• Archives of Pharmacal Research
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• v.23 no.5
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• pp.507-512
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• 2000

This study set out to improve the physical and pharmaceutical characteristics of the present formulation using an appropriate experimental design. The work described here concerns the formulation of the dispersible tablet applying direct compression method containing roxithromycin in the form of coated granules. In this study $2^3$ factorial design was used as screening test model and Central Composite Design (CCC) associated with response surface methodology was used as optimization study model to develop and to optimize the proper formulation of roxithromycin dispersible tablet. The three independent variables investigated were functional excipients like binder (X1), disintegrant (X2) and lubricant (X3). The effects of these variables were investigated on the following responses: hardness (Y1), friability (Y2) and disintegration time (Y3) of tablet. Three replicates at the center levels of the each design were used to independently calculate the experimental error and to detect any curvature in the response surface. This enabled the best formulations to be selected objectively. The effect order of each term to all response variable was X3> X2> Xl> X1＊X2> X2＊X2> X2＊X3> X3＊X3> Xl＊X3> Xl＊Xl and model equations on each response variables were generated. Optimized compositions of formula were accordingly computed using those model equations and confirmed by following demonstration study. As a result, this study has demonstrated the efficiency and effectiveness of using a systematic formulation optimization process to develop the tablet formulation of roxithromycin dispersible tablet with limited experiment.

• Journal of the Computational Structural Engineering Institute of Korea
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• v.15 no.3
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• pp.399-407
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• 2002

A three-dimensional method of analysis is presented for determining the free vibration frequencies and mode shapes of hollow bodies of revolution (i.e., thick shells), not limited to straight line generators or constant thickness. The middle surface of the shell may have arbitrary curvatures, and the wall thickness may vary arbitrarily. Displacement components$U_\Phi, U_z, U_\theta$ in the meridional, normal and circumferential directions, respectively, are taken to be sinusoidal in time, periodic in$\theta$, and algebraic polynomials in the$\Phi$and z directions. Potential(strain) and kinetic energies of the entire body are formulated, and upper bound values of the frequencies are obtained by minimizing the frequencies. As the degrees of the polynomials are increased, frequencies converge to the exact values. Novel numerical results are presented for two types of thick conical shells and thick spherical shell segments having linear thickness variations. Convergence to four digit exactitude is demonstrated for the first five frequencies of both types of shells. The method is applicable to thin shells, as well as thick and very thick ones.

• Transactions of the Korean Society for Noise and Vibration Engineering
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• v.12 no.12
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• pp.970-978
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• 2002

The differential equations governing free vibrations of the elastic arches with unsymmetric axis are derived in Cartesian coordinates rather than in polar coordinates. in which the effect of rotatory inertia is included. Frequencies and mode shapes are computed numerically for parabolic arches with both clamped ends and both hinged ends. Comparisons of natural frequencies between this study and SAP 2000 are made to validate theories and numerical methods developed herein. The convergent efficiency is highly improved under the newly derived differential equations in Cartesian coordinates. The lowest four natural frequency parameters are reported, with and without the rotatory inertia, as functions of three non-dimensional system parameters the rise to chord length ratio. the span length to chord length ratio, and the slenderness ratio. Also typical mode shapes of vibrating arches are presented.

• Journal of the Korean Society for Aeronautical & Space Sciences
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• v.47 no.1
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• pp.17-25
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• 2019

An intake of Aircraft becomes S-shaped geometry due to spatial limitation or procuring survivability. But curvature of the S-shaped geometry makes secondary flow or flow separation which is the cause of non-uniform pressure distribution. In this study, boundary layer suction is applied to RAE M 2129 S-Duct by attaching sub duct. Design variable is suction location and angle. A mass flow rate drawn out by suction at the sub duct outlet is constant over every model. A grid dependency test was conducted to verify validity of computation. The comparison among the CFD (Computation Fluid Dynamics), ARA experimental result, and ARA computation result of non-dimensional pressure distribution on the Port side and Starboard Side confirmed the validity of CFD. In this study, Distortion Coefficient was used for evaluating aerodynamic performance of S-Duct. The analysis, which was about flow separation, vortex, mass flow rate distribution, and pressure distribution were also investigated. Maximum 26.14% reduction in Distortion Coefficient was verified.

• Geomechanics and Engineering
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• v.31 no.6
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• pp.599-614
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• 2022

One of the methods of stabilizing retaining walls, embankments, and deep excavations is the implementation of plate anchors (like the Geolock wall anchor systems). Back-to-back Mechanically Stabilized Earth (BBMSE) walls are common stabilized earth structures that can be used for bridge ramps. But so far, the analysis of the interactive behavior of two back-to-back anchored walls (BBAW) by double-plates anchors (constructed closely from each other and subjected to the limited-breadth vertical loading) including interference of their failure and sliding surfaces has not been the subject of comprehensive studies. Indeed, in this compound system, the interaction of sliding wedges of these two back-to-back walls considering the shear failure wedge of the foundation, significantly impresses on the foundation bearing capacity, adjacent walls displacements and deformations, and their stability. In this study, the effect of horizontal distance between two walls (W), breadth of loading plate (B), and position of vertical loading was investigated experimentally. In addition, the comparison of using single and equivalent double-plate anchors was evaluated. The loading plate bearing capacity and displacements, and deformations of BBAW were measured and the results are presented. To evaluate the shape, form, and how the critical failure surfaces of the soil behind the walls and beneath the foundation intersect with one another, the Particle Image Velocimetry (PIV) technique was applied. The experimental tests results showed that in this composite system (two adjacent-loaded BBAW) the effective distance of walls is about W = 2.5*H (H: height of walls) and the foundation effective breadth is about B = H, concerning foundation bearing capacity, walls horizontal displacements and their deformations. For more amounts of W and B, the foundation and walls can be designed and analyzed individually. Besides, in this compound system, the foundation bearing capacity is an exponential function of the System Geometry Variable (SGV) whereas walls displacements are a quadratic function of it. Finally, as an important achievement, doubling the plates of anchors can facilitate using concrete walls, which have limitations in tolerating curvature.

• Journal of the Korea institute for structural maintenance and inspection
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• v.21 no.1
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• pp.1-8
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• 2017

Three small scale hollow circular reinforced concrete columns with aspect ratio 4.5 were tested under cyclic lateral load with constant axial load. Diameter of section is 400 mm, hollow diameter is 200 mm. The selected test variable is transverse steel ratio. Volumetric ratios of spirals of all the columns are 0.302~0.604% in the plastic hinge region. It corresponds to 45.9~91.8% of the minimum requirement of confining steel by Korean Bridge Design Specifications, which represent existing columns not designed by the current seismic design specifications or designed by seismic concept. The longitudinal steel ratio is 2.017%. The axial load ratio is 7%. This paper describes mainly crack behavior, load-displacement hysteresis loop, seismic performance such as equivalent damping ratio, residual displacement and effective stiffness and flexural over-strength of circular reinforced concrete bridge columns with respect to test variable. The regulation of flexural over-strength is adopted by Korea Bridge Design Specifications (Limited state design, 2012). The test results are compared with nominal strength, result of nonlinear moment-curvature analysis and the design specifications such as AASHTO LRFD and Korea Bridge Design Specifications(Limited state design).

• Composites Research
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• v.30 no.6
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• pp.356-364
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• 2017

Composite lattice structures are tried to be used in various fields because of its benefit in physical properties. With increase of demand of the composite lattice structure, nondestructive testing technology is also required to certificate the quality of the manufactured structures. Recently, research on the development of the composite lattice structure in Republic of Korea was started and accordingly, fast and accurate non-destructive evaluation technology was needed to finalize the manufacturing process. This paper studied non-destructive testing methods for composite lattice structure using laser ultrasonic propagation imaging systems. Pulse-echo ultrasonic propagation imaging system was able to inspect a rib structure wrapped with a skin structure. To reduce the time of inspection, a band divider, which can get signal in different frequency bands at once, was developed. Its performance was proved in an aluminum sandwich panel. In addition, to increase a quality of results, curvature compensating algorithm was developed. On the other hand, guided wave ultrasonic propagation imaging system was applied to inspect delamination in a rib structure. To increase an area of inspection, multi-source ultrasonic wave propagation image was applied, and defects were successfully highlighted with variable time window amplitude mapping algorithm. These imply that ultrasonic propagation imaging systems provides fast and accurate non-destructive testing results for composite lattice structure in a stage of the manufacturing process.

• Journal of The Geomorphological Association of Korea
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• v.25 no.3
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• pp.1-18
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• 2018

In Korea, 64% of the land is known as mountain area, but the definition and classification standard of mountain are not clear. Demand for utilization and development of mountain area is increasing. In this situation, the unclear definition and scope of the mountain area can lead to the destruction of the mountain and the increase of disasters due to indiscreet permission of forestland use conversion. Therefore, this study analyzed the variables and criteria that can extract the mountain boundaries through the questionnaire survey and the terrain analysis. We developed a mountain boundary extraction algorithm that can classify topographic mountain by using selected variables. As a result, 72.1% of the total land was analyzed as mountain area. For the three catchment areas with different mountain area ratio, we compared the results with the existing data such as forestland map and cadastral map. We confirmed the differences in boundary and distribution of mountain. In a catchment area with predominantly mountainous area, the algorithmbased mountain classification results were judged to be wider than the mountain or forest of the two maps. On the other hand, in the basin where the non-mountainous region predominated, algorithm-based results yielded a lower mountain area ratio than the other two maps. In the two maps, we was able to confirm the distribution of fragmented mountains. However, these areas were classified as non-mountain areas in algorithm-based results. We concluded that this result occurred because of the algorithm, so it is necessary to refine and elaborate the algorithm afterward. Nevertheless, this algorithm can analyze the topographic variables and the optimal value by watershed that can distinguish the mountain area. The results of this study are significant in that the mountain boundaries were extracted considering the characteristics of different mountain topography by region. This study will help establish policies for stable mountain management.