Browse > Article
http://dx.doi.org/10.7314/APJCP.2015.16.5.2019

Associations between Vitamin D Receptor (VDR) Gene Polymorphisms and Colorectal Cancer Risk and Effect Modifications of Dietary Calcium and Vitamin D in a Japanese Population  

Takeshige, Nobuyuki (Department of Preventive Medicine, Graduate School of Medical Sciences, Kyushu University)
Yin, Guang (Department of Preventive Medicine, Graduate School of Medical Sciences, Kyushu University)
Ohnaka, Keizo (Department of Geriatric Medicine, Graduate School of Medical Sciences, Kyushu University)
Kono, Suminori (Department of Preventive Medicine, Graduate School of Medical Sciences, Kyushu University)
Ueki, Takashi (Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University)
Tanaka, Masao (Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University)
Maehara, Yoshihiko (Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University)
Okamura, Takeshi (Department of Gastroenterological Surgery, National Kyushu Medical Center)
Ikejiri, Koji (Division of Surgery, National Kyushu Medical Center)
Maekawa, Takafumi (Department of Surgery, Fukuoka University Chikushi Hospital)
Yasunami, Yohichi (Department of Regenerative Medicine & Transplantation, Faculty of Medicine, Fukuoka University)
Takenaka, Kenji (Fukuoka City Hospital)
Ichimiya, Hitoshi (Hamanomachi General Hospital)
Terasaka, Reiji (Fukuoka Red Cross Hospital)
Publication Information
Asian Pacific Journal of Cancer Prevention / v.16, no.5, 2015 , pp. 2019-2026 More about this Journal
Abstract
Much interest has been drawn to possible associations between vitamin D receptor (VDR) gene polymorphisms and colorectal cancer risk in conjunction with potentially protective effects of calcium and vitamin D. In a study of 685 cases of colorectal cancer and 778 community controls in Japan, we examined the associations of the FokI, BsmI, ApaI, and TaqI polymorphisms with colorectal cancer risk and effect modification by dietary calcium and vitamin D. Genotypes were determined by the PCR-RFLP method. The ApaI polymorphism seemed to be associated with a decreased risk of colorectal cancer, particularly of rectal cancer. The adjusted odds ratio of colorectal cancer for the ApaI AA and Aa genotypes combined versus the aa genotype was 0.83 (95% confidence interval [CI] 0.67-1.02), and the corresponding value for rectal cancer was 0.75 (95%CI 0.56-0.99). A decreased risk of colorectal cancer for the ApaI AA and Aa genotypes combined was more evident in individuals with high calcium intake (interaction p=0.055). The FokI polymorphism seemed to be associated with a decreased risk of colon cancer among those with high vitamin D intake (interaction p=0.09). The BsmI and TaqI polymorphisms were unrelated to colorectal cancer risk, and the null associations were not modified by calcium or vitamin D intake. In conclusion, the ApaI polymorphism may be associated with a decreased risk of colorectal cancer in Japanese, dependent on dietary calcium intake.
Keywords
Colorectal cancer; VDR polymorphisms; calcium; vitamin D; diet; Japan;
Citations & Related Records
Times Cited By KSCI : 5  (Citation Analysis)
연도 인용수 순위
1 Atoum MF, Tchoporyan MN (2014). Association between circulating vitamin D, the Taq1 vitamin D receptor gene polymorphism and colorectal cancer risk among Jordanians. Asian Pac J Cancer Prev, 15, 7337-41.   DOI
2 Bai YH, Lu H, Hong D, et al (2012). Vitamin D receptor gene polymorphisms and colorectal cancer risk: A systematic meta-analysis. World J Gastroenterol, 18, 1672-9.   DOI   ScienceOn
3 Ferlay J, Shin HR, Bray F, et al (2010). Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. Int J Cancer, 127, 2893-917.   DOI
4 Garland C, Shekelle RB, Barrett-Connor E, et al (1985). Dietary vitamin D and calcium and risk of colorectal cancer: A 19- year prospective study in men. Lancet, 1, 307-9.
5 Gorham ED, Garland CF, Garland FC, et al (2007). Optimal vitamin D status for colorectal cancer prevention: A quantitative meta analysis. Am J Prev Med, 32, 210-6.   DOI   ScienceOn
6 Habuchi T, Suzuki T, Sasaki R, et al (2000) Association of vitamin D receptor gene polymorphism with prostate cancer and benign prostatic hyperplasia in a Japanese population. Cancer Res, 60, 305-8.
7 Holick MF (2007). Vitamin D deciciency. N Engl J Med, 357, 266-81.   DOI
8 Isomura K, Kono S, Moore MA, et al (2006). Physical activity and colorectal cancer: The Fukuoka Colorectal Cancer Study. Cancer Sci, 97, 1099-104.   DOI
9 Kono S (2004). Secular trend of colon cancer incidence and mortality in relation to fat and meat intake in Japan. Eur J Cancer Prev, 13, 127-32.   DOI
10 Kono S, Toyomura K, Yin G, Nagano J, Mizoue T (2004). A case-control study of colorectal cancer in relation to lifestyle factors and genetic polymorphisms: Design and conduct of the Fukuoka Colorectal Cancer Study. Asian Pac J Cancer Prev, 5, 393-400.
11 Li C, Li Y, Gao LB, et al (2009). Vitamin D receptor gene polymorphisms and the risk of colorectal cancer in a Chinese population. Dig Dis Sci, 54, 634-9.   DOI
12 Mahmoudi T, Karimi K, Mohebbi SR, et al (2011). Start codon FokI and intron 8 BsmI variants in the vitamin D receptor gene and susceptibility to colorectal cancer. Mol Biol Rep, 38, 4765-70.   DOI
13 Nassiri M, Kooshyar MM, Roudbar Z, Mahdavi M, Doosti M (2013). Genes and SNPs associated with non-hereditary and hereditary colorectal cancer. Asian Pac J Cancer Prev, 14, 5609-14.   DOI   ScienceOn
14 Mizoue T, Kimura Y, Toyomura K, et al (2008). Calcium, dairy foods, vitamin D, and colorectal cancer risk: The Fukuoka Colorectal Cancer Study. Cancer Epidemiol Biomarkers Prev, 17, 2800-7.   DOI   ScienceOn
15 Morita M, Le Marchand L, Kono S, et al (2009). Genetic polymorphisms of CYP2E1 and risk of colorectal cancer: The Fukuoka Colorectal Cancer Study. Cancer Epidemiol Biomarkers Prev, 18, 235-41.   DOI
16 Morita M, Yin G, Yoshimitsu S, et al (2013). Folate-related nutrients, genetic polymorphisms, and colorectal cancer risk: the Fukuoka Colorectal Cancer Study. Asian Pac J Cancer Prev, 14, 6249-56.   DOI
17 Park K, Woo M, Nam J, Kim JC (2006). Start codon polymorphisms in the vitamin D receptor and colorectal cancer risk. Cancer Lett, 237, 199-206.   DOI   ScienceOn
18 Peters U, Hayes RB, Chatterjee N, et al (2004). Circulating vitamin D metabolites, polymorphism in vitamin D receptor, and colorectal adenoma risk. Cancer Epidemiol Biomarkers Prev, 13, 546-52.
19 Raimondi S, Johansson H, Maisonneuve P, Gandini S (2009). Review and meta-analysis on vitamin D receptor polymorphisms and cancer risk. Carcinogenesis, 30, 1170-80.   DOI
20 Rasool S, Kadla SA, Khan T, et al (2013). Association of a VDR gene polymorphism with risk of colorectal cancer in Kashmir. Asian Pac J Cancer Prev, 14, 5833-7.   DOI   ScienceOn
21 Slattery ML, Yakumo K, Hoffman M, Neuhausen S (2001). Variants of the VDR gene and risk of colon cancer (United States). Cancer Causes Control, 12, 359-64.   DOI
22 Uchida K, Kimura Y, Shirota T, Kono S (2007). Validity and reproducibility of the PC-assisted dietary interview used in the Fukuoka Colorectal Cancer Study. Asian Pac J Cancer Prev, 8, 583-90.
23 Slattery ML, Neuhausen SL, Hoffman M, et al (2004). Dietary calcium, vitamin D, VDR genotypes and colorectal cancer. Int J Cancer, 111, 750-6.   DOI
24 Theodoratou E, Farrington SM, Tenesa A, et al (2008). Modification of the inverse association between dietary vitamin D intake and colorectal cancer risk by a FokI variant supports a chemoprotective action of vitamin D intake mediated through VDR binding. Int J Cancer, 123, 2170-9.   DOI   ScienceOn
25 Touvier M, Chan DS, Lau R, et al (2011): Meta-analyses of vitamin D intake, 25-hydroxyvitamin D status, vitamin D receptor polymorphisms, and colorectal cancer risk. Cancer Epidemiol Biomarkers Prev, 20, 1003-16.   DOI   ScienceOn
26 Uitterlinden AG, Fang Y, Van Meurs JB, Pols HA, Van Leeuwen JP (2004). Genetics and biology of vitamin D receptor polymorphisms. Gene, 338, 143-56.   DOI   ScienceOn
27 Willett WC (1990). Nutritional Epidemiology. Oxford University Press, Oxford.
28 Wong HL, Seow A, Arakawa K, et al (2003). Vitamin D receptor start codon polymorphism and colorectal cancer risk: Effect modification by dietary calcium and fat in Singapore Chinese. Carcinogenesis, 24, 1091-5.   DOI
29 World Cancer Research Fund and American Institute for Cancer Research (2007). Food, Nutrition, Physical Activity and the Prevention of Cancer: A Global Perspective. American Institute for Cancer Research, Washington, DC.
30 Yamaji T, Iwasaki M, Sasazuki S, et al (2012). Association between plasma 25-hydroxyvitamin D and colorectal adenoma according to dietary calcium intake and vitamin D receptor polymorphism. Am J Epidemiol, 175, 236-44.   DOI
31 Yu K, Yang J, Hang Y, Song R, Lu Q (2014). Vitamin D receptor bsmi polymorphism and colorectal cancer risk: an updated analysis. Asian Pac J Cancer Prev, 15, 4801-7.   DOI
32 Zmuda JM, Cauley JA, Ferell RE (2000). Molecular epidemiology of vitamin D receptor gene variants. Epidemiol Rev, 22, 203-17.   DOI