• Proceedings of the Ginseng society Conference
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• 2002.10a
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• pp.55-65
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• 2002

Ginseng has been used as a key constituent in traditional medicine prescriptions for centuries. Other than its well-known anti-stress and adaptogenic properties, ginseng has also been shown to be very effective in treating age-related deterioration in metabolic and memory functions. Although it is generally believed that the saponin (GS) fraction of the ginseng root accounts for the bioactivity of ginseng, a direct demonstration on which ginsenoside does what is still generally lacking. In the past decade, our laboratory has endeavored to identify the active GS components involved in energy metabolism, memory, and anti-neurotoxicity. To examine the ergogenic effects of GS in enhancing aerobic capacity, rats were subjected to either severe cold ($40^{\circ}C$ under helium-oxygen, two hours) or exercise workload $(70\%\;VO_{2}max,$ to exhaustion). Acute systemic injection (i.p.) of ginseng GS (5-20 mg/kg) significantly elevated both the total and maximum heat production in rats and improved their cold tolerance. However, pretreating the animal with the optimal dose (10 mg/kg) of GS devoid of $Rg_1\;and\;Rb_1$ failed to elicit any beneficial effects in improving cold tolerance. This indicates that either $Rb_1\;and/or\;Rg_1$ may be essential in exemplifying the thermogenic effect of GS. Further studies showed that only pretreating the animals with $Rb_1(2.5-5\;mg/kg),\;but\;not\;Rg_l,$ resulted in an increase in thermogenesis and cold tolerance. In contrast to the acute effect of GS on cold tolerance, enhancement of exercise performance in rats was only observed after chronic treatment (4 days). Further, we were able to demonstrate that both $Rb_1\;and\;Rg_1$ are effective in enhancing aerobic endurance by exercise. To illustrate the beneficial effects of GS in learning and memory, a passive avoidance paradigm (shock prod) was used. Our results indicated that the scopolamineinduced amnesia can be significantly reversed by chronically treating (4 days) the rats with either $Rb_1\;or\;Rg_1$ (1.25 - 2.5 mg/kg). To further examine its underlying mechanisms, the effects of various GS on ${\beta}-amyloid-modulated$ acetylcholine (ACh) release from the hippocampal slices were examined. It was found that inclusion of $Rb_1$ (0.1 ${\mu}M$), but not $Rg_1$, can attenuate ${\beta}-amyloid-suppressed$ ACh release from the hippocampal slices. Our results demonstrated that $Rb_1\;and\;Rg_1$ are the key components involved in various beneficial effects of GS but they may elicit their effects through different mechanisms.

• Journal of the Korean Society of Environmental Restoration Technology
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• v.22 no.1
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• pp.13-31
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• 2019

Green spaces are recognised for the benefits. They bring to the quality of people's lives. However, since the 1980s there has been a general increase in poorly-managed green spaces. In an attempt to address this issue, green space policy has changed its focus on green space management through the gradual introduction of green space evaluation tools, such as the Green Flag Award (GFA). The GFA, as an established green space evaluation tool in the UK, reflects a shift in policy drivers of green spaces management. However, there is a lack of research investigating the contextualisation between a wide range of policy contexts and such green space evaluation tools (the GFA in this study). The aims of this study are therefore to explore the development of green space evaluation since the late 1990s, with respect to the growth of the GFA and its impact on other evaluation tools across the UK and several countries. To address the aims, this study employs in-depth literature reviews on UK green space policy mainly conducted by government. In addition, case studies are presented, focusing on the GFA and independent green space evaluation tools intrinsically derived from the GFA in the UK's cities and Nordic countries. Results show that based on the awareness of the severity of declining standards of green spaces, newly emerging policy arrangements have been adopted to address negative issues, which affect the standard of green spaces such as the transfer of responsibility for green space management, the implementation of Compulsory Competitive Tendering and ongoing budget cuts. Significantly, the GFA's indicators reflect the emerging changes of economic and social contexts associated with green spaces management where, in particular, the prospect of continuous budget cuts, which encourages communities to become involved in green space management. The GFA has widely contributed to leading such UK's cities and other countries to be able to create their independent green space evaluation tools in different approaches based on stakeholders' (mainly community) involvement in the decision-making process of green space evaluation. In conclusion, this study implies that successful green space evaluation tools do embody the value of green spaces and address drivers of emerging green space management with correspondence to the context of policy arrangements. Importantly, stakeholders have an opportunity to be involved in a partnership in the decision-making process through some green space evaluation tools. It is hoped that for well-managed green spaces this study will contribute valuable knowledge to our existing understanding of green space management in an era of austerity.

• Journal of the Korean Society of Environmental Restoration Technology
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• v.22 no.4
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• pp.15-34
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• 2019

Today, there is increasing recognition of the importance of urban regeneration for better public places. Urban parks as a public area play an important role in harnessing its positive impact on people's well-being: where the standards and funding of/for the parks are getting worse. There is however less a focus on policy approach to park regeneration in the country. Neverthless, a few UK's cases of such innovative park management(PM) has shown successful park regeneration based on policy support. Therefore, the aim of this research is to draw policy implications by exploring a case of successful park regeneration. To address the aim, this research conducts an in-depth case study of 'Manor Fields Park, UK', digging into its PM structure and PM body 'Green Estate Ltd' in relation to relevant policy. The data is mainly collected by interviews including a group interview. The analytical framework 'Place-keeping(PK)' and its six dimensions are employed to determine the characteristics of MFP's PM structure. Resultingly, there is a significant shift in the approach to PM which stresses the principle of long-term and self-sustaining structure led by a non-profit organisation and strong impacts of policy. In this context, PK highlights significant drivers for parks regeneration particularly in terms of policy implications: 1)providing policy support to encourage non-profit organisations in PM, 2)extending community involvement in decision-making processes, 3)promoting income generation by community groups, 4)shifting public awareness of shared responsibility for PM, 5)completing regular park maintenance assessment by community groups, and 6)delivering low-maintenance approaches to PM. To support these implications, PM structure for successful parks regeneration does meet a holistic and multi-dimensional approach of place-keeping underlined by understanding policy contexts and rethinking current status quo of PM. Addressing these implications will shed light on urban PM in an era of austerity and ultimately contribute to improving people's well-being.

• Parasites, Hosts and Diseases
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• v.58 no.6
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• pp.709-714
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• 2020

Knockdown resistance (kdr) mutations in the voltage-gated sodium channel (VGSC) of mosquitoes confer resistance to insecticides. Although insecticide resistance has been suspected to be widespread in the natural population of Aedes aegypti in Myanmar, only limited information is currently available. The overall prevalence and distribution of kdr mutations was analyzed in Ae. aegypti from Mandalay areas, Myanmar. Sequence analysis of the VGSC in Ae. aegypti from Myanmar revealed amino acid mutations at 13 and 11 positions in domains II and III of VGSC, respectively. High frequencies of S989P (68.6%), V1016G (73.5%), and F1534C (40.1%) were found in domains II and III. T1520I was also found, but the frequency was low (8.1%). The frequency of S989P/V1016G was high (55.0%), and the frequencies of V1016G/F1534C and S989P/V1016G/F1534C were also high at 30.1% and 23.5%, respectively. Novel mutations in domain II (L963Q, M976I, V977A, M994T, L995F, V996M/A, D998N, V999A, N1013D, and F1020S) and domain III (K1514R, Y1523H, V1529A, F1534L, F1537S, V1546A, F1551S, G1581D, and K1584R) were also identified. These results collectively suggest that high frequencies of kdr mutations were identified in Myanmar Ae. aegypti, indicating a high level of insecticide resistance.

• Journal of Korean Society of Water Science and Technology
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• v.26 no.6
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• pp.99-107
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• 2018

This research has developed a high temperature steam cleaning technology using a ceramic membrane with durability against temperature and pressure conditions. In steam cleaning, steam of $120^{\circ}C$ is injected into the ceramic membrane to induce pyrolysis by the endothermic reaction to remove fouling from the membrane. The water quality of raw water was adjusted to turbidity 10, 25 NTU and DOC 2.5 mg/L, and the membrane was uniformly fouled by constant pressure operation at 100, 200, and 300 kPa. Physical backwashing was performed with water and air at a pressure of 500 kPa and steam at $120^{\circ}C$ was injected for 0 to 5 minutes. As the turbidity concentration and the operating pressure increased, the flux decreased by 0.7 to 14.4%. It is confirmed that 10.7 to 53.8% recovery is possible than physical cleaning at the injection of steam for 3 minutes, so it is considered that the steam cleaning of the ceramic membrane is effective. Compared with CEB after NaOCl (300 mg/L) filtration at 25 NTU and 300 kPa of turbidity, the steam cleaning result for 3 minutes was similar to 46.7% of CEB for 3 hours. It has been confirmed that steam cleaning is suitable for a ceramic membrane having excellent heat resistance against high temperature. It was considered to have better cleaning efficiency as compared with general physical backwashing.

• Journal of Korean Society of Water Science and Technology
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• v.26 no.6
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• pp.61-72
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• 2018

In this study, applicability of the decentralized water supply system were investigated by the high flux evaluation using ceramic membrane with combined pretreatment process. A) filtration process increased the transmembrane pressure of 1.4 kPa and 89.5 kPa on 2 and $5m^3/m^2{\cdot}d$ of filtration flux, respectively, the physical backwashing recovery rate were less than 28.6%. The (B) Coag./Floc. - Sedi. combined process with 4 mg / L of A-PAC showed that the transmembrane pressure increased to within 6 kPa, the physical backwashing recovery rate was over 37.9 % higher than (A) Filtration process. (C) Coag./Floc. combined process showed an increase of transmembrane pressure compared with (B) Coag./Floc. - Sedi. combined process, physical backwashing recovery rate was over 84%. As a result of the membrane fouling analysis using the resistance in series model, the combined pretreatment process showed that the cake resistance (Rc) was more than 92% at membrane filtration flux of $2m^3/m^2{\cdot}d$. In the (C) Coag./Floc. combined process, cake resistance(Rc) was over 86% on high flux conditions. The coagulation floc contained in influent was removed by the membrane, and the cake layer formed with the removed floc was identified as reversible fouling resistance which could be recovered by physical backwashing. The decentralized water supply system, which has the limitation of site area and installation space, is considered to could be operation of high flux of ceramic membrane by applying (C) Coag./Floc. combined process without sedimentation process.

• Journal of the Korea Institute of Military Science and Technology
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• v.24 no.6
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• pp.645-654
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• 2021

In this paper, we proposed a protocol to convert 2W telephone analog signals to Ethernet data in a private PSTN 2W tactical voice system. There are several kinds of operational problems in the tactical telephone network where 2W telephone copper lines are installed hundreds of meters away from the PBX in a headquarter site. The reason is that it is difficult to install and maintain the 2W telephone copper cable in severe operational fields and to meet safety and stability operational requirements of the telephone line under lighting and electromagnetic environments. In order to solve these challenging demands, we proposed an efficient method that the 2W analog interface signals between a private PBX system and a 2W telephone is converted to Ethernet messages using the optical Ethernet data communication network already deployed in the tactical weapon system. Thus, it is not necessary to install an additional optic cable for the ethernet telephone line and to maintain the private PSTN 2W telephone network. Also it provides safe and secure telecommunication operation under lightning and electromagnetic environments. This paper presents the conversion protocol from 2W telephone signals over Ethernet interface between PBX systems and 2W telephones, the mutual exchange protocol of ethernet messages between two converters, and the rule to process analog signal interface. Finally, we demonstrate that the proposed technique can provide a feasible solution in the tactical weapon system by analyzing its performance and experimental results such as the bandwidth of 2W telephone ethernet network and the transmission latency of voice signal, and the stability of optic ethernet voice network along with the ethernet data network.

• Journal of Ginseng Research
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• v.47 no.1
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• pp.44-53
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• 2023

Background: The genus Panax in the Araliaceae family has been used as traditional medicinal plants worldwide and is known to biosynthesize ginsenosides and phytosterols. However, genetic variation between Panax species has influenced their biosynthetic pathways is not fully understood. Methods: Simultaneous analysis of transcriptomes and metabolomes obtained from adventitious roots of two tetraploid species (Panax ginseng and P. quinquefolius) and two diploid species (P. notoginseng and P. vietnamensis) revealed the diversity of their metabolites and related gene expression profiles. Results: The transcriptome analysis showed that 2,3-OXIDOSQUALENE CYCLASEs (OSCs) involved in phytosterol biosynthesis are upregulated in the diploid species, while the expression of OSCs contributing to ginsenoside biosynthesis is higher in the tetraploid species. In agreement with these results, the contents of dammarenediol-type ginsenosides were higher in the tetraploid species relative to the diploid species. Conclusion: These results suggest that a whole-genome duplication event has influenced the triterpene biosynthesis pathway in tetraploid Panax species during their evolution or ecological adaptation. This study provides a basis for further efforts to explore the genetic variation of the Panax genus.

• Journal of Dental Rehabilitation and Applied Science
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• v.38 no.4
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• pp.249-256
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• 2022

The implant prosthesis of anterior maxilla requires careful consideration in planning. In order to satisfy both esthetic and functional needs of a patient, fusion of intra-oral scan in Cone-beam computed tomography (CBCT) and facial scan can be considered. Bony structures and soft tissues captured in CBCT and occlusal surfaces of intra oral scan were incorporated into personal characteristics from facial scan. The patient had insufficient buccal bone on maxillary anterior area. The maxillary implants could not be placed on the most ideal position. However, the "top down" approach completed by computer-generated arranging of teeth in implant planning and surgery with surgical guide resulted in esthetically and functionally satisfying result regardless of the limitation. Careful diagnosis with digital technique and the usage of surgical guide resulted in successful surgery and esthetic restoration. The temporary fixed prostheses were designed, restored and evaluated. The patient was not satisfied with the first design of temporary prosthesis, which showed uneven space distribution between teeth due to the position of maxillary implant. The design was modified by changing proximal emergence contours and line angle to alter the perceived since of incisors. The patient was satisfied with the new design of provisional restoration. A digital occlusion analyzer (Arcus Digma II, KaVo, Leutkirch, Germany) was used to measure inherent condylar guidance and anterior guidance of a patient to provide a definitive prosthesis.

• Journal of the Korean Geotechnical Society
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• v.24 no.9
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• pp.41-48
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• 2008

The aim of this study is to present a graphical method in order to evaluate stages in shrinkage cracking. Firstly, the distribution of crack openings is established by sorting the openings of individual cracks in the soil cracking system. Secondly, it is normalized in a range of 0 to 1 to obtain the normalized crack opening distribution. Thirdly, three S-shape curve models introduced by Brooks and Corey(1964), Fredlund and Xing(1994) and van Genuchten(1980) are chosen to fit the normalized crack opening distribution using a curve fitting method. The accuracy of fitting which is described through fitting parameters by the van Genuchten equation is much higher than that by the Brooks and Corey equation and slightly higher than that by the Fredlund and Xing equation; thus the van Genuchten model is used. Finally, the stages of shrinkage cracking are graphically evaluated by drawing three separate straight lines corresponding to three linear parts of the fitted normalized crack opening distribution. The proposed method is tested with different sample thicknesses. The measured data are fitted by the selected model with the fairly high regression coefficient and small root mean square error. The results show graphically that shrinkage cracking comprises three stages; namely, primary, secondary and residual stages. Subsequently, the ranges of evaluated crack opening for each of these stages are presented.