• The Journal of the Acoustical Society of Korea
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• v.32 no.2
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• pp.131-137
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• 2013

In this paper we propose an improved voice activity detection (VAD) algorithm using statistical models in the signal subspace domain. A uncorrelated signal subspace is generated using embedded prewhitening technique and the statistical characteristics of the noisy speech and noise are investigated in this domain. According to the characteristics of the signals in the signal subspace, a new statistical VAD method using GGD (Generalized Gaussian Distribution) is proposed. Experimental results show that the proposed GGD-based approach outperforms the Gaussian-based signal subspace method at 0-15 dB SNR simulation conditions.

• Proceedings of the KOSOMBE Conference
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• v.1995 no.05
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• pp.247-250
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• 1995

The purpose of this paper is to develop diaphragm-type pneumatic ventricular assist device(VAD) for clinical application and to evaluate its performance through the mock circulation system. The blood housing and diaphragm are made by coating pellethane on the metallic mold and the back plate is made by machining process. The relations of cardiac output(CO) vs. beat rate and CO vs. systolic-to-diastolic rate was estimated through the mock test and hemodynamic waves are recorded for the evaluation of VAD. As a result, the volume of blood pump is 70 ml, maximum CO is 5 L/min and CO has a close relation to the input resistance of blood pump. The hemodynamic data and waves showed this system can be applicable to the animal experiment.

• The Journal of the Acoustical Society of Korea
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• v.28 no.3
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• pp.285-289
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• 2009

In this paper, we propose a novel double-talk detection (DTD) technique based on soft decision in the frequency domain. In the proposed method, global near-end speech presence probability (GNSPP) considering the statistical model assumption and voice activity detection (VAD) decision of the near-end and far-end signal are applied to the DTD algorithm in the frequency domain instead of the traditional hard decision scheme using cross-correlation coefficients. The performance of the proposed algorithm is evaluated by the objective test under various environments, and yields better results compared with the conventional scheme.

• The Journal of the Acoustical Society of Korea
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• v.27 no.8
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• pp.443-449
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• 2008

One of the key issues in practical speech processing is to achieve robust Voice Activity Deteciton (VAD) against the background noise. Most of the statistical model-based approaches have tried to employ equally weighted likelihood ratios (LRs), which, however, deviates from the real observation. Furthermore voice activities in the adjacent frames have strong correlation. In other words, the current frame is highly correlated with previous frame. In this paper, we propose the effective VAD approach based on a minimum classification error (MCE) method which is different from the previous works in that different weights are assigned to both the likelihood ratio on the current frame and the decision statistics of the previous frame.

• Korean Journal of Clinical Pharmacy
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• v.13 no.1
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• pp.29-39
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• 2003

Neurodegenerative disorders are associated with apoptosis as a causing factor or an inducer. On the other hand, it has been reported that epigallocatechin gallate (EUG), one of antioxidants and flavonoids, and z-VAD-fmk, a nonselective caspase inhibitor, suppress oxidative-radical-stress-induced apoptosis. However, it is not yet known what is the effects of EGCG and z-VAD-fmk on the apoptotic pathway is through phosphoinositide 3-kinase (PI3K), Akt and glycogen synthase kinase-3 (GSK-3) as well as mitochondria, caspase-3 and poly (ADP-ribose) polymerase (PARP). We investigated the effects of EGCG by using $H_2O_2$ treated N18D3 cells, mouse DRG hybrid neurons. Methods: Following 30 min $100\;{\mu}m\;H_2O_2$ exposure, the viability of N18D3 cells (not pretreated vs. EGCG or z-VAD-fmk pretreated) was evaluated by using MTT assay. The effect of EGCG on immunoreactivity (IR) of cytochrome c, caspase-3, PARP, PI3K/Akt and GSK-3 was examined by using Western blot, and was compared with that of z-Y4D-fmk. Results: EGCG or z-VAD-fmk pretreated N18D3 cells showed increased viability. Dose-dependent inhibition of caspase-3 activation accompanied by PARP cleavage were demonstrated by pretreatment of both agents. However, inhibition of cytochrome c release was only detected in EGCG pretreated N18D3 cells. On the pathway through PI3K/Akt and GSK-3, however, the result of Western blot in EGCG pretreated N18D3 cells showed decreased IR of Akt and GSK-3 and increased IR of p85a PI3K, phosphorylated Akt and GSK-3, and contrasted with that in z-VAD-fmk pretreated N18D3 cells showing no changes on each molecule. Conclusion: These data show that EGCG affects apoptotic pathway through upstream signal including PI3K/Akt and GSK-3 pathway as well as downstream signal including cytochrome c and caspase-3 pathway. Therefore, these results suggest that EGCG mediated activation of PI3K/Akt and inhibition GSK-B could be new potential therapeutic strategy for neurodegenerative diseases associated with oxidative injury.

• Journal of Life Science
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• v.16 no.1
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• pp.30-36
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• 2006

Neutrophils are short-lived leukocytes that play a vital role in immune responses to bacteria, yeast, and fungi. This study was performed to investigate the effect of 4-O-methyl-ascochlorin (MAC), an anti-tumor, antibiotic, and anti-fungal prenyl-phenol compound on the spontaneous apoptosis of human neutrophils. MAC time- and dose-dependently accelerated the spontaneous apoptosis of human neutrophils. The effect of MAC on neutrophil apoptosis was blocked by pre-treatment of the neutrophils with specific inhibitors of pancaspase (zVAD-fmk), caspase-8 (zIETD-fmk), or caspase-3 (zDEVD-fmk). The cleavage of procaspase-8 and procaspase-3 was increased by MAC. Mitochondrial permeability, which was measured by the retention of $DiOC_6(3)$, was dose-de-pendently increased by MAC but the change of mitochondrial permeability was not blocked by pretreatment of neutrophils with zIETD-fmk. These results suggest that MAC induces neutrophil apoptosis by caspase-8-dependent but mitochondria-independent manner.

• Journal of the KSME
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• v.34 no.4
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• pp.239-252
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• 1994

광섬유 모재제조공정인 OVD와 VAD방식에서의 입자부착 증진을 위해서 외부에서 전기장을 가 해서 실리카입자를 대전시킨 뒤에 타겟으로 부착을 시키는 전기영동원리를 이용하는 방법을 소 개하였다. 실험에서는 디스크형 타겟을 사용하여 타겟 근방에서의 온도, 전기장분포를 측정하였고 입자부착실험을 수행했다. 그 결과 9cm 타겟에 -1.6kv가 가해\ulcorner을 때 전기영동으로 인한 부착률 증가는 열영동으로 인한 효과의 약 35%가 되었다.

• Journal of the Institute of Electronics Engineers of Korea SP
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• v.49 no.3
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• pp.81-88
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• 2012

In this paper, we propose a novel speech enhancement algorithm for effective noise suppression in various noisy environments. In the proposed method, to result in improved decision performance for speech and noise segments, local speech absence probability (LSAP, local SAP) based on Teager energy of noisy speech is used as the feature parameter for voice activity detection (VAD) in each frequency subband instead of conventional LSAP. In addition, The presented method utilizes global SAP (GSAP) derived in each frame as the weighting parameter for the modification of the adopted TE operator to improve the performance of TE operator. Performances of the proposed algorithm are evaluated by objective test under various environments and better results compared with the conventional methods are obtained.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.41 no.8
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• pp.851-858
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• 2016

This paper presents a new statistical voice activity detection (VAD) based on the probabilistic interpretation of nonnegative matrix factorization (NMF). The objective function of the NMF using Kullback-Leibler divergence coincides with the negative log likelihood function of the data if the distribution of the data given the basis and encoding matrices is modeled as Poisson distributions. Based on this probabilistic NMF, the VAD is constructed using the likelihood ratio test assuming that speech and noise follow Poisson distributions. Experimental results show that the proposed approach outperformed the conventional Gaussian model-based and NMF-based methods at 0-15 dB signal-to-noise ratio simulation conditions.

• Transactions of the Korean Society for Noise and Vibration Engineering
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• v.24 no.4
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• pp.282-288
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• 2014

Three-dimensional multimedia industry such as 3D TV, movie and broadcast has been developed vividly. For generating 3D contents with high quality, virtual auditory display, so called VAD, is being researched to offer more realistic experience to listeners. When people render VAD using headphones or two speakers, head-related transfer function(HRTF) plays a key role. The best solution is measuring all individuals' HRTFs, but it is hard to measure all listeners' HRTFs. To overcome this difficulty, many research groups have tried to construct their own measurement system and to build HRTF databases. However, some of them have not enough subjects or spatial resolution and they are mainly focused on Caucasian. There exists difference between Korean and Caucasian in a view of physical features. In other words, if Koreans hear three-dimensional sound rendered by HRTF database based on Caucasian, performance might be hindered. To verify this possibility and remedy the drawbacks, construction of new HRTF database aimed at Korean is needed. Therefore, our laboratory built HRTF measurement system which can measure HRTF of three-dimensional space with dense spatial resolution. With this system, 55 Korean males and 45 females' HRTFs were measured and Korean HRTF database was built based on these data.