• 한국치위생학회지
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• 제5권2호
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• pp.219-233
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• 2005

This study was conducted on 185 workers at 73 dental clinics and university hospitals in Daegu to investigate the actual prevention of infection and vaccination against B-type hepatitis among dental workers. 1. According to the result of medical examination, only 35 out of 144 (24%) dental clinic workers had periodic health examination while 7 out of 9 (78%) university hospital workers did. 2. In a survey on vaccination against B-type hepatitis, 52 workers aged 29 or younger (96.3%), 38 dental hygienists (51.9%) and 44 dental workers at dental clinics (81.5%) have not had any vaccination against B-type hepatitis. The rest appeared to have had vaccination or be aware that they had antibody against B-type hepatitis without having to have any vaccination. 3. According to the result of a survey on the existence of antibody by job, 42 (56%) of dental hygienists, 15 (20%) of assistant nurses, 12 (16%) of medical assistants and 6 (8%) of dental technicians did not know whether or not they had antibody. This suggests that all types of dental workers except dental hygienists have low awareness of whether or not they have antibody. 4. In a survey on the relation between general characteristics of subjects and the sterilization of dental equipment, alcohol disinfection of high speed handpiece and low speed handpiece was most common among dental workers aged 29 or younger, and all of those aged over 40 used autoclave. By position, alcohol disinfection was used most commonly for high-speed handpiece. antiseptic solution deposition for disposable suction lips, and autoclaving for impression. By workplace, dental workers at university hospitals used autoc1aving most frequently for high/low speed handpiece while those at dental hospitals and dental clinics used alcohol disinfection most frequently and even some respondents replied that they did not disinfect. For metal cups, workers at dental clinics and dental hospitals did not use any sterilizing method while those at university hospitals used autoclaving. For disposable suction tips, workers at dental clinics used antiseptic solution deposition and those at dental hospitals used alcohol disinfection but some respondents replied that they did not disinfect. For metal suctions and impression trays, autoclaving was most common in all workplaces but some dental clinics replied that they did not disinfect impression trays. According to work experience, alcohol disinfection was most common for high/low speed handpiece. For disposable suction tips, dental workers with 3 years' or shorter work experience, those with 3~6 years' experience and those with 9~12 years' experience used antiseptic solution deposition most commonly, and many of those with 6~9 years replied that they did not disinfect. The results of this study stated above suggest that systematic education is necessary for all dental workers for enhancing th eir awareness of B-type hepatitis and the prevention of infection. Moreover, dental workers are required to make efforts to prevent infection with B-type hepatitis voluntarily and actively.

• 농촌의학ㆍ지역보건
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• 제27권1호
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• pp.125-142
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• 2002

This study was carried out to purpose drawing up the efficient method of rural residents' health management, analyzing factors having influences on the behavioral intention and the behavior of hepatitis B vaccination of rural residents, using the theory of planned behavior(TPB). Surveying the first questionnaire about TPB to 439 people of rural adults over 40-year old who participated to hepatitis B examination program was made from March 14 to April 23 in 2001 at two primary health care posts in a city in Gyeongsangbuk-do and the second survey for hepatitis B vaccination was made to the last subjects of 332 people(75.6%) that had been proved as subjects of inoculation against the hepatitis B as the result of examination after two months of notification. In the behavioral intention rate of hepatitis B vaccination of the subjects within a month, 100%(the top) was 45.2%, 80-90%(the middle) was 21.1% and under 70%(the low) was 33.7%. In simple analysis, vaccination intention was related with significantly health security type and economic status(p<0.05). And vaccination intention was related with significantly all variables of attitude toward behavior and subjective norm, and economic power of utilizing medical facilities and perceived power variable of perceived behavioral control(p<0.01). The vaccination rate of the subjects within a month was 31.3%. In simple analysis, the vaccination rate was higher significantly in the lower the age was, the higher the educational level was(p<0.01), the larger the family was, and subjects having transport(p<0.05). And the vaccination rate was higher in the higher the economic power was and the higher the perceived ability was. As the results of making generalized logit analysis for behavioral intention, the more positive the subjective norm was, the higher was the score of the perceived behavioral control, the intention was higher significantly in the top class on a basis of the low class of behavioral intention. In multiple logistic regression analysis for vaccination(behavior) using intention and perceived behavioral control as dependent variables, it showed that perceived behavioral control variable only influenced significantly. The higher was the score of perceived behavioral control, it showed that they got the more vaccination(p<0.01). And even in the result having analyzed, adding the significant general characteristics variables in the simple analysis to the independent variable, the higher was the score of perceived behavioral control, it showed that they got vaccination more.

• Molecules and Cells
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• 제22권2호
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• pp.175-181
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• 2006

Delivery of DNA vaccines to airway mucosa would be an ideal method for mucosal immunization. However, there have been few reports of a suitable gene delivery system. In this study we used a cationic emulsion to immunize mice via the intranasal route with pCMV-S coding for Hepatitis B virus surface antigen (HBsAg). Complexing pCMV-S with a cationic emulsion dramatically enhanced HBsAg expression in both nasal tissue and lung, and was associated with increases in the levels of HBs-specific Abs in serum and mucosal fluids, of cytotoxic T lymphocytes (CTL) in the spleen and cervical and iliac lymph nodes, and of delayed-type hypersensitivity (DTH) against HBsAg. In contrast, very weak humoral and cellular immunities were observed following immunization with naked DNA. In support of these observations, a higher proliferative response of spleenocytes was detected in the group immunized with the emulsion/pCMV-S complex than in the group immunized with naked pCMV-S. These findings may facilitate development of an emulsion-mediated gene vaccination technique for use against intracellular pathogens that invade mucosal surfaces.

• Pediatric Infection and Vaccine
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• 제13권2호
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• pp.163-173
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• 2006

목 적 : 근래에 영아 백신의 숫자가 증가하면서 동시에 접종하는 혼합백신의 개발이 증가하고 있다. 본 연구에서는 우리나라 영아에서 b형 H. influenzae에 대한 단백 결합 백신(PRP-OMP)과 B형 간염 백신의 혼합백신인 $Comvax^{TM}$(Merck & Co.)의 면역원성 및 안전성을 평가하고자 하였다. 대상 및 방법 : 생후 직후 B형 간염 백신(유박스 $B^{TM}$ 또는 헤파박스-진$^{TM}$)을 접종받은 영아를 대상으로 $Comvax^{TM}$를 단독으로 또는 DTaP, IPV, Prevenar 등과 2, 4개월에 접종한 후, 2회 접종 전(4개월 연령) 및 2회 접종 2개월 후(6개월 연령)에 혈청 내 항 PRP 항체가와 anti-HBs를 효소면역법과 chemiluminescent microparticle immunoassay로 측정하였다. 결 과 : 총 65명(남아 35명)이 포함되었으며, 58명이 계획된 접종을 완료하였다. 1회 접종 후 항PRP 항체가의 기하 평균치는 1.96 ${\mu}g/mL$(95% CI 1.38~2.78), 2회 접종 후의 기하평균치는 10.02 ${\mu}g/mL$(95% CI 7.04~14.26)이었다. 항체가가 1.0 ${\mu}g/mL$ 이상인 비율은 1회 접종 후 63.2%(95% CI 53.75~72.65), 2회 접종 후 96.6%(95% CI 93.05~100)이었다. 한편 anti-HBs가 10 mIU/mL 이상인 영아의 비율은 4개월에 73.7%(95% CI 65.07~82.33), 6개월에 94.8%(95% CI 90.45~99.15)이었으며, 기하 평균치는 4개월에 38.32 mIU/mL(95% CI 22.42~65.51), 6개월에 101.17 mIU/mL(95% CI; 65.94~155.25)이었다. 백신 접종 후 발생한 이상반응 중 전신 증세로서 보챔(24.8%)이 가장 많았고 졸음(19.2%), 식욕부진(19.2%) 그리고 발열(7.2%) 등이 있었다. 국소 증세로는 동통이 25.6%, 발적이 19.2%, 부종이 4.8%에서 관찰되었다. 이러한 이상반응은 대부분 경증에 속하는 것으로 모두 회복되었다. 결 론 : $Comvax^{TM}$는 우리나라 영아에서 안전하고, 매우 우수한 항-PRP 항체 반응을 보였으며, 본 연구에서 B형 간염에 대해서는 아직 표준화되지 않은 방법으로 접종되었으나 비교적 우수한 항체 반응을 보여 B형 간염에 대해서도 우수한 면역원성을 지녔을 것으로 추측된다.