에너지학회:학술대회논문집
• /
• 한국신재생에너지학회 2010년도 추계학술대회 초록집
• /
• pp.73.1-73.1
• /
• 2010

For the successful cold starting of a fuel cell engine, either internal of external heat supply must be made to overcome the formation of ice from water below the freezing point of water. In the present study, switchable vanadium oxide compounds as variable temperature-electrical resistance materials onto the surface of flat metallic bipolar plates have been prepared by a dip-coating technique via an aqueous sol-gel method. Subsequently, the chemical composition and micro-structure of the polycrystalline solid thin films were analyzed by X-ray diffraction, X-ray fluorescence spectroscopy, and field emission scanning electron microscopy. In addition, it was carefully measured electrical resistance hysteresis loop over a temperature range from $-20^{\circ}C$ to $80^{\circ}C$ using the four-point probe method. The experimental results revealed that the thin films was mainly composed of Karelianite $V_2O_3$ which acts as negative temperature coefficient materials. Also, it was found that thermal dissipation rate of the vanadium oxide thin films partially satisfy about 50% saving of the substantial amount of energy required for ice melting at $-20^{\circ}C$. Moreover, electrical resistances of the vanadium-based materials converge on an extremely small value similar to that of pure flat metallic bipolar plates at higher temperature, i.e. $T{\geq}40^{\circ}C$. As a consequence, experimental studies proved that it is possible to apply the variable temperature-electrical resistance material based on vanadium oxides for the cold starting enhancement of a fuel cell vehicle and minimize parasitic power loss and eliminate any necessity for external equipment for heat supply in freezing conditions.

• 한국지리정보학회지
• /
• 제14권3호
• /
• pp.11-21
• /
• 2011

본 연구는 인접한 국가간에도 scenic byway가 실현 가능한지를 양국 연구진이 순수한 관광객의 입장에서 조사하였으며, 이의 활성화를 위해 한 일 양국을 대상으로 한 scenic byway 데이터베이스를 구축했다. 여객수송과 달리 자동차로 상대국에 입국하는 것은 수출 입 절차에 준하는 서류준비와 절차가 복잡하며, 비용과 시간이 많이 소요된다. 일본에서 인지가능한 자동차 번호판 별도제작, 차량 검사, 사전 예약, 도로안내표지판 및 음식메뉴판 한자병기 필요성 대두 등 다양한 문제점이 도출되었다. 반면 자신의 계획대로 자유로운 개별여행이 가능하고, 그에 따른 DB구축도 용이하다는 장점도 있다. 이 연구결과는 한 일 양국의 scenic byway의 기초자료로 활용 할 수 있으며 행정지원과 제도개선이 함께 이루어진다면 인접 국가간의 통행량 증가와 더불어 scenic byway가 실현 가능 할 것으로 사료된다.

• Biomolecules & Therapeutics
• /
• 제5권2호
• /
• pp.117-124
• /
• 1997

The analgesic effects of DA-5018, a new caosaucin derivative, were evaluated in various experimental pain models. Drugs were administered subcutaneously or topically. When drugs were administered subcutaneously, 1) the $ED_{50}$ of DA-5018, morphine . HCI, capsaicin and acetaminophen were 0.091-2.0, 0.3-4.3, 1.4-26.5 and 45.4-643 mg/kg, respectively in various pain or inflammatory models including acetic acid writhing, formalin, tail flick, Randall-Selitto, hot plate and crouton oil-induced ear edema test, 2) the AD2 values (the dose for doubling of pain threshold of vehicle control) of DA-5018, capsaicin and ketoprpgin were 1.07 $\pm$ 0. 18, 23.47$\pm$4.46 and 2.97$\pm$0.43 mg/kg in Freund's complete adjuvant (FCA)-induced arthritic pain model. And by topical application, 1) neither DA-5018 0.3% cream nor Zostrix-HP (capsaicin 0.075%) were effective in formalin test, 2) although DA-5018 0.3% cream significantly inhibited the croton oil-induced ear edema being better than Zostrix-HP and Kenofen (ketoprofen 3%). 3) In FCA model, DA-5018 0.3% cream reversed the decreased pain threshold of arthritic rat from 136.4 g (day 0) to 289.0 g (day 5) and 250.1 g (day 10), which was similar to Zostrix-HP. These results suggest that DA-5018 administered subcutaneously has a potent and broad analgesic spectrum than nonsteroidal antiinflammatory drugs against acute and chronic pain, and by topical application it exerts comparable analgesic and antiinglammaatory effects to capsaicin cream.

• Biomolecules & Therapeutics
• /
• 제2권3호
• /
• pp.286-291
• /
• 1994

The mutagenicity of DA-3030(rhG-CSF)was studied by reverse mutation test, chromosome aberration test and micronucleus test. The reverse mutatuon test in bacteria was performed using salmonella typhimurium strain TA100, TA98, TA1535 and TA1537 with rhG-CSF in any of the concentrations(150, 75, 37.5, 18.75, 9.375 and 4,6875 $\mu\textrm{g}$/plate), no increase in the number of revertant colonies in each strain was observed, irrespective of treatment with the metabolic activation system(S-9 mix) The chromosome aberration test was carried out using CHL cells, cell line from chinese hamster lung. With 4 doses(75, 37.5, 18.75 and 9.375 $\mu\textrm{g}$/ml) of rhG-/CSF the cells were treated for 24 or 48 hours in the direct method or for 6 hours followed by 18 hour-expression time in the metabolic activation method. Results of the study showed, by the direct method or metabolic activation method, no trend toward increase in the number of aberrant metaphase. The micronucleus test was carried out using ICR mice at the age of 8 weeks. Three doses(862.5, 1725 and 3450 $\mu\textrm{g}$/kg) of DA-3030 were admintstered intraperitoneally with single shot and bone marrow cells were sampled at 24 hours after administration. Neither the number of polychromatic erythrocytes with micronuclei nor the ratio of normochromatic erythrocytes to polychromatic erythrocytes increased singinficantly in each dose, compared with a vehicle control. These results indicate that rhG-CSF has not mutagenic potential under the condiions.

• 대한한의학회지
• /
• 제20권2호
• /
• pp.121-127
• /
• 1999

Oriental herbal medicines were examined for mutagenicity in the reverse mutation test on Salmonella typimurium T A98/100 and chromosomal aberration test on cultured mammalian cells (Chinese hamster cell lines). The reverse mutation test was performed by a plate incorporation method with and without a metabolic activation system (S9 mix). The tested herbal medicines did not significantly increase revertible colonies on any of the test strains with and without a metabolic activation system (S9 mix) at concentrations of 1 mg/ml. In the chromosomal aberration test, most tested herbal medicines did not significantly increase the number of aberrant cells on any of the test strains with a metabolic activation system (S9 mix) at concentrations of 1 mg/ml, compared with the vehicle control. However. Ansu Semen significantly increased the number of aberrant cells without a metabolic activation system (S9 mix). Paeoniae Radix. Hoelen, Aurantii nobilis Pericarpium, Cnidii Rhizoma, Angeliacae gigantis Radix, Perillae Herba and Moutan Cortex Radicis slightly increased revertible colonies on any of the test strains with a metabolic activation system (S9 mix), These results indicate that most herbal medicines might be carefully used in obstetrics and gynecology, although they do not have the potent mutagenic potential under the present test conditions.

• 한국산학기술학회논문지
• /
• 제12권3호
• /
• pp.1091-1097
• /
• 2011

본 논문은 자동차용 시트의 내부에 설치되어 탑승자의 등 부위를 지지하여 편안한 승차감을 제공하는 자동차용 시트의 플라스틱 서스펜션 어셈블리 개발에 관한 것이다. 운전자의 허리를 균등하게 지지하여 주는 구조를 갖도록 설계하고 시트 백 프레임과 플라스틱 서스펜션이 원활하게 조합될 수 있는 구조로 개발하고자 한다. 체압 분포 특성을 고려하여 서스펜션의 단품을 설계하고 기능성을 평가하였다. 또한 실제와 동일한 사이즈의 서스펜션을 모델링하고 구조해석을 수행하였다. 기존 스프링 서스펜션과 새로 개발된 플라스틱 서스펜션의 해석결과 및 실제 측정값이 유사함을 확인하고 최적의 해석 및 설계를 확립하였다.

• 한국압력기기공학회 논문집
• /
• 제12권1호
• /
• pp.93-100
• /
• 2016

Since the sodium-cooled fast reactor is operated in a hostile environment due to the use of liquid sodium as its coolant, advanced techniques for in-service inspection are required to periodically verify the integrity of the reactor. This paper presents the development of in-service inspection techniques for Proto-type Generation IV Sodium-cooled Fast Reactor. First, the 10 m long plate-type ultrasonic waveguide sensor has been developed for in-service inspection of reactor internals, and its feasibility was verified through several under-water and under-sodium experiments. Second, the combined inspection system for in-service inspection of ferromagnetic steam generator tubes has been developed. The remote field eddy current testing and magnetic flux leakage testing can be conducted simultaneously by using the developed inspection system, and the detectability was demonstrated through several damage detection experiments. Finally, the electro-magnetic acoustic transducer which can withstand high temperature and be installable in the remote operated vehicle has been developed for in-service inspection of the reactor vessel, and its detectability was investigated through damage detection experiments.

• 한국항행학회논문지
• /
• 제20권5호
• /
• pp.496-502
• /
• 2016

본 논문에서는 영상처리를 통해 GUI를 기반으로 산업용 디지털 기기의 측정값을 인식하고 기록하는 시스템을 제안하고 구현하였다. 제안한 시스템은 기존의 차량번호판 인식과 달리 산업용 측정기의 LCD화면에 표시되는 값은 디지털 숫자로 표시하고 있어 소수점과 마이너스 표시, LCD보호유리의 반사광등의 여러 가지 장애요인을 고려하였다. LCD화면에 표시된 숫자를 인식하기 위해 블롭 레이블링 (blob-labeling)기법을 사용하였으며, 인식한 숫자 이미지는 템플릿 매칭(template matching)을 통해 숫자가 무엇인지 판별하여, 인식한 측정값을 측정시간과 함께 저장장치에 기록하였다. 본 논문에서 제안한 시스템은 산업현장에서 제품의 내외경이나 높이를 측정하고 기록할 때 수기로 작성하는 번거로움을 줄이고, 수기로 작성 시 잘못 기입하는 경우를 방지함으로써 생산 공정 과정에서 오류가 없는 효율적인 공정관리가 가능하게 하였다.

• 대한영양사협회학술지
• /
• 제13권4호
• /
• pp.389-406
• /
• 2007

This study was conducted to estimate the safety level of non-cooking and cooking processed foods to propose the sanitary management of foods donated to foodbanks. The time and temperature were measured and the microbial levels of aerobic plate counts (APC), coliforms, E. coli, Salmonella spp., S. aureus, B. cereus, and E. coli O157:H7 were analyzed on ten food items donated to seven foodbanks. The amount of cooked foods donated to each foodbank was about 10 to 40 servings. All foodbanks hired a supervisor and had at least one refrigerator/freezer and one temperature-controlled vehicle, but only four foodbanks had the separate offices to manage the foodbank operation. The flow of donated foods was gone through the steps; production, meal service and holding at donator, collection by foodbank, transport (or holding after transport) and distribution to recipients. After production, the levels of APC of both non-cooking and cooking processed foods were complied with the standards by Ministry of Education & Human Resources Development, and were not increased till distribution. Only the level of coliforms in dried squid & cucumber salad (1.5×$10^3$ CFU/g) was not met the standards. E. coli and other pathogens were not detected in all tested samples. The microbial levels of delivery vessels and work tables were satisfactory, but the APC levels of two of four tested serving tables (6.9×$10^3$ and 5.3×$10^3$ CFU/100$cm^2$) and the coliforms level of one (1.1×$10^3$ CFU/100$cm^2$) were over the standards. The air-borne microflora level in serving room was estimated as satisfactory. It took about 3.0 to 6.5 hours from after-production to distribution and the temperatures of donated foods were exposed mostly to temperature danger zone, which had a high potential of microbial growth. These results imply that a checklist to monitor time and temperature in each step should be provided and the employees involving foodbank operation should be properly educated to ensure the safety of donated foods.

• Toxicological Research
• /
• 제24권2호
• /
• pp.151-159
• /
• 2008

Rhus verniciflua Stokes(RVS), one of traditional medicinal plants in Asia, was found to have pharmacological activities such as antioxidative and antiapoptotic effects, raising the possibility for the development of a novel class of anti-cancer drugs. Thus, potential genotoxic effects of RVS in three short-term mutagenicity assays were investigated, which included the Ames assay, in vitro Chromosomal aberration test, and the in vivo Micronucleus assay. In Ames test, the addition of RVS water extracts at doses from 313 up to 5000 mg/plate induced an increase more than 2-fold over vehicle control in the number of revertant colonies in TA98 and TA1537 strains for detecting the frame-shift mutagens. The similar increase in reversion frequency was observed after the addition of RVS ethanol extracts. To assess clastogenic effect, in vitro chromosomal aberration test and in vivo micronucleus assay were performed using Chinese hamster lung cells and male ICR mice, respectively. Both water and ethanol extracts from RVS induced significant increases in the number of metaphases with structural aberrations mostly at concentrations showing the cell survival less than 60% as assessed by in vitro CA test. Also, there was a weak but statistically significant increase in number of micronucleated polychromatic erythrocytes(MNPCEs) in mice treated with water extract at 2000 mg/kg while ethanol extracts of RVS at doses of up to 2000 mg/kg did not induce any statistically significant changes in the incidence of MNPCEs. Therefore, our results lead to conclusion that RVS acts as a genotoxic material based on the available in vitro and in vivo results.