• 항공우주시스템공학회지
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• 제7권2호
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• pp.42-46
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• 2013

In 2010, Airworthiness standard for VLA(Very Light Airplane) category was newly introduced as KAS Part VLA. KAS Part VLA is an adaption of EASA CS-VLA which was developed to reduce unnecessary burden of manufacturer of very light, simple, single-reciprocating-engine/propeller powered airplanes having low stall speeds by tailoring some requirements of Part 23. In this paper, difference and similarity of structural requirements between Part 23 and VLA was analyzed.

• 공업화학
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• 제5권5호
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• pp.801-807
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• 1994

락토오스 치환 스티렌 단량체, N-(p-vinylbenzyl)-D-lactonamide(VLA)는 락토오스락톤과 p-비닐벤질아민과의 아미드화반응을 따라 제조하였고, 비오틴 치환 스티렌 당량체, N-(p-vinylbenzyl)-biotinamide(VBA)는 비오틴의 카르복실기를 N, N'-dicyclohexylcarbodiimide 존재하에서 N-hydroxysuccinimide와 반응하여 활성화된 비오틴을 제조한 것을 이어서 p-비닐벤질아민과 아미드화시켜 합성하였다 합성한 이들 단량체(VLA와 VBA)의 반응 몰비를 바꿔가면서 라디칼 중합에 의하여 공중합체인 poly(vlnytbenzyl-lactonamide-co-vinylbenzylbiotinamide), p(VLA-co-VBA)을 합성하였고, 67~71%의 수율을 얻었다. 합성된 공중합체들은 친수성의 락토오스 부위와 소수성의 비닐벤질 부위 그리고 소량의 biotin 부위를 함께 갖고 있는 양친매성 중합체였음을 기기분석으로 확인하였다.

• 분석과학
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• 제9권1호
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• pp.84-90
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• 1996

본 연구에서는 스티렌 골격에 올리고당 및 비오틴 잔기를 결사슬에 갖는 새로운 세포 특이성 고분자 재료를 설계하여 합성하였다. 이들 고분자 재료를 간세포의 다점 인식 재료로서의 사용 가능성을 검토한 실험 결과를 보고하고자 한다. 간세포의 초기 접착 거동을 조사하기 위하여 합성된 고분자 재료 p(VLA-co- VBA) 90 : 10, p(VLA-co-VBA) 80 : 20 및 대조 물질로 PVLA의 농도가 각각 0.01%(w/v) 되도록 조절하여 1mL 씩 폴리스티렌 페트리 접시에 넣고, 혈청 존재 및 비존재하에서 Seglen법으로 단리한 간세포를 각각 첨가한 결과 60분 경과 후에는 혈청 비존재하에서와 같은 70% 정도의 높은 접착률을 보여 주었다. 폴리머 p(VLA-co-VBA) 70:30에 함유된 비오틴 잔기와 아비딘과의 분자 회합에 의한 응집형상은 UV 투과율의 변화로 확인 하였다.

• Journal of Communications and Networks
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• 제12권5호
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• pp.510-517
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• 2010

In this paper, an adaptive MAC protocol (variable load adaptive (VLA)-MAC) is proposed for wireless sensor networks. This protocol can achieve high energy efficiency and provide low latency under variable-traffic-load conditions. In the case of VLA-MAC, traffic load is measured online and used for adaptive adjustment. Sensor nodes transmit packets in bursts under high load conditions to alleviate packet accumulation and reduce latency. This also removes unnecessary listen action and decreases energy consumption in low load conditions. Simulation results show that the energy efficiency, latency, and throughput achieved by VLA-MAC are higher than those achieved by some traditional approaches.

• 천문학회보
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• 제42권1호
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• pp.38.2-38.2
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• 2017

We present the observational study toward the multiple outflows around $LkH{\alpha}$ 234 star formation region. The high-resolution, near-IR spectral mapping using the Immersion Grating Infrared Spectrograph (IGRINS) allowed us to distinguish at least four separate outflows with the molecular hydrogen ($H_2$) and forbidden iron ([Fe II]) emission lines. The outflow associated with the radio continuum source VLA 3B is detected in both H2 and [Fe II] emission, while the outflows driven by MM 1, VLA 2 sources were only detected in $H_2$, indicating the different physical conditions of outflows. We confirm the axis of VLA 3B jet, the position angle of ${\sim}240^{\circ}$. We firstly identified the redshifted, near-IR H2 outflow associated with VLA 2, which is coincident with the previous detections of $H_2O$ masers. From the $H_2$ line ratios, we interpret the gas properties of the shock excited blue- and redshifted components, and UV excited surrounding photodissociation region. We also discuss the origin of the high-velocity (|VLSR| > $150km\;s^{-1}$) $H_2$ emission.

• IMMUNE NETWORK
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• 제14권6호
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• pp.296-306
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• 2014

There is growing evidence that crosstalk between mantle cell lymphoma (MCL) cells and stromal microenvironments, such as bone marrow and secondary lymphoid tissues, promotes tumor progression by enhancing survival and growth as well as drug resistance of MCL cells. Recent advances in the understanding of lymphoma microenvironment have led to the identification of crucial factors involved in the crosstalk and subsequent generation of their targeted agents. In the present study, we evaluated the combinatory effect of blocking antibodies (Ab) targeting CXCR4 and VLA-4, both of which were known to play significant roles in the induction of environment-mediated drug resistance (EMDR) in MCL cell line, Jeko-1. Simultaneous treatment with anti-CXCR4 and anti-VLA-4 Ab not only reduced the migration of Jeko-1 cells into the protective stromal cells, but also enhanced sensitivity of Jeko-1 to a chemotherapeutic agent to a greater degree than with either Ab alone. These combinatorial effects were associated with decreased phosphorylation of ERK1/2, AKT and NF-${\kappa}B$. Importantly, drug resistance could not be overcome once the adhesion of Jeko-1 to the stromal occurred despite the combined use of Abs, suggesting that the efforts to mitigate migration of MCLs should be attempted as much as possible. Our results provide a basis for a future development of therapeutic strategies targeting both CXCR4 and VLA-4, such as Ab combinations or bispecific antibodies, to improve treatment outcomes of MCL with grave prognosis.

• Bulletin of the Korean Chemical Society
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• 제31권7호
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• pp.1931-1936
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• 2010

Discovery and isolation of compounds capable of blocking the interactions between VCAM-1 and VLA-4, a major pair of adhesion molecules contributing to the different steps of leukocyte migration across the endothelium in inflammatory responses, has been a major goal of this lab. Through bioactivity-guided fractionation, five saikosaponins were subsequently isolated from the methanol extracts of the roots of Bupleurum falcatum L. Their structures were elucidated by spectroscopic analysis ($^1H-$, $^{13}C$-NMR and 2D-NMR), as follows, saikosaponins: A (1); D (2); C (3); B3 (4); B4 (5). Compounds 1 and 2 inhibited interaction of sVCAM-1 and VLA-4 of THP-1 cells with respective $IC_{50}$ values of 7.8 and 1.7 ${\mu}M$. The aglycone structure of 2 also showed cell adhesion inhibitory activity with an $IC_{50}$ value of 21.1 ${\mu}M$. With these results, we suspect these two saikosaponins from the Bupleurum falcatum L. roots to be prime candidates for therapeutic strategies towards inflammation.

• International Journal of Aeronautical and Space Sciences
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• 제14권2호
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• pp.122-132
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• 2013

In this research the development of unstructured grid discretization solution techniques is presented. The purpose is to describe such a conservative discretization scheme applied for experimental validation work. The objective of this paper is to better establish the effects of mesh generation techniques on velocity fields and particle deposition patterns to determine the optimal aerodynamic characteristics. In order to achieve the objective, the mesh surface discretization approaches used the VLA prototype manufacturing tolerance zone of the outer surface. There were 3 schemes for this discretization study implementation. They are solver validation, grid convergence study and surface tolerance study. A solver validation work was implemented for the simple 2D and 3D model to get the optimum solver for the VLA model. A grid convergence study was also conducted with a different growth factor and cell spacing, the amount of mesh can be controlled. With several amount of mesh we can get the converged amount of mesh compared to experimental data. The density around surface model can be calculated by controlling the number of element in every important and sensitive surface area of the model. The solver validation work result provided the optimum solver to employ in the VLA model analysis calculation. The convergence study approach result indicated that the aerodynamic trend characteristic was captured smooth enough compared with the experimental data. During the surface tolerance scheme, it could catch the aerodynamics data of the experiment data. The discretization studies made the validation work more efficient way to achieve the purpose of this paper.

• 대한전자공학회논문지SP
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• 제43권1호
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• pp.75-84
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• 2006

NTSS 알고리즘 (New Three-Step Search Algorithm)은 대표적인 고속 블록 정합 알고리즘(Block Matching Algorithm: BMA)의 하나인 TSS 알고리즘 (Three-Step Search Algorithm)에 동영상이 갖는 중앙 편향적(Center-Biased) 특성을 반영한 방법이다. 그러나 NTSS는 움직임이 작은 동영상인 경우에는 TSS보다 개선된 성능을 보여주지만, 움직임이 큰 동영상에 대해서는 TSS와 큰 차이가 없으며, 탐색범위가 커질수록 오히려 성능이 떨어지는 단점이 있다 본 논문에서는 움직임 벡터의 특성에 따라 적응적으로 탐색범위를 결정하여 탐색범위의 증가로 발생되는 NTSS의 단점을 보완함으로써 움직임이 큰 동영상에 대해서도 향상된 성능을 갖는 방법을 제안한다. 제안한 방법을 적용하였을 때 움직임이 작은 동영상에서는 기존 NTSS 방법과 동일한 화질을 유지하면서 움직임이 큰 동영상에서는 최대 0.5dB 이상 성능이 개선되었다.

• 천문학회보
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• 제31권1호
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• pp.38.2-38.2
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• 2006