• Journal of Microbiology and Biotechnology
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• v.31 no.12
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• pp.1643-1655
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• 2021

Recent studies have reported dysbiosis of the microbiome in breast tissue collected from patients with breast cancer and the association between the microbiota and disease progression. However, the role of the microbiota in breast tissue remains unclear, possibly due to the complexity of breast cancer and various factors, including racial and geographical differences, influencing microbiota in breast tissue. Here, to determine the potential role of microbiota in breast tumor tissue, we analyzed 141 tissue samples based on three different tissue types (tumor, adjacent normal, and lymph node tissues) from the same patients with breast cancer in Korea. The microbiota was not simply distinguishable based on tissue types. However, the microbiota could be divided into two cluster types, even within the same tissue type, and the clinicopathologic factors were differently correlated in the two cluster types. Risk of regional recurrence was also significantly different between the microbiota cluster types (p = 0.014). In predicted function analysis, the pentose and glucuronate interconversions were significantly different between the cluster types (q < 0.001), and Enterococcus was the main genus contributing to these differences (q < 0.01). Results showed that the microbiota of breast tissue could interact with the host and influence the risk of regional recurrence. Although further studies would be recommended to validate our results, this study could expand our understanding on the breast tissue microbiota, and the results might be applied to develop novel prediction methods and treatments for patients with breast cancer.

• Journal of the Korean Home Economics Association
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• v.38 no.5
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• pp.137-152
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• 2000

North Korean fugitives is one of various nominations referring to the North Koreans who have secretly crossed the territorial border of their country. It is a new terminology that huts gained wider usage in our society as we entered the 1990s. North Koreans list various motives for escaping their county, such as food shortage and disillusionment of belief in the system. Most of the forced repatriation of North Korean escapees takes place in China. The purpose of this study examines the family knife of female fugitives from North Korea in order to provide pertinent alterntives which are needed to secure basic human right of the female fugitives and enable them to keep stability of their family lives and to adapt themselves into new socio-cultural circumstances in China. For this, the preliminary survey performed to examine the demographic characteristics on the female fugitives; to find out the incentives and channels of their escape out of North Korea; to investigate what types of family life and family relationship they manage in China; to grasp their problems and need of family life in adaptation into Chinese society. The specific questions for grasping the general characteristics of the female fugitives are composed of age, education level residential district in North Korea. In order to find out main causes and influential factors of their escape from North Korea, the following questions are included: what the most important incentives and motives are; the frequency of escape; and whether they discuss their escape with their family or not. The questions to find out their present actual life situations in China are about difficult things to adjust in China, family life, relationship with husband, and their conversational diction, the degree of their mastering the chinese language, the degree of their adaptation to chinese way of living, and so forth, which reveal to what extent they are adapted themselves to new cultural situation in China. This study collected the data through face-to-face personal interview from July to October, 1999 Yenben province along the China-North Korea border. Data from 202 female fugitives were used in final analysis. This study uses the SAS PC program for windows, Ver, 6.12 to analyze the data such as the distribution of frequency, percentage, mean and so on. The results from this analysis are follows; the most principal motive of North Korean women's escape to china is to eat to live because of famine. Concerning the year when the fugitives escape from North Korea, all of the interviewees haute escaped since 1990. After escape their continual contact with their family in North Korea, 81.7% of the respondent have not been in touch with their family. The main reasons for their not contacting with their family in North Korea are that it is not helpful although they contacts with their family. Female fugitives from North Korea have difficulties in life. They have rather stable relationship to their husband, but they have experienced difficulties in other aspects of family life. Their main difficulties are largely from their relationships to husbands'family members, and from the problems relate to their family in North Korea, and their children. Based on this study, further research has to present supportive policies that help North Korean female escapees live without being deprived and protect their human rights. And the development of practical program to help their efficient social adaptation has to be continued without stop together.

• Journal of the Korean housing association
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• v.21 no.2
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• pp.123-132
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• 2010

The housing market requires customized housing to be supplied according to the various characteristics of households. Multinominal Logistic Regression was used to analyze the effects of variables of household characteristics according to the number of family members on the choice of housing size in the scope of the whole country's housing market. Analysis showed that the number of family members has its own characteristics. When a household has a smaller number of family members, there are more variables affecting choice of housing size. Living and housing expenses variables served as significant variables that affect all household types. Results showed that households with more living and housing expenses are more likely to choose a large sized house and where households have a greater number of family members, there is more influence on that choice. The age of the householder was only found to be a meaningful variable in 1-2 person households and 3-4 person households, particularly in the choice of a small or large sized house. This shows that the age of the householder does not play an important role in choosing medium sized houses for households of under 4 people, but affects the choice of small and large sized houses. The academic ability of household members also served as a significant variable. While 1-2 person households with high academic ability tend to select a large sized house, 3-4 person households with high academic ability tend to select a small sized house. It is observed that members of both 1-2 person households and 3-4 person households tend to select their house between a large sized house and a small sized house in order to own their own houses. The result of this research suggests that there are various and detailed variables on the choice of housing size. Especially, a notable result is that household characteristics more significantly affect the housing size choice of 1-2 person households, while the trend of an aging society will more significantly affect a 3-4 person households' choice of a large sized house. Therefore, a study on the choice of housing size according to characteristics of elderly households and 1-2 person households should be continually analyzed.

• The Korean Journal of Applied Statistics
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• v.23 no.1
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• pp.95-111
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• 2010

Recently, there have been lots of study for disease-genetic association using SNPs and haplotypes. Statistical methods and tools for various types of data are developed by many researchers. However, there is no unified software which can handle most of major analysis, and the methods and manners to deal with data are quite different through softwares. And thus it is not easy to researcher to choose proper software. In this study, we devide analyzing procedures into three steps: preliminary analysis, population-based analysis and family-based analysis. We review the statistical methods for each step and compare the features of the FBAT, SAS/Genetics, SAGE and R as major integrating softwares for genetic study.

• Proceeding of Spring/Autumn Annual Conference of KHA
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• 2009.11a
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• pp.11-16
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• 2009

Public rental apartment has suffered social exclusion problem, stemmed from its closed planing for a very specific range of the disadvantaged population. Thereby, it has been recognized as a disliked residential facility. To alleviate this problem, various approaches have been tried such as ownership-tenant mixture, and different unit size mixture. The purpose of this study is to grasp the expected social relation among neighboring residents according to socially integrative planing elements such as ownership, unit size and family life cycle match. Thirty eight graduate students in architecture and housing field responded to the questionnaire which was specifically made to identify relations of 28 neighboring situations based on $2{\times}2{\times}2$ variable composition. Frequency, percentage and MDS(multidimensional scaling) were used to analyze data. As a result, the order of preferred matchy were identified. The match between rental/small/children group and ownership/middle/children group was turned out to be the most desirable while the match between rental/small/children family group and rental/small/elderly group was found the least desirable. Spatial representations of the relationships among 8 household types were delineated. In conclusion, the definite patterns of the favorable and unfavorable match were found. This result is expected to be used as a reference in developing a strategic match to promote the rental apartments social integration in Korea.

• Toxicological Research
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• v.23 no.1
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• pp.1-9
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• 2007

Transporters are membrane proteins that mediate the transfer of substrate across the cellular membrane. In this overview, the characteristics and the toxicological relevance were discussed for various types of transporters. For drug transporters, the overview focused on ATP-binding cassette transporters and solute carrier family 21A/22A member transporters. Except for OCTN transporters and OATP transporters, drug transporters tend to have broad substrate specificity, suggesting drug-drug interaction at the level of transport processes (e.g., interaction between methotrexate and non-steroidal anti-inflammatory agents) is likely. For metal transporters, transporters for zinc, copper and multiple metals were discussed in this overview. These metal transporters have comparatively narrow substrate specificity, except for multiple metal transporters, suggesting that inter-substrate interaction at the level of transport is less likely. In contrast, the expressions of the transporters are often regulated by their substrates, suggesting cellular adaptation mechanism exists for these transporters. The drug-drug interactions in drug transporters and the cellular adaptation mechanisms for metal transporters are likely to lead to alterations in pharmacokinetics and cellular metal homeostasis, which may be linked to the development of toxicity. Therefore, the transporter-mediated alterations may have toxicological relevance.

• Korean Institute of Interior Design Journal
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• v.16 no.1 s.60
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• pp.73-82
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• 2007

With the change of family type and diversify of life style, residents need various unit plan in quality. A rate of economically productive women has increased, and generally double-income households will continuously increase in the future. So a research is requested to consider the double-income households's satisfaction for a unit plan based on their life characteristics. The purpose of this study is to find out double-income households's lifestyles, and to search and analyze users' needs for spatial composition according to their lifestyles, and then, embody spatial composition of Apartment Unit plans. The findings are as follows. (1) Housing lifestyles of users living in apartment arc categorized into 5 types: pursuing the trend and personality, pursuing the convenience and leisure, pursuing being domestic, making a livelihood and practicality, the type of unspecification. (2) The type of pursing the trend and individuality requests new plan and a shower bath, the type of pursing the convenience and leisure requests facility with home appliances and likes traveling and sports, the type of making a hearth and home wants a talk with their family and discuss some problem, the type of making a livelihood and practicality requests storage space, the type of unspecification wants a comfortable master bedroom zone. Consequently factors of residental space plan are need for double-income households.

• Proceedings of the Korean Institute of Interior Design Conference
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• 2006.11a
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• pp.205-208
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• 2006

This research investigated the public rental houses In Yangchon-gu, whose locational attribute are suitable for the public rental house and has superior position in both inhabitants' participation and public welfare program. The public rental house has several types, such as permanent lease house, public lease. And several programs, the aged support police and medical services delivery system, have been the leading models for other local governments. Also, there are residents who are in their forties and fifties in the public rental houses in Yangchon-gu. un occupied is less than 1% and it seems that there is few turnover rate. 1 household rate and 2 households rate look like similar in the number of family member, total social public welfare program is focus on family welfare, juvenile welfare, teenager welfare, handicapped person welfare local, welfare and old people welfare. Accordingly, this research is used for base data of questionnaire and the first data for grope various improvement while planning group public rental house for low income group. And this research will be improved directional grope for improve livable public rental house around residents.

• International Journal of Human Ecology
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• v.7 no.2
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• pp.29-41
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• 2006

Various current events provide evidence that society is undergoing changes in perceptions of social relationships. Specifically, visual media in the form of advertisements can convey images which reflect society's values and concepts about role relationships. The purpose of this research was to examine ads in fashion magazines to determine what types of model roles and role relationships typically appear in fashion advertising which can mirror society's values. A content analysis was conducted of ads obtained from US Vogue and US GQ for the year 2002. Six kinds of roles/relationships were found: (1) Narcissism (representing self absorption), (2) sexually enticing opposite-sex relationships, (3) close/romantic same-sex relationships, (4) friend relationships, (5) family relationships, and (6) independent relationships. Of these, narcissism predominated, however, a small number of sexually provocative ads appeared as well as same-sex romantic relationships. Because sole (single) models were more typical, they also were examined to determine ways in which they relate to the audience. Characteristics examined included body presentation & pose, eye gaze, and facial expression. Direct eye gaze was the typical way to engage the audience. Gender differences were apparent: smiling was more typical of women, indifference for men. The symbolic meaning and values investigated from this research are the blurring of gender identity portrayed in homosexual imagery, family values, and the value of youth. The consistency of models' race in ads does not portray the diversity reflected in the demographic census.

• Journal of the Korean housing association
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• v.15 no.1
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• pp.95-102
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• 2004

The purpose of this study is to actualize the planning method of the shared community space (SCS). For this, it analyzed the residents' needs for the SCS and grasped the composition system of the needs and estimated the factors considered in the planning of the SCS. This study focused on seeking out the user-oriented design criteria for the planning of the SCS. The results of this study are as follows: First, as the results subdividing the residents' needs to understand the various requirements for the SCS, the composition system was classified into the fundamental SCS and the individual SCS. The fundamental SCS's to be considered as basic facilities in the planning of the multi-family housing complex, and the individual SCS to be more suited to a particular group. Second, regarding the investigation of detail guidelines in the SCS planning, it was found that there was a difference in the considered factors and the preferred locations according to the kinds of each SCS, the types of facilities, the main users of facilities, and the contents of activities available in the facilities.