• Asian Pacific Journal of Cancer Prevention
• /
• v.15 no.8
• /
• pp.3359-3362
• /
• 2014

Increasing attention is being devoted to the mechanisms by which cells receive signals and then translate these into decisions for growth, death, or migration. Recent findings have presented significant breakthroughs in developing a deeper understanding of the activation or repression of target genes and proteins in response to various stimuli and of how they are assembled during signal transduction in cancer cells. Detailed mechanistic insights have unveiled new maps of linear and integrated signal transduction cascades, but the multifaceted nature of the pathways remains unclear. Although new layers of information are being added regarding mechanisms underlying ovarian cancer and how polymorphisms in VDR gene influence its development, the findings of this research must be sequentially collected and re-interpreted. We divide this multi-component review into different segments: how vitamin D modulates molecular network in ovarian cancer cells, how ovarian cancer is controlled by tumor suppressors and oncogenic miRNAs and finally how vitamin D signaling regulates miRNA expression. Intra/inter-population variability is insufficiently studied and a better understanding of genetics of population will be helpful in getting a step closer to personalized medicine.

• Journal of Aerospace System Engineering
• /
• v.1 no.4
• /
• pp.13-21
• /
• 2007

As one of YHF digital data link technologies, VDL Mode 2 is designed to be an air-to-ground subnetwork of the Aeronautical Telecommunication Network (ATN) based on the Open System Interconnection (OSI) architecture. VDL Mode 2 can be used in ATS Applications especially for CPDLC and ADS. And it is also expected to replace ACARS (Aircraft Communications Addressing and Reporting System) which has broadly been used in AOC for over 20 years. This paper presents the design result of VDL Mode 2 system under AOA (ACARS Over AVLC) environment for the implementation of bit-oriented ATS applications. The system is composed of airborne and ground subsystem. Airborne subsystem consists of VDR, CMU and an aircraft test equipment with CPDLC/ADS client applications for operational test and ground system consists of Ground Station which includes ground VDR and ground communication controller, simple DSP (Datalink Service Processor) and a ground test equipment with CPDLC/ADS server applications.

• Journal of the Korean institute of surface engineering
• /
• v.52 no.6
• /
• pp.310-315
• /
• 2019

The use of a silicon carbide (SiC)-based composite ceramic layer for the mold of a curved cover glass was demonstrated. The stress of SiC/VDR/graphite-based mold structure was evaluated via finite element analysis. The results revealed that the maximum tensile stress primarly occured at the edge region. Moreover, the stress can be reduced by employing a relatively thick SiC coating layer and, therefore, layers of various thicknesses were deposited by means of chemical vapor deposition. During growth of the layer, the orientation of the facets comprising the SiC grain became dominant with additional intense SiC(220) and SiC(004). However, the roughness of the SiC layer increased with increasing thickness of the layer and. Hence, the thickness of the SiC layer needs to be adjusted by values lower than the tolerance band of the curved cover glass mold.

• Journal of Power Electronics
• /
• v.18 no.1
• /
• pp.34-44
• /
• 2018

This paper presents a pulse-width adjustment (PWA) strategy for a novel bidirectional DC-DC boost converter to improve the performance of the dynamic inductor current response. This novel converter consists of three main components: a full-bridge converter (FBC), a high-frequency isolated transformer with large leakage inductance, and a three-level voltage-doubler rectifier (VDR). A number of scholars have analyzed the principles, such as the soft-switching performance and high-efficiency characteristic, of this converter based on pulse-width modulation plus phase-shift (PPS) control. It turns out that this converter is suitable for energy storage applications and exhibits good performance. However, the dynamic inductor current response processes of control variable adjustment is not analyzed in this converter. In fact, dc component may occur in the inductor current during its dynamic response process, which can influence the stability and reliability of the converter system. The dynamic responses under different operating modes of a conventional feedforward control are discussed in this paper. And a PWA strategy is proposed to enhance the dynamic inductor current response performance of the converter. This paper gives a detailed design and implementation of the PWA strategy. The proposed strategy is verified through a series of simulation and experimental results.

• Asian Pacific Journal of Cancer Prevention
• /
• v.16 no.5
• /
• pp.2019-2026
• /
• 2015

Much interest has been drawn to possible associations between vitamin D receptor (VDR) gene polymorphisms and colorectal cancer risk in conjunction with potentially protective effects of calcium and vitamin D. In a study of 685 cases of colorectal cancer and 778 community controls in Japan, we examined the associations of the FokI, BsmI, ApaI, and TaqI polymorphisms with colorectal cancer risk and effect modification by dietary calcium and vitamin D. Genotypes were determined by the PCR-RFLP method. The ApaI polymorphism seemed to be associated with a decreased risk of colorectal cancer, particularly of rectal cancer. The adjusted odds ratio of colorectal cancer for the ApaI AA and Aa genotypes combined versus the aa genotype was 0.83 (95% confidence interval [CI] 0.67-1.02), and the corresponding value for rectal cancer was 0.75 (95%CI 0.56-0.99). A decreased risk of colorectal cancer for the ApaI AA and Aa genotypes combined was more evident in individuals with high calcium intake (interaction p=0.055). The FokI polymorphism seemed to be associated with a decreased risk of colon cancer among those with high vitamin D intake (interaction p=0.09). The BsmI and TaqI polymorphisms were unrelated to colorectal cancer risk, and the null associations were not modified by calcium or vitamin D intake. In conclusion, the ApaI polymorphism may be associated with a decreased risk of colorectal cancer in Japanese, dependent on dietary calcium intake.

• Nutrition Research and Practice
• /
• v.18 no.1
• /
• pp.1-18
• /
• 2024

BACKGROUND/OBJECTIVES: Endoplasmic reticulum (ER) stress in adipose tissue causes an inflammatory response and leads to metabolic diseases. However, the association between vitamin D and adipose ER stress remains poorly understood. In this study, we investigated whether 1,25-dihydroxyvitamin D₃ (1,25(OH)₂D₃) alleviates ER stress in adipocytes. MATERIALS/METHODS: 3T3-L1 cells were treated with different concentrations (i.e., 10-100 nM) of 1,25(OH)₂D₃ after or during differentiation (i.e., on day 0-7, 3-7, or 7). They were then incubated with thapsigargin (TG, 500 nM) for an additional 24 h to induce ER stress. Next, we measured the mRNA and protein levels of genes involved in unfold protein response (UPR) and adipogenesis using real-time polymerase chain reaction and western blotting and quantified the secreted protein levels of pro-inflammatory cytokines. Finally, the mRNA levels of UPR pathway genes were measured in adipocytes transfected with siRNA-targeting Vdr. RESULTS: Treatment with 1,25(OH)₂D₃ during various stages of adipocyte differentiation significantly inhibited ER stress induced by TG. In fully differentiated 3T3-L1 adipocytes, 1,25(OH)₂D₃ treatment suppressed mRNA levels of Ddit3, sXbp1, and Atf4 and decreased the secretion of monocyte chemoattractant protein-1, interleukin-6, and tumor necrosis factor-α. However, downregulation of the mRNA levels of Ddit3, sXbp1, and Atf4 following 1,25(OH)₂D₃ administration was not observed in Vdr-knockdown adipocytes. In addition, exposure of 3T3-L1 preadipocytes to 1,25(OH)₂D₃ inhibited transcription of Ddit3, sXbp1, Atf4, Bip, and Atf6 and reduced the p-alpha subunit of translation initiation factor 2 (eIF2α)/eIF2α and p-protein kinase RNA-like ER kinase (PERK)/PERK protein ratios. Furthermore, 1,25(OH)₂D₃ treatment before adipocyte differentiation reduced adipogenesis and the mRNA levels of adipogenic genes. CONCLUSIONS: Our data suggest that 1,25(OH)₂D₃ prevents TG-induced ER stress and inflammatory responses in mature adipocytes by downregulating UPR signaling via binding with Vdr. In addition, the inhibition of adipogenesis by vitamin D may contribute to the reduction of ER stress in adipocytes.

• Proceedings of the IEEK Conference
• /
• 2009.05a
• /
• pp.178-181
• /
• 2009

본 논문에서는 선박용 항해정보기록장치의 개발을 위해 필요한 요구사항을 만족할 수 있는 기능을 갖추고, 향후 여러 가지 부가 기능이 쉽게 추갇힐 수 있는 구조를 갖도록 WnCE O/S 기반 ARM embedded 시스템용 플랫폼을 설계하였고, 주요 기능 중 영상 정보 압축 및 저장 회로를 구현하여 기능을 검증하였다.

• Proceedings of the Korean Institute of Navigation and Port Research Conference
• /
• 2011.06a
• /
• pp.74-76
• /
• 2011

다기능 선박조종시뮬레이터(Full-mission Shiphandling Simulator)를 이용한 사고분석 방법은 먼저 사고관련 정보기록을 수집하여 이에 맞는 항만/해역의 데이터베이스를 만들고 이를 바탕으로 사고 선박의 제원, 사진 및 기타정보를 토대로 일반적인 변수 값 기관 특성정보, Hydrodynamic 특성 변경과 선박의 외형에 따라 선박의 데이터베이스를 만들고, 시험운항을 통한 수치를 보정한다. 그리고 이 데이터베이스를 기초로 하여 시뮬레이션 시나리오를 만들어서 사고 당시를 재연하면서 그때, 그때의 상황의 자료를 수집하여 분석하게 된다.

• Molecules and Cells
• /
• v.40 no.9
• /
• pp.677-684
• /
• 2017

Postmenopausal atrophic vagina (PAV) is the thinning of the walls of the vagina and decreased lugae of the vagina. PAV is caused by decreased estrogen levels in postmenopausal women. However, the harmful effects of hormone replacement therapy (HRT) have resulted in considerable caution in its use. Various estrogen agonist treatment options are available. Vitamin D is influences the regulation of differentiation and proliferation of various cells, especially tissues lining stratified squamous epithelium, such as the vaginal epithelium. In this study, we hypothesized that vitamin D could provide an alternative and a safe treatment option for PAV by promoting the proliferation and differentiation of the vaginal epithelium. Thirty six patients were enrolled in this case-control study. Vitamin D associated proteins in a vitamin D and sex hormone treated vaginal epithelial cell line as well as normal and PAV tissues were measured. To confirm of cell-to-cell junction protein expression, cell line and tissue studies included RT-PCR, immunohistochemistry staining, and immunoblot analyses. The expression of cell-to-cell junction proteins was higher in women with symptoms of atrophic vagina tissue compared to women without the symptoms. Vitamin D stimulated the proliferation of the vaginal epithelium by activating p-RhoA and Erzin through the vitamin D receptor (VDR). The results suggest that vitamin D positively regulates cell-to-cell junction by increasing the VDR/p-RhoA/p-Ezrin pathway. This is the first study to verify the relationship of the expression of RhoA and Ezrin proteins in vaginal tissue of PAV.

• Journal of the Korean institute of surface engineering
• /
• v.53 no.6
• /
• pp.293-299
• /
• 2020

The characteristics of the polycarbosilane (PCS)-based composite ceramic layer was studied by controlling the curing temperature. The stress at the interface of the graphite and SiOC composite layer was evaluated v ia finite element analysis. As a result, the tensile stress was released as the carbon ratio of the SiC decreases. In experiment, the SiOC layers were coated on the VDR graphite block by dip-coating process. It was revealed that the composition of Si and C was effectively adjusted depending on the curing temperature. As the solution-based process is employed, the surface roughness was reduced for the appropriate PCS curing temperature. Hence, it is expected that the cured SiOC layer can be utilized to reduce cracking and peeling of SiC ceramic composites on graphite mold by improving the interfacial stress and surface roughness.