• The Korean Journal of Physiology and Pharmacology
• /
• v.1 no.6
• /
• pp.741-748
• /
• 1997

In the present study, we have investigated the effect of metabolic inhibition on the inward rectifier K current ($I_{K1}$). Using whole cell patch clamp technique we applied voltage ramp from +80 mV to -140 mV at a holding potential of -30 mV and recorded the whole cell current in single ventricular myocytes isolated from the rabbit heart. The current-voltage relationship showed N-shape (a large inward current and little outward current with a negative slope) which is a characteristic of $I_{K1}$. Application of 0.2 mM dinitrophenol (DNP, an uncoupler of oxidative phosphorylation as a tool for chemical hypoxia) to the bathing solution with the pipette solution containing 5 mM ATP, produced a gradual increase of outward current followed by a gradual decrease of inward current with little change in the reversal potential (-80 mV). The increase of outward current was reversed by glibenclamide ($10\;{\mu}M$), suggesting that it is caused by the activation of $K_{ATP}$. When DNP and glibenclamide were applied at the same time or glibenclamide was pretreated, DNP produced same degree of reduction in the magnitude of the inward current. These results show that metabolic inhibition induces not only the increase of $K_{ATP}$ channel but also the decrease of $I_{K1}$. Perfusing the cell with ATP-free pipette solution induced the changes very similar to those observed using DNP. Long exposure of DNP (30 min) or ATP-free pipette solution produced a marked decrease of both inward and outward current with a significant change in the reversal potential. Above results suggest that the decrease of $I_{K1}$ may contribute to the depolarisation of membrane potential during metabolic inhibition.

• Magazine of the Korean Society of Agricultural Engineers
• /
• v.18 no.2
• /
• pp.4116-4120
• /
• 1976

With the use of many rivers increased nearly to the capacity, the need for information concerning daily quantities of water and the total annual or seasonal runoff has became increased. A systematic record of the flow of a river is commonly made in terms of the mean daily discharge Since. a single observation of stage is converted into discharge by means of rating curve, it is essential that the stage discharge relations shall be accurately established. All rating curves have the looping effect due chiefly to channel storage and variation in surface slope. Loop rating curves are most characteristic on streams with somewhat flatter gradients and more constricted channels. The great majority of gauge readings are taken by unskilled observers once a day without any indication of whether the stage is rising or falling. Therefore, normal rating curves shall show one discharge for one gauge height, regardless of falling or rising stage. The above reasons call for the correction of the discharge measurements taken on either side of flood waves to the theoretical steady-state condition. The correction of the discharge measurement is to consider channel storage and variation in surface slope. (1) Channel storage As the surface elevation of a river rises, water is temporarily stored in the river channel. There fore, the actual discharge at the control section can be attained by substracting the rate of change of storage from the measured discharge. (2) Variation in surface slope From the Manning equation, the steady state discharge Q in a channel of given roughness and cross-section, is given as {{{{Q PROPTO SQRT { 1} }}}} When the slope is not equal, the actual discharge will be {{{{ { Q}_{r CDOT f } PROPTO SQRT { 1 +- TRIANGLE I} CDOT TRIANGLE I }}}} may be expressed in the form of {{{{ TRIANGLE I= { dh/dt} over {c } }}}} and the celerity is approximately equal to 1.3 times the mean watrr velocity. Therefore, The steady-state discharge can be estimated from the following equation. {{{{Q= { { Q}_{r CDOT f } } over { SQRT { (1 +- { A CDOT dh/dt} over {1.3 { Q}_{r CDOT f }I } )} } }}}} If a sufficient number of observations are available, an alternative procedure can be applied. A rating curve may be drawn as a median line through the uncorrected values. The values of {{{{ { 1} over {cI } }}}} can be yielded from the measured quantities of Qr$.$f and dh/dt by use of Eq. (7) and (8). From the 1/cI v. stage relationship, new vlues of 1/cI are obtained and inserted in Eq. (7) and (8) to yield the steady-state discharge Q. The new values of Q are then plotted against stage as the corrected steadystate curve.

• Journal of the Korean Institute of Electrical and Electronic Material Engineers
• /
• v.16 no.1
• /
• pp.26-32
• /
• 2003

Then-channel poly-Si thin-film transistors (poly-Si TFT's) formed by solid phase crystallization (SPC) method on glass were measured to obtain the electrical parameters such as of I-V characteristics, mobility, leakage current, threshold voltage, and subthreshold slope. Then, devices were analyzed to obtain the reliability and appliability on TFT-LCD with large-size and high density. In n-channel poly-Si TFT with 5$\mu\textrm{m}$/2$\mu\textrm{m}$, 8$\mu\textrm{m}$, 30$\mu\textrm{m}$ devices of channel width/length, the field effect mobilities are 111, 116, 125 $\textrm{cm}^2$/V-s and leakage currents are 0.6, 0.1, and 0.02 pA/$\mu\textrm{m}$, respectively. Low threshold voltage and subthreshold slope, and good ON-OFF ratio are shown, as well. Thus. the poly-Si TFT's used by SPC are expected to be applied on TFT-LCD with large-size and high density, which can integrate the display panel and peripheral circuit on a targe glass substrate.

• Journal of the Korea institute for structural maintenance and inspection
• /
• v.20 no.3
• /
• pp.49-57
• /
• 2016

This study intended to analyze reinforcement effects of PSC I girder bridges to which prestresses are introduced using V type of external strands. So that series of bridge loading tests are carried out on existing PSC I girder bridge for the cases of before-reinforcement and reinforcement. The measured results from tests being analyzed and compared with the ones from MIDAS structural analyzing program, the reinforcing effects of the reinforcement system adopted in this study were investigated. It is found out that when the V type systems are applied to the bridge girders, the slope of load distribution factor curves become lower improving soundness of bridge upper structure. And also it is confirmed that the reinforcement system in this study can be taken as helpful for improvement of both flexural and shear ability of PSC I girder bridges, as well as dynamic behavior. Furthermore it is found when the elastic pads are applied to the system, dynamic reinforcing effects are maximized.

• Proceedings of the KSRS Conference
• /
• v.2
• /
• pp.1007-1010
• /
• 2006

This study investigates the spatial structure of the total cloud liquid water content Q fields over the Northwest Pacific Ocean during winter monsoon. The distributions of Q have been estimated from the brightness temperatures of the ocean - atmosphere system $T_B(f)$, where f is frequency, measured by AQUA AMSR-E in January -March 2003. Marine strati (St) and stratocumuli (Sc) are typical for winter monsoon season. They were analysed using mainly high-frequency channel at f = 36.5 GHz, vertical polarisation. $T_B$ data were accompanied by the data on near surface wind speed, air temperature and humidity from the nearest meteorological stations. Tow one-dimensional spectra were computed for downwind and crosswind sections of Q fields. The AMSR-E antenna field of view (14-8 km) and the cloud field sizes (100-1000 km) restricted the spatial scales. The results of case study Jan 31 2003 are presented. Scale-invariant spectrum is typical. In the cases of extended St levels a spectral slope equals about -1.7, conforming to classical -5/3 of turbulence theory. For Sc cases the absolute magnitude of spectral slope is rather higher, as a rule. The value is about -2. In the case when cloud streets are presented, a strait line form of spectrum is less reliable with a slope being rather lower (about -1.4).

• Journal of the Korean Chemical Society
• /
• v.62 no.4
• /
• pp.269-274
• /
• 2018

Surface renewable nano-$RuO_2$/poly(methyl methacrylate) polymeric composite pH electrodes were prepared. The composite electrode with 53 wt% of nano-$RuO_2$ showed similar good response characteristics to nano-$IrO_2$ composite electrode reported earlier. It showed response slope of -58.7 mV/pH, response time of <1 s, surface renewability of $-57.0{\pm}0.3mV/pH$ (n=5) and long time stability for a month as well as low interferences but high interferences by electrochemically active species like $I^-$ and $Fe(CN){_6}^{3-}$. However, the response slope and time became worse at higher pH than 9 compared to those of nano-$IrO_2$ composite electrodes possibly due to the difference of physical properties resulting from higher content of nano-$RuO_2$ in polymeric composite matrix.

• Bulletin of the Korean Chemical Society
• /
• v.23 no.10
• /
• pp.1409-1412
• /
• 2002

Polymeric membrane electrodes for acetate anion based on meso-(${\alpha}$,${\alpha}$,${\alpha}$,${\alpha}$)-5,10,15,20-tetrakis[2-(penta-fluorophenylurea) phenyl]porphyrin I and similar urea-functionalized porphyrins Ⅱ-Ⅳ as neutral ionophores were prepared. The membrane based on porphyrin I exhibits the best potentiometric properties in pH 6.0 rather than pH 7.0: linear stable response over a wide concentration range (6.0 ${\times}$$10^{-5}$-1.0 ${\times}$$10^{-2}$) with a slope of -59.6 mV/decade and a detection limit of log[CH3CO$O^-$] = -5.32. Selectivity coefficients obtained from the matched potential method (MPM) in pH 6.0 indicate that interferences of hydrophobic anions are very small for the membranes of porphyrins I and II having the strong withdrawing group. The electronic effect of urea-functionalized porphyrins and pH effect of buffer solutions are discussed on the potentiometric response.

• Bulletin of the Korean Chemical Society
• /
• v.27 no.12
• /
• pp.1985-1988
• /
• 2006

The polymeric membrane electrodes based on urea derivative as an ionophore were prepared and studied for the iodide-ion selective electrode. This membrane exhibits a linear stable response over a wide concentration range ($1.0\;{\times}\;10^{-5}\sim1.0\;{\times}\;10^{-2}$) with a slope of -57.7 mV/decade, a detection limit of log[$I^-$] = -5.63, and a selectivity coefficient for iodide against perchlorate anion (log$K^{pot}_{I^-,j}$ = -1.42). The selectivity series of the membrane gives the follow as $I^-$ > $SCN^-$, $Sal^-$ > $ClO_4^-$ > $NO_3^-$ > $Br^-$ > $NO_2^-$ > $Cl^-$ > $F^-$. The proposed electrode showed good selectivity and response for iodide anion over a wide variety of other anions in pH 5.0 buffer solutions.

• Bulletin of the Korean Chemical Society
• /
• v.22 no.12
• /
• pp.1345-1349
• /
• 2001

New quadruply-bridged calix[6]arenes (I-V) have been studied as cesium selective ionophores in poly(vinyl chloride) (PVC) membrane electrodes. PVC membranes were prepared with dioctyl sebacate (DOS) or 2-nitrophenyl octyl ether (o-NPOE) as the sol vent mediator and potassium tetrakis(p-chlorophenyl)borate as the lipophilic salt additive. These ionophores produced electrodes with near-Nernstian slope. The selectivity coefficients for cesium ion with respect to alkali, alkaline earth and ammonium ions have been determined. The lowest detection limit (logaCs+ = -6.3) and the higher selectivity coefficient (logkpotCs+,Rb+ = -2.1 by SSM, -2.3 by FIM for calix[6]arene I) for Cs+ have been obtained for membranes containing quadruply-bridged calix[6]arenes (I, Ⅱ, Ⅲ), which have no para t-butyl substituents on the bridging benzene ring.

• Journal of the Korea Institute of Military Science and Technology
• /
• v.23 no.5
• /
• pp.502-515
• /
• 2020

To identify the dynamic characteristics of the Auto-leveling system applied to the Tractor-Trailer type Transporter for mounting a large scale precision equipment, Dynamics Modeling & Simulation were performed using general Dynamics Analysis Program - RecurDyn(V9R2). The axial load data, transverse load data and pad trace data of leveling actuators were obtained from M&S. And they were analyzed and compared with each other by parameters, i.e. friction coefficients on the ground, landing ram speed of actuators, and direction & quantity of ground slope. It was observed that ground contact friction coefficients affected to transverse load and pad trace; the landing ram speed of actuators to both amplitude of axial & transverse load, and this phenomena was able to explain from the frequency analysis of the axial load data; the direction of ground slope to driving sequence of landing ram of actuators. But the dynamic behaviors on the two-directional slope were very different from them on the one-directional slope and more complex.