• 디지털산업정보학회논문지
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• 제19권4호
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• pp.97-115
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• 2023

In South Korea, chronic kidney disease(CKD) impacts around 4.6 million adults, leading to a high reliance on hemodialysis. For effective dialysis, vascular access is crucial, with decisions about vascular surgeries often made during dialysis sessions. Anticipating these needs could improve dialysis quality and patient comfort. This study investigates the use of Artificial Intelligence(AI) to predict the timing of surgeries for dialysis vessels, an area not extensively researched. We've developed an AI algorithm using predictive maintenance methods, transitioning from machine learning to a more advanced deep learning approach with Long Short-Term Memory(LSTM) models. The algorithm processes variables such as venous pressure, blood flow, and patient age, demonstrating high effectiveness with metrics exceeding 0.91. By shortening the data collection intervals, a more refined model can be obtained. Implementing this AI in clinical practice could notably enhance patient experience and the quality of medical services in dialysis, marking a significant advancement in the treatment of CKD.

• Journal of Periodontal and Implant Science
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• 제47권5호
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• pp.292-311
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• 2017

Purpose: Beyond the limited scope of non-specific polyclonal regulatory T cell (Treg)-based immunotherapy, which depends largely on serendipity, the present study explored a target Treg subset appropriate for the delivery of a novel epitope spreader Pep19 antigen as part of a sophisticated form of immunotherapy with defined antigen specificity that induces immune tolerance. Methods: Human polyclonal $CD4^+CD25^+CD127^{lo-}$ Tregs (127-Tregs) and $na\ddot{i}ve$ $CD4^+CD25^+CD45RA^+$ Tregs (45RA-Tregs) were isolated and were stimulated with target peptide 19 (Pep19)-pulsed dendritic cells in a tolerogenic milieu followed by ex vivo expansion. Low-dose interleukin-2 (IL-2) and rapamycin were added to selectively exclude the outgrowth of contaminating effector T cells (Teffs). The following parameters were investigated in the expanded antigen-specific Tregs: the distinct expression of the immunosuppressive Treg marker Foxp3, epigenetic stability (demethylation in the Treg-specific demethylated region), the suppression of Teffs, expression of the homing receptors CD62L/CCR7, and CD95L-mediated apoptosis. The expanded Tregs were adoptively transferred into an $NOD/scid/IL-2R{\gamma}^{-/-}$ mouse model of collagen-induced arthritis. Results: Epitope-spreader Pep19 targeting by 45RA-Tregs led to an outstanding in vitro suppressive T cell fate characterized by robust ex vivo expansion, the salient expression of Foxp3, high epigenetic stability, enhanced T cell suppression, modest expression of CD62L/CCR7, and higher resistance to CD95L-mediated apoptosis. After adoptive transfer, the distinct fate of these T cells demonstrated a potent in vivo immunotherapeutic capability, as indicated by the complete elimination of footpad swelling, prolonged survival, minimal histopathological changes, and preferential localization of $CD4^+CD25^+$ Tregs at the articular joints in a mechanistic and orchestrated way. Conclusions: We propose human $na\ddot{i}ve$ $CD4^+CD25^+CD45RA^+$ Tregs and the epitope spreader Pep19 as cellular and molecular targets for a novel antigen-specific Treg-based vaccination against collagen-induced arthritis.

• Molecules and Cells
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• 제25권1호
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• pp.64-69
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• 2008

Although the arthritis symptoms observed in the K/BxN model have been shown to be dependent on the functions of T and B cells specific to the self antigen glucose-6-phosphate isomerase, less is known about the in vivo roles of $CD4^{+}CD25^{+}$ regulatory T($T_{reg}$) cells in the pathology of K/BxN mice. We determined the quantitative and functional characteristics of the $T_{reg}$ cells in K/BxN mice. These mice contained a higher percentage of $Foxp3^+\;T_{reg}$ cells among the $CD4^+$ T cells than their BxN littermates. These $T_{reg}$ cells were anergic and efficiently suppressed the proliferation of $na\ddot{i}ve$ $CD4^+$ T cells and cytokine production by effector $CD4^+$ T cells in vitro. Antibody-mediated depletion of $CD25^+$ cells caused K/BxN mice to develop multi-organ inflammation and autoantibody production, while the symptoms of arthritis were not affected. These results demonstrate that despite the inability of the $T_{reg}$ cells to suppress arthritis development, they play a critical role protecting the arthritic mice from systemic expansion of autoimmunity.

• 응용통계연구
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• 제13권2호
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• pp.457-476
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• 2000

본 연구에서는 선형추세를 갖는 모집단에 대한 효율적인 표본추출방법과 모평균 추정법을 제안하였다. 이 방법은 계통추출을 확장한 중심균형계통추출을 써서 표본을 뽑은 뒤 표본평균보다 수정된 추정량을 써서 모평균을 추정하는 것이다. 수정된 추정량을 정하는 데에 보간법의 개념을 사용하였다. 제안된 추정량과 기존의 방법에 으한 추정량들의 효율을 Cochran(1946)의 무한초모집단모형에 근거를 둔 기대평균제곱오차를 기준으로 하여 비교하였다. 제안된 방법은 표본크기 n($\geq$5)이 홀수이고 추출률의 역수인 $textsc{k}$가 짝수인 경우에 사용하기 위한 것이다. 모의실험을 이용한 예어서도 역시 좋은 결과가 얻어졌다.

• International Journal of Oral Biology
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• 제42권3호
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• pp.129-135
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• 2017

The present study investigated the role of spinal glutamate recycling in the development of orofacial inflammatory pain or trigeminal neuropathic pain. Experiments were carried out on male Sprague-Dawley rats weighing between 230 and 280 g. Under anesthesia, a polyethylene tube was implanted in the atlanto-occipital membrane for intracisternal administration. IL-$1{\beta}$-induced inflammation was employed as an orofacial acute inflammatory pain model. IL-$1{\beta}$ (10 ng) was injected subcutaneously into one vibrissal pad. We used the trigeminal neuropathic pain animal model produced by chronic constriction injury of the infraorbital nerve. DL-threo-${\beta}$-benzyloxyaspartate (TBOA) or methionine sulfoximine (MSO) was administered intracisternally to block the spinal glutamate transporter and the glutamine synthetase activity in astroglia. Intracisternal administration of TBOA produced mechanical allodynia in naïve rats, but it significantly attenuated mechanical allodynia in rats with interleukin (IL)-$1{\beta}$-induced inflammatory pain or trigeminal neuropathic pain. In contrast, intracisternal injection of MSO produced anti-allodynic effects in rats treated with IL-$1{\beta}$ or with infraorbital nerve injury. Intracisternal administration of MSO did not produce mechanical allodynia in naive rats. These results suggest that blockade of glutamate recycling induced pro-nociception in na?ve rats, but it paradoxically resulted in anti-nociception in rats experiencing inflammatory or neuropathic pain. Moreover, blockade of glutamate reuptake could represent a new therapeutic target for the treatment of chronic pain conditions.

• 대한기계학회논문집B
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• 제35권4호
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• pp.425-429
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• 2011

원자로의 노심 손상에 따른 노심 용융물의 노외 유출시 코어캐처라고 불리는 설비를 통해 용융물을 억제하고 냉각시키게 된다. 이 때 노외 노심용융물의 거동은 희생물질과의 반응을 포함한 복잡한 물리적, 화학적 현상에 의해 결정된다. 이 연구는 기존의 용융물 거동 실험결과에 대해 용융물의 유동과 열전달의 세부적인 특성을 상용코드를 이용해 해석하여 검증함으로써 코어캐처의 설계에 활용할 수 있도록 하기 위한 것이다. 단순화된 채널에서 시간에 따른 용융물과 공기의 이상유동과 복사열전달을 VOF 모델과 구분종좌법을 적용하여 비정상상태에서 해석한 결과, 열전달에 따른 용융물 내부의 온도 변화 및 이에 따른 점성 변화 등을 예측할 수 있음을 확인하였다. 이러한 접근방식을 기초로 향후 용융물의 조성, 유량 및 용도 등의 조건에 따른 용융물의 거동에 대한 자세한 평가가 필요하다.

• 한국빅데이터학회지
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• 제3권2호
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• pp.35-49
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• 2018

대한민국에서 치킨집은 전 세계 맥도날드 매장 수보다 많을 정도로 자영업의 큰 비중을 차지하는 창업 업종이다. 치킨집은 꾸준히 생겨나고 있지만, 소상공인의 창업 후 폐업률은 3년 62%, 5년 71%에 육박하는 것으로 나타났다. 특히, 숙박 및 음식점의 경우 70%가 3년을, 82%가 5년을 버티지 못하는 것으로 집계되었다. 이에 본 연구는 '서울 치킨집 폐업 예측 모형'을 개발하여, 예비창업자가 개업 후보지를 선정하는 의사결정 과정에 도움을 주고자 하였다. 먼저 행정자치부 지방행정 인허가 데이터의 업소별 개 폐업 신고 일자를 중심으로 다양한 변수를 수집하였다. 이후 다양한 분류 알고리즘을 적용하고, 예측 모형의 성능을 비교하였다. 그 결과, 인공신경망(Neural Networks)이 가장 높은 정확도를 보였지만 특이도와 민감도가 불균형적이었다. 이에 비해 유연판별분석(FDA)은 인공신경망보다 정확도는 낮지만, 상대적으로 균형적인 예측 성능을 보였다.

• 수산경영론집
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• 제40권2호
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• pp.105-126
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• 2009

This study applies the cointegration theory to analyse the causality of the prices between imported fisheries and domestic fisheries in distribution channel. We've focused on the prices of import, wholesale and retail about the frozen Alaska pollack, hairtail and croaker which take up high portion and are popular among most of the consumers. In process of analysis, the unit root test was adopted to find the stability of time series data prior to the cointegration test. If the time series data was found as stable one in unit root test, we should analyse the VAR model. If unstable, the cointegratioin test was adopeted to find the long-run equilibrium relationship between the data. When the long-run equilibrium relationship was found among the price of the import, wholesale and retail price, the VECM model was adoped. If not, the differenced VAR model was adopted. The main findings of this study could be summarized as follows ; First, according to the result of the analysis on VAR model, time series data of frozen Alaska pollack was found as stable and has causality relationship and close effect was existing among the import, wholesale and retail price. Second, the data of frozen hairtail was found as an unstable one in unit root test and the result of cointegration test showed the long-run equilibrium relationship at lag 1. From the results of VECM model, we could find that the coefficient of error correction is effective, and the sign is negative(-). It means that the existence of adjustment tendency to long-run equilibrium after a short-run deviation. But the short-run causality of the prices were not found except the price of wholesale. Third, according to the results of differenced VAR model, data from frozen croaker did not have the stability and long-run equilibrium. Moreover, it was found that the import price has a weak causality on the retail price. Because of having difficulties in collecting data, the result of this paper could not explain the relationship among the prices of import, wholesale and retail perfectly. However, it more or less contributed to a long-lasted debate on the direction of causality of price-setting in academic research and provided a useful guide for the policy makers in charge of the price-setting of fisheries products as well.

• 동의생리병리학회지
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• 제21권6호
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• pp.1549-1554
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• 2007

To verify the effects of JAUN-1, which is a water-extracted herbal mixture, on gastroenteric disorders induced by 0.1 percent of iodoacetamide (IA) in rats. We divided four groups, $Na{\"{\i}}ve$ + Distilled Water (DW), 0.1% IA + DW, 0.1% IA + Proton pump inhibitor (Lansoprazole, 5 mg/kg) and 0.1% IA + Herbal mixture (JAUN-1, 50mg/kg) and performed following experimental methods to confirm its advantageous effects against ulcerogenic stomach in rats induced by 0.1% IA; cell cytotoxicity, analysis of lesions score, Hematoxylin & Eosin (H&E) stain, RT-PCR for ${\beta}-actin$, COX-1 and COX-2 and evaluation of intestinal prokinetic activity. No cytotoxicity was elucidated at the concentration of 1, 5, 10, 50, 100, $500\;{\mu}g/ml$ and 1mg/ml JAUN-1 through MTT Assay using by human stomach epithelial AGS cells, respectively. In addition, the JAUN-1 treated group and the lansoprazole treated group significantly decreased in lesions score compared to the DW treated group in the gastritis induced rat model, and results of immunohistochemistry by H&E staining showed that histological recovery in Proton Pump Inhibitor (PPI) and JAUN-1 treated groups rather than the DW administrated group. Another outcome was that ${\beta}-actin$ relative COX-2 expression level was significantly promoted in the DW treated group while ${\beta}-actin$ relative COX-1 expression level was no meaningful change in this rat model. Finally, intestinal prokinetic activity was recovered from low level of prokinetic activity due to 0.1% IA induced gastritis to the similar level of Normal group. These results suggested that JAUN-1 may have beneficial effects against 0.1% IA-induced gastritis rat model through decreasing lesions score, histological recovery, ${\beta}-actin$ relative COX-1, 2 expression level and prokinetic activity.

• 한국BIM학회 논문집
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• 제2권1호
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• pp.1-6
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• 2012

With the increased awareness of energy consumption as well as the environmental impact of building operations, architects, designers and planners are required to place more consideration on sustainability and energy performance of the building. To ensure most of those considerations are reflected in the building performance, critical design decisions should be made by key stakeholders early during the design development stage. The application of BIM during building energy simulations has profoundly improved the energy analysis process and thus this approach has gained momentum. However, despite rapid advances in BIM-based processes, the question still remains how ordinary building stakeholders can perform energy performance analysis, which has previously been conducted predominantly by professionals, to maximize energy efficient building performance. To address this issue, we identified two leading building performance analysis software programs, Energy Plus and IES (IES ), and compared their effectiveness and suitability as BIM-based energy simulation tools. To facilitate this study, we examined a case study on Building Performance Model (BPM) of a single story building with one door, multiple windows on each wall, a slab and a roof. We focused particularly on building energy performance by differing building orientation and window sizes and compared how effectively these two software programs analyzed the performance. We also looked at typical decision-making processes implementing building energy simulation program during the early design stages in the U.S. Finally, conclusions were drawn as to how to conduct BIM-based building energy performance evaluations more efficiently. Suggestions for further avenues of research are also made.