• Journal of the korean academy of Pediatric Dentistry
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• v.41 no.2
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• pp.125-133
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• 2014

The purpose of this study was to investigate the effect of various surface treatment methods on the shear bond strength of orthodontic brackets in vitro. Ninety six specimens, 6 mm in diameter and 5 mm in height, were made with composite resin ($Filtek^{TM}$ Z350 XT, 3M ESPE, USA) and treated with an aging procedure. After aging, the specimens were randomly separated in six groups: (1) control with no surface treatment, (2) 37% phosphoric acid gel, (3) 4% hydrofluoric acid gel, (4) sodium bicarbonate particle abrasion, (5) diamond bur, and (6) 1 W carbon dioxide laser for 5s. The metal brackets were bonded to composite surfaces by means of an orthodontic adhesive (Transbond XT, 3M Unitek, USA). Shear bond strength values were evaluated with a universal testing machine (R&B Inc., Korea). Analysis of variance showed a significant difference between the groups. Group 5 had the highest mean shear bond strength (11.9 MPa), followed by group 6 (11.1 MPa). Among the experimental groups, group 2 resulted in the weakest mean shear bond strength (5.22 MPa). The results of this study suggest that the repair shear bond strength of the aged composite resin was acceptable by surface treatment with a carbon dioxide laser.

• Korean Journal of Clinical Pharmacy
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• v.15 no.1
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• pp.21-26
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• 2005

A bioequivalence study of CKD $Cefaclor^{(R)}$ capsule (Chong Kun Dang Pharm Co., Ltd) to $Ceclor^{(R)}$ capsule (Lilly Korea Co., Ltd.) was conducted according to the guidelines of Korea Food and Drug Administration (KFDA). Twenty four healthy male Korean volunteers received each medicine at the cefaclor dose of 250 mg in a $2{\times}2$ crossover study. There was a one-week washout period between the doses. An improved high-performance liquid chromatorgraphy (HPLC) analytical method with UV detection was used to determine plasma cefaclor concentration in human volunteers for 8 hr after oral drug administration. The area under the plasma concentration-time curve from time zero to 8 hr ($AUC_{0-8hr}$) was calculated by the linear trapezoidal rule. the $C_{max}$ (maximum plasma drug concentration) and $T_{max}$ (time to reach $C_{max}$) were compiled from the plasma concentration-time data. Analysis of variance was carried out using logarithmically transformed $AUC_{0-8hr}\;and\;C_{max}$. No significant sequence effect was found for all of the bioavailability parameters indicating that the cross-over design was properly performed. The $90{\%}$ confidence intervals of the $AUC_{0-8hr}$ ratio and the $C_{max}$ ratio for CKD $Cefaclor^{(R)}$ and $Ceclor^{(R)}$ were $0.9400{\leq}{\delta}{\leq}1.0345$ and $0.8858{\leq}{\delta}{\leq}1.1021$, respectively. These values were within the acceptable bioequivalence intervals of 0.80-1.25. Thus, our study demonstrated the of CKD $cefaclor^{(R)}$ capsule was bioequivalent to $Cefaclor^{(R)}$ capsule with respect to its bioavailability.

• Journal of Korean Society of Coastal and Ocean Engineers
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• v.25 no.1
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• pp.11-19
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• 2013

As the temperature data show a distribution pattern with a number of peaks, assumption of normal distribution will result in a serious bias in the analysis. In this study, the Gaussian Mixture Distribution (GMD), a type of bimodal distribution, is presumed as a frequency distribution for the water temperature, in order to estimate the optimal parameter and to carry out the relation analysis between the optimal parameter and the basic statistical information such as mean and variance on the data. By the way, an estimation formulae to compute the frequency distribution of the data is developed by computing the parameters of GMD (i.e. ${\alpha}_1$, ${\mu}_1$, ${\sigma}_1$, ${\alpha}_2$, ${\mu}_2$, ${\sigma}_2$) by means of the major characteristic values, such as mean, standard deviation and skewness of the data. The formulae shows an excellent coincidence with the result from the observation data, in the RMS limit accuracy of 5%.

• The Journal of Engineering Geology
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• v.19 no.1
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• pp.81-88
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• 2009

Two dimensional Monte-Carlo simulations of a non-reactive solute plume in isotropic porous media which are physically and chemically heterogeneous are conducted to determine the variations of moment. Retardation factors of 1, 2 and 5 are given to ascertain how the second moments are changed as adsorption increased. Retarded longitudinal second spatial moment, ${Z_{11}}^{'R}(t',l')$, increased during the transport process and as the dimensionless lengths of line plume source, $l_2'$, increased. ${Z_{11}}^{'R}(t',l')$ decreased as the retardation factors increased, and the simulated moments fit well to the first-order analytical results. Retarded longitudinal plume centroid variance, ${Z_{11}}^{'R}(t',l')$, decreased as the dimensionless lengths of line plume source, $l_2'$, increased and as the retardation factor increased. The result indicates that the uncertainty about the plume center decreased, and the ergodic condition for the second spatial moments is far from reaching. Simulated longitudinal one particle displacement covariance, ${Z_{11}}^{'R}(t')$, well consistent with the first-order analytical results for the three degrees of retardation factors of 1, 2 and 5 respectively. It is, consequently, concluded that the retarded longitudinal second moments could be produced by stochastic simulation, and that the first-order analytical results definitely provides very close values of the longitudinal retarded moments.

• Journal of Pharmaceutical Investigation
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• v.33 no.3
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• pp.215-221
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• 2003

A bioequivalence study of $Ambrect^{TM}$ tablets (Dong Wha Pharm. Ind. Co., Ltd.) to $Mucopect^{TM}$ tablets (Boehringer Ingelheim Korea, Ltd.) was conducted according to the guideline of Korea Food and Drug Administration (KFDA). Twenty four healthy male Korea volunteers received each medicine at the ambroxol hydrochloride dose of 30 mg in a $2{\times}2$ crossover study. There was a one-week wash out period between the doses. Plasma concentrations of ambroxol were monitored by a high-performance liquid chromatography for over a period of 24 hours after the administration. $AUC_t$ (the area under the plasma concentration-time curve from time zero to 24 hr) was calulated by the linear trapezoidal rule method. $C_{max}$ (maximum plasma drug concentration) and $T_{max}\;(time\;to\;reach\;C_{max})$ were compiled from the plasma concentration-time data. Analysis of variance was carried out using logarithmically transformed $AUC_t\;and\;C_{max}$. No significant sequence effect was found for all of the bioavailability parameters indicating that the crossover design was properly performed. The 90% confidence intervals of the $AUC_t$ ratio and the $C_{max}$ ratio for $Ambrect^{TM}/Mucopect^{TM}$ were 0.89-1.01 and 0.89-1.02, respectively. These values were within the acceptable bioequivalence intervals of 0.80-1.25. Thus, our study demonstrated the bioequivalence of $Ambrect^{TM}\;and\;Mucopect^{TM}$ with respect to the rate and extent of absorption.

• Journal of the Korean Institute of Landscape Architecture
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• v.42 no.1
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• pp.41-49
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• 2014

This study spatially assesses the impact of trees on residential rooftop solar energy potential using urban three-dimensional models derived from Light Detection and Ranging(LiDAR) data in San Francisco, California. In recent years on-site solar energy generation in cities has become an essential agenda in municipal climate action plans. However, it can be limited by neighboring environments such as shade from topography, buildings and trees. Of all these effects, the impact of trees on rooftop photovoltaics(PVs) requires careful attention because improper situation of solar panels without considering trees can result in inefficient solar energy generation, tree removal, and/or increasing building energy demand and urban heat island effect. Using ArcMap 9.3.1, we calculated the incoming annual solar radiation on individual rooftops in San Francisco and the reduced insolation affected by trees. Furthermore, we performed a multiple regression analysis to see what attributes of trees in a neighborhood(tree density, tree heights, and the variance of tree heights) affect rooftop insolation. The result shows that annual total residential rooftops insolation in San Francisco is 18,326,671 MWh and annual total light-loss reduction caused by trees is 326,406 MWh, which is about 1.78%. The annual insolation shows a wide range of values from $34.4kWh/m^2/year$ to $1,348.4kWh/m^2/year$. The result spatially maps the locations that show the various levels of impact from trees. The result from multiple regression shows that tree density, average tree heights and the variation of tree heights in a neighborhood have statistically significant effects on the rooftop solar potential. The results can be linked to municipal energy planning in order to manage potential conflicts as cities with low to medium population density begin implementing on-site solar energy generation. Rooftop solar energy generation makes the best contribution towards achieving sustainability when PVs are optimally located while pursuing the preservation of urban trees.

• International Journal of Highway Engineering
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• v.7 no.2 s.24
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• pp.97-107
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• 2005

Since the purpose of wheel tracking test is to find out relative difference of mixture's rut resistance, the wheel is an important part in the test for obtaining a consistent output. This study is performed to examine efficiency of different wheel material, rubber and steel in wheel tracking test. The rubber was inserted as a ring on the outer face of the steel wheel, and thickness of rubber ring was 15mm and 7.5mm and 0mm (steel wheel without rubber), making the total outer diameter 200mm. The objective of this study was to select reliable wheel material type in wheel tracking test at $60^{\circ}C$ based on variance in output (rut depth and dynamic stability) and correlation with SD (deformation strength). The result of regression analysis of rut depth with Sd showed that $R^2$ values of wheel rubber thickness of 15mm, 7.5mm and 0mm were 0.7, 0.8 and over 0.9, respectively. In a case of steel wheel (0mm), the highest $R^2$ value was 0.9569. Therefore, the wheel without rubber ring was the best in output consistency level and coefficient of determination $(R^2)$ with deformation strength. Therefore, the steel wheel without rubber ring is suggested as the best choice for wheel tracking test of asphalt concrete.

• Tunnel and Underground Space
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• v.13 no.4
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• pp.279-286
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• 2003

Many trials to set up the correlation between the rock mass classification and the earth resistivity have been carried out to design tunnel support type based on the interpreted electrical resistivity acquired by surface electrical survey. But it is hard to find reports on the comparison of the real rock support type determined during the excavation with the electrical resistivity by the inversion of the survey data acquired before the tunneling. In this study, the rock mass classification based on the face mapping data and the resistivity inversion data are investigated to see if it is possible to design reliably the rock support type based on the surface electrical survey. To get the quantitative correlation, rock engineering indices such as RCR(rock condition rating), N(Rock mass number), Q-system and RMR(rock mass rating) are calculated. Since resistivity data has low resolution, Kriging method as a post processing technique which minimizes the estimated variance is used to improve resolution. The result of correlation analysis shows that the 2D electrical resistivity survey is appropriate to see the general trend of the geology in the sense of rock type, though there might be some local area where these two factors do not coincide. But the correlation between the result of 3D survey and the rock mass classification turns out to be very high, and then 3D electrical resistivity survey can make it possible to set up more reliable rock support type.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.5 no.2
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• pp.109-120
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• 1985

This thesis is a study on multiple close range photogrammetry, and the purpose of this study is to develop the most accurate adjustment method of three dimensional object coordinates. This was achieved by comparing the standard errors of actual data to the computed values from 2 photos and multiple photos. The conventional methods for multiple photos have been analyzed by using geometric model formation. But in this study, the equation of collinearity condition which has been applied to aerial photogrammetry was derived to be a basic principle of close range photogrammetry, and the algorithm for analyzing multiple photos was developed using simultaneous bundle adjustment. The method used in this study, showed more homogeneous accuracy in coordinate and more consistent variance of error than those of conventional methods. It was found that the cases using 3, 4, and 5 photos were more accurate than using 2 photos; the accuracies were improved to 15%, 35%, and 50%, for each case. Thus this study is expected to be useful in measuring the geometry of historic monuments and other structures requiring high accuracy. Also the combined case of multiple photos is considered to be effective for the precise analysis of the objects which are difficult to measure for obstacles.

• Journal of Pharmaceutical Investigation
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• v.35 no.2
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• pp.117-122
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• 2005

After establishing improved HPLC analytical method of cefaclor in human plasma samples, a bioavailability study of cefaclor capsules was conducted according to the guidelines of Korea Food and Drug Administration (KFDA). The standard calibration curve using an HPLC with UV detector was constructed in a range of $0.0324{\sim}16\;{\mu}g/ml$. The 6% perchloric acid instead of 6% trichloroacetic acid was used to precipitate plasma protein. The HPLC chromatograms were precisely and accurately resolved when spiked with human plasma spiked with cefaclor and cephalexin (internal standard). Twenty healthy male Korean volunteers received two commercial cefaclor capsules, $Neocef^{\circledR}$ capsule (Jinyang Pharm. Co., Ltd) or $Ceclor^{\circledR}$ capsule (Lilly Korea. Co., Ltd.) at the 250 mg cefaclor in a $2{\times}2$ crossover study. There was a one-week washout period between the doses. Plasma concentrations of cefaclor were monitored for 8 hours after oral drug administration. $AUC_t$ the area under the plasma concentration-time curve from time zero to 8 hr (13 points), was calculated by the linear trapezoidal rule method. $C_{max}$ (maximum plasma drug concentration) and $T_{max}$ (time to reach $C_{max}$) were compiled from the plasma concentration-time data. Analysis of variance was carried out using logarithmically transformed $AUC_t$ and $C_{max}$. No significant sequence effect was found for all of the bioavailability parameters indicating that the cross-over design was properly performed. The 90% confidence intervals of the $AUC_t$ ratio and the $C_{max}$ ratio for $Neocef^{\circledR}/Ceclor^{\circledR}$ were $0.9049{\leq}{\delta}{\leq}1.226$, respectively. These values were within the acceptable bioequivalence intervals of 0.80-1.25. Thus, our study demonstrated the bioequivalence of $Neocef^{\circledR}/Ceclor^{\circledR}$ with respect to the extent of absorption.