• IMMUNE NETWORK
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• v.3 no.4
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• pp.281-286
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• 2003

Background: Hepatitis B virus (HBV) infection is one of the worldwide public health problem affecting about 300 million people. The envelope protein of HBV consists of three components known as preS1, preS2, and S antigen. According to the recent study, anti-HBs Ab showed effective neutralization ability against HBV from chronic hepatitis B and liver transplant patients, suggesting the possible development of therapeutic antibody. Methods: Spleen cells immunized with S antigen of HBV were fused with myeloma cell line to obtain HBsAg specific monoclonal antibodies. High affinity antibodies against HBsAg (adr, ad and ay type) were selected by competitive ELISA method. Nucleotide sequence of the variable regions of monoclonal antibodies was analyzed by RT-PCR followed by conventional sequencing method. Results: We produced 14 murine monoclonal antibodies which recognize S antigen of HBV. Two of them, A9-11 and C6-9 showed the highest affinity. The sequence analysis of A9-11 revealed that variable regions of the heavy chain and light chains are members of mouse heavy chain I (B) and light chain lambda 1, respectively. Likewise, the sequence analysis of C6-9 revealed that variable regions of the heavy chain and light chains are members of mouse heavy chain II (B) and light chain kappa 1, respectively. Neutralization assay showed that A9-11 and C6-9 effectively neutralize the HBV infection. Conclusion: These results suggest that A9-11 and C6-9 mouse monoclonal antibodies can be used for the development of therapeutic antibody for HBV infection.

• Journal of The Korean Association For Science Education
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• v.25 no.2
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• pp.111-121
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• 2005

The purpose of this study was to analyze characteristics of experimental design and evidence choice of the elementary school students in problem solving process related to controlling variable. For this study, 96 6th grade students were selected and tested with Science Reasoning Task. This study revealed that the types of experimental design were categorized as variance of control variable, controlling of causal variable, perfect controlling variable, imperfect controlling variable, variance of all variable. Prior belief had a strong influence on student's experimental design. The types of evidence choice were categorized as perfect controlling variable, controlling causal variable, variance of causal variable. The degree of controlling variable in evidence choice process was much lower than that in experimental design. Most students tended to choose evidence according to prior belief without controlling variable. The results of this study implied that student's prior belief and characteristic of science process skills should be considered to develop program for promoting controlling variable ability.

• International Journal of Automotive Technology
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• v.8 no.5
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• pp.593-598
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• 2007

A new continuously variable transmission for bicycles(B-CVT) is developed by using a traction drive mechanism having inner and outer spherical rotors. The B-CVT has high power efficiency, large torque capacity, improved drivability and good packageability. The ratio change mechanism for the B-CVT is very simple, in contrast with other traction drive CVTs. After completing a conceptual design, a performance analysis and a detail design, a prototype of the B-CVT has been manufactured. The prototype has rated power of 100 watts, pedal speed of 6 rad/s and an overall speed ratio of 1.0-4.0. A bench test and an actual bicycle test have been performed to verify the practicability of the B-CVT.

• The Transactions of The Korean Institute of Electrical Engineers
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• v.59 no.11
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• pp.2066-2072
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• 2010

In this paper, a variable structure dynamic output feedback controller with an transformed sliding surface is designed for the improved robust control of a uncertain system under unmatched system uncertainty, matched input matrix uncertainty, and disturbance satisfying some conditions. This paper is extended from the results of the static output feedback VSS in [9]. To effectively remove the reaching phase problems, an initial condition of the dynamic output is determined. The previous some limitations on the dynamic output feedback variable structure controller is overcome in this systematic design. A stabilizing control is designed to generate the sliding mode on the predetermined sliding surface S=0 and as a results the closed loop exponential stability is obtained and proved together with the existence condition of the sliding mode on S=0 for all unmatched system matrix uncertainties. To show the usefulness of the algorithm, a design example and computer simulations are presented.

• Korean Journal of Human Ecology
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• v.17 no.2
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• pp.207-221
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• 2008

This study examined different individual, family factors and classroom environment that affect children's perceived competency. For an analysis, achievement motivation, intrinsic locus of control and anxiety were included in individual variables. For family factors, parental support and marital conflict were examined. For classroom psycho-social environment, teacher support, peer relations, classroom involvement and teacher control were used. The sample consisted of 565 fifth and sixth grade children. Statistics and methods used for the data analysis were Cronbach's alpha, Factor analysis, frequency, percentage, t-test, Pearson's correlation, and Hierarchical Regression. Several major results were found from the analysis. First, boy's perceived academic competency was higher than girl's. And no sex difference was in children's social and athletic competency. Second, boy's and girl's perceived academic and social competency and boy's perceived athletic competency had a positive correlation with achievement motivation, intrinsic locus of control, parental support, teacher support, peer relations and classroom involvement. And girl's perceived athletic competency had a positive correlation with achievement motivation, intrinsic locus of control, parental support and peer relations. But boy's and girl's perceived academic and social competency and boy's perceived athletic competency had a negative correlation with anxiety and parental marital conflict. Third, the most important variable predicting boy's and girl's perceived academic competency was achievement motivation. The most important variable predicting boy's and girl's perceived social competency was peer relations. And the most important variable predicting boy's perceived athletic competency was peer relations. On the other hand, the most important variable predicting girl's perceived athletic competency was father's support.

• Advances in aircraft and spacecraft science
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• v.7 no.2
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• pp.115-134
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• 2020

This paper proposes a bending analysis for a functionally graded piezoelectric (FGP) plate through utilizing a two-variable shear deformation plate theory under simply-supported edge conditions. The number of unknown functions used in this theory is only four. The electric potential distribution is assumed to be a combination of a cosine function along the cartesian coordinate. Applying the analytical solutions of FGP plate by using Navier's approach and the principle of virtual work, the equilibrium equations are derived. The paper also discusses thoroughly the impact of applied electric voltage, plate's aspect ratio, thickness ratio and inhomogeneity parameter. Results are compared with the analytical solution obtained by classical plate theory, first-order-shear deformation theory, higher-order shear deformation plate theories and quasi-three-dimensional sinusoidal shear deformation plate theory.

• The KIPS Transactions:PartA
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• v.8A no.1
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• pp.56-62
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• 2001

This paper presents a neural network based variable structure control scheme for nonlinear systems. In this scheme, a set of local variable structure control laws are designed on the basis of the linear models about preselected representative points which cover the range of the system operation of interest. From the combination of the set of local variable structure control laws, neural networks infer the approximate control input in between the operating points. The neural network based variable structure control alleviates the effects of model uncertainties, which cannot be compensated by the control techniques using feedback linearization. It also relaxes the discontinuity in the system’s behavior that appears when the control schemes based on the family of the linear models are applied to nonlinear systems. Simulation results of a ball and beam system, to which feedback linearization cannot be applied, demonstrate the feasibility of the proposed method.

• Journal of the Korean housing association
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• v.26 no.4
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• pp.75-82
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• 2015

Although the government has revised the child welfare act, institutionalized the establishment of local children's centers, and given financial support for them, there are a number of problems with respect to their operation. Specifically, one of main problems is their limited space. Diverse problems that go with the arrangement of limited space and usability have occurred, however there are only a few strategies to use limited space flexibly. This study assumed variability as one of the methods to solve spatial problems. As a basic research for the assumption, Analyzing the variable method and characteristics of domestic and foreign child-care facility guidelines was performed trying to take advantage of as a basic data in order to seek a variable scheme of local children centers' indoor space. For this purpose, study analysed the methods and characteristics of variability centering on aspects related to variability which are environmental design elements required by local children's centers as suggested in previous studies. The results are as follows. First, the variability of space should be planned according to activity and time, and consider the methods of division, storage, and other facilities necessary. Second, methods of variability in space can be classified into creating areas and structures that are variable. Third, as a result of analysing the environmental design elements required by local children's centers, this study discovered the following characteristics: multi-purpose usability through a combination of variable devices, transition through a variable space medium and setting up areas and expansion of indoor variability assuming usability through internal and external connections.

• 한국방재학회:학술대회논문집
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• 2008.02a
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• pp.265-268
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• 2008

The safety of a tunnel under seismic motion is most often evaluated by ovalling deformation of tunnel. This paper research about tunnel's longitudinal deformation. Because of spatial variation of seismic ground motion, the longitudinal structures like tunnel are likely to experience relative displacements along longitudinal direction. The spatially variable ground motion can be estimated by coherency function obtained empirically, and can be considered from different arrival times of ground motion. As a result of estimating tunnel's relative displacements at maximum curvature of tunnel, the displacements and curvatures estimated by coherency function affect the tunnel's safety more than different arrival times. However, if tunnel's displacements by coherency function superpose on displacements by different arrival times, the relative displacements and curvatures of tunnel will be more severe. Therefore, to estimate accurately tunnel's deformation in longitudinal direction has to consider both coherency and wave passage effects.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.29 no.11B
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• pp.891-899
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• 2004

Ethernet passive optical network (EPON) has drawn many attention as a promising access network technology because it can provide a high bandwidth with a low cost. Since the uplink in the EPON system is shared by many users, it is necessary for an EPON system to have an efficient bandwidth allocation mechanism. In addition, as the users demand more QoS-oriented applications, it is necessary for an EPON system to have an efficient mechanism supporting QoS. In this paper, we propose a variable window dynamic bandwidth allocation (DBA) algorithm for the EPON system. Unlike the previously proposed DBA algorithms, the variable window algorithm guarantees the QoS for the highest priority class, and at the same time provides more enhanced QoS for the lower priority classes by dynamically allocating bandwidth if necessary. It is verified through the simulations that the variable window algorithm can provide more enhanced QoS performance than other DBA algorithms.