• Applied Biological Chemistry
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• 제50권2호
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• pp.127-131
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• 2007

일련의 새로운 3-benzylidenemyosmine 유도체들의 구조 변화와 미국 바퀴벌래(Periplaneta. americana L.)의 nicotin acetylcholine 수용체 (nAChRs) 사이의 결합 친화력 상수에 관한 정량적인 구조와 활성과의 관계를 분자 홀로그램(H) QSAR 방법으로 검토하였다. 친화력 상수에 관하여 가장 양호한 HQSAR 모델은 분자조각 크기 5${\sim}$8 bin 조건에서 유도된 모델(IV-2)이었다. HQSAR 모델(VI-2)은 높은 예측성(q$^2$=0.507)과 상관성(r$^2_{nev.}$=0.944)에 근거하여 양호한 통계값들을 나타내었다. 그리고 HQSAR 기여도로부터 결합 친화력 상수는 분자내 anabaseine 고리에 의존적이었으며 결합 친화력성이 높은 화합물들이 최적화된 모델(VI-2)에 의하여 설계되었다.

• 정보보호학회논문지
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• 제16권1호
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• pp.71-77
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• 2006

인터넷의 사용이 증가하면서, DDoS (분산 서비스 공격)를 비롯한 여러 가지 네트워크 공격들이 오늘날 인터넷의 안정성에 커다란 위협을 가하고 있다 인터넷과 같은 대규모 망을 대상으로 한 이러한 네트워크 공격들은 특정 호스트에 대한 피해뿐만 아니라, 전체 네트워크의 성능 저하를 유발한다. 이러한 피해를 막기 위해서 대규모 기간망에서 적용 가능한 효율적이고 간단한 공격 탐지 기법이 필요하다. 이를 위해 빈도의 분포에 대한 간단한 통계치인 엔트로피를 이용하고자 한다. 네트워크 공격에 따라서 특정 근원지 주소, 특정 목적지 주소 그리고 특정 목적지 포트의 비정상적인 빈도가 관찰되기 때문에 위 세가지 항목에 대한 엔트로피의 변화를 이용하여 네트워크 공격을 탐지한다. 세가지 엔트로피의 변화하는 형태를 분석하여 네트워크 공격의 종류 또한 파악할 수 있다.

• Journal of Gastric Cancer
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• 제21권1호
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• pp.49-62
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• 2021

Purpose: This study aimed to investigate the prognostic value of lymph node ratio (LNR) in patients with locally advanced gastric cancer who received neoadjuvant chemotherapy. Materials and Methods: We retrospectively enrolled gastric cancer patients treated with neoadjuvant chemotherapy and curative surgery at the First Affiliated Hospital of Zhejiang University from 2004 to 2015 as the study cohort. Patients with the same inclusion criteria treated in 2016-2017 were enrolled as the validation cohort. Kaplan-Meier curves were assessed using the log-rank test to analyze the differences in overall survival (OS). Multivariate survival analysis was performed using the Cox proportional hazards model. The areas under the receiver operating characteristic curve of ypN and LNR categories for predicting the actual 3-year OS were compared. Results: A total of 265 patients were included in the proposal cohort. The median number of retrieved lymph nodes (rLNs) was 32. The number of positive lymph nodes (pLNs) increased as rLN increased (P=0.037), but the LNR remained relatively constant (P=0.462). The LNR was categorized into 4 groups according to the prognosis: ypNr0, node-negative with rLN>25; ypNr1, node-negative with rLN≤25 or 00.3. In the validation cohort of 43 enrolled patients, there was a clear distinction in OS that significantly (P<0.001) varied depending on the LNR values and LNR was the only independent prognostic factor in multivariate analysis (P<0.001). Conclusions: LNR was an independent prognostic factor for survival of patients with gastric cancer after preoperative chemotherapy and might be an alternative predictor for ypN stage.

• 패션비즈니스
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• 제26권2호
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• pp.95-109
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• 2022

This study was aimed at developing a new textile design based on the authentic and cultural resources of the Gangneung Subo pattern and applying the textile design to knitted fashion products. Gangneung has been recognized for its outstanding artistry in the field of Gyubang art. Gangneung Subo is an embroidered wrapping cloth. The discovered and preserved Subo at this time was from the Kwandong region centered in Gangeung, and is regarded as the product of the indigenous native culture in Kwandong. Therefore, as a representative cultural resource of Gangneung, the Gangneung Subo has sufficient value as a material for the development of cultural products with uniqueness, distinctiveness, and historicality. As a research method, the background of Gangneung Subo was investigated. A total of 12 motifs were created while preserving the authentic originality of the Gangneung Subo pattern and minimizing unwanted deformations of the pattern during the developing process. The created motifs were repeatedly applied to the pattern and new textile designs were created. Eighteen knit fashion products, including narrow and wide-width mufflers and neck warmers, were developed by applying the new textile designs. As a significant cultural resource for cultural goods development, this study ascertained the value of Gangneung Subo, preserving its unique distinction and history. This study was especially significant since the Gangneung cultural goods developed used knitted material and extended the development to producing real products.

• 패션비즈니스
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• 제28권2호
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• pp.125-138
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• 2024

The purpose of this study is to develop and implement a step-by-step upcycling fashion education program that can be utilized within the local community. This program aims to provide basic data by analyzing the current state of community-based upcycling projects and upcycling center programs. To achieve this, the study first examined the meaning and value of upcycling in fashion through literature research and explored upcycling projects and programs in connection with local communities. Subsequently, an upcycling fashion education program platform was developed and applied using the design thinking process. The program involved students from nine high schools in Gwangju Metropolitan City. Depending on the school's circumstances, the time and difficulty level of the upcycling education program were adjusted accordingly. A unique eco-bag making kit, using jeans developed in this study, was employed. Following the completion of the program, a satisfaction survey was conducted among 167 participating students from the high school community class. The findings indicated that the majority of students experienced an increased appreciation, attraction, and interest in upcycling products. They also demonstrated an understanding of the environmental impact of upcycling products and the distinction between upcycling and recycling. It is believed that the educational program developed in this study can promote ethical fashion and foster a sense of value-based consumption. This program can be customized and flexibly adapted to different educational levels and institutional characteristics, making it accessible to a wide range of learners.

• 유통과학연구
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• 제15권3호
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• pp.61-72
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• 2017

Purpose - The ICT development is affecting the consumer behaviors in selecting channel or distribution system. This study aims to advance the theory on the influence and interaction with omni-channel behaviors. Specifically, analyzing moderating variable is category knowledge that effect between propensity of brand loyalty and its precedence factor which is perceived difference, perceived value, authenticity and consumer-brand relationship. Research design, data, and methodology - The subject of this research is consumers who purchase goods in omni-channel situation. The hypothesis of this research is derived from the literature of the preceding research analysis on brand loyalty, omni-channel and consumer behaviors. This study have constructs that were defined operationally with reference to previous studies, and the research model was designed to figure out the structural relationship among perceived difference, perceived value, authenticity, consumer-brand relationship and brand loyalty. From 2016 Sept. 1 to Dec. 31, a questionnaire survey was performed targeting customers using omni-channel. 327 questionnaire survey had conducted. 316 survey data were used for empirical analysis except data that had missing and wrong value. AMOS(structural equation) was used to confirm the hypothesis which developed by researcher. Results - The results of this study are as follows. First, an authenticity has significant effect on brand loyalty. Second, in the omni-channel situation, but perceived differentiation, perceived value, consumer-brand relationship does not affect brand loyalty. According to this result, it is judged that it is easy to search for information in the situation of omni-channel and integrated decision making is done without distinction between channels. Third, category knowledge has moderating effect between brand loyalty and precedence factors. When the category knowledge level is low, preceding factors have a significant effect on brand loyalty. when the category knowledge level is high, the preceding factors did not have a significant effect on brand loyalty except the authenticity. Conclusions - This study finds out omni-channel's phenomenon is different from other distribution channel phenomenon. In the situation of omni-channel, it is suggested that brand loyalty may be relatively low for a certain brand because it raises the knowledge level of the category. Then this study provides a managerial implications based on the role of the moderate effect on category knowledge, brand loyalty and omni-channel.

• 한국전통조경학회지
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• 제30권4호
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• pp.81-92
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• 2012

본 연구의 목적은 세계유산 및 잠정목록에 등재되어 있는 동아시아 성곽유산의 비교를 통해 성곽유산을 특성에 따라 분류하여 그 차이점과 공통점을 살펴보고, 세계유산 등재경향을 고찰하는 것이다. 동아시아의 성곽유산은 지역적 인접성, 도성형식, 형태 및 재료 등의 유사성에 의해 그 차별성을 입증하기 쉽지 않지만 세계유산 및 잠정목록에 등재되어 있는 성곽유산들은 등재 평가기준에 따라 각 유산별로 차별성과 독창성을 기술하고 있다. 그러나 그 차이를 분명하고 일관된 방식으로 제시하지 못하는 문제점을 드러내고 있다. 따라서 동아시아 성곽유산들 의 차별성과 독창성을 명확하게 드러내기 위해서는 각 유산을 특성에 따라 구분하고, 체계적으로 기술하는 노력이 필요하다. 이를 위해 본 연구는 먼저 성곽과 관련된 용어에 대해 살펴보고, 각 유산별 특성 파악을 위해서 다음 네 가지 측면을 검토하였다. 1) 기능과 목적에 따른 구분, 2) 성곽의 형상과 규모에 따른 구분, 3) 입지와 지형지세에 따른 구분, 4) 축성기술과 재료에 따른 구분, 그리고 동아시아 성곽유산의 세계유산 등재 경향을 분석하여 유산별로 제시하고 있는 가치기준의 공통점과 차이점을 살펴보았다. 결론적으로 향후 동아시아 성곽유산의 정확한 가치 비교를 위해서는 다음 두 가지 측면의 검토가 보완되어야 한다. 첫째, 성곽유산을 세부 항목으로 구분하여 유사유산과의 차이점과 공통점을 쉽게 비교할 수 있는 체계(틀)를 마련해야 한다. 둘째, 동아시아 성곽유산의 가치를 인류가 서로 공유할 수 있도록 세계유산제도에 근거한 OUV의 평가기준을 고려하여, 보편적 가치기준에 부합하도록 기술(설명)하는 노력이 필요하다.

• 한국재료학회지
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• 제22권1호
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• pp.46-53
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• 2012

In this study, mechanical tests and microstructural analyses including TEM analyses with EDX of precipitates in modified 9Cr-1Mo steel were carried out to determine the cause of embrittlement observed after heat-treatment, which limits the usage of the alloy for power plants. Mod. 9Cr-1Mo steel specimens at austenite temperature were quenched to the molten salt baths at $760^{\circ}C$ and $700^{\circ}C$, in which the specimens were kept for 10 min ~ 10 hr with subsequent air-cooling. Impact tests showed that the impact value dropped abruptly when the specimens were kept longer than 30 min at $\sim760^{\circ}C$ reaching to minima in about 1 hr, and then increasing at further retention. The tensile strength of the specimens reached the minimum value without much change afterward, whereas the values of elongation showed the same trend as that of the impact value. The isothermally heat-treated steel at $700^{\circ}C$ also showed a minimum impact value in about 1 hr. These results suggest that the isothermal heattreatment at 760 and $700^{\circ}C$ for about 1 hr induces temporal embrittlement in Mod. 9Cr-1Mo steel. The microstructural examination of all the specimens with extraction replica of the carbides revealed that the specimens with temporal embrittlement had $Cr_2C$, indicating that the cause of the embrittlement was the precipitation of the $Cr_2C$. In addition, TEM/EDX results showed that the Fe/Cr ratio was 0.033 to 0.055 for $Cr_2C$, whereas it was 0.48 to 0.75 for $Cr_{23}C_6$, making the distinction of the $Cr_2C$ and $Cr_{23}C_6$ possible even without direct electron diffraction analyses.

• Asia pacific journal of information systems
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• 제19권1호
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• pp.83-111
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• 2009

Despite the growing emphasis on the importance of knowledge exchange among supply chain participants, few companies have fully exploited the knowledge resources held by their supply chain partners. Among many reasons for this phenomenon, recent literature on inter-firm knowledge exchange identifies knowledge complementarities between the supply channel partners as an important determinant of knowledge exchange. Firms participating in a supply chain are likely to exchange partners' complementary knowledge. In order to extract value from them, it is important to recognize the difference between the potential value and the implementation of this potential value. However, the literature fails to distinguish between potential knowledge complementarities and implemented knowledge complementarities. In order to realize the value of potential knowledge complementarities, knowledge should be exchanged and effectively integrated in the supply channel. Further, investigating inter-firm knowledge exchange from both partners' perspectives is important especially when there are interdependencies between the channel partners. The purpose of this research is to investigate the impact of potential knowledge complementarities on knowledge exchange in buyer-supplier relationships by looking at both partners' perspectives. This research also includes trust in partner's competence and inter-organizational information systems (IOIS) as they are relevant when the complementary knowledge flows between organizations. The data required for this field study was collected from 70 buyers and their suppliers in three multinational enterprises in two different industries (Automobile manufacturing and Telecommunication services) headquartered in Korea. The results indicate that potential knowledge complementarities between buyer and supplier do not directly influence knowledge exchange, but indirectly through trust in partner's competence. And the results indicate that competence-based trust and IOIS have direct effects on knowledge exchange. Empirical results also show that IOIS moderates the relationship between potential knowledge complementarities and knowledge exchange. This study is a first attempt to empirically verify the theoretical model about potential knowledge complementarities and to investigate the impact of potential knowledge complementarities on interfirm knowledge exchange. From a theoretical perspective, this study not only clarifies the distinction between potential knowledge complementarities and implemented knowledge complementarities, but also develops an instrument to measure the concept of potential knowledge complementarities in the context of operational and planning knowledge in a supply chain. Further, we develop a theoretical framework suggesting that potential knowledge complementarities of partners in a supply chain affect knowledge exchange directly and indirectly through competence-based trust. The findings from this study have some managerial implications for practicing managers as well. First, buyers should search for suppliers that have potential complementary knowledge, which can be integrated to create synergy through interfirm knowledge exchange. Furthermore, firms must develop mechanisms to identify potential complementary knowledge of partners. Second, firms should continue their endeavor to develop their own unique knowledge so that their knowledge can benefit the entire supply channel. Finally, trust among supply chain partners turns out to be an important factor for interfirm knowledge exchange. Therefore, effective management for engendering trustworthy buyer-supplier relationships should receive appropriate attention from managers.

• 한국자원식물학회:학술대회논문집
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• 한국자원식물학회 2020년도 춘계학술대회
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• pp.101-101
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• 2020

Soybean is known as to have a several healthy ingredients. Among them, isoflavones are effective in reducing obesity, menopausal symptom. Isoflavones consist of 12 isomers, including Aglycon, Glucoside, Malonyl glucoside, Acetyl glucoside, and are usually found in soybean seeds. The content is determined by the sum of 12 isomers, and the content value difference between the varieties is huge. In this study, we investigated the agronomic traits, 12 isomer of isoflavone content and composition for 49 soybean germplasms. This germplasms were selected from the 23,000 germplasms with the highest total content of isoflavones possessed by the National Agrobiodiversity Center. Seed samples were cultivated in experimental field located in Jeonju City on April 04, 2019. Matured seeds were harvested and portions of each seed samples were oven-dried, pulverized, and analyzed for their isoflavone compositions using HPLC-DAD. The soybean samples showed distinction in their agronomic traits, isoflavone compositions and contents. The days to flowering ranged between 38 and 69 days while the days to maturity ranged between 103 and 156 days. The seed coat color of soybean germplasms was 24 in black, 10 in yellow, 2 in green, 5 in yellowish green, 4 in green with black spot, 4 in pale yellow. The germplasm with the highest total content of isoflavones was the IT178054(1257.61±7.98 ㎍/g), but the germplasms containing the largest number of isoflavone isomers were IT274592, IT275005, both germplasms had 11 isoflavone isomers excluding Malonyl glycitin. The largest source of Aglycon, the most easily absorbed isoflavone form in the human body, was IT274592(DZ: 8.83±0.30 ㎍/g, GL: 11.14±0.81 ㎍/g, GE: 8.16±0.26 ㎍/g), while only IT274592, IT275005, IT308619 contained all three components of Aglycon. In Principal Component Analysis(PCA), the first two principal components showed more than 3.5 Eigen value and accounted for 58.2% of variability. The total content value had strong relationship with Malonyl genistin content value. Acetyl isomers had strong relationship, but Malonyl isomers were only related to isomers except Malonyl glycitin. These results will help in research on soybean varieties to enhance isoflavone ingredients.